Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 30

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Seven-day Green Tea Supplementation Revamps Gut Microbiome and Caecum/Skin Metabolome in Mice from Stress

Jung, Eun Sung, Park, Jong il, Park, Hyunjoon, Holzapfel, Wilhelm, Hwang, Jae Sung, Lee, Choong Hwan·2019·Scientific Reports
DOI 10.1038/s41598-019-54808-5
Open this paper in CoChat — free account

Abstract

Green tea supplementation has beneficial health effects. However, its underlying mechanisms, such as effects on modulating the intestinal microbiome and endogenous metabolome, particularly following short-term supplementation, are largely unclear. We conducted an integrative metabolomics study to evaluate the effects of short-term (7-day) supplementation of green tea extract (GTE) or its components, epigallocatechin gallate, caffeine, and theanine, on the caecum microbiota and caecum/skin metabolome in mice. Further, we established an integrative metabolome-microbiome model for correlating gut and skin findings. The effects of short-term supplementation with dietary compounds were evaluated with respect to UV stress response, with GTE showing the most remarkable effects. Biplot analysis revealed that Bifidobacteria and Lactobacillus spp. were considerably influenced by short-term GTE supplementation, while Clostridium butyricum was significantly increased by UV stress without supplementation. GTE supplementation helped the skin metabolome defend against UV stress. Interestingly, a significant positive correlation was observed between caecum bacteria (Bifidobacteria, Lactobacillus spp.) and metabolites including skin barrier function-related skin metabolites, caecal fatty acids, and caecal amino acids. Overall, 7-day GTE supplementation was sufficient to alter the gut microbiota and endogenous caecum/skin metabolome, with positive effects on UV stress response, providing insight into the mechanism of the prebiotic effects of GTE supplementation.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/s41598-019-54808-5

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 2 references

Research works printed but not linked: 57

  1. Hervert-Hernandez, D. & Goñi, I. Dietary polyphenols and human gut microbiota: a review. Food Rev. Int. 27, 154–169 (2011). · DOI
  2. Jin, J. S., Touyama, M., Hisada, T. & Benno, Y. Effects of green tea consumption on human fecal microbiota with special reference to Bifidobacterium species. Microbiol. Immunol. 56, 729–739 (2012). · DOI
  3. Yuan, X. et al. Green tea liquid consumption alters the human intestinal and oral microbiome. Mol. Nutr. Food Res. 62, 1800178 (2018). · DOI
  4. Zhang, X. et al. Metagenomics analysis of gut microbiota modulatory effect of green tea polyphenols by high fat diet-induced obesity mice model. J. Funct. Food. 46, 268–277 (2018). · DOI
  5. Wang, L. et al. The effect of green tea polyphenols on gut microbial diversity and fat deposition in C57BL/6J HFA mice. Food Funct. 7, 4956–4966 (2016). · DOI
  6. Stahl, W., Heinrich, U., Aust, O., Tronnier, H. & Sies, H. Lycopene-rich products and dietary photoprotection. Photochem. Photobiol. Sci. 5, 238–242 (2006). · DOI · Paper page
  7. Rhodes, L. E. et al. Oral green tea catechin metabolites are incorporated into human skin and protect against UV radiation-induced cutaneous inflammation in association with reduced production of pro-inflammatory eicosanoid 12-hydroxyeicosatetraenoic acid. Br. J. Nutr. 110, 891–900 (2013). · DOI
  8. Lu, Y. P. et al. Stimulatory effect of oral administration of green tea or caffeine on ultraviolet light-induced increases in epidermal wild-type p53, p21 (WAF1/CIP1), and apoptotic sunburn cells in SKH-1 mice. Cancer Res. 60, 4785–4791 (2000).
  9. Arakaki, A. K., Skolnick, J. & McDonald, J. F. Marker metabolites can be therapeutic targets as well. Nature 456, 443 (2008). · DOI
  10. Zhang, A., Sun, H., Wang, P., Han, Y. & Wang, X. Recent and potential developments of biofluid analyses in metabolomics. J. Proteomics 75, 1079–1088 (2012). · DOI · Paper page
  11. Turnbaugh, P. J. & Gordon, J. I. An invitation to the marriage of metagenomics and metabolomics. Cell 134, 708–713 (2008). · DOI · Paper page
  12. Lu, K. et al. Arsenic exposure perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and metabolomics analysis. Environ. Health Perspect. 122, 284 (2014). · DOI
  13. Abrahamsson, T. R. et al. Low diversity of the gut microbiota in infants with atopic eczema. J. Allergy Clin. Immunol. 129, 434–440 (2012). · DOI · Paper page
  14. Arck, P. et al. Is there a ‘gut–brain–skin axis’? Exp. Dermatol. 19, 401–405 (2010). · DOI
  15. Jung, E. S. et al. The green tea modulates large intestinal microbiome and exo/endogenous metabolome altered through chronic UVB-exposure. PLoS One 12, e0187154 (2017). · DOI
  16. Venables, M. C., Hulston, C. J., Cox, H. R. & Jeukendrup, A. E. Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Am. J. Clin. Nutr. 87, 778–784 (2008). · DOI
  17. Hodgson, A. B. et al. Acute effects of green tea extract intake on exogenous and endogenous metabolites in human plasma. J. Agric. Food Chem. 62, 1198–1208 (2014). · DOI
  18. Cabrera, C., Artacho, R. & Giménez, R. Beneficial effects of green tea—a review. Am. Coll. Nutr. 25, 79–99 (2006). · DOI · Paper page
  19. Graham, H. N. Green tea composition, consumption, and polyphenol chemistry. Prev. Med. 21, 334–350 (1992). · DOI · Paper page
  20. Xu, J. et al. The influence of selenium on the antioxidant activity of green tea. J. Sci. Food Agric. 83, 451–455 (2003). · DOI
  21. Higashi‐Okai, K., Taniguchi, M. & Okai, Y. Potent antioxidative activity of non‐polyphenolic fraction of green tea (Camellia sinensis)–association with pheophytins a and b. J. Sci. Food Agric. 80, 117–120 (2000). · DOI
  22. Clydesdale, G. J., Dandie, G. W. & Muller, H. K. Ultraviolet light induced injury: immunological and inflammatory effects. Immunol. Cell. Biol. 79, 547–568 (2001). · DOI · Paper page
  23. Lye, H. S., Alias, A. K., Rusul, G. & Liong, M. T. Enhanced cholesterol removal ability of lactobacilli via alteration of membrane permeability upon ultraviolet radiation. Ann. Microbiol. 62, 1709–1721 (2012). · DOI
  24. Sato, R. & Tanaka, M. Intestinal distribution and intraluminal localization of orally administered Clostridium butyricum in rats. Microbiol. Immunol. 41, 665–671 (1997). · DOI
  25. Brown, K. L. Control of bacterial spores. Br. Med. Bull. 56, 158–171 (2000). · DOI
  26. Ferraris, L., Butel, M. J. & Aires, J. Antimicrobial susceptibility and resistance determinants of Clostridium butyricum isolates from preterm infants. Int. J. Antimicrob. Agents 36(5), 420–423 (2010). · DOI
  27. Jay, J. M., Loessner, M. J., & Golden, D. A. Radiation protection of foods, and nature of microbial radiation resistance. (ed. Jay J. M.) Modern Food Microbiology, Springer, Boston, MA, 371–394 (2005).
  28. Takahashi, M. et al. The effect of probiotic treatment with Clostridium butyricum on enterohemorrhagic Escherichia coli O157: H7 infection in mice. FEMS Immunol. Med. Microbiol. 41, 219–226 (2004). · DOI · Paper page
  29. Ichikawa, H. et al. Probiotic bacteria stimulate gut epithelial cell proliferation in rat. Dig. Dis. Sci. 44, 2119–2123 (1999). · DOI
  30. Zhang, H. Q. et al. Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats. World J. Gastroenterol. 15, 1821–1828 (2009). · DOI
  31. Bouilly‐Gauthier, D. et al. Clinical evidence of benefits of a dietary supplement containing probiotic and carotenoids on ultraviolet‐induced skin damage. Br. J. Dermatol. 163, 536–543 (2010). · DOI
  32. Lee, D. E. et al. Clinical evidence of effects of Lactobacillus plantarum HY7714 on skin aging: a randomized, double blind, placebo-controlled study. J. Microbiol. Biotechnol. 25, 2160–2168 (2015). · DOI
  33. Sugimoto, S. et al. Photoprotective effects of Bifidobacterium breve supplementation against skin damage induced by ultraviolet irradiation in hairless mice. Photodermatol. Photoimmunol. Photomed. 28, 312–319 (2012). · DOI
  34. Ishii, Y. et al. Oral administration of Bifidobacterium breve attenuates UV-induced barrier perturbation and oxidative stress in hairless mice skin. Arch. Dermatol. Res. 306, 467–473 (2014). · DOI
  35. Nermes, M., Kantele, J. M., Atosuo, T. J., Salminen, S. & Isolauri, E. Interaction of orally administered Lactobacillus rhamnosus GG with skin and gut microbiota and humoral immunity in infants with atopic dermatitis. Clin. Exp. Allergy 41, 370–377 (2011). · DOI
  36. Rather, I. A. et al. Park, Probiotics and atopic dermatitis: an overview. Front. Microbiol. 7, 507 (2016). · DOI
  37. Clemente, J. C., Ursell, L. K., Parfrey, L. W. & Knight, R. The impact of the gut microbiota on human health: an integrative view. Cell. 148, 1258–1270 (2012). · DOI · Paper page
  38. Dunn, W. B. & Ellis, D. I. Metabolomics: current analytical platforms and methodologies. Trac-Trends. Anal. Chem. 24, 285–294 (2005).
  39. Barresi, C. et al. Increased sensitivity of histidinemic mice to UVB radiation suggests a crucial role of endogenous urocanic acid in photoprotection. J. Invest. Dermatol. 131, 188–194 (2011). · DOI
  40. Kim, E. J. et al. UV decreases the synthesis of free fatty acids and triglycerides in the epidermis of human skin in vivo, contributing to development of skin photoaging. J. Dermatol. Sci. 57, 19–26 (2010). · DOI
  41. Feingold, K. R. The outer frontier: the importance of lipid metabolism in the skin. J. Lipid Res. 50(Supplement), S417–S422 (2009). · DOI
  42. Ryborg, A. K., Grøn, B. & Kragballe, K. Increased lysophosphatidylcholine content in lesional psoriatic skin. Br. J. Dermatol. 133, 398–402 (1995). · DOI
  43. Yahagi, S., Koike, M., Okano, Y. & Masaki, H. Lysophospholipids improve skin moisturization by modulating of calcium‐dependent cell differentiation pathway. Int. J. Cosmetic Sci. 33, 251–256 (2011). · DOI
  44. Jung, E. S. et al. A metabolomics approach shows that catechin-enriched green tea attenuates ultraviolet B-induced skin metabolite alterations in mice. Metabolomics 11, 861–871 (2015). · DOI
  45. Elmets, C. A. et al. Cutaneous photoprotection from ultraviolet injury by green tea polyphenols. J. Am. Acad. Dermatol. 44, 425–432 (2001). · DOI · Paper page
  46. Türkoğlu, M., Uğurlu, T., Gedik, G., Yılmaz, A. M. & Yalçin, A. S. In vivo evaluation of black and green tea dermal products against UV radiation. Drug Discov. Ther. 4, 362–367 (2010).
  47. Jeon, H. Y., Kim, J. K., Kim, W. G. & Lee, S. J. Effects of oral epigallocatechin gallate supplementation on the minimal erythema dose and UV-induced skin damage. Skin Pharmacol. Physiol. 22, 137–141 (2009). · DOI
  48. Chow, H. H. S. et al. Pharmacokinetics and safety of green tea polyphenols after multiple-dose administration of epigallocatechin gallate and polyphenon E in healthy individuals. Clin. Cancer Res. 9, 3312–3319 (2003).
  49. Camouse, M. M., Hanneman, K. K., Conrad, E. P. & Baron, E. D. Protective effects of tea polyphenols and caffeine. Expert Rev. Anticancer Ther. 5, 1061–1068 (2005). · DOI
  50. Saeed, M. et al. Green tea (Camellia sinensis) and l-theanine: Medicinal values and beneficial applications in humans—A comprehensive review. Biomed. Pharmacother. 95, 1260–1275 (2017). · DOI
  51. Svobodova, A. R. et al. Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless mice. Biol. Pharm. Bull. 34, 471–479 (2011). · DOI
  52. Sharma, M. R., Werth, B. & Werth, V. P. Animal models of acute photodamage: comparisons of anatomic, cellular and molecular responses in C57BL/6J, SKH1 and Balb/c mice. Photochem. Photobiol. 87, 690–698 (2011). · DOI
  53. Lew, L. C. & Liong, M. T. Bioactives from probiotics for dermal health: functions and benefits. J. Appl. Microbiol. 114, 1241–1253 (2013). · DOI · Paper page
  54. Hullar, M. A. & Fu, B. C. Diet, the gut microbiome, and epigenetics. Cancer J. 20, 170–175 (2014). · DOI
  55. Bergström, A. et al. Introducing Gut Low-Density Array (GULDA) – a validated approach for qPCR-based intestinal microbial community analysis. FEMS microbial. Lett. 337, 38–47 (2012).
  56. Suh, D. H. et al. In vivo metabolomics interpretation of the anti-obesity effects of hyacinth bean (Dolichos lablab L.) administration in high-fat diet mice. Mol. Nutr. Food Res. 61, 1600895 (2017). · DOI
  57. Jung, E. S. et al. Integrative metabolomic analysis reveals diet supplementation with green tea alleviates UVB-damaged mouse skin correlated with ascorbate metabolism and urea cycle. Metabolomics 13, 82 (2017). · DOI

Cited by

Metadata

Authors
Jung, E. S., Park, J. I., Park, H., Holzapfel, W., Hwang, J. S., & Lee, C. H.
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2019-12-05
Volume
9
Issue
1
ISSN
2045-2322
DOI
10.1038/s41598-019-54808-5
Cited by
30
References
2
Language
en
Licence
Funders
National Research Foundation of Korea (2016M3A9A5923160, 2018M3A9F3021968)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.