Cited by 34Fibromyalgia and Chronic Fatigue Syndrome ResearchPain Mechanisms and TreatmentsMitochondrial Function and Pathology

Role of mitochondrial dysfunction and biogenesis in fibromyalgia syndrome: Molecular mechanism in central nervous system

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Marino, Ylenia, Inferrera, Francesca, D'Amico, Ramona, Impellizzeri, Daniela, Cordaro, Marika, Siracusa, Rosalba, Gugliandolo, Enrico, Fusco, Roberta +2 more·2024·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Abstract

A critical role for mitochondrial dysfunction has been shown in the pathogenesis of fibromyalgia. It is a chronic pain syndrome characterized by neuroinflammation and impaired oxidative balance in the central nervous system. Boswellia serrata (BS), a natural polyphenol, is a well-known able to influence the mitochondrial metabolism. The objective of this study was to evaluate the mitochondrial dysfunction and biogenesis in fibromyalgia and their modulation by BS. To induce the model reserpine (1 mg/Kg) was subcutaneously administered for three consecutive days and BS (100 mg/Kg) was given orally for twenty-one days. BS reduced pain like behaviors in reserpine-injected rats and the astrocytes activation in the dorsal horn of the spinal cord and prefrontal cortex that are recognized as key regions associated with the neuropathic pain. Vulnerability to neuroinflammation and impaired neuronal plasticity have been described as consequences of mitochondrial dysfunction. BS administration increased PGC-1α expression in the nucleus of spinal cord and brain tissues, promoting the expression of regulatory genes for mitochondrial biogenesis (NRF-1, Tfam and UCP2) and cellular antioxidant defence mechanisms (catalase, SOD2 and Prdx 3). According with these data BS reduced lipid peroxidation and the GSSG/GSH ratio and increased SOD activity in the same tissues. Our results also showed that BS administration mitigates cytochrome-c leakage by promoting mitochondrial function and supported the movement of PGC-1α protein into the nucleus restoring the quality control of mitochondria. Additionally, BS reduced Drp1 and Fis1, preventing both mitochondrial fission and cell death, and increased the expression of Mfn2 protein, facilitating mitochondrial fusion. Overall, our results showed important mitochondrial dysfunction in central nervous system in fibromyalgia syndrome and the role of BS in restoring mitochondrial dynamics.

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Crossref · 10.1016/j.bbadis.2024.167301

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Authors
Marino, Y., Inferrera, F., D'Amico, R., Impellizzeri, D., Cordaro, M., Siracusa, R., Gugliandolo, E., Fusco, R., Cuzzocrea, S., & Di Paola, R.
Affiliations
University of Messina (IT)
Corresponding author
Fusco, Roberta
Venue
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher
Elsevier BV
Published
2024-10
Volume
1870
Issue
7
Pages
167301
ISSN
0925-4439 (ISSN-L)
OpenAlex
W4399617808
Cited by
33
References
112
Citations by year
2026: 12 · 2025: 17 · 2024: 4
FWCI
9.72
Type
journal article
Language
en
Open access
Locations
  • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
University of Messina
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Keywords
fibromyalgia, mitochondrial dysfunction, mitochondrial biogenesis, Boswellia serrata, PGC-1α, neuroinflammation, oxidative stress, astrocyte activation, mitochondrial dynamics, mitochondrial fission, mitochondrial fusion, Drp1, Fis1, mitofusin 2, lipid peroxidation, antioxidant enzymes, chronic pain
MeSH terms
Animals, Organelle Biogenesis, Central Nervous System, Disease Models, Animal, Fibromyalgia, Male, Mitochondria, Plant Extracts, Spinal Cord, Rats, Wistar, Oxidative Stress, Rats

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