The DOI matches its Crossref record; 156 of the 156 references it cites were found in a registry or an index.
Engineered cellular immunotherapies in cancer and beyond
Open accessAbstract
This year marks the tenth anniversary of cell therapy with chimeric antigen receptor (CAR)-modified T cells for refractory leukemia. The widespread commercial approval of genetically engineered T cells for a variety of blood cancers offers hope for patients with other types of cancer, and the convergence of human genome engineering and cell therapy technology holds great potential for generation of a new class of cellular therapeutics. In this Review, we discuss the goals of cellular immunotherapy in cancer, key challenges facing the field and exciting strategies that are emerging to overcome these obstacles. Finally, we outline how developments in the cancer field are paving the way for cellular immunotherapeutics in other diseases. Oncology is trailblazing the field of engineered cellular therapeutics. This Review discusses the goals of cellular immunotherapy in cancer, key challenges facing the field and strategies to overcome them—paving the way for treatment of other diseases.
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1 retracted
RETRACTED ARTICLE: Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs
Yarmarkovich, M., Marshall, Q. F., Warrington, J. M., Premaratne, R., Farrel, A., Groff, D., Li, W., di Marco, M., Runbeck, E., Truong, H. V., et al. (2021) · Nature · doi:10.1038/s41586-021-04061-6 · Cited by 97
RetractedOncology meets immunology: the cancer-immunity cycle.
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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
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Cancer immunoediting: from immunosurveillance to tumor escape
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Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
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Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia
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Self-citationEffectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants
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Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
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Chimeric Antigen Receptor Therapy
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Self-citation
Cited by
Metabolic programming and immune suppression in the tumor microenvironment
Arner, E. N., & Rathmell, J. C. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.01.009 · Cited by 668
Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications
Cerneckis, J., Cai, H., & Shi, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01809-0 · Cited by 452
Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments
Xu, J., Ding, L., Mei, J., Hu, Y., Kong, X., Dai, S., Bu, T., Xiao, Q., & Ding, K. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02325-5 · Cited by 389
CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors
Peng, L., Sferruzza, G., Yang, L., Zhou, L., & Chen, S. (2024) · Cellular & Molecular Immunology · doi:10.1038/s41423-024-01207-0 · Cited by 373
Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
Nava Lauson, C. B., Tiberti, S., Corsetto, P. A., Conte, F., Tyagi, P., Machwirth, M., Ebert, S., Loffreda, A., Scheller, L., Sheta, D., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.02.013 · Cited by 291
Metadata
- Authors
- Finck, A. V., Blanchard, T., Roselle, C. P., Golinelli, G., & June, C. H.
- Venue
- Nature Medicine
- Published
- 2022-04
- Volume
- 28
- Issue
- 4
- Pages
- 678-689
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W4224293261
- Cited by
- 269
- References
- 156
- FWCI
- 22.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Finck, A. V., Blanchard, T., Roselle, C. P., Golinelli, G., & June, C. H. (2022). Engineered cellular immunotherapies in cancer and beyond. Nature Medicine. https://doi.org/10.1038/s41591-022-01765-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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