The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Acute and postacute sequelae associated with SARS-CoV-2 reinfection
Open accessAbstract
First infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risk of acute and postacute death and sequelae in various organ systems. Whether reinfection adds to risks incurred after first infection is unclear. Here we used the US Department of Veterans Affairs’ national healthcare database to build a cohort of individuals with one SARS-CoV-2 infection ( n = 443,588), reinfection (two or more infections, n = 40,947) and a noninfected control ( n = 5,334,729). We used inverse probability-weighted survival models to estimate risks and 6-month burdens of death, hospitalization and incident sequelae. Compared to no reinfection, reinfection contributed additional risks of death (hazard ratio (HR) = 2.17, 95% confidence intervals (CI) 1.93–2.45), hospitalization (HR = 3.32, 95% CI 3.13–3.51) and sequelae including pulmonary, cardiovascular, hematological, diabetes, gastrointestinal, kidney, mental health, musculoskeletal and neurological disorders. The risks were evident regardless of vaccination status. The risks were most pronounced in the acute phase but persisted in the postacute phase at 6 months. Compared to noninfected controls, cumulative risks and burdens of repeat infection increased according to the number of infections. Limitations included a cohort of mostly white males. The evidence shows that reinfection further increases risks of death, hospitalization and sequelae in multiple organ systems in the acute and postacute phase. Reducing overall burden of death and disease due to SARS-CoV-2 will require strategies for reinfection prevention.
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Persistent Symptoms in Patients After Acute COVID-19
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Making Neighborhood-Disadvantage Metrics Accessible — The Neighborhood Atlas
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Characterizing long COVID in an international cohort: 7 months of symptoms and their impact
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Long-term cardiovascular outcomes of COVID-19
Xie, Y., Xu, E., Bowe, B., & Al-Aly, Z. (2022) · Nature Medicine · doi:10.1038/s41591-022-01689-3 · Cited by 2,029
Self-citationNegative Controls: A Tool for Detecting Confounding and Bias in Observational Studies
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Increased risk of SARS-CoV-2 reinfection associated with emergence of Omicron in South Africa
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Long COVID science, research and policy
Al-Aly, Z., Davis, H., McCorkell, L., Soares, L., Wulf-Hanson, S., Iwasaki, A., & Topol, E. J. (2024) · Nature Medicine · doi:10.1038/s41591-024-03173-6 · Cited by 538
Self-citationAltmann, D. M., Whettlock, E. M., Liu, S., Arachchillage, D. J., & Boyton, R. J. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-023-00904-7 · Cited by 389
Mechanisms of long COVID and the path toward therapeutics
Peluso, M. J., & Deeks, S. G. (2024) · Cell · doi:10.1016/j.cell.2024.07.054 · Cited by 341
Association of Treatment With Nirmatrelvir and the Risk of Post–COVID-19 Condition
Xie, Y., Choi, T., & Al-Aly, Z. (2023) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2023.0743 · Cited by 303
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Metadata
- Authors
- Bowe, B., Xie, Y., & Al-Aly, Z.
- Venue
- Nature Medicine
- Published
- 2022-11
- Volume
- 28
- Issue
- 11
- Pages
- 2398-2405
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W4308767470
- Cited by
- 639
- References
- 40
- FWCI
- 66.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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