Association of a variant in the gene encoding for ERV1/ChemR23 with reduced inflammation in visceral adipose tissue from morbidly obese individuals
Open accessAbstract
Obesity comorbidities are closely associated with chronic low-grade adipose tissue inflammation. A number of SNPs associated with inflammation has been identified, underscoring the impact of genetic determinants on this process. Here, we screened SNPs in genes with pro-inflammatory (IL-1β, IL-6, STAT3 and JAK2), anti-inflammatory (IL-10 and SOCS3) and pro-resolving (ERV1/ChemR23) properties in 101 obese and 99 non-obese individuals. Among the SNPs analyzed, we identified that individuals carrying a C allele in the rs1878022 polymorphism of the ERV1/ChemR23 gene, which encodes for the receptor of the pro-resolving mediator RvE1, had increased ERV1/ChemR23 protein expression and reduced levels of the inflammatory cytokine IL-6 in adipose tissue. Moreover, patients carrying the C allele in homozygosity had lower plasma levels of IL-6, IFN-α2, IL-15, IL-1ra, IL-10, GM-CSF, G-CSF and VEGF and enhanced leukocyte responsiveness to RvE1. C-carriers also exhibited decreased TAG to HDL ratio, a surrogate marker of insulin resistance and a predictor of incident fatty liver. Finally, we confirmed in vivo that the ERV1/ChemR23 receptor regulates systemic and tissue inflammation since mice lacking ERV1/ChemR23 expression showed increased IL-6 levels in adipose tissue and peritoneal macrophages. Together, our study identified an ERV1/ChemR23 variant that protects patients with obesity from excessive inflammatory burden.
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Murine macrophages derived from ChemR23-deficient mice have increased production of pro-inflammatory cytokines and lack RvE1-induced effects on phagocytosis compared with wild-type macrophages.
“murine macrophages derived from ChemR23-deficient mice have increased production of pro-inflammatory cytokines105,117 and a lack of RvE1-induced effects on phagocytosis compared with wild-type macrophages105.”
From Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities (2019) · cites this paper as [117]
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Self-citation
- Authors
- López-Vicario, C., Rius, B., Alcaraz-Quiles, J., González-Périz, A., Martínez-Puchol, A. I., Casulleras, M., Duran-Güell, M., Ibarzabal, A., Corcelles, R., Laguna-Fernández, A., Back, M., Titos, E., & Clària, J.
- Affiliations
- Hospital Clínic de Barcelona (ES)
- Karolinska University Hospital (SE)
- Corresponding author
- Clària, Joan
- ORCID
- Venue
- Scientific Reports
- Published
- 2017-11-16
- Volume
- 7
- Issue
- 1
- Pages
- 15724-15724
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5691181
- OpenAlex
- W2767283967
- Cited by
- 37
- References
- 42
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 6 · 2020: 9 · 2019: 2 · 2018: 5
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Centres de Recerca de Catalunya
- Generalitat de Catalunya (00045, FI-DGR2015)
- Ministerio de Economía y Competitividad (PIE14‐00045, SAF15-63674-R)
- Instituto de Salud Carlos III (PIE14/00045)
- European Regional Development Fund
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- visceral adipose tissue inflammation, morbid obesity, single nucleotide polymorphisms, interleukin-6, specialized pro-resolving mediators, insulin resistance, hepatic steatosis, peritoneal macrophages, adipose tissue cytokines
- MeSH terms
- Animals, Female, Gene Frequency, Homozygote, Humans, Inflammation, Liver, Male, Middle Aged, Models, Genetic, Obesity, Morbid, Omentum, Interleukin-6, Receptors, Chemokine, Polymorphism, Single Nucleotide, Inheritance Patterns, Intra-Abdominal Fat, Mice, Genetic Association Studies
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