The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Moving beyond the glial scar for spinal cord repair
Open accessAbstract
Traumatic spinal cord injury results in severe and irreversible loss of function. The injury triggers a complex cascade of inflammatory and pathological processes, culminating in formation of a scar. While traditionally referred to as a glial scar, the spinal injury scar in fact comprises multiple cellular and extracellular components. This multidimensional nature should be considered when aiming to understand the role of scarring in limiting tissue repair and recovery. In this Review we discuss recent advances in understanding the composition and phenotypic characteristics of the spinal injury scar, the oversimplification of defining the scar in binary terms as good or bad, and the development of therapeutic approaches to target scar components to enable improved functional outcome after spinal cord injury.
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Cites
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Cited by
Spinal cord injury: molecular mechanisms and therapeutic interventions
Hu, X., Xu, W., Ren, Y., Wang, Z., He, X., Huang, R., Ma, B., Zhao, J., Zhu, R., & Cheng, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01477-6 · Cited by 770
Astrocytes in human central nervous system diseases: a frontier for new therapies
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Fan, L., Liu, C., Chen, X., Zheng, L., Zou, Y., Wen, H., Guan, P., Lu, F., Luo, Y., Tan, G., et al. (2022) · Advanced Science · doi:10.1002/advs.202105586 · Cited by 401
Regulation of axonal regeneration after mammalian spinal cord injury
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Microglia as hackers of the matrix: sculpting synapses and the extracellular space
Crapser, J. D., Arreola, M. A., Tsourmas, K. I., & Green, K. N. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-021-00751-3 · Cited by 178
Metadata
- Authors
- Bradbury, E. J., & Burnside, E. R.
- Venue
- Nature Communications
- Published
- 2019-08-28
- Volume
- 10
- Issue
- 1
- Pages
- 3879-3879
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2970959902
- Cited by
- 743
- References
- 35
- FWCI
- 46.01
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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