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Cited by 60Gastrointestinal motility and disordersPain Mechanisms and TreatmentsIon Channels and Receptors

Evidence for long-term sensitization of the bowel in patients with post-infectious-IBS

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Balemans, D., Mondelaers, S. U., Cibert-Goton, V., Stakenborg, N., Aguilera-Lizarraga, J., Dooley, J., Liston, A., Bulmer, D. C. +3 more·2017·Scientific Reports
DOI 10.1038/s41598-017-12618-7PMC PMC5648751
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Abstract

Post-infectious irritable bowel syndrome (PI-IBS) is a common gastrointestinal disorder characterized by persistent abdominal pain despite recovery from acute gastroenteritis. The underlying mechanisms are unclear, although long-term changes in neuronal function, and low grade inflammation of the bowel have been hypothesized. We investigated the presence and mechanism of neuronal sensitization in a unique cohort of individuals who developed PI-IBS following exposure to contaminated drinking water 7 years ago. We provide direct evidence of ongoing sensitization of neuronal signaling in the bowel of patients with PI-IBS. These changes occur in the absence of any detectable tissue inflammation, and instead appear to be driven by pro-nociceptive changes in the gut micro-environment. This is evidenced by the activation of murine colonic afferents, and sensitization responses to capsaicin in dorsal root ganglia (DRGs) following application of supernatants generated from tissue biopsy of patients with PI-IBS. We demonstrate that neuronal signaling within the bowel of PI-IBS patients is sensitized 2 years after the initial infection has resolved. This sensitization appears to be mediated by a persistent pro-nociceptive change in the gut micro-environment, that has the capacity to stimulate visceral afferents and facilitate neuronal TRPV1 signaling.

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  • Genome-wide association studies have provided associations with variants on chromosome 9 (9q31.2 locus) that are linked to the functions of diverse ion channels and autonomic dysfunction, and mutations in the sucrase-isomaltase gene.

    “genome-wide association studies have provided associations with variants on chromosome 9 (9q31.2 locus) that are linked to the functions of diverse ion channels and autonomic dysfunction, 56 and mutations in the sucrase-isomaltase gene, 38,39 as previously discussed.”

    From Irritable bowel syndrome (2020) · cites this paper as [56]

    The Methods section describes experiments on sensory neurons, and the Discussion addresses TRP-channel sensitization in post-infectious IBS. Neither passage addresses genome-wide associations at 9q31.2, autonomic-dysfunction variants, or sucrase-isomaltase mutations; searches for those terms found no supporting passage in our copy. Page numbers were not available. (LLM, conf=0.76)

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Authors
Balemans, D., Mondelaers, S. U., Cibert-Goton, V., Stakenborg, N., Aguilera-Lizarraga, J., Dooley, J., Liston, A., Bulmer, D. C., Vanden Berghe, P., Boeckxstaens, G. E., & Wouters, M. M.
Affiliations
  • KU Leuven (BE)
  • VIB-KU Leuven Center for Microbiology (BE)
  • Queen Mary University of London (GB)
Corresponding author
Boeckxstaens, G. E.
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2017-10-19
Volume
7
Issue
1
Pages
13606-13606
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-017-12618-7
PMC
PMC5648751
OpenAlex
W2763849432
Cited by
60
References
5
Citations by year
2026: 4 · 2025: 5 · 2024: 3 · 2023: 11 · 2022: 6 · 2021: 12 · 2020: 10 · 2019: 5 · 2018: 4
FWCI
5.46
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Lirias (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Queen Mary Research Online (Queen Mary University of London) (submittedVersion, cc-by)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • Apollo (cc-by)
Funders
  • Fonds Wetenschappelijk Onderzoek (G.0905.07, 1248513 N, 1127415N)
  • KU Leuven (GOA 14.011)
  • Vlaamse regering
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
post-infectious irritable bowel syndrome, neuronal sensitization, visceral afferents, dorsal root ganglia, TRPV1, capsaicin, drinking water contamination, acute gastroenteritis, visceral pain, gut-brain signaling
MeSH terms
Adult, Animals, Capsaicin, Colon, Female, Ganglia, Spinal, Gastroenteritis, Humans, Intestinal Mucosa, Male, Mice, Inbred C57BL, Middle Aged, Neurons, Receptors, Histamine H1, Signal Transduction, Case-Control Studies, Cytokines, Irritable Bowel Syndrome, TRPV Cation Channels, Mice

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