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Cited by 266

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Global phylogenetic analysis of Escherichia coli and plasmids carrying the mcr-1 gene indicates bacterial diversity but plasmid restriction

Open access
Matamoros, Sébastien, van Hattem, Jarne M., Arcilla, Maris S., Willemse, Niels, Melles, Damian C., Penders, John, Vinh, Trung Nguyen, Thi Hoa, Ngo, Bootsma, Martin C. J., van Genderen, Perry J., Goorhuis, Abraham, Grobusch, Martin, Molhoek, Nicky, Oude Lashof, Astrid M. L., Stobberingh, Ellen E., Verbrugh, Henri A., de Jong, Menno D., Schultsz, Constance·2017·Scientific Reports
DOI 10.1038/s41598-017-15539-7
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Abstract

To understand the dynamics behind the worldwide spread of the mcr-1 gene, we determined the population structure of Escherichia coli and of mobile genetic elements (MGEs) carrying the mcr-1 gene. After a systematic review of the literature we included 65 E. coli whole genome sequences (WGS), adding 6 recently sequenced travel related isolates, and 312 MLST profiles. We included 219 MGEs described in 7 Enterobacteriaceae species isolated from human, animal and environmental samples. Despite a high overall diversity, 2 lineages were observed in the E. coli population that may function as reservoirs of the mcr-1 gene, the largest of which was linked to ST10, a sequence type known for its ubiquity in human faecal samples and in food samples. No genotypic clustering by geographical origin or isolation source was observed. Amongst a total of 13 plasmid incompatibility types, the IncI2, IncX4 and IncHI2 plasmids accounted for more than 90% of MGEs carrying the mcr-1 gene. We observed significant geographical clustering with regional spread of IncHI2 plasmids in Europe and IncI2 in Asia. These findings point towards promiscuous spread of the mcr-1 gene by efficient horizontal gene transfer dominated by a limited number of plasmid incompatibility types.

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Metadata

Authors
Matamoros, S., van Hattem, J. M., Arcilla, M. S., Willemse, N., Melles, D. C., Penders, J., Vinh, T. N., Thi Hoa, N., Bootsma, M. C. J., van Genderen, P. J., Goorhuis, A., Grobusch, M., Molhoek, N., Oude Lashof, A. M. L., Stobberingh, E. E., Verbrugh, H. A., de Jong, M. D., & Schultsz, C.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2017-11-10
Volume
7
Issue
1
Pages
15364-15364
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-017-15539-7
OpenAlex
W2949907272
Cited by
266
References
51
FWCI
8.51
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Global phylogenetic analysis of Escherichia coli and plasmids carrying the mcr-1 gene indicates bacterial diversity but plasmid restriction. https://app.cochat.ai/papers/10.1038/s41598-017-15539-7
The paper
Matamoros, S., van Hattem, J. M., Arcilla, M. S., Willemse, N., Melles, D. C., Penders, J., Vinh, T. N., Thi Hoa, N., Bootsma, M. C. J., van Genderen, P. J., Goorhuis, A., Grobusch, M., Molhoek, N., Oude Lashof, A. M. L., Stobberingh, E. E., Verbrugh, H. A., de Jong, M. D., & Schultsz, C. (2017). Global phylogenetic analysis of Escherichia coli and plasmids carrying the mcr-1 gene indicates bacterial diversity but plasmid restriction. Scientific Reports. https://doi.org/10.1038/s41598-017-15539-7

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.