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Cited by 40Pancreatic function and diabetesDiabetes Treatment and ManagementDiabetes and associated disorders

Insulin, glucagon and somatostatin stores in the pancreas of subjects with type-2 diabetes and their lean and obese non-diabetic controls

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Henquin, Jean-Claude, Ibrahim, Majeed M., Rahier, Jacques·2017·Scientific Reports
DOI 10.1038/s41598-017-10296-zPMC PMC5591190
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Abstract

In type-2 diabetes, both insufficient insulin and excessive glucagon secretion contribute to hyperglycemia. We compared insulin, glucagon and somatostatin stores in pancreas obtained at autopsy of 20 lean and 19 obese non-diabetic (ND), and 18 type-2 diabetic (T2D) subjects. From concentrations and pancreas weight, total content of hormones was calculated. Insulin content was 35% lower in T2D than ND subjects (7.4 versus 11.3 mg), whereas glucagon content was similar (0.76 versus 0.81 mg). The higher ratio of glucagon/insulin contents in T2D was thus explained by the decrease in insulin. With increasing BMI of ND subjects, insulin and glucagon contents respectively tended to increase and decrease, resulting in a lower glucagon/insulin ratio in obesity. With aging, insulin and glucagon contents did not significantly change in ND subjects but declined in T2D subjects, without association with the duration of diabetes or type of treatment. The somatostatin content was lower in T2D than ND subjects (0.027 versus 0.038 mg), but ratios somatostatin/insulin and somatostatin/glucagon were not different. In conclusion, insulin stores are about 1/3 lower in T2D than ND subjects, whereas glucagon stores are unchanged. Abnormal secretion of each hormone in type-2 diabetes cannot be attributed to major alterations in their pancreatic reserves.

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  • Beta-cell secretory function was fitted to data from glucose-induced insulin secretion in perfused human islets.

    “the beta-cell secretory function was fitted to data from glucose-induced insulin secretion in perfused human islets ( 44, 45 );”

    From Dynamic modulation of glucose utilisation by glucocorticoid rhythms in health and disease (2020) · cites this paper as [45]

    The Methods (Pancreas processing; page unavailable) describe measuring hormone concentrations in extracted pancreatic tissue, not fitting a beta-cell secretory function. Searches for perfused human islets, glucose-induced insulin secretion, and a fitted secretory function found no passage addressing the claimed fit. (LLM, conf=0.77)

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Cited by

Sorted by citations

Authors
Henquin, J.-C., Ibrahim, M. M., & Rahier, J.
Affiliations
UCLouvain (BE)
Corresponding author
Henquin, Jean-Claude
ORCID
Henquin, Jean-Claude
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2017-09-08
Volume
7
Issue
1
Pages
11015-11015
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-017-10296-z
PMC
PMC5591190
OpenAlex
W2753472776
Cited by
40
References
3
Citations by year
2026: 3 · 2025: 1 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 3
FWCI
3.92
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords
type 2 diabetes, glucagon/insulin ratio, obesity, body mass index, aging, hyperglycemia
MeSH terms
Adult, Aged, Aged, 80 and over, Diabetes Mellitus, Type 2, Female, Glucagon, Humans, Insulin, Male, Middle Aged, Obesity, Pancreas, Somatostatin

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