Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases

Liu, Ying; Vu, Vivian; Sweeney, Gary

doi:10.3389/fendo.2019.00842

Cited by 69Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases

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Liu, Ying, Vu, Vivian, Sweeney, Gary·2019·Frontiers in Endocrinology

DOI 10.3389/fendo.2019.00842PMC PMC6918867

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Abstract

Cardiometabolic diseases encompass those affecting the heart and vasculature as well as other metabolic problems, such as insulin resistance, diabetes, and non-alcoholic fatty liver disease. These diseases tend to have common risk factors, one of which is impaired adiponectin action. This may be due to reduced bioavailability of the hormone or resistance to its effects on target tissues. A strong negative correlation between adiponectin levels and cardiometabolic diseases has been well-documented and research shown that adiponectin has cardioprotective, insulin sensitizing and direct beneficial metabolic effects. Thus, therapeutic approaches to enhance adiponectin action are widely considered to be desirable. The complexity of adiponectin structure and function has so far made progress in this area less than ideal. In this article we will review the effects and mechanism of action of adiponectin on cardiometabolic tissues, identify scenarios where enhancing adiponectin action would be of clinical value and finally discuss approaches via which this can be achieved.

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Several short peptides and small molecules have been identified to target AdipoRs and mimic some ApN effects.
“Several short peptides and small molecules have been identified today to target AdipoRs and mimic some of ApN effects.”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [120]
These receptor agonists can induce similar downstream signaling cascades to ApN, such as AMPK, p38MAPK, and PPARα.
“These receptor agonists can induce similar downstream signaling cascades to ApN, such as AMPK, p38MAPK, and PPARα [120] (Table 1).”
From Adiponectin and Its Mimics on Skeletal Muscle: Insulin Sensitizers, Fat Burners, Exercise Mimickers, Muscling Pills … or Everything Together? (2020) · cites this paper as [120]

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An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart
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Deficiency of Adiponectin Receptor 2 Reduces Diet-Induced Insulin Resistance but Promotes Type 2 Diabetes
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Adiponectin deficiency exacerbates cardiac dysfunction following pressure overload through disruption of an AMPK-dependent angiogenic response
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iPOP Goes the World: Integrated Personalized Omics Profiling and the Road toward Improved Health Care
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Individualized Responses of Gut Microbiota to Dietary Intervention Modeled in Humanized Mice
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Adiponectin homolog novel osmotin protects obesity/diabetes-induced NAFLD by upregulating AdipoRs/PPARα signaling in ob/ob and db/db transgenic mouse models
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Adiporon, an adiponectin receptor agonist acts as an antidepressant and metabolic regulator in a mouse model of depression
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“Higher adiponectin levels were also associated with a reduced risk of developing type 2 diabetes and the subsequent risk of cardiovascular events in a large population of healthy patients (77).”
Background
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Identification of Adiponectin Receptor Agonist Utilizing a Fluorescence Polarization Based High Throughput Assay
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Authors: Liu, Y., Vu, V., & Sweeney, G.
Affiliations: York University (CA)
Corresponding author: Liu, Ying
Sweeney, Gary
ORCID: Liu, Ying
Sweeney, Gary
Venue: Frontiers in Endocrinology
Publisher: Frontiers Media SA
Published: 2019-12-11
Volume: 10
Pages: 842-842
ISSN: 1664-2392 (ISSN-L)
DOI: 10.3389/fendo.2019.00842
PMC: PMC6918867
OpenAlex: W2995030404
Cited by: 69
References: 222
Citations by year: 2026: 5 · 2025: 6 · 2024: 12 · 2023: 14 · 2022: 8 · 2021: 15 · 2020: 7 · 2018: 2
FWCI: 1.09
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Frontiers in Endocrinology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Canadian Institutes of Health Research
Topics: Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: adiponectin, cardiometabolic disease, insulin resistance, diabetes mellitus, non-alcoholic fatty liver disease, adiponectin resistance, cardioprotection, insulin sensitization

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Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases

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