Phospholipase A2-Responsive Phosphate Micelle-Loaded UCNPs for Bioimaging of Prostate Cancer Cells
Open accessAbstract
We report the effective synthesis of biocompatible upconversion nanoparticles (UCNP)-loaded phosphate micelles and successful delivery of UCNPs to prostate cancer cells via secreted phospholipase A2 (sPLA-2) enzyme cleavage of the loaded micelles for the first time. The activity of the (sPLA-2) enzyme toward the synthesized micelles was investigated and confirmed by LC-MS. TEM results showed that the micelles have a size distribution of 80 to 150 nm, whereas UCNP-loaded micelles range from 200 to 350 nm, indicating the successful loading of UCNPs. The selective release of UCNPs to prostate cancer cells rather than other cells, specifically cervical cancer cells, was observed and confirmed by a range of bioimaging studies. Moreover, cytotoxicity assays confirmed the biocompatibility of the UCNP-loaded micelles.
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The cytotoxicity results demonstrated that UCNPs-encapsulated phosphate micelles possess low toxicity toward prostate cancer cells.
“The cytotoxicity results demonstrated that UCNPs-encapsulated phosphate micelles possess low toxicity toward prostate cancer cells.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [21]
Our group prepared a novel biocompatible micelles-based phosphate for UCNPs targeting to prostate cancer cells.
“Our group [21] prepared a novel biocompatible micelles-based phosphate for UCNPs targeting to prostate cancer cells.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [21]
The developed micelles were found to be sPLA-2 enzyme responsive.
“The developed micelles were found to be sPLA-2 enzyme responsive, as illustrated in Figure 16.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [21]
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- Authors
- Sharipov, M., Tawfik, S. M., Gerelkhuu, Z., Huy, B. T., & Lee, Y.-I.
- Affiliations
- Changwon National University (KR)
- Corresponding author
- Lee, Yong-Ill
- Venue
- Scientific Reports
- Published
- 2017-11-22
- Volume
- 7
- Issue
- 1
- Pages
- 16073-16073
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5700164
- OpenAlex
- W2768680678
- Cited by
- 52
- References
- 36
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 3 · 2022: 11 · 2021: 13 · 2020: 3 · 2019: 4 · 2018: 6
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Research Foundation
- National Research Foundation of Korea ((NRF-2017R1A2B4006388)., 2017R1A2B4006388)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence Properties of Advanced Materials
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Keywords
- upconversion nanoparticles, secretory phospholipase A2, enzyme-responsive drug delivery, prostate cancer, bioimaging, targeted nanoparticle delivery, micelle size distribution, biocompatibility, cytotoxicity
- MeSH terms
- Bee Venoms, Diagnostic Imaging, Humans, Male, Micelles, Phosphates, Prostatic Neoplasms, Surface-Active Agents, Cell Death, Cell Line, Tumor, Nanoparticles, Phospholipases A2
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