Role of mitochondrial dysfunction and biogenesis in fibromyalgia syndrome: Molecular mechanism in central nervous system
Open accessAbstract
A critical role for mitochondrial dysfunction has been shown in the pathogenesis of fibromyalgia. It is a chronic pain syndrome characterized by neuroinflammation and impaired oxidative balance in the central nervous system. Boswellia serrata (BS), a natural polyphenol, is a well-known able to influence the mitochondrial metabolism. The objective of this study was to evaluate the mitochondrial dysfunction and biogenesis in fibromyalgia and their modulation by BS. To induce the model reserpine (1 mg/Kg) was subcutaneously administered for three consecutive days and BS (100 mg/Kg) was given orally for twenty-one days. BS reduced pain like behaviors in reserpine-injected rats and the astrocytes activation in the dorsal horn of the spinal cord and prefrontal cortex that are recognized as key regions associated with the neuropathic pain. Vulnerability to neuroinflammation and impaired neuronal plasticity have been described as consequences of mitochondrial dysfunction. BS administration increased PGC-1α expression in the nucleus of spinal cord and brain tissues, promoting the expression of regulatory genes for mitochondrial biogenesis (NRF-1, Tfam and UCP2) and cellular antioxidant defence mechanisms (catalase, SOD2 and Prdx 3). According with these data BS reduced lipid peroxidation and the GSSG/GSH ratio and increased SOD activity in the same tissues. Our results also showed that BS administration mitigates cytochrome-c leakage by promoting mitochondrial function and supported the movement of PGC-1α protein into the nucleus restoring the quality control of mitochondria. Additionally, BS reduced Drp1 and Fis1, preventing both mitochondrial fission and cell death, and increased the expression of Mfn2 protein, facilitating mitochondrial fusion. Overall, our results showed important mitochondrial dysfunction in central nervous system in fibromyalgia syndrome and the role of BS in restoring mitochondrial dynamics.
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Inhibition of astrocytic activation in the spinal cord and prefrontal cortex using Boswellia serrata attenuates pain hypersensitivity in FMS model rats.
“Similarly, inhibition of astrocytic activation in the spinal cord and prefrontal cortex using Boswellia serrata attenuated pain hypersensitivity was attenuated in FMS model rats (118).”
From Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization (2026) · cites this paper as [118]
Activation of central glial cells plays a critical role in NPP development.
“Collectively, these studies indicate that activation of central glial cells activation plays a critical role in NPP development.”
From Nociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization (2026) · cites this paper as [118]
Cites
3 retracted
Zhou, J., Yang, Z., Shen, R., Zhong, W., Zheng, H., Chen, Z.-G., Tang, J., & Zhu, J. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.620683 · Cited by 75 · see citing works
RetractedImpellizzeri, D., Siracusa, R., Cordaro, M., Peritore, A. F., Gugliandolo, E., D’Amico, R., Fusco, R., Crupi, R., Rizzarelli, E., Cuzzocrea, S., et al. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110023 · Cited by 49 · see citing works
Self-citationRetractedMarino, Y., Arangia, A., D’Amico, R., Cordaro, M., Siracusa, R., Impellizzeri, D., Gugliandolo, E., Fusco, R., Cuzzocrea, S., & Paola, R. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411510 · Cited by 10 · see citing works
Self-citationRetractedFree Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
Mitochondrial Fission, Fusion, and Stress
Youle, R. J., & van der Bliek, A. M. (2012) · Science · doi:10.1126/science.1219855 · Cited by 3,674 · see citing works
Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211046 · Cited by 2,601 · see citing works
Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part I
Helmick, C. G., Felson, D. T., Lawrence, R. C., Gabriel, S. E., Hirsch, R., Kwoh, C. K., Liang, M. H., Kremers, H. M., Mayes, M. D., Merkel, P. A., et al. (2007) · Arthritis & Rheumatism · doi:10.1002/art.23177 · Cited by 2,054 · see citing works
Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655 · see citing works
Transfer of mitochondria from astrocytes to neurons after stroke
Hayakawa, K., Esposito, E., Wang, X., Terasaki, Y., Liu, Y., Xing, C., Ji, X., & Lo, E. H. (2016) · Nature · doi:10.1038/nature18928 · Cited by 1,423 · see citing works
OPA1 requires mitofusin 1 to promote mitochondrial fusion
Cipolat, S., de Brito, O. M., Dal Zilio, B., & Scorrano, L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407043101 · Cited by 1,300 · see citing works
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
Losón, O. C., Song, Z., Chen, H., & Chan, D. C. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-10-0721 · Cited by 1,235 · see citing works
Chen, H., Vermulst, M., Wang, Y. E., Chomyn, A., Prolla, T. A., McCaffery, J. M., & Chan, D. C. (2010) · Cell · doi:10.1016/j.cell.2010.02.026 · Cited by 1,211 · see citing works
Mitochondrial control of inflammation
Marchi, S., Guilbaud, E., Tait, S. W. G., Yamazaki, T., & Galluzzi, L. (2023) · Nature Reviews Immunology · doi:10.1038/s41577-022-00760-x · Cited by 1,027 · see citing works
Virbasius, J. V., & Scarpulla, R. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.4.1309 · Cited by 819 · see citing works
Role of the Prefrontal Cortex in Pain Processing
Ong, W., Stohler, C. S., & Herr, D. R. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1130-9 · Cited by 790 · see citing works
Mitochondrial reactive oxygen species drive proinflammatory cytokine production
Naik, E., & Dixit, V. M. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110367 · Cited by 783 · see citing works
Mitofusin 1 and 2 play distinct roles in mitochondrial fusion reactions via GTPase activity
Ishihara, N., Eura, Y., & Mihara, K. (2004) · Journal of Cell Science · doi:10.1242/jcs.01565 · Cited by 731 · see citing works
Vazquez, F., Lim, J.-H., Chim, H., Bhalla, K., Girnun, G., Pierce, K., Clish, C. B., Granter, S. R., Widlund, H. R., Spiegelman, B. M., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2012.11.020 · Cited by 715 · see citing works
PGC-1 α , Inflammation, and Oxidative Stress: An Integrative View in Metabolism
Rius‐Pérez, S., Torres-Cuevas, I., Millán, I., Ortega, Á., & Pérez, S. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1452696 · Cited by 648 · see citing works
Mitochondria at the neuronal presynapse in health and disease
Devine, M. J., & Kittler, J. T. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.170 · Cited by 615 · see citing works
Bordt, E. A., Clerc, P., Roelofs, B. A., Saladino, A. J., Tretter, L., Ádám‐Vizi, V., Cherok, E., Khalil, A., Yadava, N., Ge, S. X., et al. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.02.020 · Cited by 598 · see citing works
PGC-1α regulates the mitochondrial antioxidant defense system in vascular endothelial cells
VALLE, I., ALVAREZBARRIENTOS, A., ARZA, E., LAMAS, S., & MONSALVE, M. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.01.026 · Cited by 556 · see citing works
Quality control of mitochondria: protection against neurodegeneration and ageing
Tatsuta, T., & Langer, T. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601972 · Cited by 519 · see citing works
Novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity
Qi, X., Qvit, N., Su, Y.-C., & Mochly‐Rosen, D. (2012) · Journal of Cell Science · doi:10.1242/jcs.114439 · Cited by 441 · see citing works
Hudson, G., Amati-Bonneau, P., Blakely, E. L., Stewart, J. D., He, L., Schaefer, A. M., Griffiths, P. G., Ahlqvist, K., Suomalainen, A., Reynier, P., et al. (2008) · Brain · doi:10.1093/brain/awm272 · Cited by 428 · see citing works
Ding, M., Feng, N., Tang, D., Feng, J., Li, Z., Jia, M., Liu, Z., Gu, X., Wang, Y., Fu, F., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12491 · Cited by 384 · see citing works
Cheng, G., Kong, R., Zhang, L., & Zhang, J. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02025.x · Cited by 345 · see citing works
Wang, Y., Zhao, X., Lotz, M., Terkeltaub, R. A., & Liu‐Bryan, R. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39182 · Cited by 303 · see citing works
Nagakura, Y., Oe, T., Aoki, T., & Matsuoka, N. (2009) · Pain · doi:10.1016/j.pain.2009.05.024 · Cited by 261 · see citing works
Macrophages transfer mitochondria to sensory neurons to resolve inflammatory pain
van der Vlist, M., Raoof, R., Willemen, H. L. D. M., Prado, J., Versteeg, S., Gil, C. M., Vos, M. W., Lokhorst, R. E., Pasterkamp, R. J., Kojima, T., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.11.020 · Cited by 257 · see citing works
Mai, S., Klinkenberg, M., Auburger, G., Bereiter-Hahn, J., & Jendrach, M. (2010) · Journal of Cell Science · doi:10.1242/jcs.059246 · Cited by 256 · see citing works
Mitochondrial dynamics in neuronal injury, development and plasticity
Flippo, K. H., & Strack, S. (2017) · Journal of Cell Science · doi:10.1242/jcs.171017 · Cited by 254 · see citing works
Protective effect of silymarin on oxidative stress in rat brain
Nencini, C., Giorgi, G., & Micheli, L. (2006) · Phytomedicine · doi:10.1016/j.phymed.2006.02.005 · Cited by 228 · see citing works
Mitochondrial heterogeneity and homeostasis through the lens of a neuron
Pekkurnaz, G., & Wang, X. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00594-w · Cited by 195 · see citing works
Khacho, M., Clark, A., Svoboda, D. S., MacLaurin, J. G., Lagace, D. C., Park, D. S., & Slack, R. S. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx217 · Cited by 190 · see citing works
Mitochondrial translocation of α-synuclein is promoted by intracellular acidification
Cole, N. B., DiEuliis, D., Leo, P., Mitchell, D. C., & Nussbaum, R. L. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.03.012 · Cited by 183 · see citing works
Mitochondrial network structure homeostasis and cell death
Xie, L., Shi, F., Tan, Z., Li, Y., Bode, A. M., & Cao, Y. (2018) · Cancer Science · doi:10.1111/cas.13830 · Cited by 178 · see citing works
Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome
Littlejohn, G. O. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.100 · Cited by 175 · see citing works
Salemi, S., Rethage, J., Wollina, U., Michel, B. A., Gay, R. E., Gay, S., & Sprott, H. (2003) · PubMed · Cited by 167 · see citing works
Cordero, M. D., De Miguel, M., Moreno Fernández, A. M., Carmona López, I. M., Garrido Maraver, J., Cotán, D., Gómez Izquierdo, L., Bonal, P., Campa, F., Bullon, P., et al. (2010) · Arthritis Research & Therapy · doi:10.1186/ar2918 · Cited by 165 · see citing works
Impact of Aging and Exercise on Mitochondrial Quality Control in Skeletal Muscle
Kim, Y., Triolo, M., & Hood, D. A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/3165396 · Cited by 158 · see citing works
Meeus, M., Nijs, J., Hermans, L., Goubert, D., & Calders, P. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.818657 · Cited by 152 · see citing works
Romero‐Garcia, S., & Prado-Garcı́a, H. (2019) · International Journal of Oncology · doi:10.3892/ijo.2019.4696 · Cited by 146 · see citing works
Hung, C. H.-L., Cheng, S. S., Cheung, Y.-T., Wuwongse, S., Zhang, N. Q., Ho, J. Y. S., Lee, S. M., & Chang, R. C. (2017) · Redox Biology · doi:10.1016/j.redox.2017.08.010 · Cited by 144 · see citing works
Vergara, R. C., Jaramillo-Riveri, S., Luarte, A., Moënne‐Loccoz, C., Fuentes, R., Couve, A., & Maldonado, P. (2019) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2019.00049 · Cited by 143 · see citing works
Metabolism of Boswellic Acids in Vitro and in Vivo
Krüger, P., Daneshfar, R., Eckert, G. P., Klein, J., Volmer, D. A., Bahr, U., Müller, W. E., Karas, M., Schubert‐Zsilavecz, M., & Tawab, M. A. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.018424 · Cited by 132 · see citing works
Bhushan, S., Kumar, A., Malik, F. A., Andotra, S. S., Sethi, V. K., Kaur, I. P., Taneja, S. C., Qazi, G. N., & Singh, J. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0105-5 · Cited by 131 · see citing works
Amyloid-β-Derived Diffusible Ligands Cause Impaired Axonal Transport of Mitochondria in Neurons
Wang, X., Perry, G. L., Smith, M. A., & Zhu, X. (2010) · Neurodegenerative Diseases · doi:10.1159/000283484 · Cited by 126 · see citing works
Kim, H. K., Zhang, Y. P., Gwak, Y. S., & Abdi, S. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181ca31bd · Cited by 125 · see citing works
Ye, X., Feng, D., Tao, K. X., Wang, R., Shi, Y., Qin, H., Murphy, M. P., Yang, Q., & Zhao, G. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.05.018 · Cited by 117 · see citing works
Effect of melatonin on brain oxidative damage induced by traumatic brain injury in immature rats.
Ozdemir, D., Uysal, N., Gönenç, S., Acikgoz, O., Sönmez, A., Topçu, A., Özdemir, N., Duman, M., Şemin, İ., & Özkan, H. (2005) · Physiological Research · doi:10.33549/physiolres.930709 · Cited by 116 · see citing works
DeSantana, J. M., Cruz, K. M. L., & Sluka, K. A. (2013) · Arthritis Research & Therapy · doi:10.1186/ar4402 · Cited by 115 · see citing works
Pharmacokinetic study of 11-Keto β-Boswellic Acid
Sharma, S., Thawani, V., Hingorani, L., Shrivastava, M., Bhate, V., & Khiyani, R. (2004) · Phytomedicine · doi:10.1078/0944-7113-00290 · Cited by 112 · see citing works
ROS as Regulators of Mitochondrial Dynamics in Neurons
Cid‐Castro, C., Hernández-Espinosa, D. R., & Morán, J. (2018) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-0584-7 · Cited by 111 · see citing works
Cordaro, M., Siracusa, R., Fusco, R., D’Amico, R., Peritore, A. F., Gugliandolo, E., Genovese, T., Scuto, M. C., Crupi, R., Mandalari, G., et al. (2020) · Antioxidants · doi:10.3390/antiox9080660 · Cited by 110 · see citing works
Self-citationKlein, C. P., Sperotto, N. D. D. M., Maciel, I. D. S., Leite, C. E., de Souza, A. H., & Campos, M. M. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.05.043 · Cited by 91 · see citing works
Total antioxidant capacity and the severity of the pain in patients with fibromyalgia
Altındağ, Ö., & Çelık, H. (2006) · Redox Report · doi:10.1179/135100006x116628 · Cited by 88 · see citing works
Oxidative stress and mitochondrial dysfunction in fibromyalgia.
Cordero, M. D., de Miguel, M., Carmona-López, I., Bonal, P., Campa, F. J., & Moreno‐Fernández, A. M. (2010) · PubMed · Cited by 81 · see citing works
Protective effect of snail secretion filtrate against ethanol-induced gastric ulcer in mice
Gugliandolo, E., Cordaro, M., Fusco, R., Peritore, A. F., Siracusa, R., Genovese, T., D’Amico, R., Impellizzeri, D., Di Paola, R., Cuzzocrea, S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-83170-8 · Cited by 81 · see citing works
Self-citationWeil, R., Laplantine, E., Curic, S., & Génin, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01243 · Cited by 80 · see citing works
Fusco, R., Siracusa, R., D’Amico, R., Peritore, A. F., Cordaro, M., Gugliandolo, E., Crupi, R., Impellizzeri, D., Cuzzocrea, S., & Paola, R. D. (2019) · Antioxidants · doi:10.3390/antiox8120628 · Cited by 80 · see citing works
Self-citationFusco, R., Cordaro, M., Siracusa, R., D’Amico, R., Genovese, T., Gugliandolo, E., Peritore, A. F., Crupi, R., Impellizzeri, D., Cuzzocrea, S., et al. (2020) · Antioxidants · doi:10.3390/antiox9090781 · Cited by 78 · see citing works
Self-citationPeripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model
Taguchi, T., Katanosaka, K., Yasui, M., Hayashi, K., Yamashita, M., Wakatsuki, K., Kiyama, H., Yamanaka, A., & Mizumura, K. (2015) · Pain · doi:10.1097/01.j.pain.0000460334.49525.5e · Cited by 77 · see citing works
Segura‐Jiménez, V., Borges‐Cosic, M., Soriano‐Maldonado, A., Estévez‐López, F., Álvarez‐Gallardo, I. C., Herrador‐Colmenero, M., Delgado‐Fernández, M., & Ruiz, J. R. (2015) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12630 · Cited by 76 · see citing works
Gomaa, A. A., Makboul, R. M., Al-Mokhtar, M. A., & Nicola, M. A. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.10.056 · Cited by 75 · see citing works
Animal models of fibromyalgia: What is the best choice?
Brum, E. S., Becker, G., Fialho, M. F. P., & Oliveira, S. M. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107959 · Cited by 71 · see citing works
Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats
Blasco‐Serra, A., Escrihuela-Vidal, F., González-Soler, E. M., Martínez‐Expósito, F., Blasco-Ausina, M. C., Martínez‐Bellver, S., Cervera‐Ferri, A., Teruel‐Martí, V., & Valverde‐Navarro, A. A. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.07.033 · Cited by 70 · see citing works
Puerarin ameliorates oxidative stress in a rodent model of traumatic brain injury
Wang, J., Wang, H., Cong, Z., Zhou, X., Xu, J., Jia, Y., & Ding, Y. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.08.027 · Cited by 70 · see citing works
Autophagy and Mitophagy Promotion in a Rat Model of Endometriosis
Siracusa, R., D’Amico, R., Impellizzeri, D., Cordaro, M., Peritore, A. F., Gugliandolo, E., Crupi, R., Salinaro, A. T., Raffone, E., Genovese, T., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105074 · Cited by 61 · see citing works
Self-citationFavero, G., Trapletti, V., Bonomini, F., Stacchiotti, A., Lavazza, A., Rodella, L. F., & Rezzani, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071389 · Cited by 60 · see citing works
Management of Acute Lung Injury: Palmitoylethanolamide as a New Approach
Peritore, A. F., D’Amico, R., Siracusa, R., Cordaro, M., Fusco, R., Gugliandolo, E., Genovese, T., Crupi, R., Paola, R. D., Cuzzocrea, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115533 · Cited by 60 · see citing works
Self-citationCrupi, R., Palma, E., Siracusa, R., Fusco, R., Gugliandolo, E., Cordaro, M., Impellizzeri, D., Caro, C. D., Calzetta, L., Cuzzocrea, S., et al. (2020) · Frontiers in Veterinary Science · doi:10.3389/fvets.2020.00136 · Cited by 57 · see citing works
Self-citationCordaro, M., Salinaro, A. T., Siracusa, R., D’Amico, R., Impellizzeri, D., Scuto, M. C., Ontario, M. L., Cuzzocrea, S., Paola, R. D., Fusco, R., et al. (2021) · Antioxidants · doi:10.3390/antiox10111664 · Cited by 55 · see citing works
Self-citationRole of PGC-1α in Mitochondrial Quality Control in Neurodegenerative Diseases
Zhang, Q., Lei, Y.-H., Zhou, J.-P., Hou, Y.-Y., Wan, Z., Wang, H., & Meng, H. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02858-6 · Cited by 52 · see citing works
Serum antioxidants and nitric oxide levels in fibromyalgia: a controlled study
Şendur, Ö. F., Turan, Y., Taştaban, E., Yenisey, Ç., & Serter, M. (2008) · Rheumatology International · doi:10.1007/s00296-008-0738-x · Cited by 51 · see citing works
Favero, G., Bonomini, F., Franco, C., & Rezzani, R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030765 · Cited by 51 · see citing works
D’Amico, R., Fusco, R., Siracusa, R., Impellizzeri, D., Peritore, A. F., Gugliandolo, E., Interdonato, L., Sforza, A. M., Crupi, R., Cuzzocrea, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126471 · Cited by 51 · see citing works
Self-citationChronic pain is common in mitochondrial disease
van den Ameele, J., Fuge, J., Pitceathly, R. D. S., Berry, S., McIntyre, Z., Hanna, M. G., Lee, M., & Chinnery, P. F. (2020) · Neuromuscular Disorders · doi:10.1016/j.nmd.2020.02.017 · Cited by 46 · see citing works
Kim, S. H., Kim, D. H., Oh, D.-H., & Clauw, D. J. (2007) · Clinical Rheumatology · doi:10.1007/s10067-007-0807-7 · Cited by 44 · see citing works
Fusco, R., Cordaro, M., Siracusa, R., Peritore, A. F., D’Amico, R., Licata, P., Crupi, R., & Gugliandolo, E. (2020) · Antioxidants · doi:10.3390/antiox9080693 · Cited by 43 · see citing works
Self-citationPEA/Polydatin: Anti-Inflammatory and Antioxidant Approach to Counteract DNBS-Induced Colitis
Peritore, A. F., D’Amico, R., Cordaro, M., Siracusa, R., Fusco, R., Gugliandolo, E., Genovese, T., Crupi, R., Paola, R. D., Cuzzocrea, S., et al. (2021) · Antioxidants · doi:10.3390/antiox10030464 · Cited by 43 · see citing works
Self-citationPaola, R. D., Fusco, R., Gugliandolo, E., D’Amico, R., Campolo, M., Latteri, S., Carughi, A., Mandalari, G., & Cuzzocrea, S. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00051 · Cited by 43 · see citing works
Self-citationWaseem, M., Tabassum, H., & Parvez, S. (2016) · Mitochondrion · doi:10.1016/j.mito.2016.08.001 · Cited by 42 · see citing works
Ashafaq, M., Tabassum, H., & Parvez, S. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0096-8 · Cited by 40 · see citing works
Cordaro, M., Scuto, M. C., Siracusa, R., D’Amico, R., Peritore, A. F., Gugliandolo, E., Fusco, R., Crupi, R., Impellizzeri, D., Pozzebon, M., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201901584rr · Cited by 39 · see citing works
Self-citationFusco, R., Gugliandolo, E., Campolo, M., Evangelista, M., Paola, R. D., & Cuzzocrea, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178553 · Cited by 34 · see citing works
Self-citationBonaterra, G. A., Then, H., Oezel, L., Schwarzbach, H., Ocker, M., Thieme, K., Fazio, P. D., & Kinscherf, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151116 · Cited by 32 · see citing works
Gugliandolo, E., Fusco, R., Licata, P., Peritore, A. F., D’Amico, R., Cordaro, M., Siracusa, R., Cuzzocrea, S., & Crupi, R. (2020) · Veterinary Sciences · doi:10.3390/vetsci7040161 · Cited by 32 · see citing works
Self-citationImpellizzeri, D., D’Amico, R., Fusco, R., Genovese, T., Peritore, A. F., Gugliandolo, E., Crupi, R., Interdonato, L., Paola, D. D., Paola, R. D., et al. (2022) · Cells · doi:10.3390/cells11162616 · Cited by 31 · see citing works
Self-citationZheng, Y., Chen, Y., Lu, X., Weng, Q., Dai, G., Yu, Y., Yu, K., & Gao, W. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.08.013 · Cited by 30 · see citing works
D’Amico, R., Impellizzeri, D., Genovese, T., Fusco, R., Peritore, A. F., Crupi, R., Interdonato, L., Franco, G. A., Marino, Y., Arangia, A., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02982-5 · Cited by 28 · see citing works
Self-citationWater-Soluble Coenzyme Q10 Reduces Rotenone-Induced Mitochondrial Fission
Li, H., Zimmerman, M. A., Milledge, G. Z., Hou, X., Cheng, J., Wang, Z., & Li, P. A. (2017) · Neurochemical Research · doi:10.1007/s11064-016-2143-2 · Cited by 28 · see citing works
Gomaa, A. A., Farghaly, H. S. M., Elsers, D., Farrag, M. M. Y., & Al-Zokeim, N. I. (2018) · Inflammopharmacology · doi:10.1007/s10787-018-0519-4 · Cited by 27 · see citing works
Siracusa, R., Monaco, F. L., D’Amico, R., Genovese, T., Cordaro, M., Interdonato, L., Gugliandolo, E., Peritore, A. F., Crupi, R., Cuzzocrea, S., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136879 · Cited by 27 · see citing works
Self-citationSalman, M., Kaushik, P., Tabassum, H., & Parvez, S. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00884-5 · Cited by 26 · see citing works
Boswellic acids as natural anticancer medicine: Precious gift to humankind
Sharma, T., & Jana, S. (2019) · Journal of Herbal Medicine · doi:10.1016/j.hermed.2019.100313 · Cited by 25 · see citing works
Sanchez, C., Zappia, J., Lambert, C., Foguenne, J., Dierckxsens, Y., Dubuc, J., Delcoúr, J., Gothot, A., & Henrotin, Y. E. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.931914 · Cited by 24 · see citing works
Clinical and anti-aging effect of mud-bathing therapy for patients with fibromyalgia
Maeda, T., Kudo, Y., Horiuchi, T., & Makino, N. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3233-4 · Cited by 24 · see citing works
Melatonin as a Coadjuvant in the Treatment of Patients with Fibromyalgia
González, D., López‐Pingarrón, L., Castaño, M. Y., Gómez, M. Á., Rodríguez, A. B., García, J. J., & Garrido, M. (2023) · Biomedicines · doi:10.3390/biomedicines11071964 · Cited by 21 · see citing works
Fibromyalgia syndrome: metabolic and autophagic processes in intermittent cold stress mice
Oezel, L., Then, H., Jung, A. L., Jabari, S., Bonaterra, G. A., Wissniowski, T. T., Önel, S., Ocker, M., Thieme, K., Kinscherf, R., et al. (2016) · Pharmacology Research & Perspectives · doi:10.1002/prp2.248 · Cited by 19 · see citing works
D’Amico, R., Impellizzeri, D., Cordaro, M., Siracusa, R., Interdonato, L., Crupi, R., Gugliandolo, E., Macrı̀, F., Paola, D. D., Peritore, A. F., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232315348 · Cited by 19 · see citing works
Self-citationMitochondrial Imbalance as a New Approach to the Study of Fibromyalgia
Martínez‐Lara, A., Moreno‐Fernández, A. M., Guerrero, M. J., Díaz-López, C., de Miguel, M., Cotán, D., & Sánchez-Alcázar, J. A. (2020) · Open Access Rheumatology Research and Reviews · doi:10.2147/oarrr.s257470 · Cited by 18 · see citing works
D’Amico, R., Fusco, R., Cordaro, M., Interdonato, L., Crupi, R., Gugliandolo, E., Paola, D. D., Peritore, A. F., Siracusa, R., Impellizzeri, D., et al. (2022) · Antioxidants · doi:10.3390/antiox11112129 · Cited by 18 · see citing works
Self-citationShadfar, S., Khanal, S., Bohara, G., Kim, G., Sadigh‐Eteghad, S., Ghavami, S., Choi, H., & Choi, D. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02943-y · Cited by 17 · see citing works
Mitchell, R., Campbell, G. R., Mikolajczak, M., McGill, K., Mahad, D., & Fleetwood‐Walker, S. (2019) · Molecular Neurobiology · doi:10.1007/s12035-018-1455-4 · Cited by 15 · see citing works
Fusco, R., Siracusa, R., D’Amico, R., Peritore, A. F., Cordaro, M., Gugliandolo, E., Crupi, R., Impellizzeri, D., Cuzzocrea, S., & Paola, R. D. (2020) · The FASEB Journal · doi:10.1096/fasebj.2020.34.s1.05267 · Cited by 3 · see citing works
Self-citationCa2+ regulation of mitochondrial function in neurons
Satrústegui, J., Rueda, C. B., Llorente‐Folch, I., Amigo, I., Contreras, L., González‐Sánchez, P., Martínez-Valero, P., Juaristi, I., Pardo, B., & del Arc, A. (2014) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2014.05.004 · Cited by 2 · see citing works
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5 of the 112 references couldn’t be matched to a known paper.
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Fibromyalgia: one year in review 2025
Iannuccelli, C., Favretti, M., Dolcini, G., Carlo, M. D., Pellegrino, G., Bazzichi, L. M., Atzeni, F., Lucini, D., Varassi, G., Leoni, M. L. G., et al. (2025) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/buhd2z · Cited by 33 · see citing works
Macchi, C., Giachi, A., Fichtner, I., Pedretti, S., Sarzi‐Puttini, P., Mitro, N., Corsini, A., Ruscica, M., & Gualtierotti, R. (2024) · Scientific Reports · doi:10.1038/s41598-024-81298-x · Cited by 23 · see citing works
Redox reactions in chronic pain: mechanisms and relevance in fibromyalgia
Ho, T., Ryan, M., & Holle, J. (2025) · Frontiers in Pain Research · doi:10.3389/fpain.2025.1593908 · Cited by 22 · see citing works
Guo, X., Liu, H. N., Song, Y., Wang, J., Liu, D., Zheng, Z., Li, J., Li, B., Song, A., He, W., et al. (2026) · MedComm · doi:10.1002/mco2.70497 · Cited by 21 · see citing works
Cambay, V. Y., Hafeez‐Baig, A., Aydemir, E., Tuncer, T., & Doğan, Ş. (2024) · Diagnostics · doi:10.3390/diagnostics14232708 · Cited by 15 · see citing works
Effect of mitochondrial dysfunction on neuropathic pain
Li, Y., Wu, P., & Wen, Q. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118760 · Cited by 14 · see citing works
Piezo 1 and Piezo 2 in the Chemosensory Organs of Zebrafish (Danio rerio)
Aragona, M., Mhalhel, K., Cometa, M., Franco, G. A., Montalbano, G., Guerrera, M. C., Levanti, M. B., Laurà, R., Abbate, F., Vega, J. A., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137404 · Cited by 14 · see citing works
A Comprehensive Analysis of Fibromyalgia and the Role of the Endogenous Opioid System
García‐Domínguez, M. (2025) · Biomedicines · doi:10.3390/biomedicines13010165 · Cited by 13 · see citing works
Mitochondrial dysfunction as a driver of chronic pain: New insights and therapeutic prospects
Fan, Y., Dai, F.-Y., Wang, J., Dai, X.-Y., Song, W., Wu, H., Gao, S., Tao, M., Zhang, L.-Q., Liu, T., et al. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108170 · Cited by 12 · see citing works
Localization of Piezo 1 and Piezo 2 in Lateral Line System and Inner Ear of Zebrafish (Danio rerio)
Aragona, M., Mhalhel, K., Pansera, L., Montalbano, G., Guerrera, M. C., Levanti, M. B., Laurà, R., Abbate, F., Vega, J. A., & Germanà, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179204 · Cited by 12 · see citing works
Goldenberg, D. L. (2025) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2025.2516097 · Cited by 9 · see citing works
Hu, F., Tong, S., & Xu, H. (2025) · The Journal of Membrane Biology · doi:10.1007/s00232-025-00340-9 · Cited by 7 · see citing works
Zhao, F., Zhao, J., Yang, L., Song, C., Cheng, Y., Li, Y., Wu, S., He, B., Jiao, J., & Chang, C. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1535541 · Cited by 7 · see citing works
Fawzy, M. N., Badawi, G. A., & El‐Sayed, R. M. (2026) · Clinical Immunology · doi:10.1016/j.clim.2026.110704 · Cited by 6 · see citing works
Zaky, H. S., El-Said, N. T., Aboutaleb, A. S., Allam, A., Mansour, M., Ahmed, H. I., & Abdel-Sattar, S. A. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04424-9 · Cited by 6 · see citing works
Inferrera, F., Tranchida, N., Fusco, R., Cuzzocrea, S., Impellizzeri, D., Siracusa, R., D’Amico, R., Rashan, L. J., Badaeva, A. V., Danilov, A. B., et al. (2025) · Neurochemistry International · doi:10.1016/j.neuint.2025.106057 · Cited by 5 · see citing works
Self-citationNociplastic pain: the prominent role of non-neuronal cells in central and peripheral sensitization
Lai, W., Tang, X., Chen, S., Zhou, Y., Qi, Z., Cao, M., Yuan, C., Yu, J., & Wen, C. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1677310 · Cited by 4 · see citing works
Belviranlı, M., Okudan, N., & Sezer, T. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05585-y · Cited by 4 · see citing works
Belviranlı, M., Okudan, N., & Sezer, T. (2026) · Life Sciences · doi:10.1016/j.lfs.2026.124366 · Cited by 4 · see citing works
Wang, Q., Zhu, C., Song, Z., Qiao, Y., Hu, Y., Hu, L., Li, S., & Wang, R. (2025) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-025-04956-1 · Cited by 4 · see citing works
D’Elia, M., Marino, C., Celano, R., Napolitano, E., Colarusso, C., Sorrentino, R., D’Ursi, A. M., & Rastrelli, L. (2025) · Antioxidants · doi:10.3390/antiox14060753 · Cited by 3 · see citing works
Ahmed, E. A., Abd-ellatief, R. B., Ali, M. F., & Abd-Eldayem, A. M. (2025) · Brain Research · doi:10.1016/j.brainres.2025.150033 · Cited by 3 · see citing works
Negrini-Ferrari, S. E., Martínez-Martel, I., & Pol, O. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27073051 · Cited by 2 · see citing works
Dai, Z., Wu, Y., Huang, H., & Zheng, H. (2025) · Scientific Reports · doi:10.1038/s41598-025-04379-5 · Cited by 2 · see citing works
Will, M., & Stroman, P. W. (2025) · Brain Sciences · doi:10.3390/brainsci15060603 · Cited by 1 · see citing works
Metabolomics-Based Machine Learning Diagnostics of Post-Acute Sequelae of SARS-CoV-2 Infection
Cai, E., Kouznetsova, V. L., & Tsigelny, I. F. (2025) · Metabolites · doi:10.3390/metabo15120801 · Cited by 1 · see citing works
Li, K., Wang, M., Liu, Y., Lu, R., Zhang, H., Sui, X., Zhang, G., & Li, X. (2026) · Gene · doi:10.1016/j.gene.2026.150023 · Cited by 1 · see citing works
Inferrera, F., Marino, Y., Molinari, F., Tranchida, N., Remigante, A., Morabito, R., Spinelli, S., Marino, A., Cuzzocrea, S., Rashan, L. J., et al. (2025) · eFood · doi:10.1002/efd2.70097
Self-citationKraus, Y. (2026) · Zeitschrift für Komplementärmedizin · doi:10.1055/a-2864-1673
Biomarkers of Oxidative Stress in Fibromyalgia and Their Diagnostic Implications
Miteva-Ilieva, G., Geneva-Popova, M. G., Yanakiev, I., Sokolov, I., Краев, К., Hristeva, V., Dzhambazova, S., & Popova-Belova, S. D. (2026) · Rheumatology (Bulgaria) · doi:10.35465/qtfbjs97
Torres, I. L. S., Paludo, R. H., Laste, G., Fidélis, M. E. S., Moreira, E. R. A. D. S., Steimetz, L. C., Fregni, F., Caumo, W., & Stein, D. J. (2026) · Biomedicines · doi:10.20944/preprints202609.2412.v1
Katz, R. S., Farkash, T., Adler, S., Worden, J., Chavez, D., & Small, B. J. (2026) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000002406
Pınar, A. A., Belviranlı, M., & Okudan, N. (2026) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-026-10139-5
Hasan, S. A., Fathy, N., & Shaheen, A. A. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04906-4
- Authors
- Marino, Y., Inferrera, F., D'Amico, R., Impellizzeri, D., Cordaro, M., Siracusa, R., Gugliandolo, E., Fusco, R., Cuzzocrea, S., & Di Paola, R.
- Affiliations
- University of Messina (IT)
- Corresponding author
- Fusco, Roberta
- ORCID
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2024-10
- Volume
- 1870
- Issue
- 7
- Pages
- 167301
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W4399617808
- Cited by
- 33
- References
- 112
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 4
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- University of Messina
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- fibromyalgia, mitochondrial dysfunction, mitochondrial biogenesis, Boswellia serrata, PGC-1α, neuroinflammation, oxidative stress, astrocyte activation, mitochondrial dynamics, mitochondrial fission, mitochondrial fusion, Drp1, Fis1, mitofusin 2, lipid peroxidation, antioxidant enzymes, chronic pain
- MeSH terms
- Animals, Organelle Biogenesis, Central Nervous System, Disease Models, Animal, Fibromyalgia, Male, Mitochondria, Plant Extracts, Spinal Cord, Rats, Wistar, Oxidative Stress, Rats
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