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Cited by 101Biomedical Text Mining and OntologiesMachine Learning in HealthcareTopic Modeling

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A survey on clinical natural language processing in the United Kingdom from 2007 to 2022

Open access
Wu, Honghan, Wang, Minhong, Wu, Jinge, Francis, Farah, Chang, Yun-Hsuan, Shavick, Alex, Dong, Hang, Poon, Michael T. C., Fitzpatrick, Natalie, Levine, Adam P., Slater, Karin T., Handy, Alex, Karwath, Andreas, Gkoutos, Georgios V., Chelala, Claude, Shah, Anoop Dinesh, Stewart, Robert, Collier, Nigel, Alex, Beatrice, Whiteley, William, Sudlow, Cathie, Roberts, Angus, Dobson, Richard J. B.·2022·npj Digital Medicine
DOI 10.1038/s41746-022-00730-6PMC PMC9770568
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Abstract

Much of the knowledge and information needed for enabling high-quality clinical research is stored in free-text format. Natural language processing (NLP) has been used to extract information from these sources at scale for several decades. This paper aims to present a comprehensive review of clinical NLP for the past 15 years in the UK to identify the community, depict its evolution, analyse methodologies and applications, and identify the main barriers. We collect a dataset of clinical NLP projects ( n = 94; £ = 41.97 m) funded by UK funders or the European Union’s funding programmes. Additionally, we extract details on 9 funders, 137 organisations, 139 persons and 431 research papers. Networks are created from timestamped data interlinking all entities, and network analysis is subsequently applied to generate insights. 431 publications are identified as part of a literature review, of which 107 are eligible for final analysis. Results show, not surprisingly, clinical NLP in the UK has increased substantially in the last 15 years: the total budget in the period of 2019–2022 was 80 times that of 2007–2010. However, the effort is required to deepen areas such as disease (sub-)phenotyping and broaden application domains. There is also a need to improve links between academia and industry and enable deployments in real-world settings for the realisation of clinical NLP’s great potential in care delivery. The major barriers include research and development access to hospital data, lack of capable computational resources in the right places, the scarcity of labelled data and barriers to sharing of pretrained models.

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Fig. 1 The scope of this study is composed of two main parts. a A UK community survey (the lower oval); and b a literature review of the community’s research outputs (the upper oval). *NHS—National Health Service in the UK; RL/ML/LLM—NLP technologies of rule-based, machine learning and large language models.
Fig. 1 The scope of this study is composed of two main parts. a A UK community survey (the lower oval); and b a literature review of the community’s research outputs (the upper oval). *NHS—National Health Service in the UK; RL/ML/LLM—NLP technologies of rule-based, machine learning and large language models.CC BY · PubMed Central
Fig. 2 Snapshots (force-directed visualisations) of the community from 2012 to 2022. The graphs contain four types of entities: projects, persons, organisations and funders. Each graph is constructed using data from projects with a start date earlier than or in the given year. Graph data is cumulative, meaning a later year’s data is a superset of its previous years. The size of organisation nodes indicates the number of total amounts in pound sterling they received in funding.
Fig. 2 Snapshots (force-directed visualisations) of the community from 2012 to 2022. The graphs contain four types of entities: projects, persons, organisations and funders. Each graph is constructed using data from projects with a start date earlier than or in the given year. Graph data is cumulative, meaning a later year’s data is a superset of its previous years. The size of organisation nodes indicates the number of total amounts in pound sterling they received in funding.CC BY · PubMed Central
Fig. 3 Histogram of person nodes Eigenvector centrality scores. The x-axis is the eigenvector centrality score and the y-axis (log scale) is the number of people with certain scores.
Fig. 3 Histogram of person nodes Eigenvector centrality scores. The x-axis is the eigenvector centrality score and the y-axis (log scale) is the number of people with certain scores.CC BY · PubMed Central
Fig. 4 Trends in the last 15 years on budgets of all clinical NLP projects, those involving NHS and those involving industry organisations. Each tick on the x-axis is a 3-year period. The y-axis shows the total budget. The sums of NHS involved and industry involved project budgets are plotted alongside the budget of all projects across five 3-year periods.
Fig. 4 Trends in the last 15 years on budgets of all clinical NLP projects, those involving NHS and those involving industry organisations. Each tick on the x-axis is a 3-year period. The y-axis shows the total budget. The sums of NHS involved and industry involved project budgets are plotted alongside the budget of all projects across five 3-year periods.CC BY · PubMed Central
Fig. 5 The development of studentship projects in clinical NLP from 2016 to 2021. The three figures (from left to right) show the networks of studentship projects and their associated entities (funders, organisations and persons) for 2016, 2017 and 2021 respectively. The 2021 entire network is too big to be shown fully using the same scale. Therefore, a low-resolution overview is shown at the top right and a snapshot of it is displayed using the same scale as other years.
Fig. 5 The development of studentship projects in clinical NLP from 2016 to 2021. The three figures (from left to right) show the networks of studentship projects and their associated entities (funders, organisations and persons) for 2016, 2017 and 2021 respectively. The 2021 entire network is too big to be shown fully using the same scale. Therefore, a low-resolution overview is shown at the top right and a snapshot of it is displayed using the same scale as other years.CC BY · PubMed Central
Fig. 6 NLP tasks versus technical objectives. The x-axis is the categories of NLP tasks and the y-axis is the technical objectives. The size of the circles denotes the number of publications.
Fig. 6 NLP tasks versus technical objectives. The x-axis is the categories of NLP tasks and the y-axis is the technical objectives. The size of the circles denotes the number of publications.CC BY · PubMed Central
Fig. 7 NLP algorithm type breakdown and their development trends over the last 15 years. The main bar chart shows the changes of different NLP algorithms in the last 15 years. The pie chart at the top left corner depicts the overall breakdown of algorithms of all research work analysed.
Fig. 7 NLP algorithm type breakdown and their development trends over the last 15 years. The main bar chart shows the changes of different NLP algorithms in the last 15 years. The pie chart at the top left corner depicts the overall breakdown of algorithms of all research work analysed.CC BY · PubMed Central
Fig. 8 Knowledge representation and distributed representations. The pie chart at the left shows the breakdown of representation techniques. For ontologies, the bar chart on the right depicts the top five frequently used ontologies in clinical NLP applications.
Fig. 8 Knowledge representation and distributed representations. The pie chart at the left shows the breakdown of representation techniques. For ontologies, the bar chart on the right depicts the top five frequently used ontologies in clinical NLP applications.CC BY · PubMed Central
Fig. 9 Information collection and data extraction. Step 1: Data were collected for funded clinical NLP projects by querying three searchable datasets from UK and EU funding bodies and downloading project data from UK charities such as British Heart Foundation and Cancer Research UK. Step 2: Data were extracted to obtain metadata of projects and their associated entities.
Fig. 9 Information collection and data extraction. Step 1: Data were collected for funded clinical NLP projects by querying three searchable datasets from UK and EU funding bodies and downloading project data from UK charities such as British Heart Foundation and Cancer Research UK. Step 2: Data were extracted to obtain metadata of projects and their associated entities.CC BY · PubMed Central
Fig. 10 Flow chart describing publication identification for clinical NLP literature review. We started with 431 extracted publications, out of which 361 have sufficient information suitable for screening. The title/abstract screen further removed 202 papers which were deemed irrelevant. This left us 159 publications for an eligibility assessment using inclusion/exclusion criteria on their full text. After this final check step, 107 publications were included for the final review.
Fig. 10 Flow chart describing publication identification for clinical NLP literature review. We started with 431 extracted publications, out of which 361 have sufficient information suitable for screening. The title/abstract screen further removed 202 papers which were deemed irrelevant. This left us 159 publications for an eligibility assessment using inclusion/exclusion criteria on their full text. After this final check step, 107 publications were included for the final review.CC BY · PubMed Central

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Citations

Cites

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Authors
Wu, H., Wang, M., Wu, J., Francis, F., Chang, Y.-H., Shavick, A., Dong, H., Poon, M. T. C., Fitzpatrick, N., Levine, A. P., Slater, K. T., Handy, A., Karwath, A., Gkoutos, G. V., Chelala, C., Shah, A. D., Stewart, R., Collier, N., Alex, B., Whiteley, W., Sudlow, C., Roberts, A., & Dobson, R. J. B.
Affiliations
  • University College London (GB)
  • University of Edinburgh (GB)
  • University of Oxford (GB)
  • University of Birmingham (GB)
  • Queen Mary University of London (GB)
  • King's College London (GB)
  • University of Cambridge (GB)
Corresponding author
Wu, Honghan
ORCID
Venue
npj Digital Medicine
Publisher
Springer Science and Business Media LLC
Published
2022-12-21
Volume
5
Issue
1
Pages
186-186
ISSN
2398-6352 (ISSN-L)
DOI
10.1038/s41746-022-00730-6
PMC
PMC9770568
OpenAlex
W4312113143
Cited by
101
References
157
Citations by year
2026: 29 · 2025: 40 · 2024: 18 · 2023: 13 · 2022: 1
FWCI
1.87
Type
journal article
Language
en
Open access
Licence
Locations
  • npj Digital Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion, cc-by-sa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • UCL Discovery (University College London) (submittedVersion)
  • University of Birmingham Research Portal (University of Birmingham) (submittedVersion, cc-by)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
  • Apollo
  • Apollo (cc-by)
Funders
  • DH | National Institute for Health Research (NIHR202639)
  • British Council (UCL-NMU-SEU International Collaboration)
  • University of Edinburgh (The Advanced Care Research Centre Programme)
  • RCUK | Medical Research Council (MR/W014386, National Text Analytics Project)
Topics
  • Health Sciences › Medicine › Health Informatics › Biomedical Text Mining and Ontologies
  • Physical Sciences › Computer Science › Artificial Intelligence › Machine Learning in Healthcare
  • Physical Sciences › Computer Science › Artificial Intelligence › Topic Modeling
Keywords
clinical natural language processing, clinical research funding, research funding trends, disease phenotyping, clinical text mining, research collaboration networks, academia-industry collaboration, United Kingdom

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