Sexual excitation induces courtship ultrasonic vocalizations and cataplexy-like behavior in orexin neuron-ablated male mice
Open accessAbstract
Cataplexy is triggered by laughter in humans and palatable food in mice. To further evaluate mice's cataplexy, we examined courtship behavior in orexin neuron-ablated mice (ORX-AB), one of the animal models of narcolepsy/cataplexy. Wild-type female mice were placed into the home cage of male ORX-AB and cataplexy-like behavior was observed along with ultrasonic vocalizations (USVs), also known as the "love song". ORX-AB with a female encounter showed cataplexy-like behavior both during the dark and light periods, whereas ORX-AB with chocolate predominantly showed it during the dark period. During the light period observation, more than 85% of cataplexy-like bouts were preceded by USVs. A strong positive correlation was observed between the number of USVs and cataplexy-like bouts. Cataplexy-like behavior in narcoleptic mice is a good behavioral measure to study the brain mechanisms behind positive emotion because they can be induced by different kinds of positive stimuli, including chocolate and female courtship.
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Exposure to the playful environment increased both the number and frequency of ultrasonic vocalizations in mice.
“the number and frequency of ultrasonic vocalizations, which appear to be powerful measurements of a positive affective state in rodents [36–38], were both increased by the exposure to the playful environment.”
From Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system (2026) · cites this paper as [37]
The Results (no page available) report more USV calls during female than male encounters, but say the average call frequency did not differ. The study examined social encounters in orexin neuron-ablated male mice, not exposure to a playful environment. Its Introduction does support the narrower point for which the citation appears immediately after the text: courtship USVs can measure positive excitation. (LLM, conf=0.87)
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- Authors
- Kuwaki, T., & Kanno, K.
- Affiliations
- Kagoshima University (JP)
- Corresponding author
- Kuwaki, Tomoyuki
- Venue
- Communications Biology
- Published
- 2021-02-05
- Volume
- 4
- Issue
- 1
- Pages
- 165-165
- ISSN
- 2399-3642 (ISSN-L)
- PMC
- PMC7864915
- OpenAlex
- W3128845844
- Cited by
- 13
- References
- 33
- Citations by year
- 2026: 3 · 2024: 3 · 2023: 2 · 2022: 5
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Communications Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Kagoshima University Repository (submittedVersion, cc-by-nc-nd)
- Funders
- MEXT | Japan Society for the Promotion of Science (16H05130, 16K13112, 18K13371, 19H04912)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- cataplexy, narcolepsy, ultrasonic vocalizations, courtship behavior, sexual excitation, chocolate, positive emotions, male mice, love songs
- MeSH terms
- Orexins, Sexual Arousal, Animals, Behavior, Animal, Cataplexy, Courtship, Male, Mice, Transgenic, Narcolepsy, Neurons, Vocalization, Animal, Genes, Transgenic, Suicide, Mice
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