Cited by 66Antibiotic Resistance in BacteriaAntibiotic Use and ResistancePharmaceutical and Antibiotic Environmental Impacts

Factors Obscuring the Role of E. coli from Domestic Animals in the Global Antimicrobial Resistance Crisis: An Evidence-Based Review

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Loayza, Fernanda, Graham, Jay P., Trueba, Gabriel·2020·International Journal of Environmental Research and Public Health

Abstract

Recent studies have found limited associations between antimicrobial resistance (AMR) in domestic animals (and animal products), and AMR in human clinical settings. These studies have primarily used Escherichia coli, a critically important bacterial species associated with significant human morbidity and mortality. E. coli is found in domestic animals and the environment, and it can be easily transmitted between these compartments. Additionally, the World Health Organization has highlighted E. coli as a “highly relevant and representative indicator of the magnitude and the leading edge of the global antimicrobial resistance (AMR) problem”. In this paper, we discuss the weaknesses of current research that aims to link E. coli from domestic animals to the current AMR crisis in humans. Fundamental gaps remain in our understanding the complexities of E. coli population genetics and the magnitude of phenomena such as horizontal gene transfer (HGT) or DNA rearrangements (transposition and recombination). The dynamic and intricate interplay between bacterial clones, plasmids, transposons, and genes likely blur the evidence of AMR transmission from E. coli in domestic animals to human microbiota and vice versa. We describe key factors that are frequently neglected when carrying out studies of AMR sources and transmission dynamics.

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Authors
Loayza, F., Graham, J. P., & Trueba, G.
Affiliations
  • Universidad San Francisco de Quito (EC)
  • University of California, Berkeley (US)
Corresponding author
Graham, Jay P.
Venue
International Journal of Environmental Research and Public Health
Publisher
MDPI AG
Published
2020-04-28
Volume
17
Issue
9
Pages
3061
ISSN
1660-4601 (ISSN-L)
OpenAlex
W3022628550
Cited by
66
References
95
Citations by year
2026: 7 · 2025: 14 · 2024: 10 · 2023: 14 · 2022: 11 · 2021: 8 · 2020: 2
FWCI
0.62
Type
journal article
Language
en
Open access
Locations
  • International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders
National Institutes of Health (R01AI135118)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
  • Physical Sciences › Environmental Science › Pollution › Pharmaceutical and Antibiotic Environmental Impacts
Keywords
Escherichia coli, antimicrobial resistance, domestic animals, zoonotic transmission, horizontal gene transfer, transposable elements, plasmids, bacterial population genetics, human microbiota, animal products
MeSH terms
Animals, Animals, Domestic, Anti-Bacterial Agents, Escherichia coli, Escherichia coli Infections, Humans, Drug Resistance, Bacterial

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