The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies
Open accessAbstract
Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of patients. Combining bulk and single-cell transcriptomics, quantitative histopathology and in situ localization across three cohorts of patients with IBD (total n = 376), we identify coexpressed gene modules within the heterogeneous tissular inflammatory response in IBD that map to distinct histopathological and cellular features (pathotypes). One of these pathotypes is defined by high neutrophil infiltration, activation of fibroblasts and vascular remodeling at sites of deep ulceration. Activated fibroblasts in the ulcer bed display neutrophil-chemoattractant properties that are IL-1R, but not TNF, dependent. Pathotype-associated neutrophil and fibroblast signatures are increased in nonresponders to several therapies across four independent cohorts (total n = 343). The identification of distinct, localized, tissular pathotypes will aid precision targeting of current therapeutics and provides a biological rationale for IL-1 signaling blockade in ulcerating disease.
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Cited by
Zhao, J. H., Stacey, D., Eriksson, N., Macdonald-Dunlop, E., Hedman, Å. K., Kalnapenkis, A., Enroth, S., Cozzetto, D., Digby-Bell, J., Marten, J., et al. (2023) · Nature Immunology · doi:10.1038/s41590-023-01588-w · Cited by 747
Macrophages in health and disease
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Strategies for targeting cytokines in inflammatory bowel disease
Neurath, M. F. (2024) · Nature Reviews Immunology · doi:10.1038/s41577-024-01008-6 · Cited by 398
Predictive Biomarkers for Checkpoint Inhibitor Immune-Related Adverse Events
Les, I., Martínez, M., Pérez-Francisco, I., Cabero, M., Teijeira, L., Arrazubi, V., Torrego, N., Campillo-Calatayud, A., Elejalde, I., Kochan, G., et al. (2023) · Cancers · doi:10.3390/cancers15051629 · Cited by 100
The human microbiome in clinical translation: from bench to bedside
Bautista, J., Echeverría, C. E., Maldonado-Noboa, I., Ojeda-Mosquera, S., Hidalgo-Tinoco, C., & López-Cortés, A. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1632435 · Cited by 55
Metadata
- Authors
- Friedrich, M., Pohin, M., Jackson, M. A., Korsunsky, I., Bullers, S. J., Rue-Albrecht, K., Christoforidou, Z., Sathananthan, D., Thomas, T., Ravindran, R., Tandon, R., Peres, R. S., Sharpe, H., Wei, K., Watts, G. F. M., Mann, E. H., Geremia, A., Attar, M., Oxford IBD Cohort Investigators, Roche Fibroblast Network Consortium, Barone, F., Brenner, M., Buckley, C. D., Coles, M., Frei, A. P., Lassen, K. G., Powrie, F. M., McCuaig, S., Thomas, L., Collantes, E., Uhlig, H. H., Sansom, S. N., Easton, A., Raychaudhuri, S., Travis, S. P., & Powrie, F. M.
- Venue
- Nature Medicine
- Published
- 2021-10-21
- Volume
- 27
- Issue
- 11
- Pages
- 1970-1981
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W3205008568
- Cited by
- 303
- References
- 51
- FWCI
- 21.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies. https://app.cochat.ai/papers/10.1038/s41591-021-01520-5
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- Friedrich, M., Pohin, M., Jackson, M. A., Korsunsky, I., Bullers, S. J., Rue-Albrecht, K., Christoforidou, Z., Sathananthan, D., Thomas, T., Ravindran, R., Tandon, R., Peres, R. S., Sharpe, H., Wei, K., Watts, G. F. M., Mann, E. H., Geremia, A., Attar, M., Oxford IBD Cohort Investigators, . . . Powrie, F. M. (2021). IL-1-driven stromal–neutrophil interactions define a subset of patients with inflammatory bowel disease that does not respond to therapies. Nature Medicine. https://doi.org/10.1038/s41591-021-01520-5
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
