Isolation, characterization and identification of antigenotoxic and anticancerous indigenous probiotics and their prophylactic potential in experimental colon carcinogenesis
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Colorectal cancer, the third most commonly diagnosed cancer, is a lifestyle disease where diet and gut microbiome contribute intricately in its initiation and progression. Prophylactic bio-interventions mainly probiotics offer an alternate approach towards reducing or delaying its progression. Therefore, the present study was designed wherein a robust protocol for the isolation, characterization, and identification of indigenous probiotics having antigenotoxic and anticancerous activity was followed along with their prophylactic potential assessment in early experimental colorectal carcinogenesis. Among forty-six isolated lactic acid bacterial strains, only three were selected on the basis of antigenotoxicity against N,N-Dimethyl dihydrazine dihydrochloride and 4-Nitroquinoline 1-oxide and probiotic attributes. All three selected probiotic strains exhibited anticancerous potential as is evident by the reduced Aberrant Crypt Foci, reduced fecal pH, enhanced fecal lactic acid bacteria and altered fecal enzymes (β-glucuronidase, nitroreductase, β-glucosidase) that modulated gut microbiota and microenvironment resulting into restored histoarchitecture of the colon. The results are a clear indicator of the prophylactic potential of selected indigenous probiotics which may be used as an alternative prophylactic biological therapy against colon carcinogenesis particularly in highly susceptible individuals.
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Human probiotic origin of L. rhamnosus MD14 and L. plantarum GMD exhibited a high cell surface hydrophobicity with hexadecane and xylene.
“Similarly, the human probiotic origin of L. rhamnosus MD14 and L. plantarum GMD exhibited a high cell surface hydrophobicity with hexadecane and xylene [13].”
From Bioprophylactic potential of novel human colostrum probiotics via apoptotic induction of colon cancer cells and cell immune activation (2022) · cites this paper as [13]
Human probiotics Lactobacillus rhamnosus MD14 and L. plantarum GMD were previously found to effectively inhibit the proliferation of colon cancer cells.
“Moreover, human probiotics, such as Lactobacillus rhamnosus MD14 and L. plantarum GMD, were previously found to effectively inhibit the proliferation of colon cancer cells [13].”
From Bioprophylactic potential of novel human colostrum probiotics via apoptotic induction of colon cancer cells and cell immune activation (2022) · cites this paper as [13]
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Self-citationBai, J., Wang, S., Xu, F., Dong, M., Wang, J., Sun, X., & Xiao, G. (2023) · International Journal of Radiation Biology · doi:10.1080/09553002.2023.2142979 · Cited by 1 · see citing works
REVIEWING ISOLATION AND PRODUCTION OF PROBIOTICS
Ponnachan, B., Dash, N., Jaybhay, P., & Tiwari, R. (2021) · International Journal of Medical and Biomedical Studies · doi:10.32553/ijmbs.v5i5.1920 · Cited by 1 · see citing works
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Gut Microbiota and Host Immune System in Cancer
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Probiotics Based Anticancer Immunity in Skin Cancer
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Role of Synbiotics in Gastrointestinal Disorders
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Interesterified Palm Oil Leads to Slight Variation in Intestinal Microbiota Of MicePreprint
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Interesterified palm oil leads to distinct variation in the intestinal microbiota of mice
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- Authors
- Chandel, D., Sharma, M., Chawla, V., Sachdeva, N., & Shukla, G.
- Affiliations
- Panjab University (IN)
- Post Graduate Institute of Medical Education and Research (IN)
- Corresponding author
- Shukla, Geeta
- Venue
- Scientific Reports
- Published
- 2019-10-14
- Volume
- 9
- Issue
- 1
- Pages
- 14769-14769
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6791833
- OpenAlex
- W2980264530
- Cited by
- 67
- References
- 44
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 15 · 2022: 13 · 2021: 17 · 2020: 7 · 2019: 1
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- University Grants Commission (18-12/2011(ii)EU-V)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- probiotics, colorectal cancer, colon carcinogenesis, antigenotoxicity, anticancer activity, lactic acid bacteria, N,N-dimethylhydrazine, 4-nitroquinoline 1-oxide, aberrant crypt foci, fecal microbiota, beta-glucuronidase, nitroreductase, β-glucosidase, fecal pH, gut microbiota, cancer prevention
- MeSH terms
- Gastrointestinal Microbiome, Animals, Colon, Colonic Neoplasms, Feces, Humans, Lactobacillus, Male, Pediococcus, Rats, Sprague-Dawley, Probiotics, Cell Line, Tumor, Aberrant Crypt Foci, Carcinogenesis
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