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Cited by 548Diabetes, Cardiovascular Risks, and LipoproteinsBody Composition Measurement TechniquesCardiovascular Disease and Adiposity

A novel adiposity index as an integrated predictor of cardiometabolic disease morbidity and mortality

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Park, Yousung, Kim, Nam Hoon, Kwon, Tae Yeon, Kim, Sin Gon·2018·Scientific Reports
DOI 10.1038/s41598-018-35073-4PMC PMC6233180
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Abstract

We propose a new anthropometric index, weight-adjusted-waist index (WWI), to assess adiposity by standardizing waist circumference (WC) for weight. WWI, calculated as WC (cm) divided by the square root of weight (kg) (cm/√kg), was measured from 465,629 subjects in the Korean nationwide cohort (2008–2013). Cox regression analysis was used to compare WWI with BMI, WC, waist-to-height ratio (WHtR), and a body shape index (ABSI) for cardiometabolic morbidity and mortality risk in diagnostic and prognostic prediction models. For incident hypertension, type 2 diabetes and cardiovascular disease (CVD), BMI had the strongest predictive power, followed by WWI and WC. However, WWI showed the best predictive performance for CVD mortality. Also, a linear positive association between adiposity indices and cardiovascular and all-cause mortality was only shown in WWI and ABSI, not BMI, WC and WHtR which showed inverse J-shaped patterns. In the test of joint effects of each index, WWI combined with BMI was the strongest in both diagnostic and prognostic models. WWI is a unique adiposity index that shows linear positive association with both cardiometabolic morbidity and mortality. It also predicts incident cardiometabolic disease, cardiovascular and all-cause mortality risk with excellence in predictive power, especially when combined with BMI.

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Cited by

Sorted by citations

Authors
Park, Y., Kim, N. H., Kwon, T. Y., & Kim, S. G.
Affiliations
  • Korea University (KR)
  • Hankuk University of Foreign Studies (KR)
Corresponding author
Kim, Sin Gon
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2018-11-13
Volume
8
Issue
1
Pages
16753-16753
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-018-35073-4
PMC
PMC6233180
OpenAlex
W2900297440
Cited by
548
References
6
Citations by year
2026: 105 · 2025: 194 · 2024: 156 · 2023: 59 · 2022: 19 · 2021: 7 · 2020: 7 · 2019: 1
FWCI
2.97
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Ministry of Health and Welfare (HI14C2750)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
weight-adjusted waist index, adiposity indices, waist circumference, anthropometric indices, cardiometabolic disease, cardiovascular mortality, all-cause mortality, hypertension, type 2 diabetes, cardiovascular disease, body shape index, waist-to-height ratio, body mass index, prognostic model
MeSH terms
Adult, Cardiovascular Diseases, Child, Female, Humans, Male, Morbidity, Prognosis, Models, Statistical, Cohort Studies, Body Mass Index, Adiposity

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