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Cited by 66Functional Brain Connectivity StudiesNeural dynamics and brain functionPhilosophy and Theoretical Science

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Functional diversity of brain networks supports consciousness and verbal intelligence

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Naci, Lorina, Haugg, Amelie, MacDonald, Alex, Anello, Mimma, Houldin, Evan, Naqshbandi, Shakib, Gonzalez-Lara, Laura E., Arango, Miguel, Harle, Christopher, Cusack, Rhodri, Owen, Adrian M.·2018·Scientific Reports
DOI 10.1038/s41598-018-31525-zPMC PMC6125486

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Abstract

How are the myriad stimuli arriving at our senses transformed into conscious thought? To address this question, in a series of studies, we asked whether a common mechanism underlies loss of information processing in unconscious states across different conditions, which could shed light on the brain mechanisms of conscious cognition. With a novel approach, we brought together for the first time, data from the same paradigm—a highly engaging auditory-only narrative—in three independent domains: anesthesia-induced unconsciousness, unconsciousness after brain injury, and individual differences in intellectual abilities during conscious cognition. During external stimulation in the unconscious state, the functional differentiation between the auditory and fronto-parietal systems decreased significantly relatively to the conscious state. Conversely, we found that stronger functional differentiation between these systems in response to external stimulation predicted higher intellectual abilities during conscious cognition, in particular higher verbal acuity scores in independent cognitive testing battery. These convergent findings suggest that the responsivity of sensory and higher-order brain systems to external stimulation, especially through the diversification of their functional responses is an essential feature of conscious cognition and verbal intelligence.

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Metadata

Authors
Naci, L., Haugg, A., MacDonald, A., Anello, M., Houldin, E., Naqshbandi, S., Gonzalez-Lara, L. E., Arango, M., Harle, C., Cusack, R., & Owen, A. M.
Affiliations
  • University of Zurich (CH)
  • University of Toronto (CA)
  • Western University (CA)
  • Trinity College Dublin (IE)
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2018-09-05
Volume
8
Issue
1
Pages
13259-13259
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-018-31525-z
PMC
PMC6125486
OpenAlex
W2952717102
Cited by
66
References
16
Citations by year
2026: 6 · 2025: 2 · 2024: 15 · 2023: 8 · 2022: 14 · 2021: 9 · 2020: 8 · 2019: 4
FWCI
3.12
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Scholarship@Western (Western University) (submittedVersion)
  • Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
Funders
  • L'Oreal USA
  • Wellcome Trust
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Social Sciences › Arts and Humanities › Philosophy › Philosophy and Theoretical Science
Keywords
consciousness, verbal intelligence, brain networks, functional differentiation, loss of consciousness, anesthesia, brain injury, sensory processing, individual differences
MeSH terms
Adult, Anesthesia, Auditory Cortex, Brain, Consciousness, Female, Frontal Lobe, Humans, Intelligence, Male, Middle Aged, Parietal Lobe, Unconsciousness, Young Adult, Connectome

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