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A multi-omics dataset for the analysis of frontotemporal dementia genetic subtypes

Menden, Kevin, Francescatto, Margherita, Nyima, Tenzin, Blauwendraat, Cornelis, Dhingra, Ashutosh, Castillo-Lizardo, Melissa, Fernandes, Noémia, Kaurani, Lalit, Kronenberg-Versteeg, Deborah, Atasu, Burcu, Sadikoglou, Eldem, Borroni, Barbara, Rodriguez-Nieto, Salvador, Simon-Sanchez, Javier, Fischer, Andre, Craig, David Wesley, Neumann, Manuela, Bonn, Stefan, Rizzu, Patrizia, Heutink, Peter·2023·Scientific Data
DOI 10.1038/s41597-023-02598-xPMC PMC10692098

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Abstract

Understanding the molecular mechanisms underlying frontotemporal dementia (FTD) is essential for the development of successful therapies. Systematic studies on human post-mortem brain tissue of patients with genetic subtypes of FTD are currently lacking. The Risk and Modyfing Factors of Frontotemporal Dementia (RiMod-FTD) consortium therefore has generated a multi-omics dataset for genetic subtypes of FTD to identify common and distinct molecular mechanisms disturbed in disease. Here, we present multi-omics datasets generated from the frontal lobe of post-mortem human brain tissue from patients with mutations in MAPT, GRN and C9orf72 and healthy controls. This data resource consists of four datasets generated with different technologies to capture the transcriptome by RNA-seq, small RNA-seq, CAGE-seq, and methylation profiling. We show concrete examples on how to use the resulting data and confirm current knowledge about FTD and identify new processes for further investigation. This extensive multi-omics dataset holds great value to reveal new research avenues for this devastating disease.

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Metadata

Authors
Menden, K., Francescatto, M., Nyima, T., Blauwendraat, C., Dhingra, A., Castillo-Lizardo, M., Fernandes, N., Kaurani, L., Kronenberg-Versteeg, D., Atasu, B., Sadikoglou, E., Borroni, B., Rodriguez-Nieto, S., Simon-Sanchez, J., Fischer, A., Craig, D. W., Neumann, M., Bonn, S., Rizzu, P., & Heutink, P.
ORCID
Venue
Scientific Data
Publisher
Springer Science and Business Media LLC
Published
2023-12-01
Volume
10
Issue
1
ISSN
2052-4463
DOI
10.1038/s41597-023-02598-x
PMC
PMC10692098
Cited by
20
References
3
Language
en
Licence
Funders
  • NOMIS Stiftung
  • EU Joint Programme – Neurodegenerative Disease Research

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