Dvl3 polymorphism interacts with life events and pro-inflammatory cytokines to influence major depressive disorder susceptibility
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The purpose of this study is to explore Dvl3 variants and their interaction with negative life events on MDD susceptibility in a Chinese Han population. Additionally, we also attempted to identify whether there is an association between Dvl3 variants and pro-inflammatory cytokines. A total of 1102 participants, consisting of 550 patients with MDD and 552 healthy subjects, were recruited for genotyping by TaqMan allelic discrimination assay. Pro-inflammatory cytokine mRNA levels in peripheral blood were measured by QPCR. After the assessment of negative life events by the Life Events Scale, the Dvl3 gene-environment interaction (G × E) and risk factors were evaluated using generalized multifactor dimensionality reduction method (GMDR) and logistic regression analysis, respectively. This study is the first to reveal the interaction between Dvl3 allelic variations and negative life events as well as pro-inflammatory cytokines on MDD susceptibility in a Chinese Han population.
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Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature
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- Authors
- Zhang, J., Yang, J., Han, D., Zhao, X., Ma, J., Ban, B., Zhu, X., Yang, Y., Cao, D., & Qiu, X.
- Affiliations
- Harbin Medical University (CN)
- Affiliated Hospital of Jining Medical University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Corresponding author
- Yang, Yanjie
- Cao, Depin
- Qiu, Xiaohui
- ORCID
- Venue
- Scientific Reports
- Published
- 2018-09-21
- Volume
- 8
- Issue
- 1
- Pages
- 14181-14181
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6155061
- OpenAlex
- W2890228464
- Cited by
- 11
- References
- 40
- Citations by year
- 2025: 4 · 2024: 1 · 2023: 3 · 2021: 1 · 2019: 2
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Natural Science Foundation of China
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- DVL3, major depressive disorder, gene-environment interaction, negative life events, inflammatory cytokines, genetic polymorphism, Han Chinese, depression vulnerability
- MeSH terms
- Dishevelled Proteins, Adult, Alleles, Major Depressive Disorder, Female, Genotype, Humans, Inflammation, Life Change Events, Male, Risk Factors, Case-Control Studies, Cytokines, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Asian People, Gene-Environment Interaction
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