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Cited by 328Gut microbiota and healthGastrointestinal motility and disordersBariatric Surgery and Outcomes

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled phase 2 trial

Mocanu, Valentin, Zhang, Zhengxiao, Deehan, Edward C., Kao, Dina H., Hotte, Naomi, Karmali, Shahzeer, Birch, Daniel W., Samarasinghe, Kalutota K., Walter, Jens, Madsen, Karen L.·2021·Nature Medicine
DOI 10.1038/s41591-021-01399-2
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Abstract

Fecal microbial transplantation (FMT) from lean donors to patients with obesity has been associated with metabolic benefits, yet results so far have been inconsistent. In this study, we tested the application of daily fiber supplementation as an adjunct to FMT therapy to modulate cardiometabolic outcomes. We performed a double-blind randomized trial in patients with severe obesity and metabolic syndrome receiving oral FMT, to test high-fermentable (HF) and low-fermentable (LF) fiber supplements (NCT03477916). Seventy participants were randomized to the FMT-HF (n = 17), FMT-LF (n = 17), HF (n = 17) and LF (n = 19) groups. The primary outcome was the assessment of change in insulin sensitivity from baseline to 6 weeks using the homeostatic model assessment (HOMA2-IR/IS). After 6 weeks, only patients in the FMT-LF group had significant improvements in HOMA2-IR (3.16 ± 3.01 at 6 weeks versus 3.77 ± 3.57 at baseline; P = 0.02). No difference in HOMA2-IR was observed over this period for those in the FMT-HF group (3.25 ± 1.70 at 6 weeks versus 3.17 ± 1.72 at baseline; P = 0.8), the HF group (3.49 ± 1.43 at 6 weeks versus 3.26 ± 1.33 at baseline; P = 0.8) or the LF group (3.76 ± 2.01 at 6 weeks versus 3.56 ± 1.81 at baseline; P = 0.8). Interventions were safe and well-tolerated with no treatment-attributed serious adverse events. We provide proof of concept for the use of a single-dose oral FMT combined with daily low-fermentable fiber supplementation to improve insulin sensitivity…

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Crossref · 10.1038/s41591-021-01399-2

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Citations

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Research works printed but not linked: 1

  1. Chis, R., Sheth, P. M. & Petrof, E. O. in Mechanisms Underlying Host–Microbiome Interactions in Pathophysiology of Human Diseases. Physiology in Health and Disease (eds Sun, J. & Dudeja, P.) Ch. 11 (Springer, 2018).

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Metadata

Authors
Mocanu, V., Zhang, Z., Deehan, E. C., Kao, D. H., Hotte, N., Karmali, S., Birch, D. W., Samarasinghe, K. K., Walter, J., & Madsen, K. L.
Affiliations
  • University of Alberta (CA)
  • University College Cork (IE)
Corresponding author
Madsen, Karen L.
ORCID
Venue
Nature Medicine
Publisher
Springer Science and Business Media LLC
Published
2021-07
Volume
27
Issue
7
Pages
1272-1279
ISSN
  • 1078-8956 (ISSN-L)
  • 1546-170X
DOI
10.1038/s41591-021-01399-2
OpenAlex
W3182371690
Cited by
328
References
55
Citations by year
2026: 51 · 2025: 77 · 2024: 67 · 2023: 56 · 2022: 65 · 2021: 12
FWCI
15.85
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Nature Medicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Gouvernement du Canada | Canadian Institutes of Health Research
  • University of Alberta Clinical Investigator Program
  • Canadian Institutes for Health Research.
  • The W. Garfield Weston Foundation.
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
Keywords
fecal microbiota transplantation, dietary fiber supplementation, morbid obesity, metabolic syndrome, insulin sensitivity, cardiometabolic outcomes, gut microbiota
MeSH terms
Gastrointestinal Microbiome, Fecal Microbiota Transplantation, Proof of Concept Study, Dietary Fiber, Double-Blind Method, Female, Fermentation, Humans, Insulin Resistance, Male, Middle Aged, Obesity, Morbid, Dietary Supplements, Metabolic Syndrome

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