Cited by 68Cancer survivorship and carePosttraumatic Stress Disorder ResearchCancer-related cognitive impairment studies

Clinically assessed posttraumatic stress in patients with breast cancer during the first year after diagnosis in the prospective, longitudinal, controlled COGNICARES study

Voigt, Varinka, Neufeld, Franziska, Kaste, Judith, Bühner, Markus, Sckopke, Philipp, Wuerstlein, Rachel, Hellerhoff, Karin, Sztrókay-Gaul, Anikó +10 more·2017·Psycho-Oncology

Abstract

OBJECTIVE: There is ongoing debate whether cancer qualifies as traumatic stressor. We investigated prevalence and course of posttraumatic stress in patients with early breast cancer (BC) during their first year after diagnosis and determined effects of mastectomy and chemotherapy. METHODS: Patients with stage 0-III BC aged ≤65 years were evaluated with the Structured Clinical Interview for DSM-IV modules for acute and posttraumatic stress disorder (ASD and PTSD, respectively) before treatment, after chemotherapy, and 1 year after diagnosis. Matched controls were assessed at matched intervals. Effects of time, mastectomy, and chemotherapy on BC-related PTSD symptom severity were tested with linear mixed model analysis. RESULTS: Stress disorder (ASD or PTSD) related to BC was diagnosed in 6 (3.6%) of 166 patients before treatment and in 3 patients (2.0%) 1 year later. The rate of patients who experienced PTSD symptoms related to BC decreased from 82.5 to 57.3% (p < 0.001), and the mean of BC-related PTSD symptoms diminished from 3.1 to 1.7 (p < 0.001). Only university education significantly predicted the course of BC-related PTSD symptom severity (p = 0.009). In 60 controls, no diagnosis of stress disorder, a rate of 18% women experiencing PTSD symptoms, and a mean of 0.4 PTSD symptoms (p vs. patients <0.001) were found. CONCLUSIONS: Most newly diagnosed patients with BC experience PTSD symptoms, whereas full diagnoses of DSM-IV stress disorder are rare. Symptoms diminish somewhat within 1 year furthered by university education but independently from mastectomy and chemotherapy. Throughout the year after diagnosis, having BC entails markedly increased PTSD symptom burden. Copyright © 2016 John Wiley & Sons, Ltd.

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Crossref · 10.1002/pon.4102

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Authors
Voigt, V., Neufeld, F., Kaste, J., Bühner, M., Sckopke, P., Wuerstlein, R., Hellerhoff, K., Sztrókay-Gaul, A., Braun, M., von Koch, F. E., Silva-Zürcher, E., Hasmüller, S., Bauerfeind, I., Debus, G., Herschbach, P., Mahner, S., Harbeck, N., & Hermelink, K.
Affiliations
  • Ludwig-Maximilians-Universität München (DE)
  • German Red Cross (DE)
  • Breast Center, Department of Gynecology and Obstetrics; Dritter Orden Hospital; Munich Germany
  • Breast Center, Department of Gynecology and Obstetrics; Hospital of Landshut; Landshut Germany
  • Helios Amper-Klinikum Dachau (DE)
  • Technical University of Munich (DE)
Corresponding author
Hermelink, Kerstin
Venue
Psycho-Oncology
Publisher
Wiley
Published
2016-02-22
Volume
26
Issue
1
Pages
74-80
ISSN
1057-9249 (ISSN-L)
OpenAlex
W2274657772
Cited by
67
References
29
Citations by year
2026: 2 · 2025: 2 · 2024: 3 · 2023: 8 · 2022: 5 · 2021: 11 · 2020: 10 · 2019: 5 · 2018: 7 · 2017: 10 · 2016: 4
FWCI
4.67
Type
journal article
Language
en
Open access
closed
Locations
  • Psycho-Oncology (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM (Technical University of Munich) (submittedVersion)
Funders
Deutsche Krebshilfe e.V. (109132, 109736)
Topics
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
Keywords
post-traumatic stress disorder, breast cancer, acute stress disorder, mastectomy, chemotherapy, university education, early breast cancer
MeSH terms
Aged, Breast Neoplasms, Female, Humans, Longitudinal Studies, Middle Aged, Prognosis, Prospective Studies, Severity of Illness Index, Stress Disorders, Post-Traumatic, Prevalence, Diagnostic and Statistical Manual of Mental Disorders

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