Early change in circulating tumor DNA as a potential predictor of response to chemotherapy in patients with metastatic colorectal cancer
Open accessAbstract
The impact of ctDNA changes after chemotherapy on the clinical outcomes of patients with metastatic colorectal cancer (mCRC) remains unclear. The present study evaluated the clinical implications of the early change in ctDNA levels as a predictor of objective response and clinical outcome in mCRC patients who received chemotherapy. We investigated the effects of after/before ratio of ctDNA levels 2 and 8 weeks after initiation of second-line chemotherapy, on objective response rate (ORR), progression-free survival (PFS), and overall survival (OS). ctDNA was detected using amplicon-based deep sequencing with a molecular barcode encompassing >240 hotspot mutations in 14 colon cancer-related genes. In multivariate analysis, as compared to baseline, patients with lower ctDNA level (≤50%) 8 weeks after initiation of chemotherapy showed significantly longer PFS and OS than the patients with higher (>50%) ctDNA level. In patients achieving a partial response or stable disease, the after/before ratio of ctDNA level 8 weeks after initiation of chemotherapy was significantly lower than those in patients with progressive disease. The present study suggests that an early change in the ctDNA level might serve as a biomarker to predict the chemotherapeutic efficacy and clinical outcomes in patients with mCRC.
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Recent data suggest that serial ctDNA analyses may have clinical value because ctDNA clearance in patients receiving systemic chemo- or immunotherapy correlates with progression-free and overall survival.
“recent data suggests that serial analyses may have clinical value as clearance of ctDNA among patients undergoing systemic chemo- or immunotherapy correlate with progression-free and overall survival.13–17”
From Early Changes in Circulating Cell-Free <i>KRAS</i> G12C Predict Response to Adagrasib in KRAS Mutant Non–Small Cell Lung Cancer Patients (2023) · cites this paper as [14]
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Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics
Kanda, Y. (2012) · Bone Marrow Transplantation · doi:10.1038/bmt.2012.244 · Cited by 18,876 · see citing works
Erdogan, D., Heijnen, B. H. M., Bennink, R. J., Kok, M., Dinant, S., Straatsburg, I. H., Gouma, D. J., & van Gulik, T. M. (2004) · Liver International · doi:10.1111/j.1478-3231.2004.00901.x · Cited by 11,656 · see citing works
Comprehensive molecular characterization of human colon and rectal cancer
The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11252 · Cited by 8,499 · see citing works
ESMO consensus guidelines for the management of patients with metastatic colorectal cancer
Van Cutsem, E., Cervantes, A., Adam, R., Sobrero, A., Van Krieken, J. H., Aderka, D., Aranda Aguilar, E., Bardelli, A., Benson, A., Bodoky, G., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw235 · Cited by 3,421 · see citing works
The Consensus Coding Sequences of Human Breast and Colorectal Cancers
Sjöblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D. L., Leary, R. J., Ptak, J., Silliman, N., et al. (2006) · Science · doi:10.1126/science.1133427 · Cited by 3,161 · see citing works
Liquid biopsies come of age: Towards implementation of circulating tumour DNA
Wan, J. C. M., Massie, C., Garcia-Corbacho, J., Mouliere, F., Brenton, J. D., Caldas, C., Pacey, S., Baird, R., & Rosenfeld, N. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.7 · Cited by 2,809 · see citing works
Japanese Society for Cancer of the Colon and Rectum, Watanabe, T., Muro, K., Ajioka, Y., Hashiguchi, Y., Ito, Y., Saito, Y., Hamaguchi, T., Ishida, H., Ishiguro, M., et al. (2018) · International Journal of Clinical Oncology · doi:10.1007/s10147-017-1101-6 · Cited by 2,467 · see citing works
Liquid Biopsies: Genotyping Circulating Tumor DNA
Diaz, L. A., & Bardelli, A. (2014) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.2011 · Cited by 2,210 · see citing works
Integrating liquid biopsies into the management of cancer
Siravegna, G., Marsoni, S., Siena, S., & Bardelli, A. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.14 · Cited by 1,941 · see citing works
Hashiguchi, Y., Muro, K., Saitō, Y., Ito, Y., Ajioka, Y., Hamaguchi, T., Hasegawa, K., Hotta, K., Ishida, H., Ishiguro, M., et al. (2019) · International Journal of Clinical Oncology · doi:10.1007/s10147-019-01485-z · Cited by 1,936 · see citing works
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
Misale, S., Yaeger, R., Hobor, S., Scala, E., Janakiraman, M., Liska, D., Valtorta, E., Schiavo, R., Buscarino, M., Siravegna, G., et al. (2012) · Nature · doi:10.1038/nature11156 · Cited by 1,889 · see citing works
Liquid biopsy: monitoring cancer-genetics in the blood
Crowley, E. H., Nicolantonio, F. D., Loupakis, F., & Bardelli, A. (2013) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2013.110 · Cited by 1,821 · see citing works
Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy
Alix-Panabières, C., & Pantel, K. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-1483 · Cited by 1,394 · see citing works
Colon Cancer, Version 1.2017, NCCN Clinical Practice Guidelines in Oncology
Benson, A. B., Venook, A. P., Cederquist, L., Chan, E., Chen, Y., Cooper, H. S., Deming, D. A., Engstrom, P. F., Enzinger, P. C., Fichera, A., et al. (2017) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2017.0036 · Cited by 1,329 · see citing works
Merker, J. D., Oxnard, G. R., Compton, C., Diehn, M., Hurley, P., Lazar, A. J., Lindeman, N., Lockwood, C. M., Rai, A. J., Schilsky, R. L., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.76.8671 · Cited by 959 · see citing works
Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer
Yaeger, R., Chatila, W. K., Lipsyc, M. D., Hechtman, J. F., Cercek, A., Sanchez-Vega, F., Jayakumaran, G., Middha, S., Zehir, A., Donoghue, M. T. A., et al. (2018) · Cancer Cell · doi:10.1016/j.ccell.2017.12.004 · Cited by 858 · see citing works
Wu, Y.-L., Zhou, C., Liam, C.-K., Wu, G., Liu, X., Zhong, Z., Lu, S., Cheng, Y., Han, B., Chen, L., et al. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv270 · Cited by 738 · see citing works
Tie, J., Kinde, I., Wang, Y., Wong, H., Roebert, J. K., Christie, M., TACEY, M. A., Wong, R., Singh, M., Karapetis, C. S., et al. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv177 · Cited by 632 · see citing works
Liquid Biopsies, What We Do Not Know (Yet)
Bardelli, A., & Pantel, K. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.01.002 · Cited by 482 · see citing works
The Isolation of Nucleic Acids from Fixed, Paraffin-Embedded Tissues–Which Methods Are Useful When?
Gilbert, M. T. P., Haselkorn, T. S., Bunce, M., Sánchez, J. J. M., Lucas, S. B., Jewell, L. D., Marck, E. V., & Worobey, M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000537 · Cited by 395 · see citing works
Vidal, J., Muinelo, L., Dalmases, A., Jones, F. S., Edelstein, D. L., Iglesias, M., Orrillo, M., Abalo, A., Rodríguez, C., Brozos, E., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx125 · Cited by 344 · see citing works
A review of somatic single nucleotide variant calling algorithms for next-generation sequencing data
Xu, C. (2018) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2018.01.003 · Cited by 242 · see citing works
Piessevaux, H. H., Buyse, M. E., Schlichting, M., Cutsem, E. V., Bokemeyer, C., Heeger, S., & Tejpar, S. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.42.8532 · Cited by 219 · see citing works
Heinemann, V., Stintzing, S., Modest, D. P., Gießen-Jung, C., Michl, M., & Mansmann, U. (2015) · European Journal of Cancer · doi:10.1016/j.ejca.2015.06.116 · Cited by 188 · see citing works
Profile of the Roche cobas® EGFR mutation test v2 for non-small cell lung cancer
Malapelle, U., Sirera, R., Lewintre, E. J., Reclusa, P., Fariñas, S. C., Blasco, A., Pisapia, P., Rolfo, C. D., & Camps, C. (2017) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2017.1288568 · Cited by 172 · see citing works
The Clinical Viewpoint: Definitions, Limitations of RECIST, Practical Considerations of Measurement
Villaruz, L. C., & Socinski, M. A. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2935 · Cited by 166 · see citing works
Guibert, N. M., Hu, Y., Feeney, N. B., Kuang, Y., Plagnol, V., Jones, G. R., Howarth, K., Beeler, J. F., Paweletz, C. P., & Oxnard, G. R. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy005 · Cited by 135 · see citing works
Siravegna, G., Bianchi, A. S., Nagy, R. J., Raghav, K. P. S., Odegaard, J. I., Lanman, R. B., Trusolino, L., Marsoni, S., Siena, S., & Bardelli, A. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3389 · Cited by 134 · see citing works
Cell-Free DNA in Metastatic Colorectal Cancer: A Systematic Review and Meta-Analysis
Spindler, K. G., Boysen, A. K., Pallisgaard, N., Johansen, J. S., Tabernero, J. M., Mau‐Sørensen, M., Jensen, B. V., Hansen, T. F., Sefrioui, D., Andersen, R. F., et al. (2017) · The Oncologist · doi:10.1634/theoncologist.2016-0178 · Cited by 91 · see citing works
Yamada, T., Iwai, T., Takahashi, G., Kan, H., Koizumi, M., Matsuda, A., Shinji, S., Yamagishi, A., Yokoyama, Y., Tatsuguchi, A., et al. (2016) · Cancer Science · doi:10.1111/cas.12959 · Cited by 86 · see citing works
Osumi, H., Shinozaki, E., Takeda, Y., Wakatsuki, T., Ichimura, T., Saiura, A., Yamaguchi, K., Takahashi, S., Noda, T., & Zembutsu, H. (2018) · Cancer Medicine · doi:10.1002/cam4.1913 · Cited by 80 · see citing works
Self-citationGiessen, C. A., Laubender, R. P., von Weikersthal, L. F., Schalhorn, A., Modest, D. P., Stintzing, S., Haas, M., Mansmann, U., & Heinemann, V. (2013) · Cancer Science · doi:10.1111/cas.12148 · Cited by 64 · see citing works
Yoshino, T., Muro, K., Yamaguchi, K., Nishina, T., Denda, T., Kudo, T., Okamoto, W., Taniguchi, H., Akagi, K., Kajiwara, T., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.02.007 · Cited by 62 · see citing works
Self-citationSpindler, K. G., Appelt, A. L., Pallisgaard, N., Andersen, R. F., & Jakobsen, A. K. M. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.633 · Cited by 49 · see citing works
Taniguchi, H., Yamazaki, K., Yoshino, T., Muro, K., Yatabe, Y., Watanabe, T., Ebi, H., Ochiai, A., Baba, E., & Tsuchihara, K. (2015) · Cancer Science · doi:10.1111/cas.12595 · Cited by 43 · see citing works
Hsu, H., Lapke, N., Wang, C., Lin, P.-Y., You, J. F., Yeh, C. Y., Tsai, W., Hung, H., Chiang, S.-F., Chen, H., et al. (2018) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-17-1306 · Cited by 39 · see citing works
Michl, M., Stintzing, S., von Weikersthal, L. F., Decker, T. W., Kiani, A., Vehling-Kaiser, U., Al-Batran, S.-E., Heintges, T., Lerchenmueller, C., Kahl, C., et al. (2016) · Annals of Oncology · doi:10.1093/annonc/mdw222 · Cited by 36 · see citing works
Petrioli, R., Licchetta, A., Roviello, G., Pascucci, A., Francini, E., Bargagli, G., Conca, R., Miano, S. T., Marzocca, G., Francini, G., et al. (2012) · Cancer Investigation · doi:10.3109/07357907.2011.629380 · Cited by 33 · see citing works
Shin, S., Kim, Y., Oh, S. C., Yu, N., Lee, S., Choi, J. R., & Lee, K. (2017) · Oncotarget · doi:10.18632/oncotarget.16799 · Cited by 31 · see citing works
Wang, Y., Liu, H., Hou, Y., Zhou, X., Liang, L., Zhang, Z., Shi, H., Xu, S., Hu, P., Zheng, Z., et al. (2018) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s00428-018-2359-4 · Cited by 24 · see citing works
Modest, D. P., Stintzing, S., von Weikersthal, L. F., Decker, T. W., Kiani, A., Vehling‐Kaiser, U., Al‐Batran, S., Heintges, T., Lerchenmuller, C. A., Kahl, C., et al. (2016) · International Journal of Cancer · doi:10.1002/ijc.30592 · Cited by 20 · see citing works
Fukushima, Y., Yanaka, S., Murakami, K., Abe, Y., Koshizaka, T., Hara, H., Samejima, C., Kishi, Y., Kaneda, M., & Yoshino, T. (2011) · PubMed · Cited by 14 · see citing works
Sunakawa, Y., Tsuji, A., Denda, T., Segawa, Y., Negoro, Y., Shimada, K., Kochi, M., Nakamura, M., Kotaka, M., Tanioka, H., et al. (2017) · Targeted Oncology · doi:10.1007/s11523-017-0527-0 · Cited by 7 · see citing works
Fiala, O., Hošek, P., Šorejs, O., Liška, V., Büchler, T., Poprach, A., Kučera, R., Topolčan, O., Šedivcová, M., & Fínek, J. (2018) · Journal of Cancer · doi:10.7150/jca.26217 · Cited by 4 · see citing works
Taniguchi, H. (2019) · PubMed · Cited by 4 · see citing works
Flagged first, then by citations
1 of the 46 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Liquid biopsy in cancer: current status, challenges and future prospects
Ma, L., Guo, H., Zhao, Y., Liu, Z., Wang, C., Bu, J., Sun, T., & Wei, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02021-w · Cited by 785 · see citing works
Sanz‐García, E., Stutheit-Zhao, E. Y., Bratman, S. V., & Siu, L. L. (2022) · Science Advances · doi:10.1126/sciadv.abi8618 · Cited by 196 · see citing works
Dynamic liquid biopsy components as predictive and prognostic biomarkers in colorectal cancer
Raza, A., Khan, A. Q., Inchakalody, V. P., Mestiri, S., Yoosuf, Z. S. K. M., Bedhiafi, T., El-Ella, D. M. A., Taib, N., Hydrose, S., Akbar, S., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02318-0 · Cited by 159 · see citing works
Assaf, Z. J. F., Zou, W., Fine, A. D., Socinski, M. A., Young, A. G., Lipson, D., Freidin, J. F., Kennedy, M., Polisecki, E. Y., Nishio, M., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02226-6 · Cited by 152 · see citing works
Signed in Blood: Circulating Tumor DNA in Cancer Diagnosis, Treatment and Screening
Adashek, J. J., Jankú, F., & Kurzrock, R. (2021) · Cancers · doi:10.3390/cancers13143600 · Cited by 100 · see citing works
Circulating Tumor DNA in Precision Oncology and Its Applications in Colorectal Cancer
Arisi, M. F., Dotan, E., & Fernandez, S. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084441 · Cited by 88 · see citing works
Holm, M., Andersson, E. I., Österlund, E., Ovissi, A., Soveri, L., Anttonen, A., Kytölä, S. I., Aittomäki, K., Osterlund, P. J., & Ristimaki, A. P. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239819 · Cited by 77 · see citing works
Haring, C. T., Bhambhani, C., Brummel, C. V., Jewell, B. M., Bellile, E. L., Neal, M. E. H., Sandford, E., Spengler, R. M., Bhangale, A. D., Spector, M. E., et al. (2021) · Oncotarget · doi:10.18632/oncotarget.27992 · Cited by 75 · see citing works
Zhu, L., Xu, R., Yang, L., Shi, W., Zhang, Y., Liu, J., Li, X., Zhou, J., & Bing, P. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1172108 · Cited by 72 · see citing works
ctDNA and Adjuvant Therapy for Colorectal Cancer: Time to Re-Invent Our Treatment Paradigm
Naidoo, M., Gibbs, P., & Tie, J. (2021) · Cancers · doi:10.3390/cancers13020346 · Cited by 67 · see citing works
Clinical application of circulating tumour DNA in colorectal cancer
Loft, M., To, Y. H., Gibbs, P., & Tie, J. (2023) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(23)00146-2 · Cited by 65 · see citing works
Advances in the delivery of anticancer drugs by nanoparticles and chitosan-based nanoparticles
Jarmila, P., Mikušová, V., & Mikuš, P. (2024) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2024.100281 · Cited by 61 · see citing works
Chakrabarti, S., Xie, H., Urrutia, R. A., & Mahipal, A. (2020) · Cancers · doi:10.3390/cancers12102808 · Cited by 57 · see citing works
The challenges in colorectal cancer management during COVID-19 epidemic
Ren, X., Chen, B., Hong, Y., Liu, W., Jiang, Q., Yang, J., Qian, Q., & Jiang, C. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.03.158 · Cited by 49 · see citing works
Precision cancer classification using liquid biopsy and advanced machine learning techniques
Eledkawy, A., Hamza, T., & El‐Metwally, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-56419-1 · Cited by 48 · see citing works
Wang, F., Huang, Y., Wu, H., Wang, Z., Jin, Y., Yao, Y.-C., Chen, Y., Zhao, Q., Chen, S., He, M.-M., et al. (2021) · Gut · doi:10.1136/gutjnl-2021-324852 · Cited by 48 · see citing works
Kobayashi, S., Nakamura, Y., Taniguchi, H., Odegaard, J. I., Nomura, S., Kojima, M., Sugimoto, M., Konishi, M., Gotohda, N., Takahashi, S., et al. (2021) · Annals of Surgical Oncology · doi:10.1245/s10434-020-09449-8 · Cited by 45 · see citing works
Callesen, L. B., Hamfjord, J., Boysen, A. K., Pallisgaard, N., Guren, T. K., Kure, E. H., & Spindler, K. G. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-01816-4 · Cited by 43 · see citing works
EV‐ADD, a database for EV‐associated DNA in human liquid biopsy samples
Tsering, T., Li, M., Chen, Y., Nadeau, A., Laskaris, A., Abdouh, M., Bustamante, P., & Burnier, J. V. (2022) · Journal of Extracellular Vesicles · doi:10.1002/jev2.12270 · Cited by 41 · see citing works
Erve, I. V. ’., Medina, J. E., Leal, A., Papp, E., Phallen, J. A., Adleff, V., Chiao, E. J., Arun, A. S., Bolhuis, K., Simmons, J. K., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-2538 · Cited by 42 · see citing works
Martínez‐Sáez, O., Pascual, T., Brasó‐Maristany, F., Chic, N., González‐Farré, B., Sanfeliu, E., Rodríguez, A., Martínez, D., Galván, P., Rodríguez, A. B., et al. (2021) · npj Breast Cancer · doi:10.1038/s41523-021-00218-8 · Cited by 39 · see citing works
Liquid biopsy with cell free DNA: new horizons for prostate cancer
Ponti, G., Maccaferri, M., Percesepe, A., Tomasi, A., & Özben, T. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2020.1803789 · Cited by 39 · see citing works
Kim, Y. J., Kang, Y., Kim, J. S., Sung, H. H., Jeon, H. G., Jeong, B. C., Seo, S. I., Jeon, S. S., Lee, H. M., Park, D., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-85099-4 · Cited by 39 · see citing works
Prediction of the treatment response in ovarian cancer: a ctDNA approach
Sharbatoghli, M., Vafaei, S., Es, H. A., Asadi‐Lari, M., Totonchi, M., & Madjd, Z. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00729-1 · Cited by 38 · see citing works
Network approach in liquidomics landscape
Santini, D., Botticelli, A., Galvano, A., Iuliani, M., Incorvaia, L., Gristina, V., Taffon, C., Foderaro, S., Paccagnella, E., Simonetti, S., et al. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02743-9 · Cited by 37 · see citing works
Pazdírek, F., Minárik, M., Benešová, L., Hálková, T., Belšánová, B., Maçek, M., Štěpánek, L., & Hoch, J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01028 · Cited by 36 · see citing works
Circulating tumor DNA in colorectal cancer: opportunities and challenges.
Bi, F., Wang, Q., Dong, Q., Wang, Y., Zhang, L., & Zhang, J. (2020) · PubMed Central · Cited by 35 · see citing works
Patelli, G., Vaghi, C., Tosi, F., Mauri, G., Amatu, A., Massihnia, D., Ghezzi, S., Bonazzina, E. F., Bencardino, K. B., Cerea, G., et al. (2021) · Targeted Oncology · doi:10.1007/s11523-021-00795-5 · Cited by 35 · see citing works
Maspero, M., Sposito, C., Virdis, M., Citterio, D., Pietrantonio, F., Bhoori, S., Belli, F., & Mazzaferro, V. (2023) · Cancers · doi:10.3390/cancers15020345 · Cited by 35 · see citing works
Liquid Biopsy in Lung Cancer: Biomarkers for the Management of Recurrence and Metastasis
Souza, V. G. P., Forder, A., Brockley, L. J., Pewarchuk, M. E., Telkar, N., de Araújo, R. P., Trejo, J., Benard, K., Seneda, A. L., Minutentag, I. W., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108894 · Cited by 34 · see citing works
Application of different nanoparticles in the diagnosis of colorectal cancer
Ghorbani, F., Kokhaei, P., Ghorbani, M., & Eslami, M. (2020) · Gene Reports · doi:10.1016/j.genrep.2020.100896 · Cited by 28 · see citing works
Gill, A. B., Rundo, L., Wan, J. C. M., Lau, D., Zawaideh, J. P., Woitek, R., Zaccagna, F., Beer, L., Gale, D. G., Sala, E., et al. (2020) · Cancers · doi:10.3390/cancers12123493 · Cited by 28 · see citing works
Gong, J., Hendifar, A. E., Gangi, A., Zaghiyan, K. N., Atkins, K. M., Nasseri, Y. Y., Murrell, Z. A., Figueiredo, J. C., Salvy, S., Haile, R. W., et al. (2021) · Cancers · doi:10.3390/cancers13184547 · Cited by 28 · see citing works
Circulating tumor DNA in clinical trials for solid tumors: Challenges and current applications
Parisi, C., Tagliamento, M., Belcaid, L., Aldea, M. D., Bayle, A., Remon-Masip, J., Italiano, A., Planchard, D., Besse, B., & Barlési, F. (2023) · The Journal of Liquid Biopsy · doi:10.1016/j.jlb.2023.100007 · Cited by 28 · see citing works
Allegretti, M., Cottone, G., Carboni, F., Cotroneo, E., Casini, B., Giordani, E., Amoreo, C. A., Buglioni, S., Diodoro, M. G., Pescarmona, E. O., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01569-z · Cited by 26 · see citing works
Vaidya, A. M., Ayat, N. R., Buford, M., Wang, H., Shankardass, A., Zhao, Y., Gilmore, H. L., Wang, Z., & Lu, Z. (2020) · Theranostics · doi:10.7150/thno.47448 · Cited by 25 · see citing works
Paweletz, C. P., Heavey, G. A., Kuang, Y., Durlacher, E., Kheoh, T., Chao, R. C., Spira, A. I., Leventakos, K., Johnson, M. L., Ou, S.-H. I., et al. (2023) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-0795 · Cited by 23 · see citing works
Holz, A., Paul, B., Zapf, A., Pantel, K., & Joosse, S. A. (2025) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2025.102999 · Cited by 25 · see citing works
Re, M. D., Crucitta, S., Paolieri, F., Cucchiara, F., Verzoni, E., Bloise, F., Ciampi, R., Mercinelli, C., Capuano, A., Sportiello, L., et al. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03557-7 · Cited by 23 · see citing works
Unseld, M., Belic, J., Pierer, K., Zhou, Q. X., Moser, T., Bauer, R., Piringer, G., Gerger, A., Siebenhüner, A. R., Speicher, M. R., et al. (2020) · International Journal of Cancer · doi:10.1002/ijc.33303 · Cited by 22 · see citing works
Thomsen, C. B., Juul, A. D., Lefèvre, A. C., Truelsen, C. G., Dizdarevic, E., Ryssel, H., Kjær, I. M., Wind, K. L., Callesen, L. B., Faaborg, L., et al. (2022) · Cancer · doi:10.1002/cncr.34168 · Cited by 22 · see citing works
da Silva, L. F. L., Saldanha, E. F., de Menezes, J. S. A., Pereira, L. H., dos Santos, J. A. R. D. B., Buonopane, I. R., de Souza, E. M., de Menezes, C. U. G., & Junior, G. L. L. (2025) · The Oncologist · doi:10.1093/oncolo/oyae344 · Cited by 21 · see citing works
Osumi, H., Shinozaki, E., Ooki, A., Shimozaki, K., Kamiimabeppu, D., Nakayama, I., Wakatsuki, T., Ogura, M., Takahari, D., Chìn, K., et al. (2021) · Cancer Medicine · doi:10.1002/cam4.4384 · Cited by 21 · see citing works
Self-citationLueong, S., Herbst, A., Liffers, S., Bielefeld, N., Horn, P., Tannapfel, A., Reinacher‐Schick, A., Hinke, A., Hegewisch‐Becker, S., Kolligs, F. T., et al. (2020) · Clinical Chemistry · doi:10.1093/clinchem/hvaa223 · Cited by 21 · see citing works
Zhou, J., Li, L., Liu, Y., Jia, W., Liu, Q., Gao, X., Wu, A., Wu, B., Shen, Z., Wang, Z. J., et al. (2025) · EBioMedicine · doi:10.1016/j.ebiom.2024.105548 · Cited by 20 · see citing works
Strategies of nanomedicine for targeting the signaling pathways of Colorectal cancer
Habeeb, M., You, H. W., Aher, K. B., Bhavar, G. B., Khot, V. S., & Mishra, S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104487 · Cited by 20 · see citing works
Circulating Tumor DNA as a Novel Biomarker Optimizing Chemotherapy for Colorectal Cancer
Osumi, H., Shinozaki, E., & Yamaguchi, K. (2020) · Cancers · doi:10.3390/cancers12061566 · Cited by 20 · see citing works
Self-citationHamfjord, J., Guren, T. K., Glimelius, B. L. G., Sørbye, H., Pfeiffer, P., Dajani, O. F., Lingjærde, O. C., Tveit, K. M., Pallisgaard, N., Spindler, K. G., et al. (2021) · International Journal of Cancer · doi:10.1002/ijc.33672 · Cited by 19 · see citing works
Sattar, R. S. A., Verma, R., Nimisha, Kumar, A., Dar, G. M., Apurva, A., Sharma, A. K., Kumari, I., Ahmad, E., Ali, A., et al. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110413 · Cited by 18 · see citing works
RB1 Circulating Tumor DNA in the Blood of Patients with Unilateral Retinoblastoma
Francis, J. H., Gobin, Y. P., Brannon, A. R., Swartzwelder, C. E., Berger, M. F., Mandelker, D. L., Walsh, M. F., Dunkel, I. J., & Abramson, D. H. (2021) · Ophthalmology Science · doi:10.1016/j.xops.2021.100042 · Cited by 16 · see citing works
Raez, L. E., Danenberg, K. D., Sumarriva, D., Usher, J. L., Sands, J. M., Castrellon, A. B., Ferraro, P. H., Milillo, A., Huang, E., Soon‐Shiong, P., et al. (2021) · Cancer Drug Resistance · doi:10.20517/cdr.2021.78 · Cited by 12 · see citing works
Zhang, L., Zou, L., Ma, Y., Feng, C., Zhan, R., Yang, H., Song, B., & Han, Z. (2020) · Cell Biology International · doi:10.1002/cbin.11491 · Cited by 12 · see citing works
Francis, J. H., Barker, C. A., Canestraro, J., Abramson, D. H., & Shoushtari, A. N. (2024) · American Journal of Ophthalmology Case Reports · doi:10.1016/j.ajoc.2024.102021 · Cited by 11 · see citing works
Ghidini, M., Hahne, J. C., Senti, C., Heide, T., Proszek, P., Shaikh, R., Carter, P. D., Hubank, M. J. F., Trevisani, F., Garrone, O., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-24-0924 · Cited by 11 · see citing works
Angeles, A. K., Janke, F., Daum, A.-K., Reck, M., Schneider, M. A., Thomas, M., Christopoulos, P., & Sültmann, H. (2023) · British Journal of Cancer · doi:10.1038/s41416-023-02284-0 · Cited by 11 · see citing works
Heitz, F., Lakis, S., Harter, P., Heikaus, S., Sehouli, J., Talwar, J., Menon, R., Ataseven, B., Bertrand, M., Schneider, S. E., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262770 · Cited by 10 · see citing works
Fatfat, Z., Hussein, M. M., Fatfat, M., & Gali‐Muhtasib, H. U. (2025) · Molecules and Cells · doi:10.1016/j.mocell.2025.100200 · Cited by 9 · see citing works
Rahaman, S., Li, X., Yu, J. Q., & Wong, K. (2021) · Bioinformatics · doi:10.1093/bioinformatics/btab044 · Cited by 9 · see citing works
Cortés‐Hernández, L. E., Eslami‐S, Z., Costa‐Silva, B., & Alix‐Panabières, C. (2021) · Cells · doi:10.3390/cells10092221 · Cited by 8 · see citing works
Osumi, H., Wakatsuki, T., Ooki, A., Chìn, K., Shoji, H., Ogura, M., Nakayama, I., Yamamoto, N., Hirano, H., Hara, H., et al. (2025) · Therapeutic Advances in Medical Oncology · doi:10.1177/17588359251367344 · Cited by 7 · see citing works
Self-citationLavacchi, D., Gelmini, S., Calabri, A., Rossi, G., Simi, L., Caliman, E., Mancini, I., Salvianti, F., Petroni, G., Guidolin, A., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e21853 · Cited by 7 · see citing works
Mirandola, A., Kudriavtsev, A., Muñoz, C. I. C., Comas, R., Macagno, M., Daoud, S., Sánchez, C., Pastor, B., Pisareva, E., Marin, M. S., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105352 · Cited by 8 · see citing works
Eledkawy, A., Hamza, T., & El‐Metwally, S. (2025) · BioData Mining · doi:10.1186/s13040-025-00439-8 · Cited by 7 · see citing works
Extracellular Vesicles in Liver Transplantation: Current Evidence and Future Challenges
Stefano, N. D., Calleri, A., Faini, A. C., Navarro‐Tableros, V., Martini, S., Deaglio, S., Patrono, D., & Romagnoli, R. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713547 · Cited by 7 · see citing works
Zhou, F., Zhang, J., Ren, S., Chen, J., Li, F., Ma, T., Fang, Y., Wang, Q., Yao, W., Guo, R., et al. (2025) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2025.05.021 · Cited by 6 · see citing works
Xu, M., Shi, T., Xu, R., Chen, G., & He, W. (2023) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2023.05.005 · Cited by 6 · see citing works
Tanaka, K., Yoshida, Y., Yamada, T., Hayashi, T., Shimaoka, H., Yoshimura, F., Kajitani, R., Munechika, T., Matsumoto, Y., Nagano, H., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-92795-8 · Cited by 5 · see citing works
Akkermansia Muciniphila as novel powerful bacterial player in colorectal cancer biotherapeutics
Eslami, M., & Yousefi, B. (2022) · Reviews in Medical Microbiology · doi:10.1097/mrm.0000000000000328 · Cited by 6 · see citing works
Challenges in blood fractionation for cancer liquid biopsy: how can microfluidics assist?
Salomon, R., Bazaz, S. R., Mutafopulos, K., Gallego‐Ortega, D., Warkiani, M. E., Weitz, D. A., & Jin, D. (2025) · Lab on a Chip · doi:10.1039/d4lc00563e · Cited by 5 · see citing works
Hussein, M. A., & Munirathinam, G. (2026) · Cancers · doi:10.3390/cancers18050719 · Cited by 4 · see citing works
Circulating tumour DNA in colorectal cancer management
Cohen, R., Platell, C. F. E., McCoy, M. J., Meehan, K. L., & Fuller, K. A. (2023) · British journal of surgery · doi:10.1093/bjs/znad126 · Cited by 4 · see citing works
Prognostic impact of early ctDNA dynamics during chemotherapy of metastatic cancer
Faaborg, L., Andersen, R. F., Wen, S. W. C., Thomsen, C. B., Raunkilde, L., Hansen, T. F., Jensen, L. H., Steffensen, K. D., & Jakobsen, A. K. M. (2023) · Future Oncology · doi:10.2217/fon-2023-0111 · Cited by 4 · see citing works
Using circulating tumor DNA as a novel biomarker of efficacy for dose-finding designs in oncology
Chen, X., Mozgunov, P., Baird, R. D., & Jaki, T. (2025) · Statistical Methods in Medical Research · doi:10.1177/09622802251350457 · Cited by 3 · see citing works
Mutation analysis of TP53 in colorectal cancer, Peshawar, Khyber Pakhtunkhwa, Pakistan.
Kakakhel, M. A., Ali, I., Fayyaz, A., Anwar, Z., Saif, I., Khan, I., & Jahangir, M. (2021) · Journal of Clinical Medicine of Kazakhstan · doi:10.23950/jcmk/9719 · Cited by 3 · see citing works
Jin, K.-M., Bao, Q., Zhao, T., Wang, H., Huang, L.-F., Wang, K., & Xing, B.-C. (2024) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2024.102464 · Cited by 3 · see citing works
Circulating Tumour DNA and Colorectal Cancer: the Next Revolutionary Biomarker?
Naidoo, M., Piercey, O., & Tie, J. (2021) · Current Oncology Reports · doi:10.1007/s11912-021-01137-4 · Cited by 3 · see citing works
Sakai, T., Omura, G., Eguchi, K., Sakai, A., Matsumoto, Y., Fushimi, C., & Yoshimoto, S. (2025) · International Journal of Clinical Oncology · doi:10.1007/s10147-025-02739-9 · Cited by 2 · see citing works
Longitudinal methylated ctDNA increases predict immunotherapy progression across solid tumors
Anees, M., Wagner, P. L., Omstead, A. N., Grayhack, E. E., Sherry, C., McDaniel, L., Varga, M. G., Hosseiny, S. M. H., LaFramboise, W., Nakayama, J., et al. (2026) · The Journal of Liquid Biopsy · doi:10.1016/j.jlb.2026.100477 · Cited by 2 · see citing works
Individualized Cell-Free DNA Monitoring With Chromosomal Junctions for Mesothelioma
Parikh, K., Harris, F. R., Karagouga, G., Schrandt, A., Mandrekar, J. N., Johnson, S. H., McCune, A., Sadeghian, D., Roy, D., Polonis, K., et al. (2024) · JTO Clinical and Research Reports · doi:10.1016/j.jtocrr.2024.100692 · Cited by 2 · see citing works
Udagawa, C., Sasaki, Y., Tanizawa, Y., Suemizu, H., Ohnishi, Y., Nakamura, Y., Tokino, T., & Zembutsu, H. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239614 · Cited by 2 · see citing works
Self-citationAkagündüz, B., Güven, D. C., Özer, M., Ökten, I. N., Atağ, E., Ünek, İ. T., Tatlı, A. M., & Karaoğlu, A. (2022) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2022.08.016 · Cited by 1 · see citing works
Sanz‐García, E., Soleimani, S., Bruce, J. P., Pedersen, S., Tang, M., Avery, L. M., Eagles, J., Spreafico, A., Hansen, A. R., Eng, L., et al. (2025) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-25-3541 · Cited by 1 · see citing works
Zhang, L., Han, X., Gao, X., Chen, H., Shang, C., Chen, L., Lin, J., & Guo, H. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106225 · Cited by 2 · see citing works
Toyokawa, E., Ooki, A., Shinozaki, E., Yoshikawa, K., Suzuki, K., Shiozawa, M., Maeda, S., Yamaguchi, K., & Osumi, H. (2026) · Biomolecules · doi:10.3390/biom16040543 · Cited by 1 · see citing works
Self-citationSuzuki, K., Ooki, A., Shinozaki, E., Toyokawa, E., Yoshikawa, K., Shiozawa, M., Maeda, S., Yamaguchi, K., & Osumi, H. (2026) · Cancer Control · doi:10.1177/10732748261458456 · Cited by 1 · see citing works
Self-citationCirculating tumor DNA as a therapy response marker in metastatic colorectal cancer
Ma, X. M., & Yaung, S. J. (2022) · Oncoscience · doi:10.18632/oncoscience.559 · Cited by 1 · see citing works
Sun, Z., Zhong, J., Lu, J., Si, L., Pan, X., He, K., Wang, Q., Zhang, Y., & Bao, J. (2022) · Research Square · doi:10.21203/rs.3.rs-2018900/v1 · Cited by 1 · see citing works
Detection of Circulating Tumor DNA in Solid Tumors
Testa, U., Castelli, G., & Pelosi, E. (2020) · OBM Genetics · doi:10.21926/obm.genet.2003114
Mutation Analysis of TP53 in Colorectal Cancer, Peshawar, Khyber Pakhtunkhwa, Pakistan.Preprint
Ali, I., Fayyaz, A., Anwar, Z., Saif, I., Khan, I., Jahangir, M., & Kakakhel, M. A. (2020) · Research Square · doi:10.21203/rs.3.rs-131329/v1
Advances in Treatment Selection for Patients with Metastatic Colorectal Cancer
Schulte, B. C., & Benson, A. B. (2021) · Advances in Oncology · doi:10.1016/j.yao.2021.02.025
Служев, М. И., Семиглазов, В. В., Semiglazova, Т. Y., Ткаченко, Е. В., Protsenko, S. A., Латипова, Д. Х., Кондратьев, С. В., Бриш, Н. А., Alekseeva, Y. V., & Belyaev, А. М. (2021) · Siberian Journal of Oncology · doi:10.21294/1814-4861-2021-20-5-149-161
Neoadjuvant single-dose irradiation in low-risk breast cancer
Vasmel, J. E. (2021) · doi:10.33540/956
Re, M. D., Crucitta, S., Paolieri, F., Cucchiara, F., Verzoni, E., Bloise, F., Ciampi, R., Mercinelli, C., Capuano, A., Martinetti, A., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1594180/v1
Re, M. D., Crucitta, S., Paolieri, F., Cucchiara, F., Verzoni, E., Bloise, F., Ciampi, R., Mercinelli, C., Capuano, A., Sportiello, L., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1594180/v2
How ctDNA Changing the Landscape of Management of Colorectal Cancers
Shivarudraiah, S. S. M., Goyal, S., Basu, D. A., Pathak, A., & Jain, A. (2022) · Indian Cancer Awareness Journal · doi:10.25259/icaj_11_2022
Newhook, T. E., & Kawaguchi, Y. (2022) · Springer eBooks · doi:10.1007/978-3-031-09323-4_59
Zhang, L., Han, X., Chen, H., Shang, C., Chen, L., Lin, J., & Guo, H. (2023) · Research Square · doi:10.21203/rs.3.rs-3253918/v1
A panorama of colon cancer in the era of liquid biopsy
Devalle, S., Aran, V., Júnior, C. D. S. B., Pannain, V. L., Brackmann, P., Gregório, M. L., Manso, J. E. F., & Moura‐Neto, V. (2024) · The Journal of Liquid Biopsy · doi:10.1016/j.jlb.2024.100148
Liquid biopsy: an emerging field with new opportunities for cancer diagnosis and prognosis
Mashausi, D. S., & Semukunzi, H. (2025) · Asia-Pacific Journal of Oncology · doi:10.32948/ajo.2025.01.09
- Authors
- Osumi, H., Shinozaki, E., Yamaguchi, K., & Zembutsu, H.
- Affiliations
- Japanese Foundation For Cancer Research (JP)
- Corresponding author
- Zembutsu, Hitoshi
- Venue
- Scientific Reports
- Published
- 2019-11-22
- Volume
- 9
- Issue
- 1
- Pages
- 17358-17358
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC6874682
- OpenAlex
- W2991166240
- Cited by
- 114
- References
- 46
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 9 · 2023: 17 · 2022: 21 · 2021: 21 · 2020: 23
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Japan Society for the Promotion of Science (18K07310)
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- circulating tumor DNA, metastatic colorectal cancer, second-line chemotherapy, objective response rate, predictive biomarkers, progression-free survival, overall survival, mutational hotspots, treatment response prediction
- MeSH terms
- Liquid Biopsy, Circulating Tumor DNA, Adenocarcinoma, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, DNA Mutational Analysis, Female, Humans, Male, Middle Aged, Neoplasm Metastasis, Predictive Value of Tests, Prognosis, Biomarkers, Tumor, Colorectal Neoplasms, Early Diagnosis, Biomarkers, Pharmacological, High-Throughput Nucleotide Sequencing
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