Factors Obscuring the Role of E. coli from Domestic Animals in the Global Antimicrobial Resistance Crisis: An Evidence-Based Review
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Recent studies have found limited associations between antimicrobial resistance (AMR) in domestic animals (and animal products), and AMR in human clinical settings. These studies have primarily used Escherichia coli, a critically important bacterial species associated with significant human morbidity and mortality. E. coli is found in domestic animals and the environment, and it can be easily transmitted between these compartments. Additionally, the World Health Organization has highlighted E. coli as a “highly relevant and representative indicator of the magnitude and the leading edge of the global antimicrobial resistance (AMR) problem”. In this paper, we discuss the weaknesses of current research that aims to link E. coli from domestic animals to the current AMR crisis in humans. Fundamental gaps remain in our understanding the complexities of E. coli population genetics and the magnitude of phenomena such as horizontal gene transfer (HGT) or DNA rearrangements (transposition and recombination). The dynamic and intricate interplay between bacterial clones, plasmids, transposons, and genes likely blur the evidence of AMR transmission from E. coli in domestic animals to human microbiota and vice versa. We describe key factors that are frequently neglected when carrying out studies of AMR sources and transmission dynamics.
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E. coli is a common colonizer of the gastrointestinal tract in humans and animals.
“E. coli, a common colonizer of the gastrointestinal tract in humans and animals [68,69], was the most studied bacterial species, followed by species of Klebsiella, Pseudomonas, and Salmonella.”
From A Systematic Review on Antimicrobial Resistance in Ghana from a One Health Perspective (2024) · cites this paper as [68]
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“E. coli , a common colonizer of the gastrointestinal tract in humans and animals [68,69], was the most studied bacterial species, followed by species of Klebsiella , Pseudomonas , and Salmonella .”
BackgroundSwine Colibacillosis: Global Epidemiologic and Antimicrobial Scenario
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Mini-Review: Antibiotic-Resistant Escherichia coli from Farm Animal-Associated Sources
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Dawangpa, A., Lertwatcharasarakul, P., Boonsoongnern, A., Ratanavanichrojn, N., Sanguankiat, A., Pinniam, N., Jala, S., Laopiem, S., & Tulayakul, P. (2022) · Emerging contaminants · doi:10.1016/j.emcon.2022.03.002 · Cited by 16 · see citing works
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Polyphosphate Ester-Type Transporters Improve Antimicrobial Properties of Oxytetracycline
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Environmental Reservoirs, Genomic Epidemiology, and Mobile Genetic Elements
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Distribution of blaCTX-M-gene variants in E. coli from different origins in Ecuador
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Toxicity analysis of amoxicillin, polyphosphate ester and its complex with amoxicillin on mice
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New Concepts on Domestic and Wild Reservoirs and Transmission of E. coli and Its Environment
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РІЗНОВИДИ ПАТОЛОГІЙ, ЯКІ ВИКЛИКАЮТЬ ПАТОГЕННІ ШТАМИ КИШКОВОЇ ПАЛИЧКИ
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Aryal, A., Bhattarai, R. K., Upadhay, B. T., Thapa, S., Dhamala, P., Ghimire, K., & Marasini, A. (2026) · Journal of Food Protection · doi:10.1016/j.jfp.2026.100955
- Authors
- Loayza, F., Graham, J. P., & Trueba, G.
- Affiliations
- Universidad San Francisco de Quito (EC)
- University of California, Berkeley (US)
- Corresponding author
- Graham, Jay P.
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2020-04-28
- Volume
- 17
- Issue
- 9
- Pages
- 3061
- ISSN
- 1660-4601 (ISSN-L)
- PMC
- PMC7246672
- OpenAlex
- W3022628550
- Cited by
- 66
- References
- 95
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 10 · 2023: 14 · 2022: 11 · 2021: 8 · 2020: 2
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (R01AI135118)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
- Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
- Keywords
- Escherichia coli, antimicrobial resistance, domestic animals, zoonotic transmission, horizontal gene transfer, transposable elements, plasmids, bacterial population genetics, human microbiota, animal products
- MeSH terms
- Animals, Animals, Domestic, Anti-Bacterial Agents, Escherichia coli, Escherichia coli Infections, Humans, Drug Resistance, Bacterial
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