Association of functional dorsal attention network alterations with breast cancer and chemotherapy
Open accessAbstract
Breast cancer is the most common cancer among women worldwide. Adjuvant chemotherapy has significantly reduced mortality but increased cognitive impairments, including attention function, making quality of life issues a crucial concern. This study enrolled nineteen breast cancer patients who were treated with standard chemotherapy within 6 months and 20 sex-matched healthy controls to investigate the brain effects of chemotherapy. All participants underwent resting-state functional magnetic resonance imaging (rs-fMRI) with mean fractional amplitude of low-frequency fluctuation (mfALFF) analysis and were correlated with neuropsychological tests, including the Mini-Mental State Examination (MMSE), the Cognitive and Affective Mindfulness Scale-Revised (CAMS-R), and the Impact of Event Scale-Revised (IES-R), to explore the possible underlying mechanism of cognitive alternations. We found increased mfALFF over the frontoparietal lobe and decreased mfALFF over the occipital lobe in the cancer patients compared with the healthy controls; the altered brain regions may be associated with the dorsal attention network (DAN) and may be explained by a compensatory mechanism. Both MMSE and CAMS-R scores showed a positive correlation with mfALFF in the occipital lobe but a negative correlation in the frontoparietal lobe. By contrast, IES-R scores showed a positive correlation with mfALFF in the frontoparietal lobe but a negative correlation in the occipital lobe. These alterations are potentially related to the effects of both chemotherapy and psychological distress. Future research involving a larger sample size of patients with breast cancer is recommended.
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Preliminary validation of the Cognitive Affective Mindfulness Scale–Revised in cancer populations
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“R has been used in studies of patients with breast cancer 19 but has yet to be validated in cancer populations.”
Method
- Authors
- Shen, C.-Y., Chen, V. C.-H., Yeh, D.-C., Huang, S.-L., Zhang, X.-R., Chai, J.-W., Huang, Y.-H., Chou, M.-C., & Weng, J.-C.
- Affiliations
- Chung Shan Medical University Hospital (TW)
- Chang Gung University (TW)
- Cheng Ching Hospital (TW)
- Chung Shan Medical University (TW)
- China Medical University (TW)
- Taipei City Hospital (TW)
- Corresponding author
- Weng, Jun-Cheng
- ORCID
- Venue
- Scientific Reports
- Published
- 2019-01-14
- Volume
- 9
- Issue
- 1
- Pages
- 104-104
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6331552
- OpenAlex
- W2908947102
- Cited by
- 34
- References
- 69
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 1
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Science Council
- Chang Gung University (MOST107-2221-E-182-054-MY3, BMRPD1G1321, BMRPD1H0101)
- Chang Gung Medical Foundation (CORPG6G0101)
- Ministry of Science and Technology, Taiwan (MOST106-2221-E182-079, MOST104-2314-B040-001, MOST107-2221-E182-054-MY3, MOST103-2420-H040-002)
- Chung Shan Medical University Hospital
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Keywords
- breast cancer, adjuvant chemotherapy, chemotherapy-induced cognitive impairment, dorsal attention network, resting-state brain activity, fractional amplitude of low-frequency fluctuations, occipital lobe, psychological distress, mindfulness, cognitive function
- MeSH terms
- Adult, Antineoplastic Agents, Brain, Breast Neoplasms, Cognition Disorders, Drug Therapy, Female, Humans, Magnetic Resonance Imaging, Middle Aged, Neuropsychological Tests
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