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Superficial slow rhythms integrate cortical processing in humans

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Halgren, Mila, Fabó, Daniel, Ulbert, István, Madsen, Joseph R., Erőss, Lorand, Doyle, Werner K., Devinsky, Orrin, Schomer, Donald +2 more·2018·Scientific Reports
DOI 10.1038/s41598-018-20662-0PMC PMC5794750

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Abstract

The neocortex is composed of six anatomically and physiologically specialized layers. It has been proposed that integration of activity across cortical areas is mediated anatomically by associative connections terminating in superficial layers, and physiologically by slow cortical rhythms. However, the means through which neocortical anatomy and physiology interact to coordinate neural activity remains obscure. Using laminar microelectrode arrays in 19 human participants, we found that most EEG activity is below 10-Hz (delta/theta) and generated by superficial cortical layers during both wakefulness and sleep. Cortical surface grid, grid-laminar, and dual-laminar recordings demonstrate that these slow rhythms are synchronous within upper layers across broad cortical areas. The phase of this superficial slow activity is reset by infrequent stimuli and coupled to the amplitude of faster oscillations and neuronal firing across all layers. These findings support a primary role of superficial slow rhythms in generating the EEG and integrating cortical activity.

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Cited by

Sorted by citations

Authors
Halgren, M., Fabó, D., Ulbert, I., Madsen, J. R., Erőss, L., Doyle, W. K., Devinsky, O., Schomer, D., Cash, S. S., & Halgren, E.
Affiliations
  • Harvard University (US)
  • Pázmány Péter Catholic University (HU)
  • Boston Children's Hospital (US)
  • New York University (US)
  • Beth Israel Deaconess Medical Center (US)
  • University of California San Diego (US)
Corresponding author
Halgren, Mila
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2018-02-01
Volume
8
Issue
1
Pages
2055-2055
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-018-20662-0
PMC
PMC5794750
OpenAlex
W2774966395
Cited by
59
References
8
Citations by year
2026: 2 · 2025: 2 · 2024: 6 · 2023: 10 · 2022: 7 · 2021: 9 · 2020: 6 · 2019: 10 · 2018: 6 · 2017: 1
FWCI
4.62
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
  • Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • European Commission (600925)
  • Hungarian Scientific Research Fund (PD101754)
  • Magyarország Kormánya (OTKA PD101754)
  • National Institutes of Health (-0001, N00014-13-1-0672)
  • Office of Naval Research (N00014-13-1-0672, -0001, N00014)
  • National Institute of Mental Health (R01MH099645)
  • National Institute of Neurological Disorders and Stroke (R01NS062092, K24NS088568)
  • National Institute of Biomedical Imaging and Bioengineering (R01EB009282)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neuroscience and Music Perception
Keywords
superficial cortical layers, cortical integration, EEG, delta oscillations, theta oscillations, sleep, wakefulness, neuronal firing, neocortex
MeSH terms
Adolescent, Adult, Cerebral Cortex, Child, Delta Rhythm, Female, Humans, Male, Middle Aged, Sleep, Theta Rhythm, Wakefulness

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