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Cited by 102Ovarian function and disordersAntioxidant Activity and Oxidative StressDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index, and 1 are not checked yet.

Effect of vitamin E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers and hormonal functions in PCOS (polycystic ovary syndrome): a systematic review and meta‐analysis

Open access
Tefagh, Ghazale, Payab, Moloud, Qorbani, Mostafa, Sharifi, Farshad, Sharifi, Yasaman, Ebrahimnegad Shirvani, Mahbubeh Sadat, Pourghazi, Farzad, Atlasi, Rasha, Shadman, Zhaleh, Rezaei, Nafiseh, Mohammadi-Vajari, Erfan, Larijani, Bagher, Ebrahimpur, Mahbube·2022·Scientific Reports
DOI 10.1038/s41598-022-09082-3PMC PMC8985066
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Abstract

Polycystic ovary syndrome (PCOS) is a common endocrinopathy among reproductive-age women. Various therapeutical approaches are currently used to manage or control symptoms associated with PCOS. This systematic review intended to assess the effects of Vit E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers, and hormonal functions in PCOS women based on the clinical trial's results. The databases including PubMed, Scopus, Cochrane, Web of Science, and Embase were used to find all relevant studies. The authors reviewed all relevant clinical trials via systematic evaluation of abstracts and titles. Searches were conducted on August 1, 2020. After the initial search and reading of the article's title and abstract, 353 articles were reviewed; finally, 12 articles met the inclusion criteria. Vitamin E supplementation improves lipid profile, decreases insulin and HOMA-IR levels. Furthermore, while Vitamin E supplementation decreases LH and testosterone concentrations, it increases FSH and progestrone concentrations. The following meta-analysis showed that vitamin E supplementation made statistically significant improvements in triglyceride (TG) and low-density lipoproteins (LDL) levels, meanwhile, pooled mean difference for waist circumference (WC) and HOMA-IR were also statistically significant. Supplementary regimens containing vitamin E can positively affect metabolic and hormonal parameters in women with PCOS.

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Crossref · 10.1038/s41598-022-09082-3

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Figures

Figure 1 Flow chart for study identification and selection.
Figure 1 Flow chart for study identification and selection.CC BY · PubMed Central
Figure 2 Assessment of the risk of bias in the included studies. Green circle (+): Low risk, Red circle (−): High risk, ?: Unclear.
Figure 2 Assessment of the risk of bias in the included studies. Green circle (+): Low risk, Red circle (−): High risk, ?: Unclear.CC BY · PubMed Central
Figure 3 (A) Vitamin E and BMI. (B) Vitamin E and WC. (C) Vitamin E and weight.
Figure 3 (A) Vitamin E and BMI. (B) Vitamin E and WC. (C) Vitamin E and weight.CC BY · PubMed Central
Figure 4 (A) Vitamin E and total cholesterol. (B). Vitamin E and LDL. (C) Vitamin E and HDL. (D) Vitamin E and triglyceride.
Figure 4 (A) Vitamin E and total cholesterol. (B). Vitamin E and LDL. (C) Vitamin E and HDL. (D) Vitamin E and triglyceride.CC BY · PubMed Central
Figure 5 (A) Vitamin E and estradiol. (B) Vitamin E and testosterone. (C) Vitamin E and SHBG.
Figure 5 (A) Vitamin E and estradiol. (B) Vitamin E and testosterone. (C) Vitamin E and SHBG.CC BY · PubMed Central
Figure 6 (A). Vitamin E and GSH. (B) Vitamin E and TAC. (C) Vitamin E and MDA.
Figure 6 (A). Vitamin E and GSH. (B) Vitamin E and TAC. (C) Vitamin E and MDA.CC BY · PubMed Central
Figure 7 (A) Vitamin E and insulin. (B) Vitamin E and HOMA-IR. (C) Vitamin E and FBS.
Figure 7 (A) Vitamin E and insulin. (B) Vitamin E and HOMA-IR. (C) Vitamin E and FBS.CC BY · PubMed Central

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Citations

Cites

Show all 34 references

Research works printed but not linked: 4

  1. Izadi, A. et al. Hormonal and metabolic effects of coenzyme Q10 and/or vitamin E in patients with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 104(2), 319–327 (2019).
  2. Ebrahimi, F. A. et al. The effects of omega-3 fatty acids and vitamin E co-supplementation on indices of insulin resistance and hormonal parameters in patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Hormone Metab. Res. 125(06), 353–359 (2017).
  3. Shokrpour, M. & Asemi, Z. The effects of magnesium and vitamin E co-supplementation on hormonal status and biomarkers of inflammation and oxidative stress in women with polycystic ovary syndrome. 191(1), 54–60 (2019). · DOI
  4. Rahmani, E. et al. The effects of omega-3 fatty acids and vitamin E co-supplementation on gene expression of lipoprotein (a) and oxidized low-density lipoprotein, lipid profiles and biomarkers of oxidative stress in patients with polycystic ovary syndrome. Mol. Cell. Endocrinol. 439, 247–255 (2017). · DOI

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Metadata

Authors
Tefagh, G., Payab, M., Qorbani, M., Sharifi, F., Sharifi, Y., Ebrahimnegad Shirvani, M. S., Pourghazi, F., Atlasi, R., Shadman, Z., Rezaei, N., Mohammadi-Vajari, E., Larijani, B., & Ebrahimpur, M.
Affiliations
  • Imam Khomeini Hospital (IR)
  • Endocrinology and Metabolism Clinical Sciences Institute (IR)
  • Alborz University of Medical Sciences (IR)
  • Endocrinology and Metabolism Population Sciences Institute (IR)
  • Tehran University of Medical Sciences (IR)
  • Hamedan University of Medical Sciences (IR)
Corresponding author
  • Payab, Moloud
  • Ebrahimpur, Mahbube
ORCID
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2022-04-06
Volume
12
Issue
1
Pages
5770-5770
ISSN
2045-2322 (ISSN-L)
DOI
10.1038/s41598-022-09082-3
PMC
PMC8985066
OpenAlex
W4223554722
Cited by
102
References
34
Citations by year
2026: 7 · 2025: 14 · 2024: 10 · 2023: 65 · 2022: 5
FWCI
3.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Scientific Reports (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Tehran University of Medical Sciences and Health Services
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
vitamin E supplementation, polycystic ovary syndrome, cardiometabolic risk factors, insulin resistance, HOMA-IR, lipid profile, triglycerides, LDL cholesterol, waist circumference, inflammatory markers, oxidative stress, luteinizing hormone, testosterone, follicle-stimulating hormone, progesterone, hormone function
MeSH terms
Cardiometabolic Risk Factors, Female, Humans, Insulin Resistance, Polycystic Ovary Syndrome, Vitamin E, Biomarkers, Oxidative Stress, Dietary Supplements

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