The anti-hyperglycemia effects of Rhizoma Coptidis alkaloids: A systematic review of modern pharmacological studies of the traditional herbal medicine

Biochemistry and molecular cell biology of diabetic complications

Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works

Evolution of mammals and their gut microbes

Ley, R. E., Hamady, M., Lozupone, C., Turnbaugh, P. J., Ramey, R. R., Bircher, J. S., Schlegel, M. L., Tucker, T. A., Schrenzel, M. D., Knight, R., et al. (2008) · Science · doi:10.1126/science.1155725 · Cited by 3,747 · see citing works

Mechanisms of Diabetic Complications

Forbes, J. M., & Cooper, M. E. (2013) · Physiological Reviews · doi:10.1152/physrev.00045.2011 · Cited by 2,890 · see citing works

Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2

Tolhurst, G., Heffron, H., Lam, Y. S., Parker, H. E., Habib, A. M., Diakogiannaki, E., Cameron, J., Grosse, J., Reimann, F., & Gribble, F. M. (2012) · Diabetes · doi:10.2337/db11-1019 · Cited by 2,404 · see citing works

Mechanisms for Insulin Resistance: Common Threads and Missing Links

Samuel, V. T., & Shulman, G. I. (2012) · Cell · doi:10.1016/j.cell.2012.02.017 · Cited by 2,294 · see citing works

Butyrate improves insulin sensitivity and increases energy expenditure in mice

Gao, Z., Yin, J., Zhang, J., Ward, R. E., Martin, R. J., Lefevre, M., Cefalu, W. T., & Ye, J. (2009) · Diabetes · doi:10.2337/db08-1637 · Cited by 2,204 · see citing works

The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307

Aguirre, V., Uchida, T., Yenush, L., Davis, R., & White, M. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.9047 · Cited by 1,487 · see citing works

Cellular and molecular mechanisms of renal fibrosis

Liu, Y. (2011) · Nature Reviews Nephrology · doi:10.1038/nrneph.2011.149 · Cited by 1,456 · see citing works

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms

Lin, H. V., Frassetto, A., Kowalik Jr, E. J., Nawrocki, A. R., Lu, M. M., Kosinski, J. R., Hubert, J. A., Szeto, D., Yao, X., Forrest, G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035240 · Cited by 1,378 · see citing works

Structure-Function Studies of the Adipocyte-secreted Hormone Acrp30/Adiponectin

Pajvani, U. B., Du, X., Combs, T. P., Berg, A. H., Rajala, M. W., Schulthess, T., Engel, J., Brownlee, M., & Scherer, P. E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m207198200 · Cited by 1,090 · see citing works

Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States

Lee, Y. S., Kim, W. S., Kim, K. H., Yoon, M. J., Cho, H. J., Shen, Y., Ye, J.-M., Lee, C. H., Oh, W. K., Kim, C. T., et al. (2006) · Diabetes · doi:10.2337/db06-0006 · Cited by 1,054 · see citing works

The Stages in Diabetic Renal Disease: With Emphasis on the Stage of Incipient Diabetic Nephropathy

Mogensen, C. E., Christensen, C., & Vittinghus, E. (1983) · Diabetes · doi:10.2337/diab.32.2.s64 · Cited by 973 · see citing works

The role of incretins in glucose homeostasis and diabetes treatment

Kim, W., & Egan, J. M. (2008) · Pharmacological Reviews · doi:10.1124/pr.108.000604 · Cited by 824 · see citing works

The efficiency of multi-target drugs: the network approach might help drug design

CSERMELY, P., AGOSTON, V, & PONGOR, S. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.02.007 · Cited by 803 · see citing works

Rho family proteins: coordinating cell responses

Ridley, A. J. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02153-5 · Cited by 767 · see citing works

Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease

Raffetto, J. D., & Khalil, R. A. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.07.004 · Cited by 755 · see citing works

Inflammatory pathways and insulin action

Hotamisligil, G. S. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802502 · Cited by 717 · see citing works

Structural Changes of Gut Microbiota during Berberine-Mediated Prevention of Obesity and Insulin Resistance in High-Fat Diet-Fed Rats

Zhang, X., Zhao, Y., Zhang, M., Pang, X., Xu, J., Kang, C., Li, M., Zhang, C., Zhang, Z., Zhang, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042529 · Cited by 615 · see citing works

The role of gut hormones in glucose homeostasis

Drucker, D. J. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30076 · Cited by 611 · see citing works

Pathogenetic Mechanisms of Diabetic Nephropathy

Schena, F. P., & Gesualdo, L. (2005) · Journal of the American Society of Nephrology · doi:10.1681/asn.2004110970 · Cited by 586 · see citing works

Rho Kinases in Cardiovascular Physiology and Pathophysiology

Loirand, G., Guérin, P., & Pacaud, P. (2006) · Circulation Research · doi:10.1161/01.res.0000201960.04223.3c · Cited by 550 · see citing works

Berberine and Its More Biologically Available Derivative, Dihydroberberine, Inhibit Mitochondrial Respiratory Complex I

Turner, N., Li, J.-Y., Gosby, A., To, S. W. C., Cheng, Z., Miyoshi, H., Taketo, M. M., Cooney, G. J., Kraegen, E. W., James, D. E., et al. (2008) · Diabetes · doi:10.2337/db07-1552 · Cited by 535 · see citing works

Berberine and Coptidis Rhizoma as novel antineoplastic agents: A review of traditional use and biomedical investigations

Tang, J., Feng, Y., Tsao, S., Wang, N., Curtain, R., & Wang, Y. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.08.009 · Cited by 491 · see citing works

Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin receptor expression

Zhang, H., Wei, J., Xue, R., Wu, J.-D., Zhao, W., Wang, Z., Wang, S., Zhou, Z.-X., Song, D., Wang, Y., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.07.029 · Cited by 442 · see citing works

β-Cell Death and Mass in Syngeneically Transplanted Islets Exposed to Short- and Long-Term Hyperglycemia

Biarnés, M., Montolio, M., Nacher, V., Raurell, M., Soler, J., & Montanya, E. (2002) · Diabetes · doi:10.2337/diabetes.51.1.66 · Cited by 420 · see citing works

Synergy effects of herb extracts: Pharmacokinetics and pharmacodynamic basis

Yang, Y., Zhang, Z., Li, S., Ye, X., Li, X., & He, K. (2013) · Fitoterapia · doi:10.1016/j.fitote.2013.10.010 · Cited by 345 · see citing works

Receptor for advanced glycation end products (AGEs) has a central role in vessel wall interactions and gene activation in response to circulating AGE proteins.

Schmidt, A. M., Hasu, M., Popov, D., Zhang, J. H., Chen, J., Yan, S. D., Brett, J., Cao, R. Y., Kuwabara, K., & Costache, G. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8807 · Cited by 327 · see citing works

Transforming berberine into its intestine-absorbable form by the gut microbiota

Feng, R., Shou, J.-W., Zhao, Z.-X., He, C.-Y., Ma, C., Huang, M., Fu, J., Tan, X.-S., Li, X.-Y., Wen, B.-Y., et al. (2015) · Scientific Reports · doi:10.1038/srep12155 · Cited by 307 · see citing works

Diabetes is an inflammatory disease: evidence from traditional Chinese medicines

Xie, W., & Du, L. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01336.x · Cited by 305 · see citing works

Berberine reduces insulin resistance through protein kinase C–dependent up-regulation of insulin receptor expression

Kong, W., Zhang, H., Song, D., Xue, R., Zhao, W., Wei, J., Wang, Y., Shan, N., Zhou, Z., Yang, P., et al. (2008) · Metabolism · doi:10.1016/j.metabol.2008.08.013 · Cited by 266 · see citing works

Matrix metalloproteinase-9 activates TGF-β and stimulates fibroblast contraction of collagen gels

Kobayashi, T., Kim, H.-J., Liu, X., Sugiura, H., Kohyama, T., Fang, Q., Wen, F., Abe, S., Wang, X., Atkinson, J. J., et al. (2014) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00015.2014 · Cited by 227 · see citing works

Hypoglycemic activity of alkaloidal fraction of Tinospora cordifolia

Patel, M. B., & Mishra, S. (2011) · Phytomedicine · doi:10.1016/j.phymed.2011.05.006 · Cited by 220 · see citing works

The Endoplasmic Reticulum Chaperone Improves Insulin Resistance in Type 2 Diabetes

Ozawa, K., Miyazaki, M., Matsuhisa, M., Takano, K., Nakatani, Y., Hatazaki, M., Tamatani, T., Yamagata, K., Miyagawa, J.-I., Kitao, Y., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.3.657 · Cited by 209 · see citing works

Protective effect of berberine on beta cells in streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats

Zhou, J., Zhou, S., Tang, J., Zhang, K., Guang, L.-X., Huang, Y., Xu, Y. X., Ying, Y., Zhang, L., & Li, D. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.12.056 · Cited by 208 · see citing works

Pharmacovigilance practice and risk control of Traditional Chinese Medicine drugs in China: Current status and future perspective

Zhang, L., Jingbo, Y., Liu, X., Ye, Z., Yang, X., Meyboom, R. H. B., Chan, K., Shaw, D., & Duez, P. (2012) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2012.01.058 · Cited by 207 · see citing works

Berberine-induced bioactive metabolites of the gut microbiota improve energy metabolism

Wang, Y., Shou, J., Li, X., Zhao, Z., Fu, J., He, C., Feng, R., Ma, C., Wen, B., Guo, F., et al. (2017) · Metabolism · doi:10.1016/j.metabol.2017.02.003 · Cited by 206 · see citing works

Are Disturbances of Sorbitol, Phosphoinositide, and Na+-K+-ATPase Regulation Involved in Pathogenesis of Diabetic Neuropathy?

Greene, D. A., Lattimer, S. A., & Sima, A. A. F. (1988) · Diabetes · doi:10.2337/diab.37.6.688 · Cited by 199 · see citing works

ICAM-1 as a molecular target for triple negative breast cancer

Guo, P., Huang, J., Wang, L., Jia, D., Yang, J., Dillon, D. A. R., Zurakowski, D., Mao, H. Z., Moses, M. A., & Auguste, D. T. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408556111 · Cited by 192 · see citing works

Gut microbiota and immune crosstalk in metabolic disease

Burcelin, R. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.05.016 · Cited by 191 · see citing works

Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function

Murea, M., Park, J.-K., Sharma, S., Kato, H., Gruenwald, A., Niranjan, T., Si, H., Thomas, D. B., Pullman, J. M., Melamed, M. L., et al. (2010) · Kidney International · doi:10.1038/ki.2010.172 · Cited by 186 · see citing works

Role of the endothelial-to-mesenchymal transition in renal fibrosis of chronic kidney disease

He, J., Xu, Y. J., Koya, D., & Kanasaki, K. (2013) · Clinical and Experimental Nephrology · doi:10.1007/s10157-013-0781-0 · Cited by 167 · see citing works

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

Gomes, A. P., Duarte, F. V., Nunes, P., Hubbard, B. P., Teodoro, J. S., Varela, A. T., Jones, J. G., Sinclair, D. A., Palmeira, C. M., & Rolo, A. P. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.10.008 · Cited by 159 · see citing works

Rho Kinases in Cardiovascular Physiology and Pathophysiology

Shi, J., & Wei, L. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e3182a3718f · Cited by 153 · see citing works

HNF4α—role in drug metabolism and potential drug target?

Hwang‐Verslues, W. W., & Sladek, F. M. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.08.010 · Cited by 147 · see citing works

Mesenchymal stem cells ameliorate experimental peritoneal fibrosis by suppressing inflammation and inhibiting TGF-β1 signaling

Ueno, T., Nakashima, A., Doi, S., Kawamoto, T., Honda, K. K., Yokoyama, Y., Doi, T., Higashi, Y., Yorioka, N., Kato, Y., et al. (2013) · Kidney International · doi:10.1038/ki.2013.81 · Cited by 144 · see citing works

Rhizoma Coptidis alkaloids alleviate hyperlipidemia in B6 mice by modulating gut microbiota and bile acid pathways

He, K., Hu, Y., Ma, H., Zou, Z., Xiao, Y., Yang, Y., Feng, M., Li, X., & Ye, X. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.06.006 · Cited by 137 · see citing works

Berberine Modulates Gut Microbiota and Reduces Insulin Resistance via the TLR4 Signaling Pathway

Liu, D., Zhang, Y., Liu, Y., Hou, L.-Q., Li, S., Tian, H., & Zhao, T.-Y. (2018) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-0043-125066 · Cited by 136 · see citing works

Glucose metabolism: Focus on gut microbiota, the endocannabinoid system and beyond

Cani, P. D., Geurts, L., Matamoros, S., Plovier, H., & Duparc, T. (2014) · Diabetes & Metabolism · doi:10.1016/j.diabet.2014.02.004 · Cited by 130 · see citing works

Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin

Wu, D., Wen, W., Qi, C., Zhao, R., Lü, J., Zhong, C.-Y., & Chen, Y. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.03.003 · Cited by 130 · see citing works

Modulation of glucagon-like peptide-1 release by berberine: In vivo and in vitro studies

Yu, Y., Liu, L., Wang, X., Liu, X., Liu, X., Xie, L. Y., & Wang, G. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.11.017 · Cited by 123 · see citing works

Berberine Attenuates Intestinal Mucosal Barrier Dysfunction in Type 2 Diabetic Rats

Gong, J., Hu, M., Huang, Z., Fang, K., Wang, D., Chen, Q., Li, J., Yang, D., Zou, X. G., Xu, L., et al. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00042 · Cited by 116 · see citing works

AMP-Activated Protein Kinase: A Master Switch in Glucose and Lipid Metabolism

Hardie, D. G. (2004) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/b:remd.0000021433.63915.bb · Cited by 115 · see citing works

Berberine promotes glucagon-like peptide-1 (7–36) amide secretion in streptozotocin-induced diabetic rats

Lu, S.-S., Yu, Y.-L., Zhu, H., Liu, X., Liu, L., Liu, Y.-W., Wang, P., Xie, L. Y., & Wang, G.-J. (2008) · Journal of Endocrinology · doi:10.1677/joe-08-0419 · Cited by 111 · see citing works

Glucagon secretion from pancreatic α-cells

Briant, L., Salehi, A., Vergari, E., Zhang, Q., & Rorsman, P. (2016) · Upsala Journal of Medical Sciences · doi:10.3109/03009734.2016.1156789 · Cited by 109 · see citing works

The metabolic syndrome, type 2 diabetes, and cardiovascular disease: understanding the role of insulin resistance.

Kendall, D. M., & Harmel, A. P. (2002) · PubMed · Cited by 105 · see citing works

Berberine Inhibits Inflammatory Response and Ameliorates Insulin Resistance in Hepatocytes

Lou, T., Zhang, Z., Xi, Z., Liu, K., Li, L., Liu, B., & Huang, F. (2010) · Inflammation · doi:10.1007/s10753-010-9276-2 · Cited by 104 · see citing works

Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signaling

Xie, X., Chang, X., Chen, L., Huang, K., Huang, J., Wang, S., Shen, X., Liu, P., & Huang, H. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.07.019 · Cited by 102 · see citing works

Berberine improves insulin resistance in cardiomyocytes via activation of 5′-adenosine monophosphate-activated protein kinase

Chang, W., Zhang, M., Li, J., Meng, Z., Wei, S., Du, H., Chen, L., & Hatch, G. M. (2013) · Metabolism · doi:10.1016/j.metabol.2013.02.007 · Cited by 102 · see citing works

Berberine inhibits palmitate-induced NLRP3 inflammasome activation by triggering autophagy in macrophages: A new mechanism linking berberine to insulin resistance improvement

Zhou, H., Feng, L., Xu, F., Sun, Y., Ma, Y., Zhang, X., Liu, H., Xu, G., Wu, X., Shen, Y., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.03.003 · Cited by 100 · see citing works

Vascular targets for cannabinoids: animal and human studies

Stanley, C. P., & O’Sullivan, S. E. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12560 · Cited by 99 · see citing works

Berberine inhibits aldose reductase and oxidative stress in rat mesangial cells cultured under high glucose

Liu, W., Liu, P., Tao, S., Deng, Y., Li, X., Lan, T., Zhang, X., Guo, F., Huang, W., Chen, F., et al. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.04.022 · Cited by 90 · see citing works

Modulation of Microbiota-Gut-Brain Axis by Berberine Resulting in Improved Metabolic Status in High-Fat Diet-Fed Rats

Sun, H., Wang, N., Cang, Z., Zhu, C., Zhao, L., Nie, X., Cheng, J., Xia, F., Zhai, H., & Lu, Y. (2016) · Obesity Facts · doi:10.1159/000449507 · Cited by 90 · see citing works

Anti-diabetic property of Tinospora cordifolia and its active compound is mediated through the expression of Glut-4 in L6 myotubes.

Sangeetha, M., Priya, C. D. M., & Vasanthi, H. R. (2013) · Phytomedicine · doi:10.1016/j.phymed.2012.11.006 · Cited by 88 · see citing works

Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (NAFLD) rat liver

Xing, L., Zhang, L. R., Liu, T., Hua, Y., Zheng, P., & Ji, G. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.07.036 · Cited by 88 · see citing works

Effects of berberine on matrix accumulation and NF-kappa B signal pathway in alloxan-induced diabetic mice with renal injury

Liu, W., Zhang, X., Liu, P., Shen, X., Lan, T., Li, W., Jiang, Q. L., Xie, X., & Huang, H. (2010) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2010.04.033 · Cited by 82 · see citing works

Berberine exerts renoprotective effects by regulating the AGEs-RAGE signaling pathway in mesangial cells during diabetic nephropathy

Qiu, Y.-Y., Tang, L., & Wei, W. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.009 · Cited by 80 · see citing works

Protective Effects of Berberine on Renal Injury in Streptozotocin (STZ)-Induced Diabetic Mice

Zhang, X., He, H., Liang, D., Jiang, Y., Liang, W., Chi, Z., & Ma, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081327 · Cited by 79 · see citing works

An overview on adverse drug reactions to traditional Chinese medicines

Chan, K., Zhang, H., & Lin, Z. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12598 · Cited by 76 · see citing works

Berberine, an Isoquinoline Alkaloid in Herbal Plants, Protects Pancreatic Islets and Serum Lipids in Nonobese Diabetic Mice

Chueh, W.-H., & Lin, J. (2011) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf201627w · Cited by 76 · see citing works

Berberine modulates insulin signaling transduction in insulin-resistant cells

Liu, L., Cheung, S. C. K., Lan, L., Ho, S. K. S., Xu, H., Chan, J. C. N., & Tong, P. C. Y. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.12.027 · Cited by 74 · see citing works

Modulation of Gut Microbiota by Berberine Improves Steatohepatitis in High-Fat Diet-Fed BALB/C Mice.

Cao, Y. L., Pan, Q., Cai, W., Shen, F., Chen, G., Xu, L., & Fan, J. (2016) · PubMed · Cited by 74 · see citing works

Berberine activates Nrf2 nuclear translocation and inhibits apoptosis induced by high glucose in renal tubular epithelial cells through a phosphatidylinositol 3-kinase/Akt-dependent mechanism

Zhang, X., Liang, D., Lian, X., Jiang, Y., He, H., Liang, W., Zhao, Y., & Chi, Z. (2016) · APOPTOSIS · doi:10.1007/s10495-016-1234-5 · Cited by 74 · see citing works

Multiple roles of the PGE 2 ‐ EP receptor signal in vascular permeability

Omori, K., Kida, T., Hori, M., Ozaki, H., & Murata, T. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12815 · Cited by 72 · see citing works

Dose-response effect of berberine on bile acid profile and gut microbiota in mice

Guo, Y., Zhang, Y., Huang, W., Selwyn, F. P., & Klaassen, C. D. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1367-7 · Cited by 69 · see citing works

Coptisine attenuates obesity-related inflammation through LPS/TLR-4-mediated signaling pathway in Syrian golden hamsters

Zou, Z., Hu, Y., Ma, H., Wang, Y.-Z., He, K., Xia, S., Wu, H., Xue, D., Li, X., & Ye, X. (2015) · Fitoterapia · doi:10.1016/j.fitote.2015.06.005 · Cited by 68 · see citing works

Sphingosine Kinase-1 Pathway Mediates High Glucose-Induced Fibronectin Expression in Glomerular Mesangial Cells

Lan, T., Liu, W., Xie, X. S., Xu, S., Huang, K., Peng, J., Shen, X., Liu, P., Wang, L., Xia, P., et al. (2011) · Molecular Endocrinology · doi:10.1210/me.2011-0095 · Cited by 67 · see citing works

Effect of berberine on the renal tubular epithelial-to-mesenchymal transition by inhibition of the Notch/snail pathway in diabetic nephropathy model KKAy mice

Yang, G., Zhao, Z., Zhang, X., Wu, A., Huang, Y., Miao, Y., & Mei-juan, Y. (2017) · Drug Design Development and Therapy · doi:10.2147/dddt.s124971 · Cited by 66 · see citing works

Renoprotective effect of berberine on type 2 diabetic nephropathy in rats

Sun, S., Zhao, T., Zhang, H., Huang, X., Zhang, W., Zhang, L., Yan, M., Dong, X., Wang, H., Wen, Y., et al. (2015) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12402 · Cited by 65 · see citing works

Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2

Vila‐Bedmar, R., Cruces‐Sande, M., Lucas, E., Willemen, H. L. D. M., Heijnen, C. J., Kavelaars, A., Mayor, F., & Murga, C. (2015) · Science Signaling · doi:10.1126/scisignal.aaa4374 · Cited by 63 · see citing works

Berberine Reduces Fibronectin Expression by Suppressing the S1P-S1P2 Receptor Pathway in Experimental Diabetic Nephropathy Models

Huang, K., Liu, W., Lan, T., Xie, X., Peng, J., Huang, J., Wang, S., Shen, X., Liu, P., & Huang, H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043874 · Cited by 62 · see citing works

Inhibition of M1 macrophage activation in adipose tissue by berberine improves insulin resistance

Ye, L., Shu, L., Guo, C., Yu, X., Zhao, J., Zhang, H., & Shang, W. (2016) · Life Sciences · doi:10.1016/j.lfs.2016.09.025 · Cited by 62 · see citing works

Facilitating effects of berberine on rat pancreatic islets through modulating hepatic nuclear factor 4 alpha expression and glucokinase activity

Wang, Z., Lu, F., Leng, S.-H., Fang, X., Chen, G., Wang, Z.-S., Dong, L., & Yan, Z.-Q. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.6004 · Cited by 61 · see citing works

Effect ofRhizoma coptidis(Huang Lian) on Treating Diabetes Mellitus

Pang, B., Yu, X., Zhou, Q., Zhao, T., Wang, H., Gu, C., & Tong, X. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/921416 · Cited by 59 · see citing works

Alteration of the intestinal barrier and GLP2 secretion in Berberine-treated type 2 diabetic rats

Shan, C., Yang, J. H., Kong, Y., Wang, X., Zheng, M., Xu, Y., Wang, Y., Ren, H., Chang, B., & Chen, L. M. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0184 · Cited by 59 · see citing works

Protein tyrosine phosphatase 1B inhibitory activity of alkaloids from Rhizoma Coptidis and their molecular docking studies

Choi, J. S., Ali, M. Y., Jung, H. A., Oh, S. H., Choi, R. J., & Kim, E. J. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.05.020 · Cited by 57 · see citing works

Renoprotective effects of berberine through regulation of the MMPs/TIMPs system in streptozocin-induced diabetic nephropathy in rats

Ni, W., Ding, H., Zhou, H., Qiu, Y.-Y., & Tang, L. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.07.040 · Cited by 57 · see citing works

Beneficial effect of berberine on hepatic insulin resistance in diabetic hamsters possibly involves in SREBPs, LXR.ALPHA. and PPAR.ALPHA. transcriptional programs

Liu, X., Li, G., Zhu, H., Huang, L. J., Liu, Y., Ma, C., & Qin, C. (2010) · Endocrine Journal · doi:10.1507/endocrj.k10e-043 · Cited by 57 · see citing works

Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats

Wang, F. L., Tang, L. Q., Yang, F., Zhu, L. N., Cai, M., & Wei, W. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-2321-5 · Cited by 56 · see citing works

Berberine moderates glucose metabolism through the GnRH-GLP-1 and MAPK pathways in the intestine

Zhang, Q., Xiao, X., Li, M., Li, W., Yu, M., Zhang, H., Ping, F., Wang, Z., & Zheng, J. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-188 · Cited by 56 · see citing works

Berberine Improves Glucose Homeostasis in Streptozotocin-Induced Diabetic Rats in Association with Multiple Factors of Insulin Resistance

Chen, Y., Wang, Y., Zhang, J., Sun, C., & López, A. (2011) · ISRN Endocrinology · doi:10.5402/2011/519371 · Cited by 56 · see citing works

Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell and Diabetic KK‐Ay Mice

Ma, H., Hu, Y., Zou, Z., Feng, M., Ye, X., & Li, X. (2016) · Drug Development Research · doi:10.1002/ddr.21302 · Cited by 56 · see citing works

Vascular Cell Adhesion Molecule 1 Expression by Biliary Epithelium Promotes Persistence of Inflammation by Inhibiting Effector T-Cell Apoptosis

Afford, S. C., Humphreys, E. H., Reid, D. T., Russell, C. L., Banz, V. M., Oo, Y. H., Vo, T., Jenne, C. N., Adams, D., & Eksteen, B. (2013) · Hepatology · doi:10.1002/hep.26965 · Cited by 53 · see citing works

Berberine improves free-fatty-acid–induced insulin resistance in L6 myotubes through inhibiting peroxisome proliferator–activated receptor γ and fatty acid transferase expressions

Chen, Y., Li, Y., Wang, Y., Wen, Y., & Sun, C. (2009) · Metabolism · doi:10.1016/j.metabol.2009.06.009 · Cited by 52 · see citing works

Expression of adhesion molecules and extracellular matrix proteins in glioblastomas: relation to angiogenesis and spread

Vitolo, D., PARADISO, P., Uccini, S., Ruco, L., & Baroni, C. D. (1996) · Histopathology · doi:10.1046/j.1365-2559.1996.d01-471.x · Cited by 50 · see citing works

Effects of Berberine chloride on the liver of streptozotocin-induced diabetes in albino Wistar rats

Chandirasegaran, G., Elanchezhiyan, C., & Ghosh, K. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.01.007 · Cited by 49 · see citing works

Activation of AMPK by berberine promotes adiponectin multimerization in 3T3-L1 adipocytes

Li, Y., Wang, P., Zhuang, Y., Lin, H., Li, Y., Liu, L., Meng, Q., Cui, T., Liu, J., & Li, Z. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.04.051 · Cited by 48 · see citing works

The Antihyperglycemic Effects of Rhizoma Coptidis and Mechanism of Actions: A Review of Systematic Reviews and Pharmacological Research

Wang, H., Mu, W., Shang, H., Lin, J. R., & Lei, X. (2014) · BioMed Research International · doi:10.1155/2014/798093 · Cited by 46 · see citing works

Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells

Wang, Z.-S., Lu, F., Xu, L., & Dong, H. (2010) · Acta Pharmacologica Sinica · doi:10.1038/aps.2010.30 · Cited by 46 · see citing works

Renoprotective effects of berberine and its potential effect on the expression of β‐arrestins and intercellular adhesion molecule‐1 and vascular cell adhesion molecule‐1 in streptozocin‐diabetic nephropathy rats

Tang, L., Ni, W., Cai, M., Ding, H., Liu, S., & Shan-tang, Z. (2015) · Journal of Diabetes · doi:10.1111/1753-0407.12349 · Cited by 45 · see citing works

Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model

Yang, W., She, L., Yu, K., Yan, S., Zhang, X., Tian, X., Ma, S., & Zhang, X. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5634 · Cited by 44 · see citing works

Theoretical basis, application, reliability, and sample size estimates of a Meridian Energy Analysis Device for Traditional Chinese Medicine Research

Tsai, M.-Y., Chen, S., & Lin, C.-C. (2017) · Clinics · doi:10.6061/clinics/2017(04)10 · Cited by 44 · see citing works

The Intervention Effect of Traditional Chinese Medicine on the Intestinal Flora and Its Metabolites in Glycolipid Metabolic Disorders

Di, S., Wang, Y., Han, L., Bao, Q. D., Gao, Z., Wang, Q., Yang, Y., Zhao, L., & Tong, X. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/2958920 · Cited by 42 · see citing works

The C-terminus region of β-arrestin1 modulates VE-cadherin expression and endothelial cell permeability

Hebda, J. K., Leclair, H. M., Azzi, S., Roussel, C., Scott, M. G. H., Bidère, N., & Gavard, J. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-37 · Cited by 40 · see citing works

Insulin, glucagon and somatostatin stores in the pancreas of subjects with type-2 diabetes and their lean and obese non-diabetic controls

Henquin, J.-C., Ibrahim, M. M., & Rahier, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-10296-z · Cited by 40 · see citing works

Determination of Alkaloid Contents in Various Tissues of Coptis Chinensis Franch. by Reversed Phase-High Performance Liquid Chromatography and Ultraviolet Spectrophotometry

Yang, Y., Peng, J., Li, F., Liu, X., Deng, M., & Wu, H. (2017) · Journal of Chromatographic Science · doi:10.1093/chromsci/bmx009 · Cited by 38 · see citing works

Systems Pharmacology Dissection of Multiscale Mechanisms of Action for Herbal Medicines in Treating Rheumatoid Arthritis

Wang, J., Li, Y., Yang, Y., Du, J., Zhao, M., Lin, F., Zhang, S., & Wang, B. (2017) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.7b00505 · Cited by 38 · see citing works

The efficacy and safety of concentrated herbal extract granules, YH1, as an add-on medication in poorly controlled type 2 diabetes: A randomized, double-blind, placebo-controlled pilot trial

Huang, Y.-H., Chen, S., Liu, F.-H., Hsieh, S., Lin, C.-H., Liou, M., Wang, C., Huang, C., Liu, G.-H., Lin, J., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221199 · Cited by 38 · see citing works

Berberine attenuates intestinal disaccharidases in streptozotocin-induced diabetic rats

Liu, L., Deng, Y., Yu, S., Lu, S., Xie, L. Y., & Liu, X. (2008) · Die Pharmazie · doi:10.31083/ph.2008.7778 · Cited by 35 · see citing works

Uncoupling protein‐2 mediates the protective action of berberine against oxidative stress in rat insulinoma INS ‐1 E cells and in diabetic mouse islets

Liu, L., Liu, J., Gao, Y., Yu, X., Xu, G., & Huang, Y. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12666 · Cited by 35 · see citing works

Renoprotective effect of berberine via regulating the PGE 2 ‐ EP 1‐Gαq‐Ca 2+ signalling pathway in glomerular mesangial cells of diabetic rats

Ni, W., Tang, L., Zhou, H., Ding, H., & Qiu, Y.-Y. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12837 · Cited by 34 · see citing works

β-Arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation

Molteni, R., Crespo, C. L., Feigelson, S. W., Moser, C., Fabbri, M., Grabovsky, V., Krombach, F., Laudanna, C., Alon, R., & Pardi, R. (2009) · Blood · doi:10.1182/blood-2008-10-183699 · Cited by 33 · see citing works

Berberine-Improved Visceral White Adipose Tissue Insulin Resistance Associated with Altered Sterol Regulatory Element-Binding Proteins, Liver X Receptors, and Peroxisome Proliferator-Activated Receptors Transcriptional Programs in Diabetic Hamsters

Li, G., Liu, X., Zhu, H., Huang, L. J., Liu, Y., Ma, C., & Qin, C. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.644 · Cited by 30 · see citing works

Berberine attenuates high glucose-induced fibrosis by activating the G protein-coupled bile acid receptor TGR5 and repressing the S1P2/MAPK signaling pathway in glomerular mesangial cells

Yang, Z., Li, J., Xiong, F., Huang, J., Chen, C., Liu, P., & Huang, H. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.06.005 · Cited by 28 · see citing works

Quantitative analysis of the anti-inflammatory activity of orengedokuto II: berberine is responsible for the inhibition of NO production

Oshima, N., Shimizu, T., Narukawa, Y., Hada, N., & Kiuchi, F. (2018) · Journal of Natural Medicines · doi:10.1007/s11418-018-1209-7 · Cited by 25 · see citing works

Berberine suppresses high glucose-induced TGF-β1 and fibronectin synthesis in mesangial cells through inhibition of sphingosine kinase 1/AP-1 pathway

Lan, T., Liu, W., Xie, X., Huang, K., Peng, J., Huang, J., Shen, X., Liu, P., Yang, H., & Huang, H. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.10.003 · Cited by 24 · see citing works

Berberine regulates the expression of E-prostanoid receptors in diabetic rats with nephropathy

Tang, L. Q., Liu, S., Zhang, S. T., Zhu, L. N., & Wang, F. L. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3196-4 · Cited by 24 · see citing works

Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid

Ali, S., Igoli, J. O., Clements, C. J., Semaan, D., Alamzeb, M., Rashid, M. U., Shah, S. Q., Ferro, V. A., Gray, A. I., & Khan, M. R. (2013) · Bangladesh Journal of Pharmacology · doi:10.3329/bjp.v8i3.13888 · Cited by 24 · see citing works

Techniques for biological fingerprinting of traditional Chinese medicine

Tao, Y., Gu, X., Li, W., Wu, H., Cai, B., & Zhang, B. (2017) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2017.09.008 · Cited by 21 · see citing works

Berberine ameliorates renal injury by regulating G proteins-AC- cAMP signaling in diabetic rats with nephropathy

Tang, L. Q., Wang, F. L., Zhu, L. N., Lv, F., Liu, S., & Zhang, S. T. (2012) · Molecular Biology Reports · doi:10.1007/s11033-012-2468-0 · Cited by 18 · see citing works

Communication-based influence components model

Cugelman, B., Thelwall, M. A., & Dawes, P. (2009) · International Conference on Persuasive Technology · doi:10.1145/1541948.1541972 · Cited by 17 · see citing works

Knowledge, attitudes, and related practices of Filipino seafarers regarding cardiovascular diseases

Gregorio, E. R., Kobayashi, J., Medina, J. R. C., & Simbulan, N. P. (2016) · International Maritime Health · doi:10.5603/imh.2016.0039 · Cited by 17 · see citing works

In Vivo Interrelationship between Insulin Resistance and Interferon Gamma Production: Protective and Therapeutic Effect of Berberine

Mahmoud, M. A., Ghareeb, D. A., Sahyon, H. A. E., El‐Shehawy, A. A., & Elsayed, M. M. (2016) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2016/2039897 · Cited by 15 · see citing works

Study of Absorption Characteristics of the Total Saponins from Radix Ilicis Pubescentis in an In Situ Single-Pass Intestinal Perfusion (SPIP) Rat Model by Using Ultra Performance Liquid Chromatography (UPLC)

Kuang, G., Yi, H., Zhu, M., Zhou, J., Shang, X., Zhao, Z., Zhu, C., Liao, Q., Guan, S., & Zhang, L. (2017) · Molecules · doi:10.3390/molecules22111867 · Cited by 15 · see citing works

Anti‐diabetic and neuroprotective effects of pancreatic islet transplantation into the central nervous system

Lazard, D., Vardi, P., & Bloch, K. O. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2644 · Cited by 14 · see citing works

Protective role of berberine and Coptischinensis extract on T2MD rats and associated islet Rin-5f cells

Jiang, Y., Cui, H., Wang, J., Liu, H., Dang, M.-M., Zhang, Q., Yang, F., Kou, J.-T., & Tong, X. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7467 · Cited by 14 · see citing works

Molecular mechanisms of insulin resistance.

Pillay, T. S., & Makgoba, M. (1991) · PubMed · Cited by 12 · see citing works

Metabolic profile of Rhizoma coptidis in human plasma determined using ultra‐high‐performance liquid chromatography coupled with high‐resolution mass spectrometry

Zhang, Q., Wang, G., Han, Z., Chen, X., Na, R., Jin, H., Li, P., & Bu, R. (2017) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.7990 · Cited by 12 · see citing works

Antidiabetic and antimicrobial activities of fractions and compounds isolated from Berberis brevissima Jafri and Berberis parkeriana Schneid

Ali, S., Igoli, J. O., Clements, C. J., Semaan, D., Alamzeb, M., Rashid, M. U., Shah, S. Q., Ferro, V. A., Gray, A. I., & Khan, M. R. (2013) · Strathprints: The University of Strathclyde institutional repository (University of Strathclyde) · doi:10.60692/bgme6-11p06 · Cited by 9 · see citing works

Impaired insulin signaling upon loss of ovarian function is associated with a reduction of tristetraprolin and an increased stabilization of chemokine in adipose tissue

Choi, E., Rajasekaran, M., Sul, O., Joe, Y., Chung, H.-T., Yu, R., & Choi, H. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.09.002 · Cited by 8 · see citing works

Renoprotective Effect of Berberine on Streptozotocin-induced Diabetic Nephropathy Rats

Wu, Z., Xie, Z., Liu, J., Wu, Q., & Wang, X. (2017) · International Journal of Pharmacology · doi:10.3923/ijp.2017.247.256 · Cited by 7 · see citing works

Cyclooxygenase-2 in the kidney: good, BAD, or both?

Price, S. R., & Klein, J. D. (2011) · Kidney International · doi:10.1038/ki.2011.263 · Cited by 4 · see citing works

Plant Alkaloids: Structures and Bioactive Properties

Gutiérrez‐Grijalva, E. P., López-Martínez, L. X., Contreras‐Angulo, L. A., Elizalde-Romero, C. A., & Heredia, J. B. (2020) · Springer eBooks · doi:10.1007/978-981-15-2361-8_5 · Cited by 125 · see citing works

The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Guo, J., Chen, H., Zhang, X., Lou, W., Zhang, P., Qiu, Y., Zhang, C., Wang, Y., & Liu, W. J. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/2074610 · Cited by 110 · see citing works

Berberine and health outcomes: An umbrella review

Li, Z., Yang, W., Xu, Q., Ma, J., Li, X., Yan, J., Tian, Y., Wen, Y., & Chen, T. (2023) · Phytotherapy Research · doi:10.1002/ptr.7806 · Cited by 104 · see citing works

A Song of Ice and Fire: Cold and Hot Properties of Traditional Chinese Medicines

Liu, J., Feng, W., & Peng, C. Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.598744 · Cited by 50 · see citing works

Mechanisms of Rhizoma Coptidis against type 2 diabetes mellitus explored by network pharmacology combined with molecular docking and experimental validation

An, W., Huang, Y., Chen, S., Teng, T., Shi, Y., Sun, Z., & Xu, Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-00293-8 · Cited by 50 · see citing works

An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy

Xiao, Y., Liu, Y., Zhihui, L., Huang, J., Li, C., Zhang, Y., Gong, X., Deng, J., Ye, X., & Li, X. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113806 · Cited by 44 · see citing works

The Intervention Effect of Traditional Chinese Medicine on the Intestinal Flora and Its Metabolites in Glycolipid Metabolic Disorders

Di, S., Wang, Y., Han, L., Bao, Q. D., Gao, Z., Wang, Q., Yang, Y., Zhao, L., & Tong, X. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/2958920 · Cited by 42 · see citing works

The efficacy and safety of concentrated herbal extract granules, YH1, as an add-on medication in poorly controlled type 2 diabetes: A randomized, double-blind, placebo-controlled pilot trial

Huang, Y.-H., Chen, S., Liu, F.-H., Hsieh, S., Lin, C.-H., Liou, M., Wang, C., Huang, C., Liu, G.-H., Lin, J., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0221199 · Cited by 38 · see citing works

Berberine promotes peri‐implant osteogenesis in diabetic rats by ROS ‐mediated IRS ‐1 pathway

Shao, J., Liu, S., Zheng, X., Chen, J., Li, L., & Zhu, Z. (2020) · BioFactors · doi:10.1002/biof.1692 · Cited by 36 · see citing works

Brij-functionalized chitosan nanocarrier system enhances the intestinal permeability of P-glycoprotein substrate-like drugs

Xiong, W., Xiong, S. H., Chen, Q. L., Linghu, K., Zhao, G. D., Chu, J. M. T., Wong, G. T. C., Li, J., Hu, Y. J., Wang, Y., et al. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2021.118112 · Cited by 35 · see citing works

Epiberberine ameliorated diabetic nephropathy by inactivating the angiotensinogen (Agt) to repress TGFβ/Smad2 pathway

Xiao, Y., Deng, J., Li, C., Gong, X., Gui, Z., Huang, J., Zhang, Y., Liu, Y., Ye, X., & Li, X. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153488 · Cited by 27 · see citing works

The localization of the alkaloids in Coptis chinensis rhizome by time-of-flight secondary ion mass spectrometry

He, F., Huang, Y., Dai, W., Qu, X.-Y., Lu, J., Lao, C.-C., Luo, W., Sun, D., Wei, M., Xiao, S., et al. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.1092643 · Cited by 24 · see citing works

LncRNA-H19 acts as a ceRNA to regulate HE4 expression by sponging miR-140 in human umbilical vein endothelial cells under hyperglycemia with or without α-Mangostin

Luo, Y., Fang, Z., Ling, Y., & Luo, W. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109256 · Cited by 22 · see citing works

UPLC-Q-TOF/MS-Based Serum and Urine Metabonomics Study on the Ameliorative Effects of Palmatine on Helicobacter pylori–Induced Chronic Atrophic Gastritis

Chen, X., Zhang, J., Wang, R., Liu, H., Bao, C., Wu, S., Wen, J., Yang, T., Wei, Y., Ren, S., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.586954 · Cited by 22 · see citing works

Study on the mechanism of Coptis chinensis Franch. And its main active components in treating Alzheimer's disease based on SCFAs using Orbitrap Fusion Lumos Tribrid MS

Xie, M., Gu, S., Hong, Y., Liu, Y., Rong, X., Lu, W., Liu, H., Algradi, A. M., Naseem, A., Shu, Z., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116392 · Cited by 22 · see citing works

Discovery of Nine Dipeptidyl Peptidase-4 Inhibitors from Coptis chinensis Using Virtual Screening, Bioactivity Evaluation, and Binding Studies

Zhao, Z., Ma, R., Ma, Y., Zhao, L., Wang, L., Fang, Y., Zhang, Y., Wu, X., & Wang, X. (2024) · Molecules · doi:10.3390/molecules29102304 · Cited by 14 · see citing works

The role of gut microbiome and its metabolites in pancreatitis

Pan, L., Yin, N., Duan, M., Mei, Q., & Zeng, Y. (2024) · mSystems · doi:10.1128/msystems.00665-24 · Cited by 12 · see citing works

Pivotal Role of the Interaction Between Herbal Medicines and Gut Microbiota on Disease Treatment

Zhao, T., Wang, Z., Liu, Z., & Xu, Y. (2020) · Current Drug Targets · doi:10.2174/1389450121666200324151530 · Cited by 12 · see citing works

Preparation of magnetic yolk-shell structured metal-organic framework material and its application in pharmacokinetics study of alkaloids

Yin, S., Wang, X., Jiang, H., Lü, M., Zhou, X., Li, L., & Yang, F. Q. (2021) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-021-03656-2 · Cited by 12 · see citing works

Diacylated anthocyanins from purple sweet potato (Ipomoea batatas L.) attenuate hyperglycemia and hyperuricemia in mice induced by a high-fructose/high-fat diet

Shen, L., Yang, Y., Zhang, J., Feng, L.-J., & Zhou, Q. (2023) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2200587 · Cited by 12 · see citing works

In-situ formation of ion pair assisted liquid-liquid microextraction of natural alkaloids by response surface methodology

Zhu, S.-C., Shi, M., Yu, Y., Jiao, Y.-H., Zheng, H., Liu, F., & Cao, J. (2021) · Microchemical Journal · doi:10.1016/j.microc.2021.106813 · Cited by 8 · see citing works

Pharmacokinetics of Picroside I, II, III, IV in Rat Plasma by UPLCMS/ MS

Xie, H., Lu, X., Jin, W., Zhou, H., Chen, D., Wang, X., & Zhou, Y. (2019) · Current Pharmaceutical Analysis · doi:10.2174/1573412916666191022161501 · Cited by 7 · see citing works

Metabolic profile of alkaloids in Rhizoma Coptidis in rat plasma, urine and feces after oral administration using ultra‐high‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry

Liu, Y., Zhang, Y., Qi, M., Long, J., Wang, M., Zhang, X., Yan, C., & Yan, D. (2020) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.8763 · Cited by 7 · see citing works

Exploring the Regulatory Mechanism of Modified Huanglian Maidong Decoction on Type 2 Diabetes Mellitus Biological Network Based on Systematic Pharmacology

He, Q., Zhang, T., Jin, B., Wu, Y., Wu, J., Gao, P., & Wu, S. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/1768720 · Cited by 7 · see citing works

Anti-Obesity and Anti-Diabetic Effects of a Polyherbal Extract Consisting of Coptidis Rhizoma, Salviae Miltiorrhizae Radix, and Cinnamomi Cortex in High Fat Diet-Induced Obesity Mice

Jung, S. M., Kwon, S. E., Kang, S. Y., Kim, S. J., Jung, H. W., & Park, Y. (2021) · Journal of Korean Medicine for Obesity Research · doi:10.15429/jkomor.2021.21.2.59 · Cited by 7 · see citing works

Effective Dose of Rhizoma Coptidis Extract Granules for Type 2 Diabetes Treatment: A Hospital-Based Retrospective Cohort Study

Huang, Y.-H., Liu, G.-H., Hsu, T.-Y., Yang, L., Lee, M.-C., Huang, C., & Wu, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.597703 · Cited by 6 · see citing works

Effects of bacterial cellulose on glucose metabolism in an in vitro chyme model and its rheological evaluation

Zhang, L., Zhang, W., Peng, F., Chen, H., & Shu, G. (2021) · International Journal of Food Science & Technology · doi:10.1111/ijfs.15244 · Cited by 6 · see citing works

Integrated metabolomics and network pharmacology analysis to explore pig bile-processed Rhizoma Coptidis and Fructus Evodiae sauce-processed Rhizoma Coptidis in lipopolysaccharide-induced inflammatory response

Wang, J., Wu, S., Gao, H. J., Yu, C., Chen, X., & Yuan, Z. (2024) · Journal of Chromatography B · doi:10.1016/j.jchromb.2024.124192 · Cited by 5 · see citing works

Comparative drug-drug interactions of berberine and astragaloside IV in normal and type 2 diabetes mellitus rats based on UPLC-QqQ-MS/MS

Lei, Y., Xie, J., Xie, Z., Zhao, X., Huang, J., & Wang, C. (2025) · Acta Materia Medica · doi:10.15212/amm-2024-0078 · Cited by 4 · see citing works

Solid-state fermentation: an alternative for continuous and discontinuous production of bioactive compounds with biological activity

Rosa‐Esteban, K. D. L., Sepúlveda, L., Buenrostro-Figueroa, J. J., Chávez‐González, M. L., Estrada-Gil, L. E., Galindo, A. S., Aguilar, C. N., & Ascacio-Valdés, J. A. (2025) · Exploration of Foods and Foodomics · doi:10.37349/eff.2025.101085 · Cited by 2 · see citing works

Coptidis Rhizome alleviates dexamethasone- and fructose-induced metabolic disorder in rats as an inducer of HO-1 agonist via erythrocyte metabolism

Xie, X., Fu, H., Ai, Z., Huang, Z., Tan, W., Xie, Q., Liu, Y., Li, Y., Chen, J., Yang, X., et al. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120713 · Cited by 2 · see citing works

The transcriptomic-based disease network reveals synergistic therapeutic effect of total alkaloids from Coptis chinensis and total ginsenosides from Panax ginseng on type 2 diabetes mellitus

Chen, Q., Zhang, S., Jiang, X., Liao, J., Shao, X., Peng, X., Wang, Z., Lu, X., & Fan, X. (2025) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(25)60935-6 · Cited by 1 · see citing works

Evaluation of Kusuantongtiao Formula as adjunctive therapy for Insulin Resistance: An integrated in silico exploration and experimental validationPreprint

Yan, G., Wang, Y., Zhu, H., Fan, X., Wang, G., Wang, X., & Mi, J. (2022) · Research Square · doi:10.21203/rs.3.rs-2278280/v1

Food Bioactives as a Novel Source for Nutraceuticals

Ashraf, S. A., Banu, H., Elkhalifa, A. E. O., Haque, A., Ahmad, M. F., & Mahmood, D. (2025) · Springer eBooks · doi:10.1007/978-981-97-9723-3_1

Jiaotai pill and its main component enhance islet hormone secretion in type 2 diabetic rats by activating the THP1/TGase2/SERT/5-HT1FRpathway

Han, H.-C., Huang, X., Li, Y., Wang, P., Miao, Q., & Zhang, Y. (2025) · Journal of Traditional Chinese Medical Sciences · doi:10.1016/j.jtcms.2025.06.001

In Silico Docking Study of Berberine Derivatives as AMPK Activators for Diabetes Mellitus via Multi-Target Protein Approach.

Anap, H. N., Eknath, N. S., Bhagat, J. R., Medge, V. A., Katore, S. V., Pagare, N. V., Kurkute, D. G., Jadhav, S. E., & Bhor, R. J. (2025) · Biosciences Biotechnology Research Asia · doi:10.13005/bbra/3468

Oral Rhizoma Coptis Alkaloids Nanoparticle for Treating Diabetes Through Regulating PI3K/Akt Pathways

Liu, Y., Zhu, M., Su, Q., Liu, M., Zhao, Z., & Ma, P. (2026) · Pharmaceutics · doi:10.3390/pharmaceutics18030349

An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy

Xiao, Y., Liu, Y., Zhihui, L., Huang, J., Li, C., Zhang, Y., Gong, X., Deng, J., Ye, X., & Li, X. (2021) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2021.113806 · Cited by 44 · see citing works

Review Article The Antihyperglycemic Effects of Rhizoma Coptidis and Mechanism of Actions: A Review of Systematic Reviews and

Wang, H., Mu, W., Shang, H., Lin, J., & Lei, X. (2016)

Study on hypoglycemic effect of total alkaloids from Rhizoma Coptidis in diabetes rats

Guo-liang, X. (2010) · Zhongguo linchuang yaolixue yu zhiliaoxue · Cited by 2 · see citing works

Antihyperglycemia and Antihyperlipidemia Effect of Protoberberine Alkaloids From Rhizoma Coptidis in HepG2 Cell and Diabetic KK‐Ay Mice

Ma, H., Hu, Y., Zou, Z., Feng, M., Ye, X., & Li, X. (2016) · Drug Development Research · doi:10.1002/ddr.21302 · Cited by 56 · see citing works

Rhizoma coptidis as a Potential Treatment Agent for Type 2 Diabetes Mellitus and the Underlying Mechanisms: A Review

Ran, Q., Wang, J., Wang, L., Zeng, H., Yang, X., & Huang, Q. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00805 · Cited by 53 · see citing works