Replication of FTO gene associated with lean mass in a meta-analysis of genome-wide association studies
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Abstract Sarcopenia is characterized by low skeletal muscle, a complex trait with high heritability. With the dramatically increasing prevalence of obesity, obesity and sarcopenia occur simultaneously, a condition known as sarcopenic obesity. Fat mass and obesity-associated (FTO) gene is a candidate gene of obesity. To identify associations between lean mass and FTO gene, we performed a genome-wide association study (GWAS) of lean mass index (LMI) in 2207 unrelated Caucasian subjects and replicated major findings in two replication samples including 6,004 unrelated Caucasian and 38,292 unrelated Caucasian. We found 29 single nucleotide polymorphisms (SNPs) in FTO significantly associated with sarcopenia (combined p-values ranging from 5.92 × 10−12 to 1.69 × 10−9). Potential biological functions of SNPs were analyzed by HaploReg v4.1, RegulomeDB, GTEx, IMPC and STRING. Our results provide suggestive evidence that FTO gene is associated with lean mass.
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Discrepancies were also found for the association of sex, social status and quality of life with SO development, with some articles detecting higher risk in males or females and in the presence of poor social status, urban area, married individuals, or white collar subgroup.
“Discrepancies were also found for the association of sex, social status and quality of life with SO development as some articles detected a higher risk in males [23,24] or females [25,26] and in the presence of poor social status [18e20,26e29], in people living in urban area [30], married individuals [20] or in white collar subgroup [31].”
From Identification of factors associated with sarcopenic obesity development: Literature review and expert panel voting (2024) · cites this paper as [24]
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- Authors
- Ran, S., Jiang, Z.-X., He, X., Liu, Y., Zhang, Y.-X., Zhang, L., Pei, Y.-F., Zhang, M., Hai, R., Gu, G.-S., Liu, B.-L., Tian, Q., Zhang, Y.-H., Wang, J.-Y., & Deng, H.-W.
- Affiliations
- University of Shanghai for Science and Technology (CN)
- Soochow University (CN)
- Tulane University (US)
- Corresponding author
- Deng, Hong-Wen
- Venue
- Scientific Reports
- Published
- 2020-03-19
- Volume
- 10
- Issue
- 1
- Pages
- 5057-5057
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC7081265
- OpenAlex
- W3011367933
- Cited by
- 26
- References
- 44
- Citations by year
- 2025: 7 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 7
- FWCI
- 0.43
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31571291, 31571291;31501026)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- FTO, fat mass and obesity-associated gene, lean mass index, sarcopenia, sarcopenic obesity, skeletal muscle, single nucleotide polymorphisms, genetic association, obesity, gene function prediction, Caucasian population
- MeSH terms
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO, Adult, Aged, Female, Humans, Male, Middle Aged, Obesity, Thinness, Polymorphism, Single Nucleotide, White People, Genome-Wide Association Study, Sarcopenia
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