Long COVID: major findings, mechanisms and recommendations
Open accessAbstract
Long COVID is an often debilitating illness that occurs in at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms have been identified with impacts on multiple organ systems. At least 65 million individuals worldwide are estimated to have long COVID, with cases increasing daily. Biomedical research has made substantial progress in identifying various pathophysiological changes and risk factors and in characterizing the illness; further, similarities with other viral-onset illnesses such as myalgic encephalomyelitis/chronic fatigue syndrome and postural orthostatic tachycardia syndrome have laid the groundwork for research in the field. In this Review, we explore the current literature and highlight key findings, the overlap with other conditions, the variable onset of symptoms, long COVID in children and the impact of vaccinations. Although these key findings are critical to understanding long COVID, current diagnostic and treatment options are insufficient, and clinical trials must be prioritized that address leading hypotheses. Additionally, to strengthen long COVID research, future studies must account for biases and SARS-CoV-2 testing issues, build on viral-onset research, be inclusive of marginalized populations and meaningfully engage patients throughout the research process.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Long COVID has been associated with new onset of a range of physical diseases such as cardiovascular disease and type 2 diabetes.
“Long COVID has been associated with new onset of a range of physical diseases (e.g., cardiovascular disease, type 2 diabetes)120.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [120]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Characterizing long COVID in an international cohort: 7 months of symptoms and their impact
Davis, H. E., Assaf, G. S., McCorkell, L., Wei, H., Low, R. J., Re'em, Y., Redfield, S., Austin, J. P., & Akrami, A. (2021) · eClinicalMedicine · doi:10.1016/j.eclinm.2021.101019 · Cited by 2,881 · see citing works
Self-citationPüntmann, V. O., Carerj, M. L., Wieters, I., Fahim, M., Arendt, C. T., Hoffmann, J., Shchendrygina, A., Escher, F., Vasa‐Nicotera, M., Zeiher, A. M., et al. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.3557 · Cited by 2,228 · see citing works
Long-term cardiovascular outcomes of COVID-19
Xie, Y., Xu, E., Bowe, B. C., & Al‐Aly, Z. (2022) · Nature Medicine · doi:10.1038/s41591-022-01689-3 · Cited by 2,065 · see citing works
Evolution of antibody immunity to SARS-CoV-2
Gaebler, C., Wang, Z., Lorenzi, J. C. C., Muecksch, F., Finkin, S., Tokuyama, M., Cho, A., Jankovic, M., Schaefer-Babajew, D., Oliveira, T. Y., et al. (2021) · Nature · doi:10.1038/s41586-021-03207-w · Cited by 1,674 · see citing works
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
Douaud, G., Lee, S., Alfaro-Almagro, F., Arthofer, C., Wang, C., McCarthy, P., Lange, F., Andersson, J. L. R., Griffanti, L., Duff, E., et al. (2022) · Nature · doi:10.1038/s41586-022-04569-5 · Cited by 1,646 · see citing works
Fatigue and cognitive impairment in Post-COVID-19 Syndrome: a systematic review and meta-analysis
Ceban, F., Ling, S., Lui, L. M. W., Lee, Y., Gill, H., Teopiz, K. M., Rodrigues, N. B., Subramaniapillai, M., Di Vincenzo, J. D., Cao, B., et al. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2021.12.020 · Cited by 1,554 · see citing works
Kucirka, L. M., Lauer, S. A., Laeyendecker, O. B., Boon, D., & Lessler, J. (2020) · Annals of Internal Medicine · doi:10.7326/m20-1495 · Cited by 1,414 · see citing works
Yeoh, Y. K., Zuo, T., Lui, G. C.-Y., Zhang, F., Liu, Q., Li, A. Y. L., Chung, A. C., Cheung, C. P., Tso, E. Y. K., Fung, K. S., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323020 · Cited by 1,320 · see citing works
Multiple early factors anticipate post-acute COVID-19 sequelae
Su, Y., Yuan, D., Chen, D. G., Ng, R. H., Wang, K., Choi, J., Li, S., Hong, S., Zhang, R., Xie, J., et al. (2022) · Cell · doi:10.1016/j.cell.2022.01.014 · Cited by 1,156 · see citing works
Phetsouphanh, C., Darley, D. R., Wilson, D. B., Howe, A., Munier, C. M. L., Patel, S. K., Juno, J. A., Burrell, L. M., Kent, S. J., Dore, G. J., et al. (2022) · Nature Immunology · doi:10.1038/s41590-021-01113-x · Cited by 1,019 · see citing works
Diverse functional autoantibodies in patients with COVID-19
Wang, E. Y., Mao, T., Klein, J., Dai, Y., Huck, J. D., Jaycox, J. R., Liu, F., Zhou, T., Israelow, B., Wong, P., et al. (2021) · Nature · doi:10.1038/s41586-021-03631-y · Cited by 999 · see citing works
Proal, A. D., & VanElzakker, M. B. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.698169 · Cited by 894 · see citing works
Long COVID after breakthrough SARS-CoV-2 infection
Al-Aly, Z., Bowe, B., & Xie, Y. (2022) · Nature Medicine · doi:10.1038/s41591-022-01840-0 · Cited by 866 · see citing works
Persistence of somatic symptoms after COVID-19 in the Netherlands: an observational cohort study
Ballering, A., van Zon, S. K. R., Hartman, T. O., & Rosmalen, J. G. M. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01214-4 · Cited by 833 · see citing works
Distinguishing features of long COVID identified through immune profiling
Klein, J., Wood, J., Jaycox, J. R., Dhodapkar, R. M., Lu, P., Gehlhausen, J. R., Tabachnikova, A., Greene, K., TABACOF, L. R., Malik, A. A., et al. (2023) · Nature · doi:10.1038/s41586-023-06651-y · Cited by 821 · see citing works
Taquet, M., Sillett, R., Zhu, L., Mendel, J., Camplisson, I., Dercon, Q., & Harrison, P. J. (2022) · The Lancet Psychiatry · doi:10.1016/s2215-0366(22)00260-7 · Cited by 737 · see citing works
Lam, M. H.-B. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.384 · Cited by 723 · see citing works
Augustin, M., Schommers, P., Stecher, M., Dewald, F., Gieselmann, L., Gruell, H., Horn, C., Vanshylla, K., Cristanziano, V. D., Osebold, L., et al. (2021) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2021.100122 · Cited by 685 · see citing works
Acute and postacute sequelae associated with SARS-CoV-2 reinfection
Bowe, B. C., Xie, Y., & Al‐Aly, Z. (2022) · Nature Medicine · doi:10.1038/s41591-022-02051-3 · Cited by 632 · see citing works
Unexplained post-acute infection syndromes
Choutka, J., Jansari, V., Hornig, M., & Iwasaki, A. (2022) · Nature Medicine · doi:10.1038/s41591-022-01810-6 · Cited by 604 · see citing works
Swank, Z., Senussi, Y., Manickas-Hill, Z., Yu, X. G., Li, J. Z., Alter, G., & Walt, D. R. (2022) · Clinical Infectious Diseases · doi:10.1093/cid/ciac722 · Cited by 580 · see citing works
Risks and burdens of incident diabetes in long COVID: a cohort study
Xie, Y., & Al-Aly, Z. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(22)00044-4 · Cited by 564 · see citing works
Dennis, A., Wamil, M., Alberts, J., Oben, J. A., Cuthbertson, D. J., Wootton, D. G., Crooks, M. G., Gabbay, M., Brady, M., Hishmeh, L., et al. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-048391 · Cited by 562 · see citing works
Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome
Liu, Q., Mak, J. W. Y., Su, Q., Yeoh, Y. K., Lui, G. C.-Y., Ng, S. S., Zhang, F., Li, A. Y. L., Lu, W., Hui, D. S. C., et al. (2022) · Gut · doi:10.1136/gutjnl-2021-325989 · Cited by 540 · see citing works
Pretorius, E., Vlok, M., Venter, C., Bezuidenhout, J. A., Laubscher, G. J., Steenkamp, J., & Kell, D. B. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01359-7 · Cited by 532 · see citing works
18F-FDG brain PET hypometabolism in patients with long COVID
Guedj, É., Campion, J., Dudouet, P., Kaphan, E., Brégeon, F., Tissot‐Dupont, H., Guis, S., Barthélémy, F., Habert, P., Ceccaldi, M. P., et al. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-021-05215-4 · Cited by 461 · see citing works
Zuo, T., Liu, Q., Zhang, F., Lui, G. C.-Y., Tso, E. Y. K., Yeoh, Y. K., Chen, Z., Boon, S. S., Chan, F. K. L., Chan, P. K. S., et al. (2020) · Gut · doi:10.1136/gutjnl-2020-322294 · Cited by 449 · see citing works
Wong, T. L., & Weitzer, D. (2021) · Medicina · doi:10.3390/medicina57050418 · Cited by 448 · see citing works
Nervous system consequences of COVID-19
Spudich, S., & Nath, A. (2022) · Science · doi:10.1126/science.abm2052 · Cited by 437 · see citing works
Natarajan, A., Zlitni, S., Brooks, E. F., Vance, S. E., Dahlen, A., Hedlin, H., Park, R. M., Han, A., Schmidtke, D. T., Verma, R., et al. (2022) · Med · doi:10.1016/j.medj.2022.04.001 · Cited by 409 · see citing works
Kedor, C., Freitag, H., Meyer‐Arndt, L., Wittke, K., Hanitsch, L. G., Zöller, T., Steinbeis, F., Haffke, M., Rudolf, G., Heidecker, B., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32507-6 · Cited by 400 · see citing works
A systematic review describing the prognosis of chronic fatigue syndrome.
Cairns, R., & Hotopf, M. (2005) · Occupational Medicine · doi:10.1093/occmed/kqi013 · Cited by 395 · see citing works
Frequent neurocognitive deficits after recovery from mild COVID-19
Woo, M. S., Malsy, J., Pöttgen, J., Zai, S. S., Ufer, F., Hadjilaou, A., Schmiedel, S., Addo, M. M., Gerloff, C. P., Heesen, C., et al. (2020) · Brain Communications · doi:10.1093/braincomms/fcaa205 · Cited by 395 · see citing works
Katsoularis, I., Fonseca‐Rodríguez, O., Farrington, P., Jerndal, H., Lundevaller, E. H., Sund, M., Lindmark, K., & Connolly-Andersen, A.-M. (2022) · BMJ · doi:10.1136/bmj-2021-069590 · Cited by 386 · see citing works
Changes in cognitive functioning after COVID-19: a systematic review and meta-analysis
Crivelli, L., Palmer, K., Calandri, I., Guekht, A., Beghi, E., Carroll, W., Frontera, J., García‐Azorín, D., Westenberg, E., Winkler, A. S., et al. (2022) · Alzheimer's & Dementia · doi:10.1002/alz.12644 · Cited by 374 · see citing works
Wallukat, G., Hohberger, B., Wenzel, K., Fürst, J., Schulze-Rothe, S., Wallukat, A., Hönicke, A.-S., & Müller, J. (2021) · Journal of Translational Autoimmunity · doi:10.1016/j.jtauto.2021.100100 · Cited by 368 · see citing works
Bull–Otterson, L., Baca, S., Saydah, S., et al. (2022) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm7121e1 · Cited by 351 · see citing works
Bowe, B. C., Xie, Y., Xu, E., & Al-Aly, Z. (2021) · Journal of the American Society of Nephrology · doi:10.1681/asn.2021060734 · Cited by 350 · see citing works
The Use of the Karnofsky Performance Scale in Determining Outcomes and Risk in Geriatric Outpatients
Crooks, V. C., Waller, S., Smith, T., & Hahn, T. J. (1991) · Journal of Gerontology · doi:10.1093/geronj/46.4.m139 · Cited by 336 · see citing works
Shaw, B. H., Stiles, L. E., Bourne, K., Green, E. A., Shibao, C. A., Okamoto, L. E., Garland, E. M., Gamboa, A., Diedrich, A., Raj, V., et al. (2019) · Journal of Internal Medicine · doi:10.1111/joim.12895 · Cited by 326 · see citing works
SARS-CoV-2 infects human neural progenitor cells and brain organoids
Zhang, B., Chu, H., Han, S., Shuai, H., Deng, J. M., Hu, Y., Gong, H., Lee, A. C.-Y., Zou, Z., Yau, T. C. C., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0390-x · Cited by 319 · see citing works
Peluso, M. J., Lu, S., Tang, A. F., Durstenfeld, M. S., Ho, H.-E., Goldberg, S. A., Forman, C. A., Munter, S. E., Hoh, R., Tai, V., et al. (2021) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiab490 · Cited by 318 · see citing works
Postacute COVID-19 is Characterized by Gut Viral Antigen Persistence in Inflammatory Bowel Diseases
Zollner, A., Koch, R., Jukic, A., Pfister, A., Meyer, M., Rössler, A., Kimpel, J., Adolph, T. E., & Tilg, H. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.04.037 · Cited by 313 · see citing works
Characteristics and impact of Long Covid: Findings from an online survey
Ziauddeen, N., Gurdasani, D., O’Hara, M. E., Hastie, C., Roderick, P. J., Yao, G., & Alwan, N. A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0264331 · Cited by 310 · see citing works
Chronic Fatigue and Postexertional Malaise in People Living With Long COVID: An Observational Study
Twomey, R., DeMars, J., Franklin, K., Culos-Reed, S. N., Weatherald, J. C., & Wrightson, J. G. (2022) · Physical Therapy · doi:10.1093/ptj/pzac005 · Cited by 305 · see citing works
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Essentials of Diagnosis and Management
Bateman, L., Bested, A. C., Bonilla, H. F., Chheda, B., Chu, L., Curtin, J. M., Dempsey, T. T., Dimmock, M. E., Dowell, T. G., Felsenstein, D., et al. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2021.07.004 · Cited by 302 · see citing works
Course of post COVID-19 disease symptoms over time in the ComPaRe long COVID prospective e-cohort
Tran, V.-T., Porcher, R., Pane, I., & Ravaud, P. (2022) · Nature Communications · doi:10.1038/s41467-022-29513-z · Cited by 290 · see citing works
Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome
Paul, B. D., Lemle, M. D., Komaroff, A. L., & Snyder, S. H. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2024358118 · Cited by 271 · see citing works
Haffke, M., Freitag, H., Rudolf, G., Seifert, M., Doehner, W., Scherbakov, N., Hanitsch, L. G., Wittke, K., Bauer, S., Konietschke, F., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03346-2 · Cited by 268 · see citing works
Komaroff, A. L., & Lipkin, W. I. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.06.002 · Cited by 266 · see citing works
Distinct plasma immune signatures in ME/CFS are present early in the course of illness
Hornig, M., Montoya, J. G., Klimas, N. G., Levine, S. M., Felsenstein, D., Bateman, L., Peterson, D. L., Gottschalk, C. G., Schultz, A. F., Che, X., et al. (2015) · Science Advances · doi:10.1126/sciadv.1400121 · Cited by 261 · see citing works
Chronic viral coinfections differentially affect the likelihood of developing long COVID
Peluso, M. J., Deveau, T., Munter, S. E., Ryder, D., Buck, A. M., Beck‐Engeser, G., Chan, F., Lu, S., Goldberg, S. A., Hoh, R., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci163669 · Cited by 258 · see citing works
Pretorius, E., Venter, C., Laubscher, G. J., Kotze, M. J., Oladejo, S. O., Watson, L. R., Rajaratnam, K., Watson, B. W., & Kell, D. B. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01579-5 · Cited by 256 · see citing works
Taquet, M., Dercon, Q., & Harrison, P. J. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.04.013 · Cited by 246 · see citing works
Distinguishing features of Long COVID identified through immune profilingPreprint
Klein, J., Wood, J., Jaycox, J. R., et al. (2022) · medRxiv · doi:10.1101/2022.08.09.22278592 · Cited by 243 · see citing works
Peluso, M. J., Deitchman, A. N., Torres, L., Iyer, N. S., Munter, S. E., Nixon, C. C., Donatelli, J. L., Thanh, C., Takahashi, S., Hakim, J. M. C., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109518 · Cited by 241 · see citing works
Frere, J. J., Serafini, R. A., Pryce, K. D., Zazhytska, M., Oishi, K., Golynker, I., Panis, M., Zimering, J. H., Horiuchi, S., Hoagland, D. A., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abq3059 · Cited by 233 · see citing works
Charfeddine, S., Amor, H. I. H., Jdidi, J., Torjmen, S., Kraiem, S., Hammami, R., Bahloul, A., Kallel, N., Moussa, N., Touil, I., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.745758 · Cited by 232 · see citing works
Edlow, A. G., Castro, V. M., Shook, L. L., Kaimal, A. J., & Perlis, R. H. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.15787 · Cited by 232 · see citing works
Orthostatic intolerance and chronic fatigue syndrome associated with Ehlers-Danlos syndrome
Rowe, P. C., Barron, D. F., Calkins, H., Maumenee, I. H., Tong, P. Y., & Geraghty, M. T. (1999) · The Journal of Pediatrics · doi:10.1016/s0022-3476(99)70173-3 · Cited by 230 · see citing works
Use of Cardiopulmonary Stress Testing for Patients With Unexplained Dyspnea Post–Coronavirus Disease
MANCINI, D. M., Brunjes, D. L., Lala, A., Trivieri, M. G., Contreras, J., & Natelson, B. H. (2021) · JACC Heart Failure · doi:10.1016/j.jchf.2021.10.002 · Cited by 218 · see citing works
Glynne, P. A., Tahmasebi, N., Gant, V. A., & Gupta, R. (2021) · Journal of Investigative Medicine · doi:10.1136/jim-2021-002051 · Cited by 215 · see citing works
Physical phenotype of blood cells is altered in COVID-19
Kubánková, M., Hohberger, B., Hoffmanns, J., Fürst, J., i, M. H., Guck, J. R., & Kräter, M. (2021) · Biophysical Journal · doi:10.1016/j.bpj.2021.05.025 · Cited by 199 · see citing works
Development of ACE2 autoantibodies after SARS-CoV-2 infection
Arthur, J. M., Forrest, J. C., Boehme, K. W., Kennedy, J. L., Owens, S. M., Herzog, C., Liu, J., & Harville, T. (2021) · PLoS ONE · doi:10.1371/journal.pone.0257016 · Cited by 195 · see citing works
Ayoubkhani, D., Bosworth, M. L., King, S., Pouwels, K. B., Glickman, M., Nafilyan, V., Zaccardi, F., Khunti, K. K., Alwan, N. A., & Walker, A. S. (2022) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofac464 · Cited by 192 · see citing works
Mast cell activation symptoms are prevalent in Long-COVID
Weinstock, L. B., Brook, J. B., Walters, A. S., Goris, A. J., Afrin, L. B., & Molderings, G. J. (2021) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2021.09.043 · Cited by 189 · see citing works
Cheung, C. C. L., Goh, D. L. M., Lim, X., et al. (2021) · Gut · doi:10.1136/gutjnl-2021-324280 · Cited by 188 · see citing works
Peripheral Neuropathy Evaluations of Patients With Prolonged Long COVID
Oaklander, A. L., Mills, A. J., Kelley, M., Toran, L. S., Smith, B., Dalakas, M. C., & Nath, A. (2022) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000001146 · Cited by 188 · see citing works
Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates
Rutkai, I., Mayer, M. G., Hellmers, L., Ning, B., Huang, Z. J., Monjure, C. J., Coyne, C., Silvestri, R., Golden, N., Hensley, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29440-z · Cited by 188 · see citing works
Alzheimer's‐like signaling in brains of COVID‐19 patients
Reiken, S. R., Sittenfeld, L. R., Dridi, H., Yang, L., Liu, X., & Marks, A. R. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.12558 · Cited by 187 · see citing works
Vijayakumar, B., Boustani, K., Ogger, P. P., Papadaki, A., Tonkin, J., Orton, C. M., Ghai, P., Suveizdytė, K., Hewitt, R. J., Desai, S. R., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.01.017 · Cited by 184 · see citing works
Dattner, I., Goldberg, Y., Katriel, G., Yaari, R., Gal, N., Miron, Y., Ziv, A., Sheffer, R., Hamo, Y., & Huppert, A. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1008559 · Cited by 182 · see citing works
Ding, T., Wang, T., Zhang, J., Cui, P., Chen, Z., Zhou, S., Yuan, S., Ma, W., Zhang, M., Rong, Y., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.635255 · Cited by 165 · see citing works
Kompaniyets, L., Bull–Otterson, L., Boehmer, T. K., Baca, S., Alvarez, P., Hong, K., Hsu, J., Harris, A. M., Gundlapalli, A. V., & Saydah, S. (2022) · MMWR Morbidity and Mortality Weekly Report · doi:10.15585/mmwr.mm7131a3 · Cited by 161 · see citing works
The COVID-19 pandemic and the menstrual cycle: research gaps and opportunities
Sharp, G. C., Fraser, A., Sawyer, G., Kountourides, G. S., Easey, K., Ford, G., Olszewska, Z., Howe, L. D., Lawlor, D. A., Alvergne, A., et al. (2021) · International Journal of Epidemiology · doi:10.1093/ije/dyab239 · Cited by 156 · see citing works
García‐Abellán, J., Padilla, S., Fernández‐González, M., García, J. A., Agulló, V., Galera, M. A., Ruiz, S., Galiana, A., Gutiérrez, F., & Masiá, M. (2021) · Journal of Clinical Immunology · doi:10.1007/s10875-021-01083-7 · Cited by 155 · see citing works
Guntur, V. P., Nemkov, T. G., de Boer, E., Mohning, M. P., Baraghoshi, D., Cendali, F. I., San-Millán, I., Petrache, I., & D’Alessandro, A. (2022) · Metabolites · doi:10.3390/metabo12111026 · Cited by 152 · see citing works
Characterization of autonomic symptom burden in long COVID: A global survey of 2,314 adults
Larsen, N. W., Stiles, L. E., Shaik, R., Schneider, L. D., Muppidi, S., Tsui, C. T., Geng, L. N., Bonilla, H. F., & Miglis, M. G. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.1012668 · Cited by 146 · see citing works
COVID-19 and male reproductive function: a prospective, longitudinal cohort study
Maleki, B. H., & Tartibian, B. (2021) · Reproduction · doi:10.1530/rep-20-0382 · Cited by 145 · see citing works
Herpesvirus infections and post-COVID-19 manifestations: a pilot observational study
Зубченко, С., Kril, I., Надіжко, О., Matsyura, O. I., & Chopyak, V. V. (2022) · Rheumatology International · doi:10.1007/s00296-022-05146-9 · Cited by 144 · see citing works
Kresch, E., Achua, J. K., Saltzman, R., et al. (2021) · The World Journal of Men s Health · doi:10.5534/wjmh.210055 · Cited by 140 · see citing works
Elslande, J. V., Oyaert, M., Ailliet, S., Ranst, M. A. V., Lorent, N., Weygaerde, Y. V., André, E., Lagrou, K., Vandendriessche, S., & Vermeersch, P. (2021) · Journal of Clinical Virology · doi:10.1016/j.jcv.2021.104765 · Cited by 135 · see citing works
Tejerina, F., Catalán, P., Rodríguez‐Grande, C., Adán‐Jiménez, J., Rodríguez, C., Muñóz, P., Aldámiz‐Echevarría, T., Díez, C., Latorre, L. P., Fanciulli, C., et al. (2022) · BMC Infectious Diseases · doi:10.1186/s12879-022-07153-4 · Cited by 134 · see citing works
Berg, S. K., Palm, P., Nygaard, U., Bundgaard, H., Petersen, M. N. S., Rosenkilde, S., Thorsted, A. B., Ersbøll, A. K., Thygesen, L. C., Nielsen, S. D., et al. (2022) · The Lancet Child & Adolescent Health · doi:10.1016/s2352-4642(22)00154-7 · Cited by 131 · see citing works
One year on: an updated systematic review of SARS-CoV-2, COVID-19 and audio-vestibular symptoms
Almufarrij, I., & Munro, K. J. (2021) · International Journal of Audiology · doi:10.1080/14992027.2021.1896793 · Cited by 130 · see citing works
Wood, E., Hall, K., & Tate, W. P. (2020) · Chronic Diseases and Translational Medicine · doi:10.1016/j.cdtm.2020.11.002 · Cited by 129 · see citing works
The Relationship between Physical Activity and Long COVID: A Cross-Sectional Study
Wright, J., Astill, S. L., & Sivan, M. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095093 · Cited by 128 · see citing works
Hoad, A., Spickett, G., Elliott, J. J., & Newton, J. L. (2008) · QJM · doi:10.1093/qjmed/hcn123 · Cited by 127 · see citing works
Quantitative Chest CT Assessment of Small Airways Disease in Post-Acute SARS-CoV-2 Infection
Cho, J. L., Villacreses, R. A., Nagpal, P., Guo, J., Pezzulo, A. A., Thurman, A. L., Hamzeh, N. Y., Blount, R. J., Fortis, S., Hoffman, E. A., et al. (2022) · Radiology · doi:10.1148/radiol.212170 · Cited by 126 · see citing works
The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS)
König, R. S., Albrich, W. C., Kahlert, C. R., Bahr, L. S., Löber, U., Vernazza, P., Scheibenbogen, C., & Forslund, S. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.628741 · Cited by 123 · see citing works
Lung Abnormalities Detected with Hyperpolarized 129 Xe MRI in Patients with Long COVID
Grist, J. T., Collier, G. J., Walters, H. L., Kim, M., Chen, M., Eid, G. A., Laws, A., Matthews, V., Jacob, K., Cross, S., et al. (2022) · Radiology · doi:10.1148/radiol.220069 · Cited by 123 · see citing works
Patel, M. A., Knauer, M. J., Nicholson, M., Daley, M., Nynatten, L. R. V., Martin, C. M., Patterson, E. K., Cepinskas, G., Seney, S. L., Dobretzberger, V., et al. (2022) · Molecular Medicine · doi:10.1186/s10020-022-00548-8 · Cited by 123 · see citing works
Twisk, F., & Maes, M. H. J. (2009) · PubMed · Cited by 121 · see citing works
Blomberg, J., Gottfries, C., Elfaitouri, A., Rizwan, M., & Rosén, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00229 · Cited by 119 · see citing works
Multisystem Involvement in Post‐Acute Sequelae of Coronavirus Disease 19
Novák, P., Mukerji, S. S., Alabsi, H. S., Systrom, D. M., Marciano, S. P., Felsenstein, D., Mullally, W. J., & Pilgrim, D. M. (2021) · Annals of Neurology · doi:10.1002/ana.26286 · Cited by 117 · see citing works
SARS‐CoV‐2 and Mitochondrial Proteins in Neural‐Derived Exosomes of COVID‐19
Peluso, M. J., Deeks, S. G., Mustapić, M., Kapogiannis, D., Henrich, T. J., Lu, S., Goldberg, S. A., Hoh, R., Chen, J. Y., Martinez, E. O., et al. (2022) · Annals of Neurology · doi:10.1002/ana.26350 · Cited by 116 · see citing works
Littlefield, K. M., Watson, R. O., Schneider, J. M., Neff, C. P., Yamada, E., Zhang, M., Campbell, T., Falta, M. T., Jolley, S. E., Fontenot, A. P., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010359 · Cited by 114 · see citing works
Holmes, E. C., Wist, J., Masuda, R., Lodge, S., Nitschke, P., Kimhofer, T., Loo, R. L., Begum, S., Boughton, B. A., Yang, R., et al. (2021) · Journal of Proteome Research · doi:10.1021/acs.jproteome.1c00224 · Cited by 113 · see citing works
Bitirgen, G., Korkmaz, C., Zamanı, A., Özkağnıcı, A., Zengįn, N., Ponirakis, G., & Malik, R. A. (2021) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2021-319450 · Cited by 110 · see citing works
Khan, S. R., Shilen, A., Heslin, K. M., Ishimwe, P., Allen, A. M., Jacobs, E. T., & Farland, L. V. (2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2021.09.016 · Cited by 110 · see citing works
Long COVID: The Nature of Thrombotic Sequelae Determines the Necessity of Early Anticoagulation
Wang, C., Yu, C.-Y., Jing, H., Wu, X.-M., Novakovic, V., Xie, R., & Shi, J.-L. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.861703 · Cited by 105 · see citing works
Grayson, D. A., Mackinnon, A. J., Jorm, A. F., Creasey, H. M., & Broe, G. A. (2000) · The Journals of Gerontology Series B · doi:10.1093/geronb/55.5.p273 · Cited by 104 · see citing works
Shikova, E., Reshkova, V., Kumanova, А., Raleva, S. H., Alexandrova, D., Čapo, N., Murovska, M., & on behalf of the European Network on ME CFS (2020) · Journal of Medical Virology · doi:10.1002/jmv.25744 · Cited by 104 · see citing works
Keller, B. A., Pryor, J. L., & Giloteaux, L. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-104 · Cited by 102 · see citing works
Morand, A., Campion, J., Lepine, A. F., et al. (2021) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-021-05528-4 · Cited by 102 · see citing works
Fernández-Castañeda, A., Lu, P., Geraghty, A. C., Song, E., Lee, M.-H., Wood, J., Yalçın, B., Taylor, K. R., Dutton, S., Acosta-Alvarez, L., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.07.475453 · Cited by 101 · see citing works
COVID-19 symptoms over time: comparing long-haulers to ME/CFS
Jason, L. A., Islam, M. F., Conroy, K. E., Cotler, J. H., Torres, C., Johnson, M., & Mabie, B. (2021) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2021.1922140 · Cited by 100 · see citing works
Prospective Evaluation of Autonomic Dysfunction in Post-Acute Sequela of COVID-19
Jamal, S. M., Landers, D. B., Hollenberg, S. M., Turi, Z. G., Glotzer, T. V., Tancredi, J., & Parrillo, J. E. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.03.357 · Cited by 100 · see citing works
Multi-organ impairment and long COVID: a 1-year prospective, longitudinal cohort study
Dennis, A., Cuthbertson, D. J., Wootton, D. G., Crooks, M. G., Gabbay, M., Eichert, N., Mouchti, S., Pansini, M., Roca‐Fernández, A., Thomaides-Brears, H. B., et al. (2023) · Journal of the Royal Society of Medicine · doi:10.1177/01410768231154703 · Cited by 100 · see citing works
Comparison of Seroconversion in Children and Adults With Mild COVID-19
Toh, Z. Q., Anderson, J., Mazarakis, N., Neeland, M. R., Higgins, R. A., Rautenbacher, K., Dohle, K., Nguyen, J., Overmars, I., Donato, C. M., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.1313 · Cited by 96 · see citing works
Persistent capillary rarefication in long COVID syndrome
Osiaevi, I., Schulze, A. B., Evers, G., et al. (2022) · Angiogenesis · doi:10.1007/s10456-022-09850-9 · Cited by 96 · see citing works
Factors Associated With Long COVID Symptoms in an Online Cohort Study
Durstenfeld, M. S., Peluso, M. J., Peyser, N. D., Lin, F., Knight, S. J., Djibo, A., Khatib, R., Kitzman, H. E., O'Brien, E. C., Williams, N. J., et al. (2023) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofad047 · Cited by 96 · see citing works
Gastrointestinal post-acute COVID-19 syndrome
Meringer, H., & Mehandru, S. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00611-z · Cited by 95 · see citing works
Charnley, M., Islam, S., Bindra, G. K., Engwirda, J., Ratcliffe, J., Zhou, J., Mezzenga, R., Hulett, M. D., Han, K., Berryman, J. T., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30932-1 · Cited by 94 · see citing works
Sørensen, A. I. V., Spiliopoulos, L., Bager, P., Nielsen, N. M., Hansen, J. V., Koch, A., Meder, I. K., Ethelberg, S., & Hviid, A. P. (2022) · Nature Communications · doi:10.1038/s41467-022-31897-x · Cited by 91 · see citing works
Pulmonary Dysfunction after Pediatric COVID-19
Heiss, R., Wagner, A., Tan, L., Schmidt, S., Regensburger, A. P., Ewert, F., Mammadova, D., Büehler, A., Vogel‐Claussen, J., Voskrebenzev, A., et al. (2022) · Radiology · doi:10.1148/radiol.221250 · Cited by 90 · see citing works
Galán, M. Á., Vigón, L., Fuertes, D., Murciano-Antón, M. A., Casado‐Fernández, G., Domínguez-Mateos, S., Mateos, E., Ramos-Martín, F., Planelles, V., Torres, M., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.848886 · Cited by 88 · see citing works
Risk factors and abnormal cerebrospinal fluid associate with cognitive symptoms after mild COVID ‐19
Apple, A. C., Oddi, A., Peluso, M. J., Asken, B. M., Henrich, T. J., Kelly, J. D., Pleasure, S. J., Deeks, S. G., Allen, I. E., Martin, J. N., et al. (2022) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51498 · Cited by 87 · see citing works
Stellate ganglion block reduces symptoms of Long COVID: A case series
Liu, L. D., & Duricka, D. (2021) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2021.577784 · Cited by 85 · see citing works
Hu, F., Chen, F., Ou, Z., Fan, Q., Tan, X., Wang, Y., Pan, Y., Ke, B., Li, L., Guan, Y., et al. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-00550-2 · Cited by 84 · see citing works
Esfandyarpour, R., Kashi, A. A., Nemat‐Gorgani, M., Wilhelmy, J., & Davis, R. W. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901274116 · Cited by 83 · see citing works
Nunes, J. M., Kruger, A., Proal, A. D., Kell, D. B., & Pretorius, E. (2022) · Pharmaceuticals · doi:10.3390/ph15080931 · Cited by 78 · see citing works
Sen, S., Kannan, N. B., Kumar, J., Rajan, R. P., Kumar, K., Baliga, G., Reddy, H., Upadhyay, A., & Ramasamy, K. (2021) · International Ophthalmology · doi:10.1007/s10792-021-01996-7 · Cited by 75 · see citing works
Schreiner, P., Harrer, T., Scheibenbogen, C., Lamer, S., Schlösser, A., Naviaux, R. K., & Prusty, B. K. (2020) · ImmunoHorizons · doi:10.4049/immunohorizons.2000006 · Cited by 72 · see citing works
de Almeida, V. M., Engel, D. F., Ricci, M. F., Cruz, C. S., Lopes, Í. S., Alves, D. A., Auriol, M. D., Magalhães, J., Machado, E. C., Rocha, V. M., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2249146 · Cited by 69 · see citing works
Demko, Z. O., Yu, T., Mullapudi, S. K., Heslin, M. G. V., Dorsey, C. A., Payton, C., Tornheim, J. A., Blair, P. W., Mehta, S. H., Thomas, D. L., et al. (2024) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofae027 · Cited by 69 · see citing works
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from?
Toogood, P. L., Clauw, D. J., Phadke, S., & Hoffman, D. L. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105465 · Cited by 68 · see citing works
Thomas, N., Gurvich, C., Huang, K., Gooley, P. R., & Armstrong, C. W. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100995 · Cited by 68 · see citing works
Long COVID‐19 Liver Manifestation in Children
Cooper, S., Tobar, A., Konen, O., et al. (2022) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000003521 · Cited by 65 · see citing works
Long-COVID treatments: why the world is still waiting
Ledford, H. K. (2022) · Nature · doi:10.1038/d41586-022-02140-w · Cited by 65 · see citing works
Zhang, L., Xu, Z., Mak, J. W. Y., Chow, K. M., Lui, G. C.-Y., Li, T. C. M., Wong, C. K., Chan, P. K. S., Ching, J. Y. L., Fujiwara, Y., et al. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15796 · Cited by 64 · see citing works
Bragée, B., Michos, A., Fahlgren, M., Drum, B., Szulkin, R., & Bertilson, B. C. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00828 · Cited by 63 · see citing works
Raj, S. R., Bourne, K. M., Stiles, L. E., Miglis, M. G., Cortez, M. M., Miller, A. J., Freeman, R. L., Biaggioni, I., Rowe, P. C., Sheldon, R. S., et al. (2021) · Autonomic Neuroscience · doi:10.1016/j.autneu.2021.102836 · Cited by 63 · see citing works
Tsuchida, T., Hirose, M., Inoue, Y., Kunishima, H., Otsubo, T., & Matsuda, T. (2022) · Journal of Medical Virology · doi:10.1002/jmv.27689 · Cited by 63 · see citing works
Giron, L. B., Peluso, M. J., Ding, J., Kenny, G., Zilberstein, N., Koshy, J., Hong, K. Y., Rasmussen, H. E., Miller, G. E., Bishehsari, F., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.160989 · Cited by 63 · see citing works
Holdsworth, D., Chamley, R. R., Barker-Davies, R. M., O’Sullivan, O., Ladlow, P., Mitchell, J., Dewson, D., Mills, D. S., May, S., Cranley, M., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0267392 · Cited by 62 · see citing works
Hohberger, B., Harrer, T., Mardin, C. Y., et al. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.754667 · Cited by 61 · see citing works
Persistence of SARS-CoV-2 RNA in lung tissue after mild COVID-19
Ceulemans, L. J., Khan, M., Yoo, S., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00240-x · Cited by 59 · see citing works
Long-Term COVID 19 Sequelae in Adolescents: the Overlap with Orthostatic Intolerance and ME/CFS
Morrow, A. K., Malone, L. A., Kokorelis, C., Petracek, L. S., Eastin, E. F., Lobner, K. L., Neuendorff, L., & Rowe, P. C. (2022) · Current Pediatrics Reports · doi:10.1007/s40124-022-00261-4 · Cited by 59 · see citing works
Predictors of Nonseroconversion after SARS-CoV-2 Infection
Liu, W., Russell, R. M., Bibollet‐Ruche, F., Skelly, A. N., Sherrill-Mix, S. A., Freeman, D. A., Stoltz, R., Lindemuth, E., Lee, F.-H., Sterrett, S., et al. (2021) · Emerging infectious diseases · doi:10.3201/eid2709.211042 · Cited by 58 · see citing works
Cognitive decline and brainstem hypometabolism in long COVID: A case series
Hugon, J., Queneau, M., Ortiz, M. S., Msika, E. F., Farid, K., & Paquet, C. (2022) · Brain and Behavior · doi:10.1002/brb3.2513 · Cited by 58 · see citing works
Nirmatrelvir and the Risk of Post-Acute Sequelae of COVID-19Preprint
Xie, Y., Choi, T., & Al‐Aly, Z. (2022) · medRxiv · doi:10.1101/2022.11.03.22281783 · Cited by 57 · see citing works
Cardiac abnormalities in Long COVID 1-year post-SARS-CoV-2 infection
Roca‐Fernández, A., Wamil, M., Telford, A., Carapella, V., Borlotti, A., Monteiro, D., Thomaides-Brears, H. B., Kelly, M., Dennis, A., Banerjee, R., et al. (2023) · Open Heart · doi:10.1136/openhrt-2022-002241 · Cited by 55 · see citing works
Low-dose naltrexone as a treatment for chronic fatigue syndrome
Bolton, M. J., Chapman, B. P., & van Marwijk, H. (2020) · BMJ Case Reports · doi:10.1136/bcr-2019-232502 · Cited by 53 · see citing works
Renz‐Polster, H., Tremblay, M., Bienzle, D., & Fischer, J. E. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.888232 · Cited by 53 · see citing works
Menuchin-Lasowski, Y., Schreiber, A., Lecanda, A., Mecate‐Zambrano, A., Brunotte, L., Psathaki, O. E., Ludwig, S., Rauen, T., & Schöler, H. R. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.02.015 · Cited by 52 · see citing works
Barros, A., Queiruga-Piñeiro, J., Lozano, J. B., Alcalde, I., Gallar, J., Fernández-Vega-Cueto, L., Alfonso, J. F., Quirós, L. M., & Merayo-Llovés, J. (2021) · The Ocular Surface · doi:10.1016/j.jtos.2021.10.010 · Cited by 51 · see citing works
Loss of mitochondrial membrane potential (ΔΨm) in leucocytes as post-COVID-19 sequelae
Díaz-Resendiz, K. J. G., Benitez-Trinidad, A. B., Covantes-Rosales, C. E., Toledo-Ibarra, G. A., Ortiz-Lazareno, P. C., Girón-Pérez, D. A., Bueno-Durán, A. Y., Díaz, D. A. P., Barcelos-García, R. G., & Girón-Pérez, M. I. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ma0322-279rrr · Cited by 50 · see citing works
Merzon, E., Weiss, M. D., Krone, B., Cohen, S., Ilani, G., Vinker, S., Cohen, A. G., Green, I., Israel, A., Schneider, T., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19105993 · Cited by 49 · see citing works
Longitudinal immune dynamics of mild COVID-19 define signatures of recovery and persistencePreprint
Talla, A., Vasaikar, S. V., Lemos, M. P., Moodie, Z., Pebworth, M.-P., Henderson, K. E., Cohen, K. W., Czartoski, J., Lai, L., Suthar, M. S., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.05.26.442666 · Cited by 45 · see citing works
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Efficacy of Repeat Immunoadsorption
Tölle, M., Freitag, H., Antelmann, M., Hartwig, J., Schuchardt, M., van der Giet, M., Eckardt, K., Grabowski, P., & Scheibenbogen, C. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082443 · Cited by 43 · see citing works
Williamson, A. E., Tydeman, F. A. S., Miners, A. H., Pyper, K., & Martineau, A. R. (2022) · BMJ Open · doi:10.1136/bmjopen-2022-065083 · Cited by 41 · see citing works
Nkiliza, A., Parks, M., Cseresznye, A., Oberlin, S., Evans, J. E., Darcey, T. S., Aenlle, K. K., Niedospial, D., MULLAN, M. J., Crawford, F., et al. (2021) · Journal of Translational Medicine · doi:10.1186/s12967-021-03035-6 · Cited by 40 · see citing works
Vernon, S. D., Funk, S., Bateman, L., et al. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.917019 · Cited by 40 · see citing works
Early menopause and other gynecologic risk indicators for chronic fatigue syndrome in women
Boneva, R. S., Lin, J.-M. S., & Unger, E. R. (2015) · Menopause · doi:10.1097/gme.0000000000000411 · Cited by 37 · see citing works
Jarvis, K. F., & Kelley, J. B. (2021) · Scientific Reports · doi:10.1038/s41598-021-88498-9 · Cited by 37 · see citing works
Reproductive correlates of chronic fatigue syndrome
Harlow, B. L., Lb, S., Hall, J. E., Dailey, C., & Komaroff, A. L. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(98)00173-9 · Cited by 35 · see citing works
Korte, W. C., Buljan, M., Rösslein, M., et al. (2020) · Journal of Infection · doi:10.1016/j.jinf.2020.08.032 · Cited by 35 · see citing works
Self-Reported Menstrual Alterations During the COVID-19 Syndemic in Spain: A Cross-Sectional Study
Medina‐Perucha, L., López‐Jiménez, T., Holst, A. S., Jacques‐Aviñó, C., Munrós-Feliu, J., Martínez-Bueno, C., Valls-Llobet, C., Pinzón-Sanabria, D., Vicente-Hernández, M. M., & Berenguera, A. (2022) · International Journal of Women s Health · doi:10.2147/ijwh.s354655 · Cited by 34 · see citing works
van Campen, C. M. C., & Visser, F. C. (2022) · Healthcare · doi:10.3390/healthcare10102105 · Cited by 32 · see citing works
Nomura, Y., Sawahata, M., Nakamura, Y., et al. (2021) · Vaccines · doi:10.3390/vaccines9121500 · Cited by 31 · see citing works
Yu, J., Granberg, T., Shams, R., Petersson, S., Sköld, M. C., Nyrén, S., & Lundberg, J. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13558 · Cited by 31 · see citing works
Long COVID is associated with extensive in-vivo neuroinflammation on [ 18 F]DPA-714 PETPreprint
Visser, D., Golla, S. S. V., Verfaillie, S. C. J., et al. (2022) · medRxiv · doi:10.1101/2022.06.02.22275916 · Cited by 30 · see citing works
van Campen, C. M. C., & Visser, F. C. (2022) · Healthcare · doi:10.3390/healthcare10102058 · Cited by 30 · see citing works
The Use of Nirmatrelvir-ritonavir in a Case of Breakthrough Long COVID
Geng, L. N., Bonilla, H. F., Shafer, R. W., Miglis, M. G., & Yang, P. C.-M. (2023) · Exploratory Research and Hypothesis in Medicine · doi:10.14218/erhm.2022.00045 · Cited by 29 · see citing works
Cysique, L. A., Jakabek, D., Bracken, S. G., Allen‐Davidian, Y., Heng, B., Chow, S., Dehhaghi, M., Pires, A. S., Darley, D. R., Byrne, A., et al. (2022) · medRxiv · doi:10.1101/2022.06.07.22276020 · Cited by 28 · see citing works
Parosmia—a common consequence of covid-19
Walker, A., Kelly, C., Pottinger, G., et al. (2022) · BMJ · doi:10.1136/bmj-2021-069860 · Cited by 26 · see citing works
Is It Useful to Question the Recovery Behaviour of Patients with ME/CFS or Long COVID?
Vink, M., & Vink-Niese, F. (2022) · Healthcare · doi:10.3390/healthcare10020392 · Cited by 24 · see citing works
Abnormal quantitative pupillary light responses following COVID-19
Bitirgen, G., Korkmaz, C., Zamanı, A., et al. (2022) · International Ophthalmology · doi:10.1007/s10792-022-02275-9 · Cited by 24 · see citing works
Repurposing low-dose naltrexone for the prevention and treatment of immunothrombosis in COVID-19
Pitt, B., Tate, A. M., Gluck, D., Rosenson, R. S., & Goonewardena, S. N. (2022) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvac014 · Cited by 23 · see citing works
Boneva, R. S., Lin, J.-M. S., Wieser, F., Nater, U. M., Ditzen, B., Taylor, R. N., & Unger, E. R. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00195 · Cited by 22 · see citing works
Coverage of CFS within U.S. Medical Schools
Peterson, T. M., Peterson, T. W., Emerson, S., Evans, E. R. M. A., & Jason, L. A. (2013) · Universal Journal of Public Health · doi:10.13189/ujph.2013.010404 · Cited by 20 · see citing works
Thomas, R., Williams, M. M. A., Aldous, J. W. F., Yanagisawa, Y., Kumar, R., Forsyth, R., & Chater, A. (2022) · COVID · doi:10.3390/covid2040031 · Cited by 20 · see citing works
Stavılecı, B., Özdemir, E., Özdemir, B., Ereren, E., & Cengız, M. (2022) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2022.02.012 · Cited by 20 · see citing works
COVID-19 and Mitochondrial Non-Coding RNAs: New Insights From Published Data
Pozzi, A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2021.805005 · Cited by 19 · see citing works
Cardiac impairment in Long Covid 1-year post SARS-CoV-2 infection
Roca‐Fernández, A., Wamil, M., Telford, A., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac544.219 · Cited by 19 · see citing works
Levine-Tiefenbrun, M., Yelin, I., Uriel, H., Kuint, J., Schreiber, L., Herzel, E., Katz, R., Ben‐Tov, A., Gazit, S., Patalon, T., et al. (2021) · Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2021.10.010 · Cited by 18 · see citing works
Villaume, W. A. (2022) · Medical Hypotheses · doi:10.1016/j.mehy.2022.110842 · Cited by 18 · see citing works
Belcaro, G. V., Cornelli, U., Cesarone, M. R., SCIPIONE, C., SCIPIONE, V., Hu, S., Feragalli, B., Corsi, M., David, C. O. X., Cotellese, R., et al. (2022) · Minerva Medica · doi:10.23736/s0026-4806.21.07650-3 · Cited by 17 · see citing works
Impaired systemic oxygen extraction long after mild COVID-19: potential perioperative implications
Heerdt, P. M., Shelley, B., & Singh, I. (2021) · British Journal of Anaesthesia · doi:10.1016/j.bja.2021.12.036 · Cited by 16 · see citing works
de Almeida, V. M., Engel, D. F., Ricci, M. F., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1756189/v1 · Cited by 14 · see citing works
Multi-organ impairment and Long COVID: a 1-year prospective, longitudinal cohort studyPreprint
Dennis, A., Cuthbertson, D. J., Wootton, D. G., Crooks, M. G., Gabbay, M., Eichert, N., Mouchti, S., Pansini, M., Roca‐Fernández, A., Thomaides-Brears, H. B., et al. (2022) · medRxiv · doi:10.1101/2022.03.18.22272607 · Cited by 14 · see citing works
Erythrocyte Deformability As a Potential Biomarker for Chronic Fatigue Syndrome
Saha, A. K., Schmidt, B. R., Wilhelmy, J., et al. (2018) · Blood · doi:10.1182/blood-2018-99-117260 · Cited by 12 · see citing works
Schultheiß, C., Willscher, E., Paschold, L., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3963839 · Cited by 10 · see citing works
Grandjean, D., Slama, D., Gallet, C., et al. (2022) · medRxiv · doi:10.1101/2022.01.11.21268036 · Cited by 10 · see citing works
Nguyen, T. U., Johnston, S., Chacko, A., Gibson, D., Cepon, J., Smith, P. K., Staines, D., & Marshall‐Gradisnik, S. (2017) · PubMed · doi:10.12932/ap0771 · Cited by 9 · see citing works
Case Report: Famotidine for Neuropsychiatric Symptoms in COVID-19
Alper, K. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.614393 · Cited by 9 · see citing works
Jason, L. A., Kalns, J., Richarte, A. M., Katz, B. Z., & Torres, C. (2021) · Fatigue Biomedicine Health & Behavior · doi:10.1080/21641846.2021.1994222 · Cited by 9 · see citing works
Are low SARS-CoV-2 viral loads in infected children missed by RT-PCR testing?
Langeland, N., & Cox, R. J. (2021) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2021.100138 · Cited by 8 · see citing works
Charfeddine, S., Hadjamor, H. I., Torjmen, S., et al. (2021) · Archives of Cardiovascular Diseases Supplements · doi:10.1016/j.acvdsp.2021.10.007 · Cited by 8 · see citing works
Ängstlichkeit bei Patienten mit posturalem Tachykardiesyndrom (POTS)
Wagner, C., Isenmann, S., Ringendahl, H., & Haensch, C. (2012) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/s-0031-1299106 · Cited by 7 · see citing works
Persistence of residual SARS-CoV-2 viral antigen and RNA in tissues of patients with long COVID-19Preprint
Goh, D. L. M., Lim, J. C. T., Fernández, S. B., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1379777/v1 · Cited by 7 · see citing works
A reconstruction of early cryptic COVID spread
Cauchemez, S., & Bosetti, P. (2021) · Nature · doi:10.1038/d41586-021-02989-3 · Cited by 6 · see citing works
A Two-Phase, Single Cohort Study of COVID-19 Antibody Sera-Surveillance
Williams, J. O., Watkeys, L. J., Nash, J., et al. (2021) · Annals of Epidemiology and Public Health · doi:10.33582/2639-4391/1055 · Cited by 5 · see citing works
The use of oxygen as a possible screening biomarker for the diagnosis of chronic fatigue
Pifarré, F., Rosselló, L., Hileno, R., et al. (2022) · Apunts Sports Medicine · doi:10.1016/j.apunsm.2022.100379 · Cited by 4 · see citing works
Collaboratory, V. C.-1. O. R. (2022) · medRxiv · doi:10.1101/2022.03.20.22272571 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 6
- [5]Ayoubkhani, D. et al. Risk of Long Covid in people infected with SARS-CoV-2 after two doses of a COVID-19 vaccine: community-based, matched cohort study. Preprint at medRxiv10.1101/2022.02.23.22271388 (2022).
- [13]Demko, Z. O. et al. Post-acute sequelae of SARS-CoV-2 (PASC) impact quality of life at 6, 12 and 18 months post-infection. Preprint at medRxiv10.1101/2022.08.08.22278543 (2022).
- [22]Peluso MJ Evidence of recent Epstein-Barr virus reactivation in individuals experiencing Long COVID Preprint at medRxiv 2022 10.1101/2022.06.21.22276660 36523412 PMC9753782 · DOI
- [95]Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, Board on the Health of Select Populations, & Institute of Medicine. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness (National Academies Press, 2015). 25695122
- [120]Larsen NW Characterization of autonomic symptom burden in long COVID: a global survey of 2,314 adults Front. Neurol. 2022 13 1012668 10.3389/fneur.2022.1012668 36353127 PMC9639503 · DOI
- [197]Wagner C Isenmann S Ringendahl H Haensch C-A Anxiety in patients with postural tachycardia syndrome (POTS) Fortschr. Neurol. Psychiatr. 2012 80 458 462 22692879
Cited by
Sorted by citations
Berk, M., Köhler‐Forsberg, O., Turner, M., Penninx, B. W. J. H., Wrobel, A., Firth, J., Loughman, A., Reavley, N. J., McGrath, J. J., Momen, N. C., et al. (2023) · World Psychiatry · doi:10.1002/wps.21110 · Cited by 336 · see citing works
In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Cankat, S., Demael, M. U., & Swadling, L. (2023) · Cellular & Molecular Immunology · doi:10.1038/s41423-023-01116-8 · Cited by 84 · see citing works
Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology
Aguado, J., Amarilla, A. A., Taherian Fard, A., Albornoz, E. A., Tyshkovskiy, A., Schwabenland, M., Chaggar, H. K., Modhiran, N., Gómez-Inclán, C., Javed, I., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00519-6 · Cited by 80 · see citing works
Wood, G. K., Sargent, B. F., Ahmad, Z.-U.-A., Tharmaratnam, K., Dunai, C., Egbe, F. N., Martin, N. H., Facer, B., Pendered, S. L., Rogers, H. C., et al. (2025) · Nature Medicine · doi:10.1038/s41591-024-03309-8 · Cited by 67 · see citing works
- Authors
- Davis, H. E., McCorkell, L., Vogel, J. M., & Topol, E. J.
- Affiliations
- Patient-Led Research Collaborative (US)
- Scripps Research Institute (US)
- Corresponding author
- Topol, Eric J.
- Venue
- Nature Reviews Microbiology
- Published
- 2023-01-13
- Volume
- 21
- Issue
- 3
- Pages
- 133-146
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- PMC
- PMC9839201
- OpenAlex
- W4316014106
- Cited by
- 4,153
- References
- 196
- Citations by year
- 2026: 679 · 2025: 1140 · 2024: 1526 · 2023: 798 · 2022: 5 · 2013: 2
- FWCI
- 168.60
- Type
- journal article
- Language
- en
- Update notices
- correction (2023-04-17)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (UL1TR002550)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- long COVID, pathophysiological mechanisms, risk factors, chronic fatigue syndrome, postural orthostatic tachycardia syndrome, COVID-19 vaccination, research bias, COVID-19 testing, patient engagement, marginalized communities
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Testing, Post-Acute COVID-19 Syndrome, Child, Humans, Biomedical Research
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review