Saroglitazar in patients with non-alcoholic fatty liver disease and diabetic dyslipidemia: a prospective, observational, real world study
Open accessAbstract
Saroglitazar, a dual peroxisome proliferator activated receptor α/γ agonist, approved for diabetic dyslipidemia (DD), is potential therapeutic option for non-alcoholic fatty liver disease (NAFLD). This prospective, observational, real-world study aimed to determine efficacy and safety of Saroglitazar in patients with NAFLD and DD. We included patients with DD and NAFLD who received Saroglitazar 4 mg once daily for 24 weeks. Blood investigations, liver stiffness measurement (LSM) and controlled attenuation parameter (CAP) (FibroScan) were compared at baseline and 24 weeks. Of 163 patients screened, 107 were included, and 101 completed 24 weeks treatment (mean age 50.4 ± 12.3 years, 78.5% males, mean body mass index 28.8 ± 4.2). After 24 weeks, alanine transaminase (ALT) reduced significantly from 94 (47-122) to 39 (31-49) (p < 0.0001) and aspartate aminotransferase (AST) (U/L) from 89 (43-114) to 37 (30-47) (p < 0.0001) and LSM (kPa) from 8.4 (7.1-9.3) to 7.5 (6.4-8.4) (p = 0.0261). CAP, glycated hemoglobin and lipid parameters also improved significantly. On linear regression, there was significant association between percent change in ALT and AST with TG reduction after treatment (p = 0.024 and 0.037 respectively).We conclude that Saroglitazar leads to significant improvement in transaminases, LSM, and CAP in NAFLD patients with DD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Saroglitazar, a dual PPAR alpha/gamma agonist, has been shown to improve insulin resistance, liver steatosis and liver enzymes and is approved in India for the treatment of T2D and MASH.
“Saroglitazar, a dual PPAR a / c agonist has been shown to improve insulin resistance, liver steatosis and liver enzymes 426 and is approved in India for the treatment of T2D and MASH.”
From EASL-EASD-EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD). (2024) · cites this paper as [427]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Dulai, P. S., Singh, S., Patel, J., Soni, M., Prokop, L. J., Younossi, Z., Sebastiani, G., Ekstedt, M., Hagstrom, H., Nasr, P., et al. (2017) · Hepatology · doi:10.1002/hep.29085 · Cited by 1,965 · see citing works
Eddowes, P. J., Sasso, M., Allison, M., Tsochatzis, E. A., Anstee, Q. M., Sheridan, D. A., Guha, I. N., Cobbold, J., Deeks, J. J., Paradis, V., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.01.042 · Cited by 1,425 · see citing works
Wong, V. W.-S., Vergniol, J., Wong, G. L.-H., Foucher, J., Chan, H. L.-Y., Le Bail, B., Choi, P. C.-L., Kowo, M., Chan, A. W.-H., Merrouche, W., et al. (2010) · Hepatology · doi:10.1002/hep.23312 · Cited by 1,322 · see citing works
Younossi, Z. M., Ratziu, V., Loomba, R., Rinella, M., Anstee, Q. M., Goodman, Z., Bedossa, P., Geier, A., Beckebaum, S., Newsome, P. N., et al. (2019) · The Lancet · doi:10.1016/s0140-6736(19)33041-7 · Cited by 1,277 · see citing works
Ratziu, V., Harrison, S. A., Francque, S., Bedossa, P., Lehert, P., Serfaty, L., Romero-Gomez, M., Boursier, J., Abdelmalek, M., Caldwell, S., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.01.038 · Cited by 1,035 · see citing works
Caussy, C., Alquiraish, M. H., Nguyen, P., Hernandez, C., Cepin, S., Fortney, L., Ajmera, V. H., Bettencourt, R., Collier, S., Hooker, J. C., et al. (2017) · Hepatology · doi:10.1002/hep.29639 · Cited by 378 · see citing works
Mikolasevic, I., Orlic, L., Franjic, N., Hauser, G., Stimac, D., & Milic, S. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i32.7236 · Cited by 273 · see citing works
Jain, M. R., Giri, S. R., Bhoi, B., Trivedi, C. J., Rath, A., Rathod, R., Ranvir, R. K., Kadam, S. B., Patel, H., Swain, P. K., et al. (2017) · Liver International · doi:10.1111/liv.13634 · Cited by 207 · see citing works
Duseja, A. K., Singh, S. P., Saraswat, V. A., Acharya, S. K., Chawla, Y. K., Chowdhury, S., Dhiman, R. K., Jayakumar, R. V., Madan, K., Misra, S. P., et al. (2015) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2015.02.006 · Cited by 186 · see citing works
Application of transient elastography in nonalcoholic fatty liver disease
Zhang, X., Wong, G. L., & Wong, V. W. (2019) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2019.0001n · Cited by 138 · see citing works
Jani, R. H., Pai, V., Jha, P. R., Jariwala, G., Mukhopadhyay, S., Bhansali, A. K., & Joshi, S. (2013) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2013.0253 · Cited by 118 · see citing works
Kumar, D. P., Caffrey, R., Marioneaux, J., Santhekadur, P. K., Bhat, M., Alonso, C., Koduru, S. V., Philip, B., Jain, M. R., Giri, S. R., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-66458-z · Cited by 116 · see citing works
Pai, V., Paneerselvam, A., Mukhopadhyay, S., Bhansali, A. K., Kamath, D., Shankar, V., Gambhire, D., Jani, R. H., Joshi, S., & Patel, P. (2014) · Journal of Diabetes Science and Technology · doi:10.1177/1932296813518680 · Cited by 115 · see citing works
Garg, H., Aggarwal, S., Shalimar, S., Yadav, R., Gupta, S. D., Agarwal, L., & Agarwal, S. (2017) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2017.09.005 · Cited by 112 · see citing works
Anushiravani, A., Haddadi, N., Pourfarmanbar, M., & Mohammadkarimi, V. (2019) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001369 · Cited by 107 · see citing works
Gawrieh, S., Wilson, L., Cummings, O. W., Clark, J. M., Loomba, R. S., Hameed, B., Abdelmalek, M. F., Dasarathy, S., Neuschwander‐Tetri, B. A., Kowdley, K. V., et al. (2019) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000388 · Cited by 97 · see citing works
Naveau, S., Lamouri, K., Pourcher, G., Njiké‐Nakseu, M., Ferretti, S., Courie, R., Tranchart, H., Ghinoiu, M., Balian, A., Prevot, S., et al. (2014) · Obesity Surgery · doi:10.1007/s11695-014-1235-9 · Cited by 88 · see citing works
Lipid Management in Type 2 Diabetes
Solano, M. P., & Goldberg, R. B. (2006) · Clinical Diabetes · doi:10.2337/diaclin.24.1.27 · Cited by 80 · see citing works
Peroxisome Proliferator-Activated Receptors and Their Agonists in Nonalcoholic Fatty Liver Disease
Choudhary, N. S., Kumar, N., & Duseja, A. K. (2019) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2019.06.004 · Cited by 74 · see citing works
Future Pharmacotherapy for Non-alcoholic Steatohepatitis (NASH): Review of Phase 2 and 3 Trials
Connolly, J. J., Ooka, K., & Lim, J. K. (2018) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2017.00056 · Cited by 58 · see citing works
A prospective comparative assessment of the accuracy of the FibroScan in evaluating liver steatosis
Jun, B. G., Park, W. Y., Park, E. J., Jang, J. Y., Jeong, S. W., Lee, S. H., Kim, S. G., Cha, S., Kim, Y. S., Cho, Y. D., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182784 · Cited by 49 · see citing works
Jain, N., Bhansali, S., Kurpad, A. V., Hawkins, M. A., Sharma, A. D., Kaur, S., Rastogi, A., & Bhansali, A. K. (2019) · Scientific Reports · doi:10.1038/s41598-019-55466-3 · Cited by 49 · see citing works
Shetty, S., Kumar, S., Mathur, R. P., Sharma, K. H., & Jaiswal, A. D. (2015) · Indian Heart Journal · doi:10.1016/j.ihj.2015.02.007 · Cited by 43 · see citing works
Chatterjee, S., Majumder, A., & Ray, S. (2015) · Scientific Reports · doi:10.1038/srep07706 · Cited by 42 · see citing works
Alkhouri, N., & Scott, A. L. (2018) · Clinical Liver Disease · doi:10.1002/cld.708 · Cited by 41 · see citing works
Pathik, P., Ravindra, S., Choksey, A. S., Prasad, B., Jatin, P., & Prabha, S. (2015) · PubMed Central · Cited by 40 · see citing works
Chen, C., Zhu, Z., Mao, Y., Xu, Y., Du, J., Tang, X., & Cao, H. (2020) · Bioscience Reports · doi:10.1042/bsr20193996 · Cited by 34 · see citing works
Chen, W., Zhang, K., Dong, P., Fanning, G. C., Tao, C., Zhang, H., Guo, S., Wang, Z., Hong, Y., Yang, X., et al. (2020) · Hepatology International · doi:10.1007/s12072-020-10016-2 · Cited by 29 · see citing works
Value of controlled attenuation parameter in fibrosis prediction in nonalcoholic steatohepatitis
Lee, J. I., Lee, H. W., & Lee, K. S. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i33.4959 · Cited by 21 · see citing works
Chatterjee, S. (2018) · Diabetes & Obesity International Journal · doi:10.23880/doij-16000180 · Cited by 7 · see citing works
Beretta‐Piccoli, B. T., Thompson, R. J., Foskett, P., Cerny, A., Merlo, E., Vergani, D., Rougemont, A., Moix, I., Mieli‐Vergani, G., & Morris, M. A. (2019) · Hepatology · doi:10.1002/hep.30783 · Cited by 6 · see citing works
Kaul, U., Arambam, P., Kachru, R., Bhatia, V., Yumnam, D., ungla, N., Shah, M., Parmar, K., Jaiswal, A. D., & Jain, P. (2019) · doi:10.35248/2155-6156.19.10.819 · Cited by 5 · see citing works
Abstract #1311: Saroglitazar in Non-Alcoholic Fatty Liver Disease
Joshi, S., Sound, R., Saboo, B., Chawla, R., & Bhandari, S. (2016) · Endocrine Practice · doi:10.1016/s1530-891x(20)44880-3 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Tacke, F., Horn, P., Wai-Sun Wong, V., Ratziu, V., Bugianesi, E., Francque, S., Zelber-Sagi, S., Valenti, L., Roden, M., Schick, F., et al. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.04.031 · Cited by 2,210 · see citing works
(2024) · Obesity Facts · doi:10.1159/000539371 · Cited by 510 · see citing works
Badmus, O. O., Hillhouse, S. A., Anderson, C. D., Hinds, T. D., & Stec, D. E. (2022) · Clinical Science · doi:10.1042/cs20220572 · Cited by 372 · see citing works
Duseja, A. K., Singh, S. P., De, A., Madan, K., Rao, P. N., Shukla, A., Choudhuri, G., Saigal, S., Shalimar, S., Arora, A., et al. (2022) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2022.11.014 · Cited by 105 · see citing works
Mechanisms Linking Metabolic-Associated Fatty Liver Disease (MAFLD) to Cardiovascular Disease
Badmus, O. O., Hinds, T. D., & Stec, D. E. (2023) · Current Hypertension Reports · doi:10.1007/s11906-023-01242-8 · Cited by 87 · see citing works
PPAR-Targeted Therapies in the Treatment of Non-Alcoholic Fatty Liver Disease in Diabetic Patients
Lange, N. F., Graf, V., Caussy, C., & Dufour, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084305 · Cited by 81 · see citing works
Vuppalanchi, R., Caldwell, S. H., Pyrsopoulos, N., deLemos, A. S., Rossi, S., Levy, C., Goldberg, D. S., Mena, E. A., Sheikh, A., Ravinuthala, R., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2021.08.025 · Cited by 79 · see citing works
Altered Mitochondrial Function in MASLD: Key Features and Promising Therapeutic Approaches
Radosavljević, T. S., Branković, M., Samardžić, J., Djuretić, J., Vukićević, D., Vučević, D. B., & Jakovljevic, V. L. (2024) · Antioxidants · doi:10.3390/antiox13080906 · Cited by 76 · see citing works
Hepatic insulin receptor: new views on the mechanisms of liver disease
Lee, W., Najjar, S. M., Kahn, C. R., & Hinds, T. D. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155607 · Cited by 69 · see citing works
Liver Fibrosis and MAFLD: From Molecular Aspects to Novel Pharmacological Strategies
Qu, W., Ma, T., Cai, J., Zhang, X., Zhang, P., She, Z., Wan, F., & Li, H. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.761538 · Cited by 68 · see citing works
An Update on the Current and Emerging Use of Thiazolidinediones for Type 2 Diabetes
Giglio, R. V., Παπάνας, Ν., Rizvi, A. A., Ciaccio, M., Patti, A. M., Ilias, Ι., Stoian, A. P., Sahebkar, A., Janež, A., & Rizzo, M. (2022) · Medicina · doi:10.3390/medicina58101475 · Cited by 67 · see citing works
Ezhilarasan, D. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155912 · Cited by 53 · see citing works
Pharmacotherapy for Non-Alcoholic Fatty Liver Disease: Emerging Targets and Drug Candidates
Александровна, П. В., Bezborodkina, N. N., & Okovityi, S. V. (2022) · Biomedicines · doi:10.3390/biomedicines10020274 · Cited by 52 · see citing works
MASLD treatment—a shift in the paradigm is imminent
Machado, M. V. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1316284 · Cited by 51 · see citing works
Soto, A., Spongberg, C. V., Martinino, A., & Giovinazzo, F. (2024) · Biomedicines · doi:10.3390/biomedicines12020397 · Cited by 50 · see citing works
Akbari, R., Behdarvand, T., Afarin, R., Yaghooti, H., Jalali, M. T., & Mohammadtaghvaei, N. (2021) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-021-00524-8 · Cited by 40 · see citing works
Chaudhuri, S., Dutta, A., & Chakraborty, S. B. D. (2023) · JGH Open · doi:10.1002/jgh3.12878 · Cited by 38 · see citing works
Bandyopadhyay, S. K., Samajdar, S. S., & Das, S. (2023) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2023.102174 · Cited by 35 · see citing works
Hepatocyte CYR61 polarizes profibrotic macrophages to orchestrate NASH fibrosis
Mooring, M., Yeung, G. A., Luukkonen, P., Liu, S., Akbar, M. W., Zhang, G. J., Balogun, O., Yu, X., Mo, R., Nejak-Bowen, K., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.ade3157 · Cited by 33 · see citing works
Honda, A., Kamata, S., Akahane, M., Machida, Y., Uchii, K., Shiiyama, Y., Habu, Y., Miyawaki, S., Kaneko, C., Oyama, T., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094726 · Cited by 32 · see citing works
Zhang, Z., He, W.-J., Deng, S., Xu, S.-H., Zeng, X., Qian, Z., Chen, Z., Wang, S., & Tang, D. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175291 · Cited by 30 · see citing works
Saroglitazar for Nonalcoholic Fatty Liver Disease: A Single Centre Experience in 91 Patients
Padole, P., Arora, A., Sharma, P., Chand, P., Verma, N., & Kumar, A. (2021) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2021.06.015 · Cited by 28 · see citing works
Sarkar, S., Kumari, D., Gupta, S. K., Sharma, V., Mukhi, S., Kamboj, P., Vedula, S., Rai, R. K., Jatavallabhula, S. L., Mahajan, D., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112357 · Cited by 27 · see citing works
Bae, J. C., Beste, L. A., & Utzschneider, K. M. (2022) · Endocrinology and Metabolism · doi:10.3803/enm.2022.1434 · Cited by 27 · see citing works
Mo, M.-Q., Huang, Z., Liang, Y., Liao, Y., & Xia, N. (2021) · Digestive and Liver Disease · doi:10.1016/j.dld.2021.08.017 · Cited by 26 · see citing works
Pathogenesis and Therapeutic Strategies Related to Non-Alcoholic Fatty Liver Disease
Teng, T., Qiu, S., Zhao, Y., Zhao, S., Sun, D., Hou, L., Li, Y., Zhou, K., Yu, X., Yang, C., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147841 · Cited by 26 · see citing works
Saroglitazar, a dual PPAR-α/γ agonist, alleviates LPS-induced hepatic and renal injury in rats
Francis, M. R., El‐Sheakh, A. R., & Suddek, G. M. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109688 · Cited by 25 · see citing works
Emerging and Established Therapeutic Approaches for Nonalcoholic Fatty Liver Disease
Brown, E. E., Hydes, T., Hamid, A., & Cuthbertson, D. J. (2021) · Clinical Therapeutics · doi:10.1016/j.clinthera.2021.07.013 · Cited by 24 · see citing works
Emerging pharmacological treatment options for MAFLD
Rojas, Á., Lara, C., Múñoz‐Hernández, R., Gato, S., Ampuero, J., & Romero‐Gómez, M. (2022) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/20420188221142452 · Cited by 24 · see citing works
Potential Therapeutic Strategies in the Treatment of Metabolic-Associated Fatty Liver Disease
Bołdys, A., Bułdak, Ł., Maligłówka, M., Surma, S., & Okopień, B. (2023) · Medicina · doi:10.3390/medicina59101789 · Cited by 23 · see citing works
Mir, B. A., Sharma, R., Sharma, R., Bodh, V., Chauhan, A., Majeed, T., Haq, I., Sharma, N., & Sharma, D. (2024) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2024.101398 · Cited by 17 · see citing works
Applegate, C. C., Kang, Y., Deng, H., Chen, D., Medina, N. G., Cui, Y., Feng, Y., Kuo, C.-W., Shahoei, S. H., Kim, H., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads3731 · Cited by 15 · see citing works
Altered lipid metabolism and the development of metabolic-associated fatty liver disease
Foster, C., Gagnon, C. A., & Ashraf, A. P. (2024) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000933 · Cited by 19 · see citing works
Vijayakumar, A., Ökesli, A., Wang, T., Olson, I. A., Seung, M., Kusam, S., Hollenback, D., Mahadevan, S., Marchand, B., Toteva, M. M., et al. (2022) · Hepatology Communications · doi:10.1002/hep4.2011 · Cited by 14 · see citing works
Grobbee, E. J., de Jong, V., Schrieks, I. C., Tushuizen, M. E., Holleboom, A. G., Tardif, J., Lincoff, A. M., Schwartz, G. G., Cabezas, M. C., & Grobbee, D. E. (2022) · PLoS ONE · doi:10.1371/journal.pone.0277706 · Cited by 14 · see citing works
RetractedLiao, X., Ma, Q., Wu, T., Shao, C., Lin, Y., Sun, Y., Feng, S., Wang, W., Ye, J., & Zhong, B. (2022) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s356371 · Cited by 14 · see citing works
Unraveling the Potential Role of Tecomella undulata in Experimental NASH
Srinivas, A. N., Suresh, D., Suvarna, D., Pankaj, P., Giri, S. R., Suman, Satish, S., Chidambaram, S. B., & Kumar, D. P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043244 · Cited by 14 · see citing works
Peroxisome proliferator-activated receptors (PPARs) agonists as promising neurotherapeutics
Ghannam, I. A. Y., Hassan, R. M., & Abdel‐Maksoud, M. S. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108226 · Cited by 12 · see citing works
Targeting Gut–Liver Axis for Treatment of Liver Fibrosis and Portal Hypertension
Kalo, E., Read, S. A., & Ahlenstiel, G. (2021) · Livers · doi:10.3390/livers1030014 · Cited by 12 · see citing works
Wang, Y., Yang, Z., Tang, H., Sun, X., Qu, J., Lu, S., & Rao, B. (2022) · Archives of Physiology and Biochemistry · doi:10.1080/13813455.2022.2080229 · Cited by 12 · see citing works
Majeed, M. A., Nagabhushanam, K., Noureddin, M., Paulose, S., Barik, C., Saklecha, S., & Mundkur, L. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1201186 · Cited by 10 · see citing works
Cazac, G.-D., Lăcătușu, C.-M., Grigorescu, E.-D., Foșălău, A.-B., Onofriescu, A., & Mihai, B. M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14041042 · Cited by 9 · see citing works
Roy, A., Tewari, B., Giri, S., & Goenka, M. K. (2023) · Cureus · doi:10.7759/cureus.47493 · Cited by 9 · see citing works
Durga, D. R., Mounika, N., Mudimala, P., & Adela, R. (2022) · Clinical Drug Investigation · doi:10.1007/s40261-022-01219-6 · Cited by 8 · see citing works
Panuganti, V. K., Alluri, C. V., Mohammad, J., Dundigalla, M. R., Madala, P. K., KSSVV, S., & shaik, A. H. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i12.113658 · Cited by 6 · see citing works
Misceo, D., Mocciaro, G., D’Amore, S., & Vacca, M. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00871-3 · Cited by 6 · see citing works
Das, S., Gupta, S. K., Lathia, T. B., Swain, J., Mittal, S., Kumar, S., Dm, M., Garg, N., Teja, R., Beatrice, A., et al. (2025) · Cureus · doi:10.7759/cureus.89028 · Cited by 5 · see citing works
Menezes, A. D. S., Oliveira, V. M. R., Oliveira, I. C., de Sousa, A. M., Santana, A. J. P., Carvalho, D. P. C., Piai, R. F. P., Matos, F. H., de Paiva, A. M., & Reis, G. B. B. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12175674 · Cited by 4 · see citing works
Goyal, P., Chopra, R., & Goyal, O. (2024) · Indian Journal of Cardiovascular Disease in Women · doi:10.25259/ijcdw_2_2024 · Cited by 4 · see citing works
Self-citationAfarin, R., Hatami, M., Monjezi, S., Bineshfar, F., & Ahangarpour, A. (2024) · PubMed Central · doi:10.22038/ijbms.2024.76264.16497 · Cited by 4 · see citing works
Chávez-López, L. M., Carballo-López, G. I., Lugo-Ibarra, K. C., & Castro-Ceseña, A. B. (2024) · RSC Medicinal Chemistry · doi:10.1039/d4md00420e · Cited by 3 · see citing works
Metabolic‐Associated Steatotic Liver Disease: From Molecular Mechanisms to Novel Therapies
Cooper, J., Patel, P., Tristeza, J., & Yang, A. (2025) · International Journal of Hepatology · doi:10.1155/ijh/5580454 · Cited by 3 · see citing works
Emerging Combination of Saroglitazar and Vitamin E for the Treatment of NAFLD and NASH
Tavaglione, F., & Loomba, R. S. (2024) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2024.101449 · Cited by 3 · see citing works
Emerging multi-target strategies and dual agonists of PPAR-α/γ modulation in Type 2 diabetes
Arora, P., Tyagi, A., Kumar, V., Arulsamy, S., Kaushik, M., & Kumar, S. (2026) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2026.146281 · Cited by 2 · see citing works
Anand, A. C., & Acharya, S. (2022) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2022.01.008 · Cited by 2 · see citing works
Clinical Case Series on Assessment of Therapeutic Efficacy of Saroglitazar in MASLD Patients
Dang, N., & Wairokpam, T. (2024) · Asian Journal of Medicine and Health · doi:10.9734/ajmah/2024/v22i91085 · Cited by 2 · see citing works
Tiwari, K., Kumar, B., Tiwari, A., Dhamija, P., Vardhan, G., Dehade, A., & Kumar, V. (2025) · Cureus · doi:10.7759/cureus.79437 · Cited by 2 · see citing works
Shah, N. A., Paul, S., Parveen, S., Bhat, M. H., Ali, I., & Kadla, S. A. (2025) · International Journal of Basic & Clinical Pharmacology · doi:10.18203/2319-2003.ijbcp20251836 · Cited by 1 · see citing works
Mondal, S., Chowdhury, A. S., Deb, R., & Sanyal, D. (2025) · Diabetology International · doi:10.1007/s13340-025-00833-x · Cited by 1 · see citing works
Bhagat, N., De, A., Duseja, A. K., Ganesh, C. P., Kumar, M., Mehta, M., Taneja, S., Sahni, N., & Singh, V. (2026) · The Indian Journal of Medical Research · doi:10.25259/ijmr_2953_2025 · Cited by 1 · see citing works
Ahmad, P., Shah, A., Alvi, S. S., Chaturvedi, C. P., Ahmad, S., Sheeha, B. H. B., Puri, P., Alothamali, O. W., & Khan, M. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1781950 · Cited by 1 · see citing works
Jung, W., Abushukair, H. M., Patil, N. Y., Ampadu, F. A., Firouzi, M., Rus, I., Choi, J. S., Muthukrishnan, S. D., Shukla, S. K., Tarantini, S., et al. (2026) · Science Advances · doi:10.1126/sciadv.aec8681 · Cited by 1 · see citing works
Sinha, B., Ghosal, S., & Datta, D. (2024) · International Journal of Diabetes and Technology · doi:10.4103/ijdt.ijdt_10_24 · Cited by 1 · see citing works
Saroglitazar - A novel treatment for non-alcoholic steatohepatitis
Noorani, S., Ankam, M., Ganesh, C. H. S. V., Banu, R., Vani, P., Polarapu, N., Jangra, S., Shaima, K. A., & Bhyan, B. (2024) · AIP conference proceedings · doi:10.1063/5.0228900 · Cited by 1 · see citing works
Saroglitazar Versus Simvastatin for Metabolic and Alcohol-Associated Liver Disease (MetALD)
Kulkarni, A. V., Gangdany, Z. M., Ramagundam, R., Sharma, M., & Padaki, N. R. (2025) · Cureus · doi:10.7759/cureus.85652 · Cited by 1 · see citing works
Nonalcoholic Fatty Liver Disease
Wadhwa, R. P., Gosavi, D. S., & Ravindranath, A. (2021) · APIK Journal of Internal Medicine · doi:10.4103/ajim.ajim_59_20 · Cited by 1 · see citing works
Din, I.-U., Batool, T., Raza, S. H., Alard Yasir, M., Salam, R. A., & Akhtar, N. (2023) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs2023171442
The SVIN-Trial—Just Another Brick in the Wall?
Mehtani, R. (2024) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2024.102449
Jalihal, U., Nanda, R., Katariya, K., Balamurugan, R., & Kumawat, R. (2025) · Hepatic Medicine Evidence and Research · doi:10.2147/hmer.s527644
Yang, A., Zhu, X., Zhang, L., Lv, G., & Ding, Y. (2025) · Research Square · doi:10.21203/rs.3.rs-6314701/v1
Roy, A., Chakraborty, S., Jajodia, S., Goenka, U., Tewari, A., Sonthalia, N., Ghoshal, U. C., & Goenka, M. K. (2025) · Cureus · doi:10.7759/cureus.92313
Ragottham, K., Mukunda, N., & Lokesh, L. V. (2025) · Annals of African Medicine · doi:10.4103/aam.aam_454_25
Trifylli, E.-M., Charalambous, C. H., Spiliotopoulos, N., Papadopoulos, N., Oikonomou, A., Manolakopoulos, S., & Deutsch, M. J. (2025) · Livers · doi:10.3390/livers5040065
Effect of Saroglitazar on Glycemic Status: A Meta-analysis
Selvarajan, S., Anandabaskar, N., Jayakumar, I., Venkatraman, S., Shivabasappa, S., Sahoo, J., Kamalanathan, S., & George, M. (2025) · Cureus · doi:10.7759/cureus.99122
Meher, D., DAS, S., Choudhury, A. K., Sahoo, D., Sahu, S. K., Agarwal, V., Prusty, B., Das, B. K., Chappalagavi, A. S., Gupta, S., et al. (2025) · Cureus · doi:10.7759/cureus.100002
Tripathi, K., Chafekar, D. S., Verma, H., Bantwal, G., Shah, P., Bhattacharya, S., Sahay, M., Golay, V., Shanmugraj, G., Awasthi, R., et al. (2026) · Cureus · doi:10.7759/cureus.105083
Tiwari, A. K., Singh, G., Kumar, V., Yadav, D. P., Shukla, S. K., Singh, V., Mishra, G., Tiwary, N. K., Anunay, A., Singh, D., et al. (2026) · The Indian Journal of Medical Research · doi:10.25259/ijmr_2511_2025
Pharmacologic management of metabolic and alcohol-associated liver disease
Pagadala, M., Jalil, S., Dunn, N., & Singal, A. K. (2026) · Metabolism and Target Organ Damage · doi:10.20517/mtod.2026.29
Jagadeesha, A., Bhattacharya, S., SHRIVASTAVA, A., Samajdar, S. S., Gunjan, G., Bhardwaj, S., & TELANG, S. (2026) · Cureus · doi:10.7759/cureus.111328
Das, B. K., Das, S., Meher, D., Choudhury, A. K., Padhee, S., Sahu, S. K., Sahoo, D., Prusty, B., & Agarwal, V. (2026) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/ijem.ijem_848_25
Akhand, M. S., Noor-E-Alam, S. M., Rahim, M. A., Karim, R., Hasan, M. R., Karmakar, D., Mondal, D. K., Sopan, N. T., Jalal, J. B., Arafat, M. A., et al. (2026) · Journal of Indian System of Medicine · doi:10.5005/jism-11051-0050
- Authors
- Goyal, O., Nohria, S., Goyal, P., Kaur, J., Sharma, S., Sood, A., & Chhina, R. S.
- Affiliations
- Dayanand Medical College & Hospital (IN)
- Corresponding author
- Goyal, Omesh
- Venue
- Scientific Reports
- Published
- 2020-12-03
- Volume
- 10
- Issue
- 1
- Pages
- 21117-21117
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC7713236
- OpenAlex
- W3108378941
- Cited by
- 83
- References
- 33
- Citations by year
- 2026: 11 · 2025: 18 · 2024: 16 · 2023: 13 · 2022: 16 · 2021: 9
- FWCI
- 6.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- saroglitazar, non-alcoholic fatty liver disease, diabetic dyslipidemia, liver stiffness, controlled attenuation parameter, transaminases, alanine aminotransferase, aspartate aminotransferase, triglyceride lowering, HbA1c, lipid parameters, drug safety and efficacy
- MeSH terms
- Alanine Transaminase, Aspartate Aminotransferases, Diabetes Mellitus, Type 2, Female, Humans, Liver, Male, Middle Aged, Phenylpropionates, Prospective Studies, Pyrroles, Regression Analysis, Dyslipidemias, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review