2-Deoxy-D-Glucose inhibits aggressive triple-negative breast cancer cells by targeting glycolysis and the cancer stem cell phenotype
Open accessAbstract
Abstract Due to limited availability of pharmacological therapies, triple-negative breast cancer (TNBC) is the subtype with worst outcome. We hypothesised that 2-Deoxy-D-Glucose (2-DG), a glucose analogue, may hold potential as a therapy for particularly aggressive TNBC. We investigated 2-DG’s effects on TNBC cell line variants, Hs578T parental cells and their isogenic more aggressive Hs578Ts(i)8 variant, using migration, invasion and anoikis assays. We assessed their bioenergetics by Seahorse. We evaluated metabolic alterations using a Seahorse XF Analyzer, citrate synthase assay, immunoblotting and flow cytometry. We assessed the cancer stem cell (CSC) phenotype of the variants and 2-DG’s effects on CSCs. 2-DG significantly inhibited migration and invasion of Hs578Ts(i)8 versus Hs578T and significantly decreased their ability to resist anoikis. Investigating 2-DG’s preferential inhibitory effect on the more aggressive cells, we found Hs578Ts(i)8 also had significantly decreased oxidative phosphorylation and increased glycolysis compared to Hs578T. This is likely due to mitochondrial dysfunction in Hs578Ts(i)8, shown by their significantly decreased mitochondrial membrane potential. Furthermore, Hs578Ts(i)8 had a significantly increased proportion of cells with CSC phenotype, which was significantly decreased by 2-DG. 2-DG may have benefit as a therapy for TNBC with a particularly aggressive phenotype, by targeting increased glycolysis. Studies of more cell lines and patients’ specimens are warranted.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
2-DG is a promising inhibitor of glycolysis that decreases energy of cancer cells, making chemotherapy and other treatments more effective, and is most likely useful for treatment of breast cancer including TNBC.
“2-DG is a promising inhibitor of glycolysis, which decreases the energy of the cancer cells thus making chemotherapy and other treatments more effective. It underwent clinical trials and most likely is useful for the treatment of breast cancer including TNBC (Wokoun et al., 2017; Lucantoni et al., 2018; O’Neill et al., 2019).”
From An Arthropod Hormone, Ecdysterone, Inhibits the Growth of Breast Cancer Cells via Different Mechanisms (2020) · cites this paper as O’Neill et al., 2019
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Genes that mediate breast cancer metastasis to lung
Minn, A. J., Gupta, G. P., Siegel, P. M., Bos, P. D., Shu, W., Giri, D. D., Viale, A., Olshen, A. B., Gerald, W. L., & Massagué, J. (2005) · Nature · doi:10.1038/nature03799 · Cited by 2,922 · see citing works
A multigenic program mediating breast cancer metastasis to bone
Kang, Y., Siegel, P. M., Shu, W., Drobnjak, M., Käkönen, S.-M., Cordon‐Cardo, C., Guise, T. A., & Massagué, J. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00132-6 · Cited by 2,562 · see citing works
Regulation of cadherin-mediated adhesion in morphogenesis
Gumbiner, B. M. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1699 · Cited by 1,523 · see citing works
Christiansen, J. J., & Rajasekaran, A. K. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0410 · Cited by 1,051 · see citing works
Targeting cellular metabolism to improve cancer therapeutics
Zhao, Y., Butler, E. B., & Tan, M. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.60 · Cited by 994 · see citing works
The effects of extracellular pH on immune function
Lardner, A. (2001) · Journal of Leukocyte Biology · doi:10.1189/jlb.69.4.522 · Cited by 864 · see citing works
Raez, L. E., Papadopoulos, K., Ricart, A. D., Chiorean, E. G., DiPaola, R. S., Stein, M. N., Rocha Lima, C. M., Schlesselman, J. J., Tolba, K., Langmuir, V. K., et al. (2013) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-012-2045-1 · Cited by 543 · see citing works
2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy
Zhang, D., Li, J., Wang, F., Hu, J. X., Wang, S., & Sun, Y. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.09.003 · Cited by 464 · see citing works
The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models.
Gatenby, R. A., & Gawlinski, E. T. (2003) · PubMed · Cited by 314 · see citing works
Distinct types of tumor-initiating cells form human colon cancer tumors and metastases
Dieter, S. M., Ball, C. R., Hoffmann, C. M., Nowrouzi, A., Herbst, F., Zavidij, O., Abel, U., Arens, A., Weichert, W., Brand, K., et al. (2011) · Cell stem cell · doi:10.1016/j.stem.2011.08.010 · Cited by 297 · see citing works
Stein, M., Lin, H., Jeyamohan, C., Dvorzhinski, D., Gounder, M., Bray, K., Eddy, S., Goodin, S., White, E., & DiPaola, R. S. (2010) · The Prostate · doi:10.1002/pros.21172 · Cited by 291 · see citing works
Cancer metabolism: The Warburg effect today
Ferreira, L. M. R. (2010) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2010.08.006 · Cited by 281 · see citing works
O’Brien, K., Lowry, M. C., Corcoran, C., Martínez, V. G., Daly, M., Rani, S., Gallagher, W. M., Radomski, M. W., MacLeod, R. A. F., & O’Driscoll, L. (2015) · Oncotarget · doi:10.18632/oncotarget.5192 · Cited by 273 · see citing works
Ciavardelli, D., Rossi, C., Barcaroli, D., Volpe, S., Consalvo, A., Zucchelli, M., Cola, A. D., Scavo, E., Carollo, R., D'Agostino, D., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.285 · Cited by 270 · see citing works
O’Brien, K., Rani, S., Corcoran, C., Wallace, R., Hughes, L., Friel, A. M., McDonnell, S., Crown, J. P., Radomski, M. W., & O’Driscoll, L. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2013.01.017 · Cited by 239 · see citing works
Emerging targeted therapies in triple-negative breast cancer
Crown, J. P., O’Shaughnessy, J., & Gullo, G. (2012) · Annals of Oncology · doi:10.1093/annonc/mds196 · Cited by 210 · see citing works
How does cancer cell metabolism affect tumor migration and invasion?
Han, T., Kang, D., Ji, D., Wang, X., Zhan, W., Fu, M., Xin, H.-B., & Wang, J.-B. (2013) · Cell Adhesion & Migration · doi:10.4161/cam.26345 · Cited by 198 · see citing works
Williams, A. C., Collard, T. J., & Paraskeva, C. (1999) · Oncogene · doi:10.1038/sj.onc.1202660 · Cited by 198 · see citing works
Sutendra, G., Dromparis, P., Kinnaird, A. S., Stenson, T. H., Haromy, A., Parker, J. M. R., McMurtry, M. S., & Michelakis, E. D. (2012) · Oncogene · doi:10.1038/onc.2012.198 · Cited by 185 · see citing works
The Warburg effect version 2.0: Metabolic reprogramming of cancer stem cells
Menéndez, J. A., Joven, J., Cufí, S., Corominas-Faja, B., Oliveras‐Ferraros, C., Cuyàs, E., Martı́n-Castillo, B., López‐Bonet, E., Alarcón, T., & Vázquez‐Martín, A. (2013) · Cell Cycle · doi:10.4161/cc.24479 · Cited by 158 · see citing works
Zhang, W., Zhang, S., Hu, X., & Tam, K. Y. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.13325 · Cited by 153 · see citing works
Jacobson, J., Duchen, M. R., & Heales, S. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00945.x · Cited by 116 · see citing works
Hadzic, T., Aykin‐Burns, N., Zhu, Y., Coleman, M. C., Leick, K. M., Jacobson, G., & Spitz, D. R. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.01.018 · Cited by 90 · see citing works
Cancer Stem Cell-Like Phenotype and Survival Are Coordinately Regulated by Akt/FoxO/Bim Pathway
Gargini, R., Cerliani, J. P., Escoll, M., Anton, I. M., & Wandosell, F. G. (2014) · Stem Cells · doi:10.1002/stem.1904 · Cited by 85 · see citing works
Corcoran, C., Rani, S., Breslin, S., Gogarty, M., Ghobrial, I. M., Crown, J. P., & O’Driscoll, L. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-71 · Cited by 78 · see citing works
Hughes, L., Malone, C., Chumsri, S., Burger, A. M., & McDonnell, S. (2008) · Clinical & Experimental Metastasis · doi:10.1007/s10585-008-9169-z · Cited by 77 · see citing works
Galectin-3 expression alters adhesion, motility and invasion in a lung cell line (DLKP), in vitro.
O’Driscoll, L., Linehan, R., Liang, Y. H., Joyce, H., Oglesby, I. K., & CLYNES, M. M. (2002) · PubMed · Cited by 66 · see citing works
Bizjak, M., Malavašič, P., Dolinar, K., Pohar, J., Pirkmajer, S., & Pavlin, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-01801-5 · Cited by 63 · see citing works
Pyruvate Dehydrogenase Kinase as a Potential Therapeutic Target for Malignant Gliomas
Jha, M. K., & Suk, K. (2013) · Brain Tumor Research and Treatment · doi:10.14791/btrt.2013.1.2.57 · Cited by 59 · see citing works
Breslin, S., Lowry, M. C., & O’Driscoll, L. (2017) · British Journal of Cancer · doi:10.1038/bjc.2016.445 · Cited by 53 · see citing works
Beutner, G., Eliseev, R. A., & Porter, G. A., Jr. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113330 · Cited by 51 · see citing works
Rani, S., Corcoran, C., Shiels, L., Germano, S., Breslin, S., Madden, S. F., McDermott, M. S. J., Browne, B. C., O’Donovan, N., Crown, J. P., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2053 · Cited by 48 · see citing works
2DG enhances the susceptibility of breast cancer cells to doxorubicin
Ahmad, I. M., Mustafa, E. H., Mustafa, N., Tahtamouni, L. H., & Abdalla, M. Y. (2010) · Open Life Sciences · doi:10.2478/s11535-010-0060-y · Cited by 20 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mechanisms for Modulating Anoikis Resistance in Cancer and the Relevance of Metabolic Reprogramming
Adeshakin, F. O., Adeshakin, A. O., Afolabi, L. O., Yan, D., Zhang, G., & Wan, X. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.626577 · Cited by 271 · see citing works
Metabolic reprogramming in triple-negative breast cancer
Wang, Z., Jiang, Q., & Dong, C. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0210 · Cited by 248 · see citing works
“…from OXPHOS to glycolysis, and glycolytic inhibitor can indeed significantly suppress the aggressiveness and CSC phenotype of TNBC cells 101 , it is noteworthy that inhibition of glycolysis also promotes the transition of BCSC in TNBC from a quiescent, mesenchymal-like state…”
BackgroundFrom OCR and ECAR to energy: Perspectives on the design and interpretation of bioenergetics studies
Schmidt, C. A., Fisher‐Wellman, K. H., & Neufer, P. D. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101140 · Cited by 197 · see citing works
Khan, S. U., Fatima, K., & Malik, F. A. (2022) · Clinical & Experimental Metastasis · doi:10.1007/s10585-022-10172-9 · Cited by 142 · see citing works
The metabolic flexibility of quiescent CSC: implications for chemotherapy resistance
Chen, K., Zhang, C., Ling, S., Wei, R., Wang, J., & Xu, X. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04116-6 · Cited by 133 · see citing works
Glycolysis, the sweet appetite of the tumor microenvironment
Kooshan, Z., Cárdenas-Piedra, L., Clements, J. A., & Batra, J. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217156 · Cited by 129 · see citing works
Wang, D., Wei, G., Ma, J., Cheng, S., Jia, L., Song, X., Zhang, M., Ju, M., Wang, L., Zhao, L., et al. (2021) · BMC Cancer · doi:10.1186/s12885-021-08341-2 · Cited by 127 · see citing works
Anoikis resistance––protagonists of breast cancer cells survive and metastasize after ECM detachment
Dai, Y., Zhang, X., Ou, Y., Zou, L., Zhang, D., Yang, Q., Qin, Y., Du, X., Li, W., Yuan, Z., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01183-4 · Cited by 117 · see citing works
Research Progress of the Antiviral Bioactivities of Natural Flavonoids
Wang, L., Song, J., Liu, A., Xiao, B., Li, S., Wen, Z., Lu, Y., & Du, G. (2020) · Natural Products and Bioprospecting · doi:10.1007/s13659-020-00257-x · Cited by 114 · see citing works
Understanding and targeting anoikis in metastasis for cancer therapies
Fard, F. S., Jalilzadeh, N., Mehdizadeh, A., Sajjadian, F., & Velaei, K. (2022) · Cell Biology International · doi:10.1002/cbin.11970 · Cited by 85 · see citing works
Kansara, S., Pandey, V., Lobie, P. E., Sethi, G., Garg, M., & Pandey, A. K. (2020) · Cells · doi:10.3390/cells9061511 · Cited by 82 · see citing works
Targeting anoikis resistance as a strategy for cancer therapy
Wang, Y., Cheng, S., Fleishman, J. S., Chen, J., Tang, H., Chen, Z., Chen, W., & Ding, M. (2024) · Drug Resistance Updates · doi:10.1016/j.drup.2024.101099 · Cited by 78 · see citing works
Keoh, L. Q., Chiu, C.-F., & Ramasamy, T. S. (2025) · Stem Cell Reviews and Reports · doi:10.1007/s12015-025-10956-y · Cited by 66 · see citing works
Tsai, T., Yang, C., Kou, T., Yang, C., Dai, J., Chen, C., & Lin, C. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30189 · Cited by 65 · see citing works
Metabolic changes in triple negative breast cancer-focus on aerobic glycolysis
Arundhathi, J. R. D., Mathur, S. R., Gogia, A., Deo, S. V. S., Mohapatra, P., & Prasad, C. P. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06414-w · Cited by 65 · see citing works
Oxidative Stress in Breast Cancer: A Biochemical Map of Reactive Oxygen Species Production
Bel’skaya, L. V., & Dyachenko, E. I. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46050282 · Cited by 69 · see citing works
Cell line-directed breast cancer research based on glucose metabolism status
Farhadi, P., Yarani, R., Valipour, E., Kiani, S., Hoseinkhani, Z., & Mansouri, K. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112526 · Cited by 59 · see citing works
Afonso, J., Gonçalves, C. S., Costa, M. F., Ferreira, D., Santos, L. L., Longatto‐Filho, A., & Baltazar, F. (2023) · Cancers · doi:10.3390/cancers15030982 · Cited by 54 · see citing works
Challenges and Opportunities in Developing Targeted Therapies for Triple Negative Breast Cancer
Chapdelaine, A. G., & Sun, G. (2023) · Biomolecules · doi:10.3390/biom13081207 · Cited by 56 · see citing works
Correlation between the Warburg effect and progression of triple-negative breast cancer
Liu, S., Li, Y., Yuan, M., Song, Q., & Liu, M. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1060495 · Cited by 52 · see citing works
Cancer Stem Cell-Associated Pathways in the Metabolic Reprogramming of Breast Cancer
El‐Sahli, S., & Wang, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239125 · Cited by 51 · see citing works
Therapeutic Potential of Tumor Metabolic Reprogramming in Triple-Negative Breast Cancer
Munkácsy, G., Santarpia, L., & Győrffy, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24086945 · Cited by 46 · see citing works
Understanding cancer stem cells and plasticity: Towards better therapeutics
Warrier, N. M., Kelkar, N., Johnson, C. T., Govindarajan, T., Prabhu, V. K., & Kumar, P. (2023) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2023.151321 · Cited by 45 · see citing works
Zheng, H., Zhang, M., Ke, X., Deng, X., Li, D., Wang, Q., Shanjun, Y., Xue, Y., & Wang, Q. (2020) · Cancer Biomarkers · doi:10.3233/cbm-201740 · Cited by 41 · see citing works
Truong, T. H., Benner, E., Hagen, K. M., Temiz, N. A., Kerkvliet, C. J. P., Wang, Y., Cortes-Sanchez, E., Yang, C.-H., Trousdell, M. C., Pengo, T., et al. (2021) · Oncogene · doi:10.1038/s41388-021-01871-w · Cited by 39 · see citing works
Sun, X., Fan, T., Sun, G., Zhou, Y., Huang, Y., Zhang, N., Zhao, L., Zhong, R., & Peng, Y. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115029 · Cited by 39 · see citing works
Murthy, D., Dutta, D., Attri, K. S., Samanta, T., Yang, S., Jung, K. H., Latario, S. G., Putluri, V., Huang, S., Putluri, N., et al. (2023) · Cancer Letters · doi:10.1016/j.canlet.2024.216724 · Cited by 38 · see citing works
Mascaraque, M., Courtois, S., Royo-García, A., Barneda, D., Stoian, A. M., Villaoslada, I., Espiau-Romera, P., Bokil, A. A., Cano-Galiano, A., Jagušt, P., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05598-6 · Cited by 39 · see citing works
Cancer Stem Cells: Metabolic Characterization for Targeted Cancer Therapy
Kaur, J., & Bhattacharyya, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.756888 · Cited by 36 · see citing works
Metabolic Targeting of Cancer Stem Cells
Mukha, A., & Dubrovska, A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.537930 · Cited by 33 · see citing works
The emerging regulatory roles of non-coding RNAs associated with glucose metabolism in breast cancer
Kansara, S., Singh, A., Badal, A. K., Rani, R., Baligar, P., Garg, M., & Pandey, A. K. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.06.007 · Cited by 32 · see citing works
Fernando, W., Cruickshank, B. M., Arun, R. P., MacLean, M. R., Cahill, H. F., Morales-Quintanilla, F., Dean, C. A., Wasson, M. D., Dahn, M. L., Coyle, K. M., et al. (2024) · Oncogene · doi:10.1038/s41388-024-03156-4 · Cited by 32 · see citing works
Shaw, P., Bhowmik, A. D., Pillai, M. S. G., Robbins, N., Dwivedi, S. K. D., & Rao, G. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217750 · Cited by 33 · see citing works
Min, H., Pei, H., Hyun, S. Y., Boo, H., Jang, H.-J., Cho, J., Kim, J. H., Son, J., & Lee, H. (2020) · Cancers · doi:10.3390/cancers12040913 · Cited by 32 · see citing works
Fujita, M., Imadome, K., Somasundaram, V., Kawanishi, M., Karasawa, K., & Wink, D. A. (2020) · BMC Cancer · doi:10.1186/s12885-020-07414-y · Cited by 32 · see citing works
Walsh, H. R., Cruickshank, B. M., Brown, J. M., & Marcato, P. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00753 · Cited by 31 · see citing works
Shuvalov, O., Fedorova, O., Tananykina, E., Gnennaya, Y., Daks, A., Petukhov, A., & Barlev, N. A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.561537 · Cited by 30 · see citing works
Sharma, R. K., Chafik, A., & Bertolin, G. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01501-2 · Cited by 30 · see citing works
Su, M., Shan, S., Gao, Y., Dai, M., Wang, H., He, C., Zhao, M., Liang, Z., Wan, S., Yang, J., et al. (2023) · IUBMB Life · doi:10.1002/iub.2706 · Cited by 29 · see citing works
The mTOR-glycolytic pathway promotes T-cell immunobiology in oral lichen planus
Wang, F., Zhang, J., & Zhou, G. (2020) · Immunobiology · doi:10.1016/j.imbio.2020.151933 · Cited by 26 · see citing works
Fernandes, L. E., Epstein, C. G., Bobe, A. M., Bell, J. S. K., Stumpe, M. C., Salazar, M. E., Salahudeen, A. A., Benito, R. P., McCarter, C., Leibowitz, B. D., et al. (2020) · Clinical Breast Cancer · doi:10.1016/j.clbc.2020.11.012 · Cited by 24 · see citing works
Oncoviruses: Induction of cancer development and metastasis by increasing anoikis resistance
Amjad, Z. S., Shojaeian, A., Nahand, J. S., Bayat, M., Taghizadieh, M., Rostamian, M., Babaei, F., & Moghoofei, M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22598 · Cited by 24 · see citing works
Targeting the metabolism of cancer stem cells by energy disruptor molecules
Dadgar, T., Ebrahimi, N., Gholipour, A. R., Akbari, M., Khani, L., Ahmadi, A., & Hamblin, M. R. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103545 · Cited by 22 · see citing works
Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis
Hipólito, A., Martins, F., Mendes, C., Lopes‐Coelho, F., & Serpa, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.656851 · Cited by 21 · see citing works
Tõkés, A., Vári-Kakas, S., Kulka, J., & Törőcsik, B. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.850401 · Cited by 21 · see citing works
Nguyen, A., Kim, A. H., Kang, M., Park, N., Kim, R. H., Kim, Y., & Shin, K.-H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179779 · Cited by 20 · see citing works
Singh, P., Sen, K., Sa, P., Khuntia, A., Raghav, S. K., Swain, R. K., & Sahoo, S. K. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155181 · Cited by 20 · see citing works
Khajah, M. A., Khushaish, S., & Luqmani, Y. A. (2022) · PLoS ONE · doi:10.1371/journal.pone.0272449 · Cited by 17 · see citing works
Design of a Novel Recombinant Multi-Epitope Vaccine against Triple-Negative Breast Cancer
Dariushnejad, H., Ghorbanzadeh, V., Akbari, S., & Hashemzadeh, P. (2022) · PubMed Central · doi:10.52547/ibj.26.2.160 · Cited by 16 · see citing works
Zhang, T., Wang, X., Wang, D., Lei, M., Hu, Y., Chen, Z., Li, Y., Luo, Y., Zhang, L., & Zhu, Y. (2024) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.213859 · Cited by 16 · see citing works
Novel mutation in hexokinase 2 confers resistance to 2-deoxyglucose by altering protein dynamics
Hellemann, E., Walker, J. L., Lesko, M. A., Chandrashekarappa, D. G., Schmidt, M. C., O’Donnell, A. F., & Durrant, J. D. (2022) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009929 · Cited by 16 · see citing works
Garimella, S. V., Gampa, S. C., & Chaturvedi, P. (2023) · Stem Cells and Cloning Advances and Applications · doi:10.2147/sccaa.s417842 · Cited by 15 · see citing works
Zou, Z., Luo, T., Wang, X., Wang, B., & Li, Q. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31278 · Cited by 15 · see citing works
Tanawattanasuntorn, T., Rattanaburee, T., Thongpanchang, T., & Graidist, P. (2022) · Antioxidants · doi:10.3390/antiox11122347 · Cited by 13 · see citing works
Wu, J., Huang, C., Wang, P., Chen, T., Hsu, W., Chuang, J., & Chuang, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021649 · Cited by 13 · see citing works
Shifting the Gears of Metabolic Plasticity to Drive Cell State Transitions in Cancer
Wu, Z., Lee, Y. F., Yeo, X. H., Loo, S. Y., & Tam, W. L. (2021) · Cancers · doi:10.3390/cancers13061316 · Cited by 12 · see citing works
Susana Fiorentino, G., Urueña, C. P., Lasso, P., Prieto, K., & Barreto, A. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01334 · Cited by 12 · see citing works
Samuel, S. M., Varghese, E., Satheesh, N. J., Triggle, C. R., & Büsselberg, D. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114911 · Cited by 11 · see citing works
Cost-Effective Real-Time Metabolic Profiling of Cancer Cell Lines for Plate-Based Assays
Blaszczak, W., Tan, Z., & Swietach, P. (2021) · Chemosensors · doi:10.3390/chemosensors9060139 · Cited by 10 · see citing works
Liang, X. L., Tang, S., Song, Y., Li, D., Zhang, L., Wang, S.-H., Duan, Y., & Du, H. (2023) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2023.104123 · Cited by 10 · see citing works
OBHS Drives Abnormal Glycometabolis Reprogramming via GLUT1 in Breast Cancer
Wang, K., Li, Q., Fan, Y., Fang, P., Zhou, H., & Huang, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087136 · Cited by 10 · see citing works
Vengayil, V., Niphadkar, S., Adhikary, S., Varahan, S., & Laxman, S. (2024) · eLife · doi:10.7554/elife.90293.4 · Cited by 9 · see citing works
Repurposing Metabolic Inhibitors in the Treatment of Colon Adenocarcinoma Patient-Derived Models
Lee, B., Lee, C., Moon, H.-M., Jo, S., Jang, S. J., & Suh, Y. (2023) · Cells · doi:10.3390/cells12242859 · Cited by 9 · see citing works
Singh, R., Cheng, S., Li, J., Kumar, S., Zeng, Q., & Zeng, Q. (2021) · 3 Biotech · doi:10.1007/s13205-021-02688-w · Cited by 9 · see citing works
ILT4 reprograms glucose metabolism to promote tumor progression in triple-negative breast cancer
Zhang, H., Gao, A., Liu, Q., Zhang, F., Wang, S., Chen, X., Shi, W., Zhang, Y., Liu, Q., Zheng, Y., et al. (2023) · Journal of Cell Science · doi:10.1242/jcs.260964 · Cited by 8 · see citing works
Zhou, L., Wong, C., Liu, Y., Jiang, W., & Yang, Q. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17958 · Cited by 8 · see citing works
Vengayil, V., Niphadkar, S., Adhikary, S., Varahan, S., & Laxman, S. (2023) · eLife · doi:10.7554/elife.90293 · Cited by 8 · see citing works
Ye, S., Zhou, H., Chen, Y., Li, K., Jiang, S., & Hao, K. (2020) · Oncology Letters · doi:10.3892/ol.2020.12323 · Cited by 8 · see citing works
Chen, F., Zhao, B., Tian, Y., Liu, Q., & Zhang, B. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152079 · Cited by 7 · see citing works
Rajagopal, T., Talluri, S., Venkatabalasubramanian, S., & Dunna, N. R. (2020) · Biochemical Society Transactions · doi:10.1042/bst20200666 · Cited by 6 · see citing works
Emerging Protein Targets in Triple-Negative Breast Cancer: Beyond Conventional Therapy
Previtali, A., Guardamagna, I., Calandra, S., Shakarami, M., Lonati, L., Riani, C., Semerano, R., Baiocco, G., Maggi, M., & Scotti, C. (2026) · Cancers · doi:10.3390/cancers18040618 · Cited by 5 · see citing works
Frontiers and hot topics in tumor metabolic reprogramming: a bibliometric analysis from 2014 to 2023
Wen, P., Wang, G., Zhang, N., Shao, Q., Wang, L., Qu, F., & Zeng, X. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1570532 · Cited by 4 · see citing works
FOXM1 boosts glycolysis by upregulating SQLE to inhibit anoikis in breast cancer cells
Xu, M., Pan, G., Zhang, Q., Huang, J., Wu, Y., & Ashan, Y. (2025) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-025-06174-1 · Cited by 3 · see citing works
Malyarenko, O. S., Malyarenko, T. V., Kicha, A. A., Ermakova, S. P., & Ivanchina, N. V. (2026) · Marine Drugs · doi:10.3390/md24020075 · Cited by 3 · see citing works
Distinct lipidomic profiles in breast cancer cell lines relate to proliferation and EMT phenotypes
Leegwater, H., Zhang, Z., Zhang, X., Wang, X., Hankemeier, T., Zweemer, A. J. M., van de Water, B., Danen, E. H. J., Hoekstra, M., Harms, A. C., et al. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2025.159679 · Cited by 3 · see citing works
Glycolytic reprogramming impairs chondrocyte function in broilers with femoral head necrosis
Ge, H., Wang, A., Zhang, Y., & Zhou, Z. (2025) · Veterinary Quarterly · doi:10.1080/01652176.2025.2579940 · Cited by 2 · see citing works
Xue, Y., Wang, Y., Huang, T., Dong, Y., & Tong, X. (2025) · PLoS ONE · doi:10.1371/journal.pone.0335788 · Cited by 2 · see citing works
Chopra, S., Nair, A., Sharma, N., Jain, V. K., & Sharma, R. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95545-4.00001-3 · Cited by 1 · see citing works
Maloba, G. O., Were, T., Barasa, E., Mohamed, N., Arshi, A., & Gallyas, F. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104894 · Cited by 1 · see citing works
Kocemba‐Pilarczyk, K. A., Ostrowska, B., Trojan, S., & Dudzik, P. (2025) · Pharmacological Reports · doi:10.1007/s43440-025-00768-9 · Cited by 2 · see citing works
Bhattacharyya, M., Biswas, J., Sharma, T., & Majaw, S. (2025) · Springer eBooks · doi:10.1007/978-981-96-9342-9_21 · Cited by 1 · see citing works
Anoikis Resistance and Tumor Metastasis
Wang, Z., Xie, D., Lü, A., & Liang, C. (2023) · Springer eBooks · doi:10.1007/978-3-030-80962-1_45-1 · Cited by 1 · see citing works
Molecular Aspects of Cancer Cell Metabolism: Altered Glycolysis and Lipid Metabolism
Patel, S. K., Verma, D., & Garg, N. (2020) · Springer eBooks · doi:10.1007/978-981-15-1991-8_3
Vengayil, V., Niphadkar, S., Adhikary, S., Varahan, S., & Laxman, S. (2023) · eLife · doi:10.7554/elife.90293.1
Vengayil, V., Niphadkar, S., Adhikary, S., Varahan, S., & Laxman, S. (2024) · eLife · doi:10.7554/elife.90293.2
Vengayil, V., Niphadkar, S., Adhikary, S., Varahan, S., & Laxman, S. (2024) · eLife · doi:10.7554/elife.90293.3
Efficacy of LNP@2DG-DON liposomal nanoparticles in tumor inhibition and immune activation
Li, J., Feng, J., Liu, R., Du, Y., Li, Y., Liu, L., & Zhang, L. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-08039-8
Anoikis Resistance and Tumor Metastasis
Wang, Z., Xie, D., Lü, A., & Liang, C. (2025) · Springer eBooks · doi:10.1007/978-3-032-00759-9_45
Chen, Q., Meng, M., Ren, S., Zhang, T., Lu, J., Bing, Y., Li, L., & Yuan, C. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.116209
Mitochondrial dynamics: A promising tool for personalized TNBC management
Mishra, H., Yadav, A. K., Kushwaha, V. B., & Singh, M. P. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102157
Koźlak, M. (2019) · theses.fr (ABES) · doi:10.70675/0fd942ebz4198z4499za7eazb6a4014d0e09
Metabolic Inhibitors and their Impact on Cancer Cell Migration, Invasion, and Metastasis
Stepanov, Y., Yakshibaeva, Y., Semenkova, V., Stepanova, L. I., & Solyanik, G. (2026) · Experimental Oncology · doi:10.15407/exp-oncology.2026.01.011
Didamson, O. C., George, S., & Abrahamse, H. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189738
- Authors
- O’Neill, S., Porter, R. K., McNamee, N., Martinez, V. G., & O’Driscoll, L.
- Affiliations
- Trinity College Dublin (IE)
- Corresponding author
- O’Driscoll, Lorraine
- Venue
- Scientific Reports
- Published
- 2019-03-07
- Volume
- 9
- Issue
- 1
- Pages
- 3788-3788
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6405919
- OpenAlex
- W2918171807
- Cited by
- 93
- References
- 33
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 11 · 2023: 23 · 2022: 9 · 2021: 14 · 2020: 15 · 2019: 2
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion, cc-by)
- Funders
- Carrick Therapeutics
- Irish Cancer Society ((CCRC13GAL))
- Trinity College Dublin
- Tsinghua-Berkeley Shenzhen institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- 2-deoxyglucose, triple-negative breast cancer, glycolysis, cancer stem cells, Hs578T cells, anoikis resistance, cell migration and invasion, oxidative phosphorylation, mitochondrial dysfunction, mitochondrial membrane potential, tumor aggressiveness, glucose analogs
- MeSH terms
- Pyruvate Dehydrogenase Acetyl-Transferring Kinase, Cell Movement, Citrate (si)-Synthase, Deoxyglucose, Female, Glycolysis, Humans, Mitochondria, Neoplastic Stem Cells, Anoikis, Cell Line, Tumor, Voltage-Dependent Anion Channel 1, Triple Negative Breast Neoplasms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
