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Cited by 268Advanced Drug Delivery SystemsNanoparticle-Based Drug Deliverybiodegradable polymer synthesis and properties

Recent Applications of PLGA in Drug Delivery Systems

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Yang, Jie, Zeng, Huiying, Luo, Yusheng, Chen, Ying, Wang, Miao, Wu, Chuanbin, Hu, Ping·2024·Polymers
DOI 10.3390/polym16182606PMC PMC11435547
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Abstract

Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable and biocompatible copolymer in drug delivery systems (DDSs). In this article, we highlight the critical physicochemical properties of PLGA, including its molecular weight, intrinsic viscosity, monomer ratio, blockiness, and end caps, that significantly influence drug release profiles and degradation times. This review also covers the extensive literature on the application of PLGA in delivering small-molecule drugs, proteins, peptides, antibiotics, and antiviral drugs. Furthermore, we discuss the role of PLGA-based DDSs in the treating various diseases, including cancer, neurological disorders, pain, and inflammation. The incorporation of drugs into PLGA nanoparticles and microspheres has been shown to enhance their therapeutic efficacy, reduce toxicity, and improve patient compliance. Overall, PLGA-based DDSs holds great promise for the advancement of the treatment and management of multiple chronic conditions.

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  • PLGA's acidic degradation byproducts, particularly with higher glycolic acid content, can lead to localized pH drops, potentially triggering inflammatory responses and affecting tissue healing.

    “Another limitation of PLGA is its acidic degradation byproducts, particularly in formulations with higher glycolic acid content, which can lead to localized pH drops, potentially triggering inflammatory responses and affecting tissue healing [235].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [235]

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Cited by

Sorted by citations

Authors
Yang, J., Zeng, H., Luo, Y., Chen, Y., Wang, M., Wu, C., & Hu, P.
Affiliations
  • Jinan University (CN)
  • National Medical Products Administration (CN)
Corresponding author
Hu, Ping
ORCID
Venue
Polymers
Publisher
MDPI AG
Published
2024-09-14
Volume
16
Issue
18
Pages
2606
ISSN
2073-4360 (ISSN-L)
DOI
10.3390/polym16182606
PMC
PMC11435547
OpenAlex
W4402804059
Cited by
268
References
4
Citations by year
2026: 162 · 2025: 102 · 2024: 4
FWCI
9.45
Type
journal article
Language
en
Open access
Licence
Locations
  • Polymers (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Natural Science Foundation of China (82071367, 2021A1515220047, 2023A1515011135)
  • Natural Science Foundation of Guangdong Province of China (82071367, 2021A1515220047, 2023A1515011135)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
Keywords
poly(lactic-co-glycolic acid), PLGA, biodegradable polymers, drug delivery systems, PLGA nanoparticles, PLGA microspheres, drug release profile, polymer degradation, molecular weight, monomer ratio, end caps, protein and peptide delivery, small molecule drugs, antibiotics, antiviral agents, cancer therapy, neurological disorders, pain management, inflammation

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