The influence of the gut microbiome on obesity, metabolic syndrome and gastrointestinal disease

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

A human gut microbial gene catalogue established by metagenomic sequencing

MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624 · see citing works

Immunity, Inflammation, and Cancer

Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755 · see citing works

Diet rapidly and reproducibly alters the human gut microbiome

David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works

The gut microbiota as an environmental factor that regulates fat storage

Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., et al. (2001) · Nature · doi:10.1038/35079114 · Cited by 5,030 · see citing works

<i>Faecalibacterium prausnitzii</i> is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works

Functional interactions between the gut microbiota and host metabolism

Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works

Interactions Between the Microbiota and the Immune System

Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173 · see citing works

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605 · see citing works

Gut flora in health and disease

Guarner, F., & Malagelada, J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12489-0 · Cited by 3,395 · see citing works

Systematic review: the epidemiology and natural history of non‐alcoholic fatty liver disease and non‐alcoholic steatohepatitis in adults

Vernon, G. C., Baranova, A. V., & Younossi, Z. M. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04724.x · Cited by 3,067 · see citing works

Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome

Vrieze, A., Van Nood, E., Holleman, F., Salojärvi, J., Kootte, R. S., Bartelsman, J. F. W. M., Dallinga–Thie, G. M., Ackermans, M. T., Serlie, M. J., Oozeer, R., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.06.031 · Cited by 2,913 · see citing works

Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615 · see citing works

Global burden of cancers attributable to infections in 2008: a review and synthetic analysis

de Martel, C., Ferlay, J., Franceschi, S., Vignat, J., Bray, F., Forman, D., & Plummer, M. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70137-7 · Cited by 2,540 · see citing works

Pathogenesis of <i>Helicobacter pylori</i> Infection

Kusters, J. G., van Vliet, A. H. M., & Kuipers, E. J. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00054-05 · Cited by 2,526 · see citing works

Microbiota and SCFA in lean and overweight healthy subjects

Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D. (2010) · Obesity · doi:10.1038/oby.2009.167 · Cited by 2,457 · see citing works

Intestinal inflammation targets cancer-inducing activity of the microbiota

Arthur, J. C., Perez-Chanona, E., Mühlbauer, M., Tomkovich, S., Uronis, J. M., Fan, T.-J., Campbell, B. J., Abujamel, T., Dogan, B., Rogers, A. B., et al. (2012) · Science · doi:10.1126/science.1224820 · Cited by 2,263 · see citing works

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068 · see citing works

Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences

Cox, L. M., Yamanishi, S., Sohn, J., Alekseyenko, A. V., Leung, J. M., Cho, I., Kim, S. G., Li, H., Gao, Z., Mahana, D., et al. (2014) · Cell · doi:10.1016/j.cell.2014.05.052 · Cited by 1,859 · see citing works

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses

Wu, S., Rhee, K.-J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H.-R., Huso, D. L., Brancati, F. L., Wick, E., McAllister, F., et al. (2009) · Nature Medicine · doi:10.1038/nm.2015 · Cited by 1,812 · see citing works

The Microbiome in Inflammatory Bowel Disease: Current Status and the Future Ahead

Kostic, A. D., Xavier, R. J., & Gevers, D. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.009 · Cited by 1,789 · see citing works

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564 · see citing works

Structures of Gram-Negative Cell Walls and Their Derived Membrane Vesicles

Beveridge, T. J. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.16.4725-4733.1999 · Cited by 1,533 · see citing works

The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions

Johansson, M., Larsson, J. M. H., & Hansson, G. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006451107 · Cited by 1,459 · see citing works

Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk

Wroblewski, L. E., Peek, R. M., & Wilson, K. T. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00011-10 · Cited by 1,455 · see citing works

Lactobacillus and bifidobacterium in irritable bowel syndrome: Symptom responses and relationship to cytokine profiles

O’Mahony, L., McCarthy, J., Kelly, P., Hurley, G., Luo, F., Chen, K., O’Sullivan, G. C., Kiely, B., Collins, J. K., Shanahan, F., et al. (2005) · Gastroenterology · doi:10.1053/j.gastro.2004.11.050 · Cited by 1,448 · see citing works

The Antibacterial Lectin RegIIIγ Promotes the Spatial Segregation of Microbiota and Host in the Intestine

Vaishnava, S., Yamamoto, M., Severson, K. M., Ruhn, K. A., Yu, X., Koren, O., Ley, R., Wakeland, E. K., & Hooper, L. V. (2011) · Science · doi:10.1126/science.1209791 · Cited by 1,412 · see citing works

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms

Lin, H. V., Frassetto, A., Kowalik Jr, E. J., Nawrocki, A. R., Lu, M. M., Kosinski, J. R., Hubert, J. A., Szeto, D., Yao, X., Forrest, G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035240 · Cited by 1,378 · see citing works

Adenoma–linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth

Grivennikov, S. I., Wang, K., Mucida, D., Stewart, C. A., Schnabl, B., Jauch, D., Taniguchi, K., Yu, G.-Y., Österreicher, C. H., Hung, K. E., et al. (2012) · Nature · doi:10.1038/nature11465 · Cited by 1,327 · see citing works

Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors

Benson, A. K., Kelly, S. A., Legge, R., Ma, F., Low, S. J., Kim, J., Zhang, M., Oh, P. L., Nehrenberg, D., Hua, K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007028107 · Cited by 1,314 · see citing works

Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease

Ott, S. J., Musfeldt, M., Wenderoth, D. F., Hampe, J., Brant, O., Fölsch, U. R., Timmis, K. N., & Schreiber, S. (2004) · Gut · doi:10.1136/gut.2003.025403 · Cited by 1,311 · see citing works

Gut Microbiota and Metabolic Endotoxemia in Young Obese Mexican Subjects

Radilla-Vázquez, R. B., Parra‐Rojas, I., Martínez-Hernández, N. E., Márquez‐Sandoval, F., Illades‐Aguiar, B., & Castro-Alarcón, N. (2016) · Obesity Facts · doi:10.1159/000442479 · Cited by 1,200 · see citing works

<i>Escherichia coli</i> Induces DNA Double-Strand Breaks in Eukaryotic Cells

Nougayrède, J.-P., Homburg, S., Taieb, F., Boury, M., Brzuszkiewicz, E., Gottschalk, G., Buchrieser, C., Hacker, J., Dobrindt, U., & Oswald, E. (2006) · Science · doi:10.1126/science.1127059 · Cited by 1,188 · see citing works

Rifaximin Therapy for Patients with Irritable Bowel Syndrome without Constipation

Pimentel, M., Lembo, A., Chey, W. D., Zakko, S., Ringel, Y., Yu, J., Mareya, S. M., Shaw, A. L., Bortey, E., & Forbes, W. P. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1004409 · Cited by 1,036 · see citing works

AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes

Winder, W. W., & Hardie, D. G. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.1.e1 · Cited by 1,000 · see citing works

Interactions Between the Intestinal Microbiome and Liver Diseases

Schnabl, B., & Brenner, D. A. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.020 · Cited by 971 · see citing works

Probiotics and antibodies to TNF inhibit inflammatory activity and improve nonalcoholic fatty liver disease

Li, Z., Yang, S., Lin, H., Huang, J., Watkins, P. A., Moser, A. B., Desimone, C., Song, X.-Y., & Diehl, A. M. (2003) · Hepatology · doi:10.1053/jhep.2003.50048 · Cited by 930 · see citing works

Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice

Wang, J., Tang, H., Zhang, C., Zhao, Y., Derrien, M., Rocher, E., Vlieg, J. E. V. H., Strissel, K. J., Zhao, L., Obin, M. S., et al. (2014) · The ISME Journal · doi:10.1038/ismej.2014.99 · Cited by 833 · see citing works

Microbes, Microbiota, and Colon Cancer

Sears, C. L., & Garrett, W. S. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.02.007 · Cited by 820 · see citing works

Efficacy of an Encapsulated Probiotic Bifidobacterium infantis 35624 in Women with Irritable Bowel Syndrome

Whorwell, P. J., Altringer, L., Morel, J., Bond, Y., Charbonneau, D., O'Mahony, L., Kiely, B., Shanahan, F., & Quigley, E. M. M. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00734.x · Cited by 799 · see citing works

Eradication of Small Intestinal Bacterial Overgrowth Reduces Symptoms of Irritable Bowel Syndrome

Pimentel, M., Chow, E. J., & Lin, H. C. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.03368.x · Cited by 780 · see citing works

Intestinal microbiota in patients with nonalcoholic fatty liver disease

Mouzaki, M., Comelli, E. M., Arendt, B. M., Bonengel, J., Fung, S. K., Fischer, S. E., McGilvray, I. D., & Allard, J. P. (2013) · Hepatology · doi:10.1002/hep.26319 · Cited by 749 · see citing works

Dysbiosis in inflammatory bowel disease

Tamboli, C. P., Neut, C., Desreumaux, P., & Colombel, J. F. (2004) · Gut · doi:10.1136/gut.53.1.1 · Cited by 743 · see citing works

The human gut microbiome: ecology and recent evolutionary changes

Walter, J., & Ley, R. (2011) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102830 · Cited by 720 · see citing works

Regulation of abdominal adiposity by probiotics (Lactobacillus gasseri SBT2055) in adults with obese tendencies in a randomized controlled trial

Kadooka, Y., Sato, M., Imaizumi, K., Ogawa, A., Ikuyama, K., Akai, Y., Okano, M., Kagoshima, M., & Tsuchida, T. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.19 · Cited by 700 · see citing works

Fecal Microbiome and Volatile Organic Compound Metabolome in Obese Humans With Nonalcoholic Fatty Liver Disease

Raman, M., Ahmed, I., Gillevet, P. M., Probert, C. S., Ratcliffe, N. M., Smith, S., Greenwood, R., Sikaroodi, M., Lam, V., Crotty, P., et al. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.02.015 · Cited by 672 · see citing works

Alteration of Intestinal Microflora Is Associated With Reduction in Abdominal Bloating and Pain in Patients With Irritable Bowel Syndrome

Nobaek, S., Johansson, M.-L., Molin, G., Ahrné, S., & Jeppsson, B. (2000) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02015.x · Cited by 653 · see citing works

Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans

Fernandes, J., Su, W., Rahat-Rozenbloom, S., Wolever, T. M. S., & Comelli, E. M. (2014) · Nutrition &amp; Diabetes · doi:10.1038/nutd.2014.23 · Cited by 628 · see citing works

Helicobacter exploits integrin for type IV secretion and kinase activation

Kwok, T., Zabler, D., Urman, S., Rohde, M., Hartig, R., Weßler, S., Misselwitz, R., Berger, J., Sewald, N., König, W., et al. (2007) · Nature · doi:10.1038/nature06187 · Cited by 619 · see citing works

Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

Ohnishi, N., Yuasa, H., Tanaka, S., Sawa, H., Miura, M., Matsui, A., Higashi, H., Musashi, M., Iwabuchi, K., Suzuki, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711183105 · Cited by 593 · see citing works

Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency

Spencer, M. D., Hamp, T. J., Reid, R. W., Fischer, L. M., Zeisel, S. H., & Fodor, A. A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.11.049 · Cited by 593 · see citing works

Invasive potential of gut mucosa-derived fusobacterium nucleatum positively correlates with IBD status of the host

Strauss, J., Kaplan, G. G., Beck, P. L., Rioux, K. P., Panaccione, R., DeVinney, R., Lynch, T., & Allen‐Vercoe, E. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21606 · Cited by 574 · see citing works

Antibiotic therapy in inflammatory bowel disease: A systematic review and meta-analysis

Khan, K. J., Ullman, T. A., Ford, A. C., Abreu, M. T., Abadir, A., Marshall, J. K., Talley, N. J., & Moayyedi, P. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.72 · Cited by 569 · see citing works

Helicobacter infection and gastric neoplasia

Peek, R. M., & Crabtree, J. E. (2005) · The Journal of Pathology · doi:10.1002/path.1868 · Cited by 549 · see citing works

Childhood overweight after establishment of the gut microbiota: the role of delivery mode, pre-pregnancy weight and early administration of antibiotics

Ajslev, T. A., Andersen, C. S., Gamborg, M., Sørensen, T. I. A., & Jess, T. (2011) · International Journal of Obesity · doi:10.1038/ijo.2011.27 · Cited by 534 · see citing works

Double blind, placebo controlled trial of metronidazole in Crohn's disease.

Sutherland, L. R., Singleton, J., Sessions, J. T., Hanauer, S., Krawitt, E. L., Rankin, G. B., Summers, R. J., Mekhjian, H. S., Greenberger, N. J., & Kelly, M. (1991) · Gut · doi:10.1136/gut.32.9.1071 · Cited by 527 · see citing works

Inflammation and Intestinal Metaplasia of the Distal Esophagus Are Associated With Alterations in the Microbiome

Yang, L., Lü, X., Nossa, C. W., François, F., Peek, R. M., & Pei, Z. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.04.046 · Cited by 488 · see citing works

Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype

Cougnoux, A., Dalmasso, G., Martinez, R., Buc, E., Delmas, J., Gibold, L., Sauvanet, P., Darcha, C., Déchelotte, P., Bonnet, M., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-305257 · Cited by 486 · see citing works

Randomised clinical trial: the beneficial effects of <scp>VSL</scp>#3 in obese children with non‐alcoholic steatohepatitis

Alisi, A., Bedogni, G., Baviera, G., Giorgio, V., Porro, E., Paris, C., Giammaria, P., Reali, L., Anania, F., & Nobili, V. (2014) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/apt.12758 · Cited by 471 · see citing works

Volatile organic compounds from feces and their potential for diagnosis of gastrointestinal disease

Garner, C. E., Smith, S. J., Costello, B. D. L., White, P., Spencer, R. C., Probert, C. S., & Ratcliffem, N. M. (2007) · The FASEB Journal · doi:10.1096/fj.06-6927com · Cited by 442 · see citing works

Src Is the Kinase of the Helicobacter pylori CagA Protein in Vitro and in Vivo

Selbach, M., Moese, S., Hauck, C. R., Meyer, T. F., & Backert, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c100754200 · Cited by 414 · see citing works

Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells

Ma, X., Hua, J., & Li, Z. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.05.025 · Cited by 413 · see citing works

Role of the gut microbiota in defining human health

Fujimura, K. E., Slusher, N. A., Cabana, M. D., & Lynch, S. V. (2010) · Expert Review of Anti-infective Therapy · doi:10.1586/eri.10.14 · Cited by 408 · see citing works

Development of the human gastrointestinal microbiota and insights from high-throughput sequencing

Dominguez-Bello, M. G., Blaser, M. J., Ley, R. E., & Knight, R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.02.011 · Cited by 405 · see citing works

Weight Gain After Fecal Microbiota Transplantation

Alang, N., & Kelly, C. R. (2015) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofv004 · Cited by 403 · see citing works

Treatment of Ulcerative Colitis Using Fecal Bacteriotherapy

Borody, T. J., Warren, E. F., Leis, S., Surace, R., & Ashman, O. (2003) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200307000-00012 · Cited by 388 · see citing works

Pathogenesis of Helicobacter pylori infection

Camilo, V., Sugiyama, T., & Touati, E. (2017) · Helicobacter · doi:10.1111/hel.12405 · Cited by 377 · see citing works

Incidence and Epidemiology of Irritable Bowel Syndrome After a Large Waterborne Outbreak of Bacterial Dysentery

Marshall, J. K., Thabane, M. E., Garg, A. X., Clark, W. F., Salvadori, M. I., & Collins, S. M. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.053 · Cited by 370 · see citing works

Loss of intestinal core 1–derived O-glycans causes spontaneous colitis in mice

Fu, J., Wei, B., Wen, T., Johansson, M. E. V., Liu, X., Bradford, E., Thomsson, K. A., McGee, S., Mansour, L., Tong, M., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45538 · Cited by 366 · see citing works

Functional dysbiosis within the gut microbiota of patients with constipated‐irritable bowel syndrome

Chassard, C., Dapoigny, M. C., Scott, K. P., Crouzet, L., Del’Homme, C., Marquet, P., Martin, J. C., Pickering, G. P., Ardid, D., Eschalier, A., et al. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05007.x · Cited by 366 · see citing works

Effect of Probiotics on Inducing Remission and Maintaining Therapy in Ulcerative Colitis, Crohnʼs Disease, and Pouchitis: Meta-analysis of Randomized Controlled Trials

Shen, J., Zuo, Z.-X., & Mao, A.-P. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000437495.30052.be · Cited by 364 · see citing works

The Utility of Probiotics in the Treatment of Irritable Bowel Syndrome: A Systematic Review

Brenner, D. M., Moeller, M. J., Chey, W. D., & Schoenfeld, P. S. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.25 · Cited by 362 · see citing works

Two-Year Combination Antibiotic Therapy With Clarithromycin, Rifabutin, and Clofazimine for Crohn’s Disease

Selby, W. S., Pavli, P., Crotty, B. J., Florin, T., Radford‐Smith, G. L., Gibson, P. G., Mitchell, B., Connell, W., Read, R. B., Merrett, M. N., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.031 · Cited by 360 · see citing works

Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease

Miura, K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i23.7381 · Cited by 355 · see citing works

Effects of probiotics on nonalcoholic fatty liver disease: A meta-analysis

Ma, Y.-Y. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i40.6911 · Cited by 352 · see citing works

A role for the gut microbiota in IBS

Collins, S. M. (2014) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2014.40 · Cited by 351 · see citing works

Effect of <i>Lactobacillus rhamnosus</i> CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women

Sanchez, M., Darimont, C., Drapeau, V., Emady-Azar, S., Lepage, M., Rezzonico, E., Ngom-Bru, C., Berger, B., Philippe, L., Ammon-Zuffrey, C., et al. (2014) · British Journal of Nutrition · doi:10.1017/s0007114513003875 · Cited by 351 · see citing works

The role of peptide YY in appetite regulation and obesity

Karra, E., Chandarana, K., & Batterham, R. L. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.164269 · Cited by 336 · see citing works

Possible role of mycobacteria in inflammatory bowel disease

Chiodini, R. J., Kruiningen, H. J. V., Thayer, W. R., Merkal, R. S., & Coutu, J. A. (1984) · Digestive Diseases and Sciences · doi:10.1007/bf01317078 · Cited by 332 · see citing works

DSS induced colitis increases portal LPS levels and enhances hepatic inflammation and fibrogenesis in experimental NASH

Gäbele, E., Dostert, K., Hofmann, C., Wiest, R., Schölmerich, J., Hellerbrand, C., & Obermeier, F. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.02.035 · Cited by 324 · see citing works

Family and twin studies in inflammatory bowel disease

Halme, L. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i23.3668 · Cited by 323 · see citing works

Gastrointestinal Malignancy and the Microbiome

Abreu, M. T., & Peek, R. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.001 · Cited by 323 · see citing works

An antibiotic regimen for the treatment of active Crohn's disease: a randomized, controlled clinical trial of metronidazole plus ciprofloxacin.

Prantera, C., Zannoni, F., Scribano, M. L., Berto, E., Andreoli, A., Kohn, A., & Luzi, C. (1996) · PubMed · Cited by 309 · see citing works

Double-blind crossover trial of metronidazole versus placebo in chronic unremitting pouchitis

Madden, M., McIntyre, A. S., & Nicholls, R. J. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02093783 · Cited by 301 · see citing works

Improved glucose control and reduced body fat mass in free fatty acid receptor 2-deficient mice fed a high-fat diet

Bjursell, M., Admyre, T., Göransson, M., Marley, A. E., Smith, D. M., Oscarsson, J., & Bohlooly‐Y, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00229.2010 · Cited by 301 · see citing works

Lactobacillus rhamnosus GG protects against non-alcoholic fatty liver disease in mice

Ritze, Y., Bárdos, G., Claus, A., Ehrmann, V., Bergheim, I., Schwiertz, A., & Bischoff, S. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0080169 · Cited by 292 · see citing works

Lower Bifidobacteria counts in both duodenal mucosa-associated and fecal microbiota in irritable bowel syndrome patients

Kerckhoffs, A. P., Samsom, M., Rest, M. E. V. D., Vogel, J. D., Knol, J., Ben-Amor, K., & Akkermans, L. M. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.2887 · Cited by 289 · see citing works

Bacteriotherapy Using Fecal Flora: Toying With Human Motions

Borody, T. J., Warren, E. F., Leis, S. M., Surace, R., Ashman, O., & Siarakas, S. (2004) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000128988.13808.dc · Cited by 283 · see citing works

The Efficacy and Safety of Rifaximin for the Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis

Menees, S. B., Maneerattannaporn, M., Kim, H. M., & Chey, W. D. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.355 · Cited by 283 · cited 1× · see citing works

Fecal Microbiota Transplantation: Indications, Methods, Evidence, and Future Directions

Borody, T. J., Paramsothy, S., & Agrawal, G. (2013) · Current Gastroenterology Reports · doi:10.1007/s11894-013-0337-1 · Cited by 275 · see citing works

Prognosis in post-infective irritable bowel syndrome: a six year follow up study

Neal, K. R., Barker, L., & Spiller, R. E. (2002) · Gut · doi:10.1136/gut.51.3.410 · Cited by 274 · see citing works

VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet‐induced nonalcoholic steatohepatitis model in mice†

Velayudham, A., Dolganiuc, A., Ellis, M., Petrášek, J., Kodys, K., Mandrekar, P., & Szabó, G. (2008) · Hepatology · doi:10.1002/hep.22711 · Cited by 263 · see citing works

Gut microbiota and non-alcoholic fatty liver disease: new insights

Aron‐Wisnewsky, J., Gaborit, B., Dutour, A., & Clément, K. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12140 · Cited by 249 · see citing works

Obesity and the gut microbiota: does up-regulating colonic fermentation protect against obesity and metabolic disease?

Conterno, L., Fava, F., Viola, R., & Tuohy, K. M. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0230-1 · Cited by 249 · see citing works

Bacterial supplementation in the irritable bowel syndrome. A randomised doubleblind placebo-controlled crossover study

OʼSullivan, M. (2000) · Digestive and Liver Disease · doi:10.1016/s1590-8658(00)80021-3 · Cited by 245 · see citing works

Fecal Microbial Transplant Effect on Clinical Outcomes and Fecal Microbiome in Active Crohnʼs Disease

Suskind, D. L., Brittnacher, M. J., Wahbeh, G., Shaffer, M. L., Hayden, H. S., Qin, X., Singh, N., Damman, C. J., Hager, K. R., Nielson, H., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000307 · Cited by 243 · see citing works

A Randomized Controlled Trial of <i>Lactobacillus</i> GG in Children With Functional Abdominal Pain

Francavilla, R., Miniello, V., Magistà, A. M., De Canio, A., Bucci, N., Gagliardi, F., Lionetti, E., Castellaneta, S., Polimeno, L., Peccarisi, L., et al. (2010) · Pediatrics · doi:10.1542/peds.2010-0467 · Cited by 242 · see citing works

Probiotics Reduce the Inflammatory Response Induced by a High-Fat Diet in the Liver of Young Rats

Esposito, E., Iacono, A., Bianco, G., Autore, G., Cuzzocrea, S., Vajro, P., Canani, R. B., Calignano, A., Raso, G. M., & Meli, R. (2009) · Journal of Nutrition · doi:10.3945/jn.108.101808 · Cited by 238 · see citing works

Possible role of Mycobacteria in inflammatory bowel disease

Thayer, W. R., Coutu, J. A., Chiodini, R. J., Kruiningen, H. J. V., & Merkal, R. S. (1984) · Digestive Diseases and Sciences · doi:10.1007/bf01317079 · Cited by 226 · see citing works

Isolation of DNA from bacterial samples of the human gastrointestinal tract

Zoetendal, E. G., Heilig, H. G. H. J., Klaassens, E. S., Booijink, C. C., Kleerebezem, M., Smidt, H., & de Vos, W. M. (2006) · Nature Protocols · doi:10.1038/nprot.2006.142 · Cited by 224 · see citing works

Bowel-flora alteration: a potential cure for inflammatory bowel disease and irritable bowel syndrome?

Borody, T. J., George, L., Andrews, P., Brandl, S., Noonan, S., Cole, P., Hyland, L., Morgan, A., Maysey, J., & Moore‐Jones, D. (1989) · Medical Journal of Australia · doi:10.5694/j.1326-5377.1989.tb136704.x · Cited by 221 · see citing works

The Effect of a Multispecies Probiotic Mixture on the Symptoms and Fecal Microbiota in Diarrhea-dominant Irritable Bowel Syndrome: A Randomized, Double-blind, Placebo-controlled Trial

Ki Cha, B., Mun Jung, S., Hwan Choi, C., Song, I.-D., Woong Lee, H., Joon Kim, H., Hyuk, J., Kyung Chang, S., Kim, K., Chung, W.-S., et al. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31823712b1 · Cited by 216 · see citing works

Combined budesonide and antibiotic therapy for active Crohn's disease: A randomized controlled trial

Steinhart, A. H., Feagan, B. G., Wong, C. J., Vandervoort, M. K., Mikolainis, S., Croitoru, K., Seidman, E. G., Leddin, D. J., Bitton, A., Drouin, É., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.34225 · Cited by 215 · see citing works

Irritable Bowel Syndrome: Epidemiology, Natural History, Health Care Seeking and Emerging Risk Factors

Cremonini, F., & Talley, N. J. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.02.008 · Cited by 215 · see citing works

Helicobacter pylori Dampens Gut Epithelial Self-Renewal by Inhibiting Apoptosis, a Bacterial Strategy to Enhance Colonization of the Stomach

Mimuro, H., Suzuki, T., Nagai, S., Rieder, G., Suzuki, M., Nagai, T., Fujita, Y., Nagamatsu, K., Ishijima, N., Koyasu, S., et al. (2007) · Cell Host & Microbe · doi:10.1016/j.chom.2007.09.005 · Cited by 212 · see citing works

Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon‐like peptide 1 in diet‐induced obesity

Hwang, I., Park, Y. J., Kim, Y.-R., Kim, Y. N., Ka, S., Lee, H., Seong, J. K., Seok, Y., & Kim, J. B. (2015) · The FASEB Journal · doi:10.1096/fj.14-265983 · Cited by 206 · see citing works

Differential Expression of Toll-Like Receptors in Patients With Irritable Bowel Syndrome

Brint, E. K., MacSharry, J., Fanning, A., Shanahan, F., & Quigley, E. M. M. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.438 · Cited by 205 · see citing works

Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species‐specific antibody

Ohkusa, T., Sato, N., Ogihara, T., Morita, K., Ogawa, M., & Okayasu, I. (2002) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2002.02834.x · Cited by 198 · see citing works

Molecular Pathways: Pathogenesis and Clinical Implications of Microbiome Alteration in Esophagitis and Barrett Esophagus

Yang, L., Francois, F., & Pei, Z. (2012) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0934 · Cited by 192 · see citing works

Small Intestinal Bacterial Overgrowth in Nonalcoholic Steatohepatitis: Association with Toll-Like Receptor 4 Expression and Plasma Levels of Interleukin 8

SHANAB, A. A. A., Scully, P., Crosbie, O. M., Buckley, M. J. M., O’Mahony, L., Shanahan, F., Gazareen, S., Murphy, E., & Quigley, E. M. M. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1447-3 · Cited by 189 · see citing works

The Prevalence of Overgrowth by Aerobic Bacteria in the Small Intestine by Small Bowel Culture: Relationship with Irritable Bowel Syndrome

Pyleris, E., Giamarellos‐Bourboulis, E. J., Tzivras, D. M., Koussoulas, V., Barbatzas, C., & Pimentel, M. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2033-7 · Cited by 189 · see citing works

Role of Helicobacter pylori CagA+ strains and risk of adenocarcinoma of the stomach and esophagus

Wu, A. H., Crabtree, J. E., Bernstein, L., et al. (2002) · International Journal of Cancer · doi:10.1002/ijc.10887 · Cited by 185 · see citing works

Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility

Poppe, M., Feller, S. M., Römer, G., & Weßler, S. (2006) · Oncogene · doi:10.1038/sj.onc.1210139 · Cited by 179 · see citing works

Mucosal cytokine imbalance in irritable bowel syndrome

Macsharry, J., O'Mahony, L., Fanning, A., Bairead, E., Sherlock, G., Tiesman, J., Fulmer, A., Kiely, B., Dinan, T. G., Shanahan, F., et al. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802276127 · Cited by 174 · see citing works

Manipulation of the Microbiota for Treatment of IBS and IBD—Challenges and Controversies

Shanahan, F., & Quigley, E. M. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.01.050 · Cited by 172 · see citing works

Methanobrevibacter smithii Is the Predominant Methanogen in Patients with Constipation-Predominant IBS and Methane on Breath

Kim, G., Deepinder, F., Morales, W., Hwang, L. J., Weitsman, S. R., Chang, C., Gunsalus, R. P., & Pimentel, M. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2197-1 · Cited by 169 · see citing works

Commensal Bacteria Can Enter Colonic Epithelial Cells and Induce Proinflammatory Cytokine Secretion: A Possible Pathogenic Mechanism of Ulcerative Colitis

Ohkusa, T., Yoshida, T., Sato, N., Watanabe, S., Tajiri, H., & Okayasu, I. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.005801-0 · Cited by 167 · see citing works

Helicobacter pylori Exploits a Unique Repertoire of Type IV Secretion System Components for Pilus Assembly at the Bacteria-Host Cell Interface

Shaffer, C. L., Gaddy, J. A., Loh, J. T., Johnson, E., Hill, S., Hennig, E. E., McClain, M. S., McDonald, W. H., & Cover, T. L. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002237 · Cited by 163 · see citing works

An Investigation of Fecal Volatile Organic Metabolites in Irritable Bowel Syndrome

Ahmed, I., Greenwood, R., Costello, B. D. L., Ratcliffe, N. M., & Probert, C. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058204 · Cited by 163 · see citing works

Two-year-outcomes analysis of Crohn's disease treated with rifabutin and macrolide antibiotics

Gui, G. P., Thomas, P. R., Tizard, M. L., et al. (1997) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/39.3.393 · Cited by 163 · see citing works

Altered peripheral toll-like receptor responses in the irritable bowel syndrome

McKernan, D. P., Gaszner, G., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04624.x · Cited by 160 · see citing works

Preventing non-alcoholic fatty liver disease through Lactobacillus johnsonii BS15 by attenuating inflammation and mitochondrial injury and improving gut environment in obese mice

Xin, J., Zeng, D., Wang, H., Ni, X., Yi, D., Pan, K., & Jing, B. (2014) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-014-5752-1 · Cited by 154 · see citing works

Contribution of Fatty Acids Released From Lipolysis of Plasma Triglycerides to Total Plasma Fatty Acid Flux and Tissue-Specific Fatty Acid Uptake

Teusink, B., Voshol, P. J., Dahlmans, V. E. H., Rensen, P. C. N., Pijl, H., Romijn, J. A., & Havekes, L. M. (2003) · Diabetes · doi:10.2337/diabetes.52.3.614 · Cited by 153 · see citing works

Ileal short-chain fatty acids inhibit gastric motility by a humoral pathway

Cuche, G., Cuber, J.-C., & Malbert, C. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.5.g925 · Cited by 148 · see citing works

Results of Multiple Diagnostic Tests forMycobacterium aviumsubsp.paratuberculosisin Patients with Inflammatory Bowel Disease and in Controls

Collins, M. T., Lisby, G., Moser, C. E., Chicks, D. S., Christensen, S., Reichelderfer, M., Høiby, N., Harms, B. A., Thomsen, O. Ø., Skibsted, U., et al. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.12.4373-4381.2000 · Cited by 148 · see citing works

Randomised clinical trial: a liquid multi‐strain probiotic vs. placebo in the irritable bowel syndrome – a 12 week double‐blind study

Sisson, G., Ayis, S., Sherwood, R. A., & Bjarnason, I. (2014) · Alimentary Pharmacology &amp; Therapeutics · doi:10.1111/apt.12787 · Cited by 147 · see citing works

Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach

Yu, G., Gail, M. H., Shi, J., Klepac‐Ceraj, V., Paster, B. J., Dye, B. A., Wang, G., Wei, W., Fan, J., Qiao, Y., et al. (2014) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-13-0855 · Cited by 146 · see citing works

The probiotic Lactobacillus coryniformis CECT5711 reduces the vascular pro-oxidant and pro-inflammatory status in obese mice

Toral, M., Gómez‐Guzmán, M., Jiménez, R., Romero, M., Sánchez, M., Utrilla, M. P., Garrido‐Mesa, N., Rodríguez‐Cabezas, M. E., Olivares, M. M., Gálvez, J., et al. (2014) · Clinical Science · doi:10.1042/cs20130339 · Cited by 134 · see citing works

Escherichia coli Producing Colibactin Triggers Premature and Transmissible Senescence in Mammalian Cells

Sécher, T., Samba‐Louaka, A., Oswald, É., & Nougayrède, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077157 · Cited by 134 · see citing works

Toll-like receptors and diabetes: a therapeutic perspective

Dasu, M. R. K., Ramírez, S. M., & Isseroff, R. R. (2011) · Clinical Science · doi:10.1042/cs20110357 · Cited by 126 · see citing works

Update on the heritability of inflammatory bowel disease: The importance of twin studies

Brant, S. R. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21385 · Cited by 124 · see citing works

Molecular analysis of faecal and duodenal samples reveals significantly higher prevalence and numbers of Pseudomonas aeruginosa in irritable bowel syndrome

Kerckhoffs, A. P. M., Amor, K. B., Samsom, M., van der Rest, M. E., de Vogel, J., Knol, J., & Akkermans, L. M. A. (2010) · Journal of Medical Microbiology · doi:10.1099/jmm.0.022848-0 · Cited by 124 · see citing works

I.31, a new combination of probiotics, improves irritable bowel syndrome-related quality of life

Lorenzo‐Zúñiga, V. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i26.8709 · Cited by 120 · see citing works

Therapeutic faecal microbiota transplantation: current status and future developments

Borody, T. J., Brandt, L. J., & Paramsothy, S. (2014) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000027 · Cited by 114 · see citing works

PYY3–36 and Oxyntomodulin Can Be Additive in Their Effect on Food Intake in Overweight and Obese Humans

Field, B. C. T., Wren, A., Peters, V., Baynes, K., Martin, N. M., Patterson, M., Alsaraf, S., Amber, V., Wynne, K., Ghatei, M. A., et al. (2010) · Diabetes · doi:10.2337/db09-1859 · Cited by 113 · see citing works

Antimycobacterial therapy in Crohn's disease: results of a controlled, double-blind trial with a multiple antibiotic regimen.

Prantera, C., Kohn, A., Mangiarotti, R., Andreoli, A., & Luzi, C. (1994) · PubMed · Cited by 112 · see citing works

Open clinical trial of rifabutin and clarithromycin therapy in Crohn's disease

Shafran, I., Kugler, L., Kl-Zaatari, F. A. X., et al. (2002) · Digestive and Liver Disease · doi:10.1016/s1590-8658(02)80055-x · Cited by 110 · see citing works

A prospective randomized controlled trial of oral ciprofloxacin in acute ulcerative colitis.

Mantzaris, G. J., Archavlis, E., Christoforidis, P., et al. (1997) · PubMed · Cited by 108 · see citing works

Treatment of severe Crohn's disease using antimycobacterial triple therapy — approaching a cure?

Borody, T. J., Leis, S., Warren, E. F., et al. (2002) · Digestive and Liver Disease · doi:10.1016/s1590-8658(02)80056-1 · Cited by 105 · see citing works

The colonic microbiota in health and disease

Shanahan, F. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32835a3493 · Cited by 103 · see citing works

Variations of gastric corpus microbiota are associated with early esophageal squamous cell carcinoma and squamous dysplasia

Nasrollahzadeh, D., Malekzadeh, R., Ploner, A., et al. (2015) · Scientific Reports · doi:10.1038/srep08820 · Cited by 96 · see citing works

Do SCFA have a role in appetite regulation?

Darzi, J., Frost, G. S., & Robertson, M. D. (2011) · Proceedings of the Nutrition Society · doi:10.1017/s0029665110004039 · Cited by 94 · see citing works

The Role and Influence of Gut Microbiota in Pathogenesis and Management of Obesity and Metabolic Syndrome

Parekh, P. J., Arusi, E., Vinik, A. I., & Johnson, D. A. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00047 · Cited by 94 · see citing works

Do probiotics reduce adult lactose intolerance? A systematic review.

Levri, K. M., Ketvertis, K. M., Deramo, M., Merenstein, J. H., & D'Amico, F. J. (2005) · PubMed · Cited by 93 · see citing works

Open label trial of oral clarithromycin in active Crohn’s disease

Leiper, Morris, & Rhodes (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00753.x · Cited by 92 · see citing works

Controlled trial of antimycobacterial therapy in Crohn's disease

Afdhal, N. H., Long, A., Lennon, J. R., et al. (1991) · Digestive Diseases and Sciences · doi:10.1007/bf01298873 · Cited by 85 · see citing works

Randomized clinical trial: Effect of Lactobacillus plantarum 299 v on symptoms of irritable bowel syndrome

Stevenson, C., Blaauw, R., Fredericks, E., Visser, J., & Roux, S. (2014) · Nutrition · doi:10.1016/j.nut.2014.02.010 · Cited by 83 · see citing works

Effects of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 on Hepatic Steatosis in Zucker Rats

Plaza‐Díaz, J., Gómez‐Llorente, C., Abadía‐Molina, F., Sáez‐Lara, M. J., Campaña‐Martín, L., Muñoz‐Quezada, S., Romero, F., Gil, Á., & Fontana, L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098401 · Cited by 81 · see citing works

Inducible and neuronal nitric oxide synthase involvement in lipopolysaccharide-induced sphincteric dysfunction

Fan, Y., Chakder, S., Gao, F., et al. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.280.1.g32 · Cited by 74 · see citing works

Cell death in the pathogenesis of immune-mediated diseases

Pisetsky, D. S. (2011) · Swiss Medical Weekly · doi:10.4414/smw.2011.13256 · Cited by 72 · see citing works

An open-label evaluation of rifaximin in the treatment of active Crohn's disease

Shafran, I., & Johnson, L. K. (2005) · Current Medical Research and Opinion · doi:10.1185/030079905x53252 · Cited by 68 · see citing works

The role of Helicobacter pylori in primary gastric MALT lymphoma

Bouzourene, Haefliger, Delacrétaz, et al. (1999) · Histopathology · doi:10.1046/j.1365-2559.1999.00597.x · Cited by 55 · see citing works

Effect of Macrolide Antibiotics on Macrophage Functions

Xu, G., Fujita, J., Negayama, K., et al. (1996) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1996.tb01097.x · Cited by 55 · see citing works

The ProbioticE. coliStrain Nissle 1917 for the Treatment of Collagenous Colitis: First Results of an Open-Label Trial

Tromm, A., Niewerth, U., Khoury, M., Baestlein, E., Wilhelms, G., Schulze, J., & Stolte, M. (2004) · Zeitschrift für Gastroenterologie · doi:10.1055/s-2004-812709 · Cited by 53 · see citing works

Microbiota, Antibiotics, and Obesity

Jess, T. (2014) · New England Journal of Medicine · doi:10.1056/nejmcibr1409799 · Cited by 53 · see citing works

The Impact of Helicobacter pylori Infection on the Gastric Microbiota of the Rhesus Macaque

Martín, M. E., Bhatnagar, S., George, M. D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076375 · Cited by 49 · see citing works

Microbiota and innate immunity in intestinal inflammation and neoplasia

Cario, E. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32835a670e · Cited by 46 · see citing works

Pathogenesis of Helicobacter pylori Infection

de Bernard, M., & Josenhans, C. (2014) · Helicobacter · doi:10.1111/hel.12160 · Cited by 44 · see citing works

Psychometric scores and persistence of irritable bowel after infectious diarrhoea

King, T. S. (1996) · Clinical Nutrition · doi:10.1016/s0261-5614(96)80040-9 · Cited by 43 · see citing works

Replenishing our defensive microbes

Ursell, L. K., Treuren, W. V., Metcalf, J. L., Pirrung, M., Gewirtz, A. T., & Knight, R. D. (2013) · BioEssays · doi:10.1002/bies.201300018 · Cited by 43 · see citing works

Basic and Translational Understandings of Microbial Recognition by Toll-Like Receptors in the Intestine

Rhee, S. H. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.1.28 · Cited by 41 · see citing works

Prebiotics and probiotics in irritable bowel syndrome and inflammatory bowel disease in children

Guandalini, S., Cernat, E., & Moscoso, D. I. (2014) · Beneficial Microbes · doi:10.3920/bm2014.0067 · Cited by 36 · see citing works

Follow-up Study of Fecal Microbiota Transplantation (FMT) for the Treatment of Refractory Irritable Bowel Syndrome (IBS)

Pinn, D. M., Aroniadis, O. C., & Brandt, L. J. (2013) · The American Journal of Gastroenterology · doi:10.14309/00000434-201310001-01862 · Cited by 33 · see citing works

Crohn's disease-associated Nod2 mutants reduce IL10 transcription

Philpott, D. J., & Girardin, S. E. (2009) · Nature Immunology · doi:10.1038/ni0509-455 · Cited by 30 · see citing works

Bugs on the brain; brain in the gut—seeking explanations for common gastrointestinal symptoms

Quigley, E. M. M. (2012) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-012-0865-y · Cited by 25 · see citing works

Gut Microbiome in New-Onset Crohn's Disease

Hall, L. J., Walshaw, J., & Watson, A. J. M. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.08.014 · Cited by 23 · see citing works

Serial changes of cytokines in active ulcerative colitis: effects of antibiotic combination therapy.

Sato, K., Chiba, T., & Ohkusa, T. (2009) · PubMed · Cited by 17 · see citing works

Role of Toll-like receptors in microbiota-associated gastrointestinal cancer metastasis

Ding, H., Lu, Q., & Li, W. (2013) · Journal of Cancer Research and Therapeutics · doi:10.4103/0973-1482.122509 · Cited by 14 · see citing works

Bugs on the brain

Bird, L. (2015) · Nature reviews. Immunology · doi:10.1038/nri3882 · Cited by 10 · see citing works

Probiotics in the Management of Crohn's disease and Ulcerative Colitis

Müllner, K., Miheller, P., Herszényi, L., et al. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113196660727 · Cited by 8 · see citing works

Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome

Ferretti, P., Pasolli, E., Tett, A., Asnicar, F., Gorfer, V., Fedi, S., Armanini, F., Truong, D. T., Manara, S., Zolfo, M., et al. (2018) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2018.06.005 · Cited by 1,292 · see citing works

Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability

Yassour, M., Vatanen, T., Siljander, H., Hämäläinen, A.-M., Härkönen, T., Ryhänen, S. J., Franzosa, E. A., Vlamakis, H., Huttenhower, C., Gevers, D., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad0917 · Cited by 1,043 · see citing works

Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice

Yoon, H. S., Cho, C. H., Yun, M. S., Jang, S. J., You, H. J., Kim, J.-H., Han, D., Cha, K. H., Moon, S. H., Lee, K., et al. (2021) · Nature Microbiology · doi:10.1038/s41564-021-00880-5 · Cited by 602 · see citing works

Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled phase 2 trial

Mocanu, V., Zhang, Z., Deehan, E. C., Kao, D. H., Hotte, N., Karmali, S., Birch, D. W., Samarasinghe, K. K., Walter, J., & Madsen, K. L. (2021) · Nature Medicine · doi:10.1038/s41591-021-01399-2 · Cited by 328 · see citing works

Gastrointestinal Issues and Autism Spectrum Disorder

Madra, M., Ringel, R., & Margolis, K. G. (2020) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2020.02.005 · Cited by 159 · see citing works

The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice

Elderman, M., Sovran, B., Hugenholtz, F., Graversen, K., Huijskes, M., Houtsma, E., Belzer, C., Boekschoten, M., de Vos, P., Dekker, J., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0184274 · Cited by 145 · see citing works

Association of dietary patterns with the gut microbiota in older, community-dwelling men

Shikany, J. M., Demmer, R. T., Johnson, A. J., Fino, N. F., Meyer, K., Ensrud, K. E., Lane, N. E., Orwoll, E. S., Kado, D. M., Zmuda, J. M., et al. (2019) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz174 · Cited by 83 · see citing works

Exploring the molecular basis of age-related disease comorbidities using a multi-omics graphical model

Zierer, J., Pallister, T., Tsai, P.-C., Krumsiek, J., Bell, J. T., Lauc, G., Spector, T. D., Menni, C., & Kastenmüller, G. (2016) · Scientific Reports · doi:10.1038/srep37646 · Cited by 63 · see citing works

Oral, Nasal, and Gut Microbiota in Parkinson’s Disease

Li, Z., Lu, G., Luo, E., Wu, B., Li, Z., Guo, J., Xia, Z., Zheng, C., Su, Q., Zeng, Y., et al. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2021.10.011 · Cited by 52 · see citing works

Antiretroviral therapy potentiates high-fat diet induced obesity and glucose intolerance

Pepin, M. E., Padgett, L. E., McDowell, R. E., Burg, A. R., Brahma, M. K., Holleman, C., Kim, T., Crossman, D., Kutsch, O., Tse, H. M., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.04.006 · Cited by 25 · see citing works

Progress with treating the microbial dysbiosis associated with irritable bowel syndrome

Pearson, J. S., & Whorwell, P. J. (2016) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000328 · Cited by 1 · see citing works

The Microbiome in HIV-Infected Children

Green, R. J. (2020) · Springer eBooks · doi:10.1007/978-3-030-35433-6_21 · Cited by 1 · see citing works

[Vaginal microbiome: community characteristics and disease intervention].

Liu, H., Xu, X., Ling, K., et al. (2021) · PubMed · doi:10.13345/j.cjb.210204 · Cited by 1 · see citing works

Quercetin improves gut dysbiosis in antibiotic-treated mice

Shi, T., Bian, X., Yao, Z., Wang, Y., Gao, W., & Guo, C. (2020) · Food & Function · doi:10.1039/d0fo01439g · Cited by 130 · see citing works

The Gut Microbiome of Children during the COVID-19 Pandemic

Bacorn, M., Romero-Soto, H. N., Levy, S., Chen, Q., & Hourigan, S. K. (2022) · Microorganisms · doi:10.3390/microorganisms10122460 · Cited by 12 · see citing works