Physician perspectives on integration of artificial intelligence into diagnostic pathology
Open accessAbstract
Advancements in computer vision and artificial intelligence (AI) carry the potential to make significant contributions to health care, particularly in diagnostic specialties such as radiology and pathology. The impact of these technologies on physician stakeholders is the subject of significant speculation. There is however a dearth of information regarding the opinions, enthusiasm, and concerns of the pathology community at large. Here, we report results from a survey of 487 pathologist-respondents practicing in 54 countries, conducted to examine perspectives on AI implementation in clinical practice. Despite limitations, including difficulty with quantifying response bias and verifying identity of respondents to this anonymous and voluntary survey, several interesting findings were uncovered. Overall, respondents carried generally positive attitudes towards AI, with nearly 75% reporting interest or excitement in AI as a diagnostic tool to facilitate improvements in workflow efficiency and quality assurance in pathology. Importantly, even within the more optimistic cohort, a significant number of respondents endorsed concerns about AI, including the potential for job displacement and replacement. Overall, around 80% of respondents predicted the introduction of AI technology in the pathology laboratory within the coming decade. Attempts to identify statistically significant demographic characteristics (e.g., age, sex, type/place of practice) predictive of attitudes towards AI using Kolmogorov–Smirnov (KS) testing revealed several associations. Important themes which were commented on by respondents included the need for increasing efforts towards physician training and resolving medical-legal implications prior to the generalized implementation of AI in pathology.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Previous studies exploring the implementation of these models have focused on surveying clinician perspectives on future rollout.
“Previous studies exploring the implementation of these models have focused on surveying clinician perspectives on future rollout [42,49-51].”
From Integrating a Machine Learning System Into Clinical Workflows: Qualitative Study (2020) · cites this paper as [42]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Dermatologist-level classification of skin cancer with deep neural networks
Esteva, A., Kuprel, B., Novoa, R. A., Ko, J., Swetter, S. M., Blau, H. M., & Thrun, S. (2017) · Nature · doi:10.1038/nature21056 · Cited by 14,362 · see citing works
The Kolmogorov-Smirnov Test for Goodness of Fit
Massey, F. J. (1951) · Journal of the American Statistical Association · doi:10.1080/01621459.1951.10500769 · Cited by 7,210 · see citing works
Lakhani, P., & Sundaram, B. (2017) · Radiology · doi:10.1148/radiol.2017162326 · Cited by 1,775 · see citing works
Image analysis and machine learning in digital pathology: challenges and opportunities
Madabhushi, A., & Lee, G. (2016) · Medical Image Analysis · doi:10.1016/j.media.2016.06.037 · Cited by 1,093 · see citing works
Deep learning as a tool for increased accuracy and efficiency of histopathological diagnosis
Litjens, G., Sánchez, C. I., Timofeeva, N., Hermsen, M., Nagtegaal, I., Kovacs, I., Hulsbergen - van de Kaa, C., Bult, P., van Ginneken, B., & van der Laak, J. (2016) · Scientific Reports · doi:10.1038/srep26286 · Cited by 1,069 · see citing works
Cheng, J.-Z., Ni, D., Chou, Y.-H., Qin, J., Tiu, C.-M., Chang, Y.-C., Huang, C.-S., Shen, D., & Chen, C.-M. (2016) · Scientific Reports · doi:10.1038/srep24454 · Cited by 755 · see citing works
Self-driving cars and the chilling effect of liability law
Schellekens, M. (2015) · Computer Law & Security Review · doi:10.1016/j.clsr.2015.05.012 · Cited by 92 · see citing works
Flagged first, then by citations
Research works printed but not linked: 22
- [1]Kononenko I Machine learning for medical diagnosis: history, state of the art and perspective Artif. Intell. Med 2001 23 89 109 10.1016/S0933-3657(01)00077-X 11470218 · DOI
- [2]Silver D Mastering the game of Go with deep neural networks and tree search Nature 2016 529 484 489 10.1038/nature16961 26819042 · DOI · Paper page
- [3]Silver, D. H. et al. Mastering chess and shogi by self-play with a general reinforcement learning algorithm. arXiv.org arXiv:1712.01815, 1–19 (2017). · arXiv
- [4]Raghu, A. K. et al. Reinforcement learning for sepsis treatment. arXiv.org arXiv:1711.09602 (2017). · arXiv
- [7]Halicek ML Deep convolutional neural networks for classifying head and neck cancer using hyperspectral imaging J. Biomed. Opt. 2017 22 1 4 10.1117/1.JBO.22.6.060503 PMC5482930 28655055 · DOI
- [8]Huynh BL Giger H M. Digital mammographic tumor classification using transfer learning from deep convolutional neural networks J. Med. Imaging 2016 3 1 5 PMC4992049 27610399
- [9]Fujisawa Y Deep learning-based, computer-aided classifier developed with a small dataset of clinical images surpasses board-certified dermatologists in skin tumor diagnosis Br. J. Dermatol 2018 180 373 381 10.1111/bjd.16924 29953582 · DOI
- [11]Gulshan V Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs JAMA 2016 316 2402 2410 10.1001/jama.2016.17216 27898976 · DOI · Paper page
- [12]Bychkov D Deep learning based tissue analysis predicts outcome in colorectal cancer Sci. Rep. 2018 8 3395 10.1038/s41598-018-21758-3 29467373 PMC5821847 · DOI · Paper page
- [13]Veta M Assessment of algorithms for mitosis detection in breast cancer histopathology images Med. Image Anal. 2015 20 237 248 10.1016/j.media.2014.11.010 25547073 · DOI
- [14]Xie QF Deep learning for image analysis: Personalizing medicine closer to the point of care Crit. Rev. Clin. Lab. Sci. 2019 56 61 73 10.1080/10408363.2018.1536111 30628494 · DOI
- [15]Sirinukunwattana K Locality Sensitive Deep Learning for Detection and Classification of Nuclei in Routine Colon Cancer Histology Images IEEE Trans. Med. Imaging 2016 35 1196 1206 10.1109/TMI.2016.2525803 26863654 · DOI · Paper page
- [16]Ciresan DC Giusti A Gambardella LM Schmidhuber J Mitosis detection in breast cancer histology images with deep neural networks Med. Image Comput. Comput. Assist. Inter. 2013 16 411 418 24579167
- [17]Faust KX Visualizing histopathologic deep learning classification and anomaly detection using nonlinear feature space dimensionality reduction BMC Bioinforma. 2018 19 1 15 10.1186/s12859-018-2184-4 PMC5956828 29769044 · DOI
- [18]Robertson S Azizpour H Smith K Hartman J Digital image analysis in breast pathology-from image processing techniques to artificial intelligence Transl. Res. 2018 194 19 35 10.1016/j.trsl.2017.10.010 29175265 · DOI
- [19]Zhou ZH Jiang Y Yang YB Chen SF Lung cancer cell identification based on artificial neural network ensembles Artif. Intell. Med. 2002 24 25 36 10.1016/S0933-3657(01)00094-X 11779683 · DOI
- [20]Wang D Khosla A Gargeya R Irshad H Beck AH Deep learning for identifying metastatic breast cancer arXiv 2016 1606 05718
- [21]Coudray NO Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning Nat. Med. 2018 24 1559 1567 10.1038/s41591-018-0177-5 30224757 PMC9847512 · DOI · Paper page
- [24]Djuric U Zadeh G Aldape K Diamandis P Precision histology: how deep learning is poised to revitalize histomorphology for personalized cancer care npj Precisi. Oncol. 2017 22 1 5 PMC5871847 29872706
- [25]Ching, T. et al. Opportunities and obstacles for deep learning in biology and medicine. J R Soc Interface 15, pii: 20170387 (2018). PMC5938574 29618526
- [27]Griffin J Treanor D Digital pathology in clinical use: where are we now and what is holding us back? Histopathology 2017 70 134 145 10.1111/his.12993 27960232 · DOI
- [29]Kornstein MJ Byrne SP The medicolegal aspect of error in pathology: a search of jury verdicts and settlements Arch. Pathol. Lab Med 2007 131 615 618 17425394
Cited by
Sorted by citations
Artificial intelligence and computational pathology
Cui, M., & Zhang, D. Y. (2021) · Laboratory Investigation · doi:10.1038/s41374-020-00514-0 · Cited by 544 · see citing works
Lambert, S. I., Madi, M., Sopka, S., Lenes, A., Stange, H., Buszello, C.-P., & Stephan, A. (2023) · npj Digital Medicine · doi:10.1038/s41746-023-00852-5 · Cited by 404 · see citing works
Health Care Employees’ Perceptions of the Use of Artificial Intelligence Applications: Survey Study
Abdullah, R., & Fakieh, B. (2020) · Journal of Medical Internet Research · doi:10.2196/17620 · Cited by 286 · see citing works
Chen, M., Zhang, B., Cai, Z., Seery, S., Gonzalez, M. J., Ali, N. M., Ren, R., Qiao, Y., Xue, P., & Jiang, Y. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.990604 · Cited by 258 · see citing works
Wood, E. A., Ange, B. L., & Miller, D. D. (2021) · Journal of Medical Education and Curricular Development · doi:10.1177/23821205211024078 · Cited by 261 · see citing works
Ahmed, Z., Bhinder, K. K., Tariq, A., Tahir, M. J., Mehmood, Q., Tabassum, M. S., Malik, M., Aslam, S., Asghar, M. S., & Yousaf, Z. (2022) · Annals of Medicine & Surgery · doi:10.1016/j.amsu.2022.103493 · Cited by 208 · see citing works
Exploring stakeholder attitudes towards AI in clinical practice
Scott, I. A., Carter, S. M., & Coiera, E. (2021) · BMJ Health & Care Informatics · doi:10.1136/bmjhci-2021-100450 · Cited by 193 · see citing works
Artificial intelligence in oncology: path to implementation
Chua, I. S., Gaziel‐Yablowitz, M., Korach, Z. T., Kehl, K. L., Levitan, N. A., Arriaga, Y. E., Jackson, G. P., Bates, D. W., & Hassett, M. (2021) · Cancer Medicine · doi:10.1002/cam4.3935 · Cited by 179 · see citing works
Integrating a Machine Learning System Into Clinical Workflows: Qualitative Study
Sandhu, S., Lin, A. L., Brajer, N., Sperling, J., Ratliff, W., Bedoya, A. D., Balu, S., O'Brien, C., & Sendak, M. P. (2020) · Journal of Medical Internet Research · doi:10.2196/22421 · Cited by 168 · see citing works
Diverse patients’ attitudes towards Artificial Intelligence (AI) in diagnosis
Robertson, C., Woods, A., Bergstrand, K., Findley, J., Balser, C., & Slepian, M. J. (2023) · PLOS Digital Health · doi:10.1371/journal.pdig.0000237 · Cited by 158 · see citing works
Abràmoff, M. D., Tobey, D., & Char, D. S. (2020) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2020.02.022 · Cited by 140 · see citing works
A healthy debate: Exploring the views of medical doctors on the ethics of artificial intelligence
Martinho, A., Kroesen, M., & Chorus, C. (2021) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2021.102190 · Cited by 124 · see citing works
Ng, F. Y. C., Thirunavukarasu, A. J., Cheng, H., Tan, T. F., Gutierrez, L., Lan, Y., Ong, J. C. L., Chong, Y. S., Ngiam, K. Y., Ho, D., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101230 · Cited by 113 · see citing works
Are physicians and medical students ready for artificial intelligence applications in healthcare?
AlZaabi, A., AlMaskari, S., & AalAbdulsalam, A. (2023) · DIGITAL HEALTH · doi:10.1177/20552076231152167 · Cited by 93 · see citing works
Tran, A. Q., Nguyen, L. H., Nguyen, H. S. A., Nguyen, C. T., Vu, L. G., Zhang, M., Vu, T. M. T., Nguyen, S. H., Tran, B. X., Latkin, C. A., et al. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.755644 · Cited by 87 · see citing works
Botwe, B. O., Antwi, W. K., Arkoh, S., & Akudjedu, T. N. (2021) · Journal of Medical Radiation Sciences · doi:10.1002/jmrs.460 · Cited by 73 · see citing works
Can the administrative loads of physicians be alleviated by AI-facilitated clinical documentation?
Bundy, H., Gerhart, J., Baek, S., Connor, C. D., Isreal, M., Dharod, A., Stephens, C., Liu, T.-L., Hetherington, T., & Cleveland, J. (2024) · Journal of General Internal Medicine · doi:10.1007/s11606-024-08870-z · Cited by 78 · see citing works
Jebreen, K., Radwan, E., Kammoun-Rebai, W., Alattar, E., Radwan, A., Safi, W., Radwan, W., & Alajez, M. (2024) · BMC Medical Education · doi:10.1186/s12909-024-05465-4 · Cited by 63 · see citing works
Al-Medfa, M. K., Al-Ansari, A. M. S., Darwish, A. H., Qreeballa, T. A., & Jahrami, H. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14744 · Cited by 54 · see citing works
Attitudes Toward Artificial Intelligence Within Dermatopathology: An International Online Survey
Polesie, S., McKee, P. H., Gardner, J. M., Gillstedt, M., Siarov, J., Neittaanmäki, N., & Paoli, J. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.591952 · Cited by 53 · see citing works
Laukka, E., Hammarén, M., & Kanste, O. (2022) · Journal of Nursing Management · doi:10.1111/jonm.13769 · Cited by 44 · see citing works
Readiness Towards Artificial Intelligence Among Undergraduate Medical Students in Malaysia
Faculty of Medicine, M. U. C. M., Xuan, P. Y., Fahumida, M. I. F., Faculty of Medicine, M. U. C. M., Al Nazir Hussain, M. I., Faculty of Medicine, M. U. C. M., Jayathilake, N. T., Faculty of Medicine, M. U. C. M., Khobragade, S., Faculty of Medicine, M. U. C. M., et al. (2023) · Education in Medicine Journal · doi:10.21315/eimj2023.15.2.4 · Cited by 41 · see citing works
Sangers, T. E., Wakkee, M., Moolenburgh, F. J., Nijsten, T., & Lugtenberg, M. (2022) · Archives of Dermatological Research · doi:10.1007/s00403-022-02492-3 · Cited by 38 · see citing works
Ahmad, H. A., East, J. E., Panaccione, R., Travis, S., Canavan, J. B., Usiskin, K., & Byrne, M. F. (2023) · Intestinal Research · doi:10.5217/ir.2023.00020 · Cited by 37 · see citing works
Artificial Intelligence in Anesthetic Care: A Survey of Physician Anesthesiologists
Estrada Alamo, C. E., Diatta, F., Monsell, S. E., & Lane-Fall, M. B. (2024) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006752 · Cited by 36 · see citing works
Hesso, I., Kayyali, R., Dolton, D.-R., Joo, K., Zacharias, L., Charalambous, A., Lavdaniti, M., Stalika, E., Ajami, T., Acampa, W., et al. (2023) · Radiation Oncology · doi:10.1186/s13014-023-02351-z · Cited by 33 · see citing works
Ho, S., Doig, G. S., & Ly, A. (2022) · Ophthalmic and Physiological Optics · doi:10.1111/opo.13034 · Cited by 21 · see citing works
Levy, J. J., Davis, M. J., Chacko, R. S., Davis, M. J., Fu, L. J., Goel, T., Pamal, A., Nafi, I., Angirekula, A., Suvarna, A., et al. (2024) · npj Precision Oncology · doi:10.1038/s41698-023-00477-7 · Cited by 20 · see citing works
Evaluation of knowledge and attitudes of radiology department workers about artificial intelligence
Yurdaisik, I., & Aksoy, S. H. (2021) · Annals of Clinical and Analytical Medicine · doi:10.4328/acam.20453 · Cited by 13 · see citing works
“In the same study, only 17.6% of the participants reported that AI may replace themselves [16].”
BackgroundInfluential
- Authors
- Sarwar, S., Dent, A., Faust, K., Richer, M., Djuric, U., Van Ommeren, R., & Diamandis, P.
- Affiliations
- University of Toronto (CA)
- University Health Network (CA)
- Corresponding author
- Diamandis, Phedias
- Venue
- npj Digital Medicine
- Published
- 2019-04-26
- Volume
- 2
- Issue
- 1
- Pages
- 28-28
- ISSN
- 2398-6352 (ISSN-L)
- PMC
- PMC6550202
- OpenAlex
- W2940900531
- Cited by
- 297
- References
- 7
- Citations by year
- 2026: 30 · 2025: 53 · 2024: 57 · 2023: 44 · 2022: 51 · 2021: 34 · 2020: 21 · 2019: 7
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- npj Digital Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- American Society of Clinical Oncology Conquer Cancer Foundation The Brain Tumour Foundation of Canada
- Topics
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
- Physical Sciences › Computer Science › Artificial Intelligence › Artificial Intelligence Applications
- Keywords
- artificial intelligence, diagnostic pathology, clinical implementation of AI, workflow efficiency, quality assurance, physician training, medical-legal implications, computer vision
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review