Life events and affective disorders
Abstract
Objective To summarize research in life events and affective disorders Method Review of the literature. Results and conclusion Many studies have shown that episodes of unipolar depression are preceded by life events at higher rates than in control samples. A variety of stressful events are involved with only limited specificity but some relationship to social exit events. Life events also affect remission and relapse of depression. Effects of life events are less when the disorder has already been recurrent, particularly where illness is severe. Effects of life events are also weaker in bipolar disorder than unipolar, but major life events may be important in first onset. Recent evidence suggests a specific role of social rhythm disruption events in manic relapses. Causative chains are multifactorial and complex, and genetic factors can influence life event exposure.
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Interpersonal loss is the type of stress that has received the most attention in this context.
“The type of stress that has received the most attention in this context is interpersonal loss”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Paykel, 2003
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“About one-third of the relationship between life events and depression appeared to be due to selfselection into high-risk environments (63).”
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- Authors
- Paykel, E. S.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Paykel, E. S.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2003-09-04
- Volume
- 108
- Issue
- s418
- Pages
- 61-66
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2106207403
- Cited by
- 368
- References
- 68
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 8 · 2023: 8 · 2022: 11 · 2021: 13 · 2020: 12 · 2019: 20 · 2018: 16 · 2017: 22 · 2016: 21 · 2015: 25 · 2014: 20 · 2013: 25 · 2012: 18
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- life events, mood disorders, major depressive disorder, bipolar disorder, depression remission, depression relapse, recurrent depression, manic relapse, genetic factors
- MeSH terms
- Humans, Life Change Events, Recurrence, Severity of Illness Index, Stress, Psychological, Mood Disorders, Genetic Predisposition to Disease
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