Effects of Lactobacillus strains on cancer cell proliferation and oxidative stress in vitro
Abstract
AIMS: The objective of this study was to assess in vitro, whether heat-killed (HK) lactic acid bacteria cells and fractionations of HK cells could suppress the viability of human cancer cells and inhibit the cytotoxicity associated with oxidative stress. METHODS AND RESULTS: Among the strains, the HK cells of Lactobacillus acidophilus 606 and Lactobacillus casei ATCC 393 exhibited the most profound inhibitory activity in all of the tested cell lines. HK cells of L. acidophilus 606 were determined to be less toxic to healthy human embryo fibroblasts (hEF cells) than were HK cells of L. casei ATCC 393. The soluble polysaccharides from L. acidophilus 606 evidenced the most effective anticancer activity, but inhibited hEF cell growth by only 20%. The soluble polysaccharides from L. acidophilus 606 were partly observed to induce apoptosis in the HT-29 cells by DNA fragmentation and propidium iodine staining. Both the HK cells of L. acidophilus 606 and the soluble polysaccharide components of this strain also exhibited potent antioxidative activity. CONCLUSIONS: Our findings suggest that the soluble polysaccharide fraction from L. acidophilus 606 may constitute a novel anticancer agent, which manifests a high degree of selectivity for human cancer cells and antioxidative agent in the food industry. SIGNIFICANCE AND IMPACT OF THE STUDY: These soluble polysaccharide components from Lactobacillus may be applied to various foods, and used as adjuncts for cancer therapy and prevention.
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The apoptotic induction of colon cancer cell death as characterized by fragmented DNA by potential probiotics has also been studied using other strains, such as L. acidophilus 606, L. brevis and L. paracasei.
“The apoptotic induction of colon cancer cell death as characterized by fragmented DNA by the potential probiotics has also been studied using other strains, such as L. acidophilus 606 [59], L. brevis [60] and L. paracasei [61].”
From Bioprophylactic potential of novel human colostrum probiotics via apoptotic induction of colon cancer cells and cell immune activation (2022) · cites this paper as [59]
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- Authors
- Choi, S. S., Kim, Y., Han, K. S., You, S., Oh, S., & Kim, S. H.
- Affiliations
- Korea University (KR)
- Chonnam National University (KR)
- Corresponding author
- Kim, Y.
- Venue
- Letters in Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-05
- Volume
- 42
- Issue
- 5
- Pages
- 452-458
- ISSN
- 0266-8254 (ISSN-L)
- 1365-2673
- OpenAlex
- W2027893246
- Semantic Scholar
- b03391f881507bfb3a1f60aeb52deecdf337161b
- Cited by
- 292
- References
- 20
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 13 · 2023: 22 · 2022: 35 · 2021: 22 · 2020: 25 · 2019: 21 · 2018: 16 · 2017: 20 · 2016: 31 · 2015: 18 · 2014: 13 · 2013: 8 · 2012: 6
- FWCI
- 5.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Letters in Applied Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- Lactobacillus acidophilus, Lactobacillus casei, anticancer activity, tumor cell proliferation, oxidative stress, soluble polysaccharides, apoptosis, HT-29 cells, antioxidant activity, cancer prevention
- MeSH terms
- Antineoplastic Agents, Antioxidants, Cell Survival, Humans, Lactobacillus, Lactobacillus acidophilus, Lacticaseibacillus casei, Microscopy, Fluorescence, Polysaccharides, Bacterial, Propidium, Staining and Labeling, Apoptosis, Oxidative Stress, Cell Line, Tumor, Cell Proliferation, DNA Fragmentation
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