The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
The diversity and disparity of the glial scar
Open accessAbstract
Injury or disease to the CNS results in multifaceted cellular and molecular responses. One such response, the glial scar, is a structural formation of reactive glia around an area of severe tissue damage. While traditionally viewed as a barrier to axon regeneration, beneficial functions of the glial scar have also been recently identified. In this Perspective, we discuss the divergent roles of the glial scar during CNS regeneration and explore the possibility that these disparities are due to functional heterogeneity within the cells of the glial scar—specifically, astrocytes, NG2 glia and microglia. The glial scar plays critical but divergent roles during regeneration of the mammalian CNS. Here the authors propose that in-depth analysis of the functionally heterogeneous populations of reactive glia within the scar is needed to fully understand the glial scar’s dual nature.
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Neurotoxic reactive astrocytes are induced by activated microglia
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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
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Chondroitinase ABC promotes functional recovery after spinal cord injury
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Reactive Astrocytes: Production, Function, and Therapeutic Potential
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Astrocyte scar formation aids central nervous system axon regeneration
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New tools for studying microglia in the mouse and human CNS
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Moving beyond the glial scar for spinal cord repair
Bradbury, E. J., & Burnside, E. R. (2019) · Nature Communications · doi:10.1038/s41467-019-11707-7 · Cited by 743
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Ischemia-Triggered Glutamate Excitotoxicity From the Perspective of Glial Cells
Belov Kirdajova, D., Kriska, J., Tureckova, J., & Anderova, M. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00051 · Cited by 428
Ageing and rejuvenation of tissue stem cells and their niches
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Metadata
- Authors
- Adams, K. L., & Gallo, V.
- Venue
- Nature Neuroscience
- Published
- 2017-12-21
- Volume
- 21
- Issue
- 1
- Pages
- 9-15
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- OpenAlex
- W2771853756
- Cited by
- 419
- References
- 81
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- green
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