The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children
Open accessAbstract
We report neurodevelopmental outcomes in 216 infants followed since the time of PCR-confirmed maternal Zika virus (ZIKV) infection in pregnancy during the Rio de Janeiro epidemic of 2015–2016 (refs. 1,2). Neurodevelopment was assessed by Bayley Scales of Infant and Toddler Development, third edition (Bayley-III; cognitive, language and motor domains) in 146 children and through neurodevelopment questionnaires/neurological examinations in 70 remaining children. Complete eye exams (n = 137) and hearing assessments (n = 114) were also performed. Below-average neurodevelopment and/or abnormal eye or hearing assessments were noted in 31.5% of children between 7 and 32 months of age. Among children assessed by Bayley-III, 12% scored below –2 s.d. (score <70; a score of 100 ± 2 s.d. is the range) in at least one domain; and 28% scored between −1 and −2 s.d. in any domain (scores <85–70). Language function was most affected, with 35% of 146 children below average. Improved neurodevelopmental outcomes were noted in female children, term babies, children with normal eye exams and maternal infection later in pregnancy (P = 0.01). We noted resolution of microcephaly with normal neurodevelopment in two of eight children, development of secondary microcephaly in two other children and autism spectrum disorder in three previously healthy children in the second year of life. Nearly one-third of infants born to mothers with confirmed Zika virus (ZIKV) infection during pregnancy have developmental impairments that can be delayed in their presentation, warranting long-term monitoring of ZIKV-exposed children.
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Citations
Cites
Zika Virus Infection in Pregnant Women in Rio de Janeiro
Brasil, P., Pereira, J. P., Moreira, M. E., Ribeiro Nogueira, R. M., Damasceno, L., Wakimoto, M., Rabello, R. S., Valderramos, S. G., Halai, U.-A., Salles, T. S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1602412 · Cited by 2,196
Self-citationLanciotti, R. S., Kosoy, O. L., Laven, J. J., Velez, J. O., Lambert, A. J., Johnson, A. J., Stanfield, S. M., & Duffy, M. R. (2008) · Emerging Infectious Diseases · doi:10.3201/eid1408.080287 · Cited by 2,173
Bayley Scales of Infant and Toddler Development, Third Edition
Bayley, N. (2012) · PsycTESTS Dataset · doi:10.1037/t14978-000 · Cited by 1,175
Characterizing the Pattern of Anomalies in Congenital Zika Syndrome for Pediatric Clinicians
Moore, C. A., Staples, J. E., Dobyns, W. B., Pessoa, A., Ventura, C. V., Fonseca, E. B. D., Ribeiro, E. M., Ventura, L. O., Neto, N. N., Arena, J. F., et al. (2017) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2016.3982 · Cited by 960
Bayley Scales of Infant and Toddler Development
Aylward, G. P. (2017) · Encyclopedia of Clinical Neuropsychology · doi:10.1007/978-3-319-56782-2_1522-2 · Cited by 938
Honein, M. A., Dawson, A. L., Petersen, E. E., Jones, A. M., Lee, E. H., Yazdy, M. M., Ahmad, N., Macdonald, J., Evert, N., Bingham, A., et al. (2017) · JAMA · doi:10.1001/jama.2016.19006 · Cited by 765
Underestimation of Developmental Delay by the New Bayley-III Scale
Anderson, P. J. (2010) · Archives of Pediatrics & Adolescent Medicine · doi:10.1001/archpediatrics.2010.20 · Cited by 497
van der Linden, V., Pessoa, A., Dobyns, W., Barkovich, A. J., Júnior, H. V. D. L., Filho, E. L. R., Ribeiro, E. M., Leal, M. D. C., Coimbra, P. P. D. A., Aragão, M. D. F. V. V., et al. (2016) · MMWR. Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm6547e2 · Cited by 443
Sex Differences in Pediatric Infectious Diseases
Muenchhoff, M., & Goulder, P. J. R. (2014) · Journal of Infectious Diseases · doi:10.1093/infdis/jiu232 · Cited by 406
Congenital Zika Virus Infection: Beyond Neonatal Microcephaly
Melo, A. S. D. O., Aguiar, R. S., Amorim, M. M. R., Arruda, M. B., Melo, F. D. O., Ribeiro, S. T. C., Batista, A. G. M., Ferreira, T., dos Santos, M. P., Sampaio, V. V., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.3720 · Cited by 406
Cited by
Wells, M. F., Nemesh, J., Ghosh, S., Mitchell, J. M., Salick, M. R., Mello, C. J., Meyer, D., Pietilainen, O., Piccioni, F., Guss, E. J., et al. (2023) · Cell Stem Cell · doi:10.1016/j.stem.2023.01.010 · Cited by 116
Long-term alterations in brain and behavior after postnatal Zika virus infection in infant macaques
Raper, J., Kovacs-Balint, Z., Mavigner, M., Gumber, S., Burke, M. W., Habib, J., Mattingly, C., Fair, D., Earl, E., Feczko, E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16320-7 · Cited by 67
Neurocognitive impacts of arbovirus infections
Clé, M., Eldin, P., Briant, L., Lannuzel, A., Simonin, Y., Van de Perre, P., Cabié, A., & Salinas, S. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01904-3 · Cited by 67
Juntos: A Support Program for Families Impacted by Congenital Zika Syndrome in Brazil
Duttine, A., Smythe, T., Calheiros de Sa, M. R., Ferrite, S., Moreira, M. E., & Kuper, H. (2020) · Global Health: Science and Practice · doi:10.9745/ghsp-d-20-00018 · Cited by 18
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Metadata
- Authors
- Nielsen-Saines, K., Brasil, P., Kerin, T., Vasconcelos, Z., Gabaglia, C. R., Damasceno, L., Pone, M., Abreu de Carvalho, L. M., Pone, S. M., Zin, A. A., Tsui, I., Salles, T. R. S., da Cunha, D. C., Costa, R. P., Malacarne, J., Reis, A. B., Hasue, R. H., Aizawa, C. Y. P., Genovesi, F. F., Einspieler, C., Marschik, P. B., Pereira, J. P., Gaw, S. L., Adachi, K., Cherry, J. D., Xu, Z., Cheng, G., & Moreira, M. E.
- Venue
- Nature Medicine
- Published
- 2019-07-08
- Volume
- 25
- Issue
- 8
- Pages
- 1213-1217
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W2961245124
- Cited by
- 268
- References
- 37
- FWCI
- 33.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Nielsen-Saines, K., Brasil, P., Kerin, T., Vasconcelos, Z., Gabaglia, C. R., Damasceno, L., Pone, M., Abreu de Carvalho, L. M., Pone, S. M., Zin, A. A., Tsui, I., Salles, T. R. S., da Cunha, D. C., Costa, R. P., Malacarne, J., Reis, A. B., Hasue, R. H., Aizawa, C. Y. P., Genovesi, F. F., . . . Moreira, M. E. (2019). Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children. Nature Medicine. https://doi.org/10.1038/s41591-019-0496-1
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
