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Cited by 104Silk-based biomaterials and applicationsElectrospun Nanofibers in Biomedical ApplicationsNanoparticle-Based Drug Delivery

Drug release from core-shell PVA/silk fibroin nanoparticles fabricated by one-step electrospraying

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Cao, Yang, Liu, Fengqiu, Chen, Yuli, Yu, Tao, Lou, Deshuai, Guo, Yuan, Li, Pan, Wang, Zhigang +1 more·2017·Scientific Reports
DOI 10.1038/s41598-017-12351-1PMC PMC5607240
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Abstract

Silk fibroin (SF), a FDA-approved natural protein, is renowned for its great biocompatibility, biodegradability, and mechanical properties. SF-based nanoparticles provide new options for drug delivery with their tunable drug loading and release properties. To take advantage of the features of carrier polymers, we present a one-step electrospraying method that combines SF, polyvinyl alcohol (PVA) and therapeutic drugs without an emulsion process. A distinct core-shell structure was obtained with the PVA core and silk shell after the system was properly set up. The model drug, doxorubicin, was encapsulated in the core with a greater than 90% drug encapsulation efficiency. Controllable drug release profiles were achieved by alternating the PVA/SF ratio. Although the initial burst release of the drug was minimized by the SF coating, a large number of drug molecules remained entrapped by the carrier polymers. To promote and trigger drug release on demand, low intensity focused ultrasound (US) was applied. The US was especially advantageous for accelerating the drug diffusion and release. The apoptotic activity of MDA-MB-231 cells incubated with drug-loaded nanoparticles was found to increase with time. In addition, we also observed PVA/SF nanoparticles that could elicit a drug release in response to pH.

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  • Silk fibroin has excellent biocompatibility; it has been approved by the FDA for medical applications, including sutures, since 1993.

    “Silk fibroin has been approved by the FDA for medical applications, including sutures, since 1993 [92,93].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [92]

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Cited by

Sorted by citations

Authors
Cao, Y., Liu, F., Chen, Y., Yu, T., Lou, D., Guo, Y., Li, P., Wang, Z., & Ran, H.
Affiliations
  • Second Affiliated Hospital of Chongqing Medical University (CN)
  • Chongqing University of Education (CN)
Corresponding author
Ran, Haitao
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2017-09-20
Volume
7
Issue
1
Pages
11913-11913
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-017-12351-1
PMC
PMC5607240
OpenAlex
W2755994479
Cited by
104
References
1
Citations by year
2026: 6 · 2025: 13 · 2024: 14 · 2023: 11 · 2022: 11 · 2021: 12 · 2020: 16 · 2019: 14 · 2018: 5 · 2015: 1
FWCI
3.44
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • Chongqing Postdoctoral Science Foundation (Xm2015089)
  • National Natural Science Foundation of China (81401503, 81471713, 81371578)
  • China Postdoctoral Science Foundation (2015T80963, 2016M590869)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Silk-based biomaterials and applications
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Keywords
silk fibroin, polyvinyl alcohol, core-shell nanoparticles, electrospraying, drug release, doxorubicin, encapsulation efficiency, low-intensity focused ultrasound, pH-responsive drug release, MDA-MB-231 cells, apoptosis, anticancer drug delivery
MeSH terms
Antineoplastic Agents, Cell Survival, Doxorubicin, Drug Carriers, Fibroins, Humans, Polyvinyl Alcohol, Apoptosis, Cell Line, Tumor, Nanoparticles, Drug Liberation

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