Extracellular matrix scaffold and hydrogel derived from decellularized and delipidized human pancreas
Open accessAbstract
Extracellular matrix (ECM) plays an important developmental role by regulating cell behaviour through structural and biochemical stimulation. Tissue-specific ECM, attained through decellularization, has been proposed in several strategies for tissue and organ replacement. Decellularization of animal pancreata has been reported, but the same methods applied to human pancreas are less effective due to higher lipid content. Moreover, ECM-derived hydrogels can be obtained from many decellularized tissues, but methods have not been reported to obtain human pancreas-derived hydrogel. Using novel decellularization methods with human pancreas we produced an acellular, 3D biological scaffold (hP-ECM) and hydrogel (hP-HG) amenable to tissue culture, transplantation and proteomic applications. The inclusion of a homogenization step in the decellularization protocol significantly improved lipid removal and gelation capability of the resulting ECM, which was capable of gelation at 37 °C in vitro and in vivo, and is cytocompatible with a variety of cell types and islet-like tissues in vitro. Overall, this study demonstrates the characterisation of a novel protocol for the decellularization and delipidization of human pancreatic tissue for the production of acellular ECM and ECM hydrogel suitable for cell culture and transplantation applications. We also report a list of 120 proteins present within the human pancreatic matrisome.
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In vitro analysis revealed successful elimination of cellular and antigenic tissue components through decellularization treatment, and demonstrated low immunogenicity of human pancreas-derived hydrogels.
“In vitro analysis revealed successful elimination of cellular and antigenic tissue components through decellularization treatment, and demonstrated low immunogenicity of human pancreas‐derived hydrogels.”
From Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations (2025) · cites this paper as [21]
The Results (In vivo immunogenicity; page unavailable) report absent HLA class I and II staining in decellularized material and little immune-cell infiltration around hydrogel grafts, consistent with removal of cellular and antigenic components and low immunogenicity. However, immunogenicity was assessed after implantation in humanized mice, not by in vitro analysis, and the paper describes the components as largely removed rather than completely eliminated. (LLM, conf=0.89)
Experimental — accuracy not yet measuredDecellularized human ECM is capable of supporting the survival of undifferentiated hPSCs and their pancreatic lineage derivatives, including insulin-expressing beta-like cells, in vitro.
“With specific preparation methods that remove lipids, Sackett et al. found that decellularized human ECM is capable of supporting the survival of undifferentiated hPSCs and their pancreatic lineage derivatives, including insulin-expressing beta-like cells, in vitro81.”
From Towards organoid culture without Matrigel (2021) · cites this paper as [81]
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- Authors
- Sackett, S. D., Tremmel, D. M., Ma, F., Feeney, A. K., Maguire, R. M., Brown, M. E., Zhou, Y., Li, X., O’Brien, C., Li, L., Burlingham, W. J., & Odorico, J. S.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Sackett, Sara Dutton
- ORCID
- Venue
- Scientific Reports
- Published
- 2018-07-11
- Volume
- 8
- Issue
- 1
- Pages
- 10452-10452
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6041318
- OpenAlex
- W2839646944
- Cited by
- 269
- References
- 74
- Citations by year
- 2026: 14 · 2025: 24 · 2024: 33 · 2023: 39 · 2022: 44 · 2021: 42 · 2020: 42 · 2019: 26 · 2018: 4
- FWCI
- 29.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Wisconsin Alumni Research Foundation
- University of Wisconsin-Madison
- National Institutes of Health (NIH R01DK071801)
- National Institute of General Medical Sciences (P41GM108538)
- National Institute of Allergy and Infectious Diseases (R21AI126419)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK071801)
- Division of Graduate Education
- National Center for Research Resources (S10RR029531, NIH-NCRR S10RR029531, NCRRS10RR029531)
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- extracellular matrix, decellularization, human pancreas, hydrogels, acellular scaffolds, tissue engineering, tissue transplantation, homogenization, lipid removal, gelation, cytocompatibility
- MeSH terms
- Animals, Extracellular Matrix, Humans, Lipids, Pancreas, Proteins, Hydrogels, Tissue Engineering, Tissue Scaffolds
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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