The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics
Open accessAbstract
The practical application of nanoparticles (NPs) as chemotherapeutic drug delivery systems is often hampered by issues such as poor circulation stability and targeting inefficiency. Here, we have utilized a simple approach to prepare biocompatible and biodegradable pH-responsive hybrid NPs that overcome these issues. The NPs consist of a drug-loaded polylactic-co-glycolic acid (PLGA) core covalently ‘wrapped’ with a crosslinked bovine serum albumin (BSA) shell designed to minimize interactions with serum proteins and macrophages that inhibit target recognition. The shell is functionalized with the acidity-triggered rational membrane (ATRAM) peptide to facilitate internalization specifically into cancer cells within the acidic tumor microenvironment. Following uptake, the unique intracellular conditions of cancer cells degrade the NPs, thereby releasing the chemotherapeutic cargo. The drug-loaded NPs showed potent anticancer activity in vitro and in vivo while exhibiting no toxicity to healthy tissue. Our results demonstrate that the ATRAM-BSA-PLGA NPs are a promising targeted cancer drug delivery platform.
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Recent Applications of PLGA in Drug Delivery Systems
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Metadata
- Authors
- Palanikumar, L., Al-Hosani, S., Kalmouni, M., Nguyen, V. P., Ali, L., Pasricha, R., Barrera, F. N., & Magzoub, M.
- Venue
- Communications Biology
- Published
- 2020-03-03
- Volume
- 3
- Issue
- 1
- Pages
- 95-95
- ISSN
- 2399-3642 (ISSN-L)
- OpenAlex
- W3009701618
- Cited by
- 360
- References
- 17
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- gold
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- Palanikumar, L., Al-Hosani, S., Kalmouni, M., Nguyen, V. P., Ali, L., Pasricha, R., Barrera, F. N., & Magzoub, M. (2020). pH-responsive high stability polymeric nanoparticles for targeted delivery of anticancer therapeutics. Communications Biology. https://doi.org/10.1038/s42003-020-0817-4
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