Cited by 83Liver Disease Diagnosis and TreatmentPeroxisome Proliferator-Activated ReceptorsDiabetes, Cardiovascular Risks, and Lipoproteins

Saroglitazar in patients with non-alcoholic fatty liver disease and diabetic dyslipidemia: a prospective, observational, real world study

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Goyal, Omesh, Nohria, Sahil, Goyal, Prerna, Kaur, Jaskirat, Sharma, Sarit, Sood, Ajit, Chhina, Rajoo Singh·2020·Scientific Reports

Abstract

Saroglitazar, a dual peroxisome proliferator activated receptor α/γ agonist, approved for diabetic dyslipidemia (DD), is potential therapeutic option for non-alcoholic fatty liver disease (NAFLD). This prospective, observational, real-world study aimed to determine efficacy and safety of Saroglitazar in patients with NAFLD and DD. We included patients with DD and NAFLD who received Saroglitazar 4 mg once daily for 24 weeks. Blood investigations, liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) (FibroScan) were compared at baseline and 24 weeks. Of 163 patients screened, 107 were included, and 101 completed 24 weeks treatment (mean age 50.4 ± 12.3 years, 78.5% males, mean body mass index 28.8 ± 4.2). After 24 weeks, alanine transaminase (ALT) reduced significantly from 94 (47-122) to 39 (31-49) (p < 0.0001) and aspartate aminotransferase (AST) (U/L) from 89 (43-114) to 37 (30-47) (p < 0.0001) and LSM (kPa) from 8.4 (7.1-9.3) to 7.5 (6.4-8.4) (p = 0.0261). CAP, glycated hemoglobin and lipid parameters also improved significantly. On linear regression, there was significant association between percent change in ALT and AST with TG reduction after treatment (p = 0.024 and 0.037 respectively).We conclude that Saroglitazar leads to significant improvement in transaminases, LSM, and CAP in NAFLD patients with DD.

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Authors
Goyal, O., Nohria, S., Goyal, P., Kaur, J., Sharma, S., Sood, A., & Chhina, R. S.
Affiliations
Dayanand Medical College & Hospital (IN)
Corresponding author
Goyal, Omesh
Venue
Scientific Reports
Published
2020-12-03
Volume
10
Issue
1
Pages
21117-21117
ISSN
2045-2322 (ISSN-L)
OpenAlex
W3108378941
Cited by
83
References
33
Citations by year
2026: 11 · 2025: 18 · 2024: 16 · 2023: 13 · 2022: 16 · 2021: 9
FWCI
6.81
Type
journal article
Language
en
Open access
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
saroglitazar, non-alcoholic fatty liver disease, diabetic dyslipidemia, liver stiffness, controlled attenuation parameter, transaminases, alanine aminotransferase, aspartate aminotransferase, triglyceride lowering, HbA1c, lipid parameters, drug safety and efficacy
MeSH terms
Alanine Transaminase, Aspartate Aminotransferases, Diabetes Mellitus, Type 2, Female, Humans, Liver, Male, Middle Aged, Phenylpropionates, Prospective Studies, Pyrroles, Regression Analysis, Dyslipidemias, Non-alcoholic Fatty Liver Disease

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