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Cited by 22Developmental Biology and Gene RegulationZebrafish Biomedical Research ApplicationsFish Biology and Ecology Studies

A gene expression study of ornamental fin shape in Neolamprologus brichardi, an African cichlid species

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Ahi, Ehsan Pashay, Richter, Florian, Sefc, Kristina M.·2017·Scientific Reports
DOI 10.1038/s41598-017-17778-0PMC PMC5727040
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Abstract

The diversity of fin morphology within and across fish taxa offers great, but still largely unexplored, opportunities to investigate the proximate mechanisms underlying fin shape variation. Relying on available genetic knowledge brought forth mainly by the comprehensive study of the zebrafish caudal fin, we explored candidate molecular mechanisms for the maintenance and formation of the conspicuously elongated filaments adorning the unpaired fins of the East African “princess cichlid” Neolamprologus brichardi. Via qPCR assays, we detected expression differences of candidate genes between elongated and short regions of intact and regenerating fins. The identified genes include skeletogenic and growth factors (igf2b, fgf3, bmp2 and bmp4), components of the WNT pathway (lef1, wnt5b and wnt10) and a regulatory network determining fin ray segment size and junction (cx43, esco2 and sema3d), as well as other genes with different roles (mmp9, msxb and pea3). Interestingly, some of these genes showed fin specific expression differences which are often neglected in studies of model fish that focus on the caudal fin. Moreover, while the observed expression patterns were generally consistent with zebrafish results, we also detected deviating expression correlations and gene functions.

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Cited by

Sorted by citations

Authors
Ahi, E. P., Richter, F., & Sefc, K. M.
Affiliations
University of Graz (AT)
Corresponding author
Ahi, Ehsan Pashay
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2017-12-12
Volume
7
Issue
1
Pages
17398-17398
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-017-17778-0
PMC
PMC5727040
OpenAlex
W2773008619
Cited by
22
References
1
Citations by year
2025: 1 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 5 · 2020: 1 · 2019: 5 · 2018: 2
FWCI
0.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Unipub UB Graz (Universität Graz) (submittedVersion, cc-by)
Funders
Karl-Franzens-Universität Graz
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Fish Biology and Ecology Studies
Keywords
fin shape, fin regeneration, gene expression, Wnt signaling, BMP signaling, FGF signaling, SEMA3D, ESCO2, connexin 43
MeSH terms
Animals, Female, Male, Transcription Factors, Zebrafish, Connexin 43, Gene Expression Regulation, Developmental, Matrix Metalloproteinase 9, Cichlids, Fish Proteins, Intercellular Signaling Peptides and Proteins, Animal Fins, Wnt Signaling Pathway

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