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Novel microglial transcriptional signatures promote social and cognitive deficits following repeated social defeat

Goodman, Ethan J., DiSabato, Damon J., Sheridan, John F., Godbout, Jonathan P.·2024·Communications Biology
DOI 10.1038/s42003-024-06898-9PMC PMC11438916
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  1. Miller, G. E. et al. Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers. Brain Behav. Immun. 41, 191–199 (2014). · DOI · Paper page
  2. Weber, M. D. et al. The influence of microglial elimination and repopulation on stress sensitization induced by repeated social defeat. Biol. Psychiatry 85, 667–678 (2019). · DOI
  3. McKim, D. B. et al. Social stress mobilizes hematopoietic stem cells to establish persistent splenic myelopoiesis. Cell Rep. 25, 2552–2562.e3 (2018). · DOI · Paper page
  4. Biltz, R. G., Sawicki, C. M., Sheridan, J. F. & Godbout, J. P. The neuroimmunology of social-stress-induced sensitization. Nat. Immunol. 23, 1527–1535 (2022). · DOI · Paper page
  5. McKim, D. B. et al. Microglial recruitment of IL-1β-producing monocytes to brain endothelium causes stress-induced anxiety. Mol. Psychiatry 23, 1421–1431 (2018). · DOI · Paper page
  6. Biltz, R. G. et al. Antagonism of the brain P2X7 ion channel attenuates repeated social defeat induced microglia reactivity, monocyte recruitment and anxiety-like behavior in male mice. Brain Behav. Immun. 115, 356–373 (2024). · DOI
  7. Yin, W. et al. Unique brain endothelial profiles activated by social stress promote cell adhesion, prostaglandin E2 signaling, hypothalamic–pituitary–adrenal axis modulation, and anxiety. Neuropsychopharmacology 47, 2271–2282 (2022). · DOI
  8. Wohleb, E. S. et al. Re-establishment of anxiety in stress-sensitized mice is caused by monocyte trafficking from the spleen to the brain. Biol. Psychiatry 75, 970–981 (2014). · DOI · Paper page
  9. DiSabato, D. J. et al. IL-1 receptor-1 on Vglut2+ neurons in the hippocampus is critical for neuronal and behavioral sensitization after repeated social stress. Brain Behav. Immun. Health 26, 100547 (2022). · DOI
  10. Weber, M. D. et al. The influence of microglial elimination and repopulation on stress sensitization induced by repeated social defeat. Biol. Psychiatry 85, 667–678 (2019). · DOI
  11. Baharikhoob, P. & Kolla, N. J. Microglial dysregulation and suicidality: a stress-diathesis perspective. Front. Psychiatry 11, 781 (2020). · DOI
  12. DiSabato, D. J. et al. Interleukin-1 receptor on hippocampal neurons drives social withdrawal and cognitive deficits after chronic social stress. Mol. Psychiatry 26, 4770–4782 (2021). · DOI
  13. Goodman, E. J. et al. Enhanced fear memory after social defeat in mice is dependent on interleukin-1 receptor signaling in glutamatergic neurons. Mol. Psychiatry https://doi.org/10.1038/s41380-024-02456-1 (2024). · DOI
  14. O’Neil, S. M., Hans, E. E., Jiang, S., Wangler, L. M. & Godbout, J. P. Astrocyte immunosenescence and deficits in interleukin 10 signaling in the aged brain disrupt the regulation of microglia following innate immune activation. Glia 70, 913–934 (2022). · DOI
  15. Witcher, K. G. et al. Traumatic brain injury causes chronic cortical inflammation and neuronal dysfunction mediated by microglia. J. Neurosci. 41, 1597–1616 (2021). · DOI · Paper page
  16. Kulkarni, A., Anderson, A. G., Merullo, D. P. & Konopka, G. Beyond bulk: a review of single cell transcriptomics methodologies and applications. Curr. Opin. Biotechnol. 58, 129–136 (2019). · DOI
  17. Bray, C. E. et al. Chronic cortical inflammation, cognitive impairment, and immune reactivity associated with diffuse brain injury are ameliorated by forced turnover of microglia. J. Neurosci. 42, 4215–4228 (2022). · DOI
  18. Pettas, S. et al. Profiling microglia through single-cell RNA sequencing over the course of development, aging, and disease. Cells 11, 2383 (2022). · DOI
  19. Wohleb, E. S., Powell, N. D., Godbout, J. P. & Sheridan, J. F. Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior. J. Neurosci. 33, 13820–13833 (2013). · DOI · Paper page
  20. Heithoff, B. P. et al. Astrocytes are necessary for blood–brain barrier maintenance in the adult mouse brain. Glia 69, 436–472 (2021). · DOI
  21. Luarte, A. et al. Astrocyte-derived extracellular vesicles in stress-associated mood disorders. Does the immune system get astrocytic? Pharmacol. Res. 194, 106833 (2023). · DOI
  22. Gross, I. et al. Sprouty2 inhibits BDNF-induced signaling and modulates neuronal differentiation and survival. Cell Death Differ. 14, 1802–1812 (2007). · DOI
  23. Zhang, Y. et al. Overexpression of long noncoding RNA Malat1 ameliorates traumatic brain injury induced brain edema by inhibiting AQP4 and the NF‐κB/IL‐6 pathway. J. Cell. Biochem. 120, 17584–17592 (2019). · DOI
  24. Steiner, B. et al. Differential regulation of gliogenesis in the context of adult hippocampal neurogenesis in mice. Glia 46, 41–52 (2004). · DOI
  25. Liu, J., Wu, X. & Lu, Q. Molecular divergence of mammalian astrocyte progenitor cells at early gliogenesis. Development 149, dev199985 (2022). · DOI
  26. Ramirez, K., Niraula, A. & Sheridan, J. F. GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations. Brain Behav. Immun. 51, 154–168 (2016). · DOI · Paper page
  27. Rosenberg, A. B. et al. Single-cell profiling of the developing mouse brain and spinal cord with split-pool barcoding. Science 360, 176–182 (2018). · DOI · Paper page
  28. Packer, J. M. et al. Impaired cortical neuronal homeostasis and cognition after diffuse traumatic brain injury are dependent on microglia and type I interferon responses. Glia 72, 300–321 (2024). · DOI
  29. Zhong, S. et al. Single-nucleus RNA sequencing reveals transcriptional changes of hippocampal neurons in APP23 mouse model of Alzheimer’s disease. Biosci. Biotechnol. Biochem. 84, 919–926 (2020). · DOI
  30. Niraula, A., Witcher, K. G., Sheridan, J. F. & Godbout, J. P. Interleukin-6 induced by social stress promotes a unique transcriptional signature in the monocytes that facilitate anxiety. Biol. Psychiatry 85, 679–689 (2019). · DOI · Paper page
  31. Lin, H.-Y. et al. Chemokine receptor 5 signaling in PFC mediates stress susceptibility in female mice. Preprint at bioRxiv https://doi.org/10.1101/2023.08.18.553789 (2023). · DOI
  32. Baron, C. S. et al. Cell type purification by single-cell transcriptome-trained sorting. Cell 179, 527–542.e519 (2019). · DOI
  33. Ishikawa, Y. et al. Repeated social defeat stress induces neutrophil mobilization in mice: maintenance after cessation of stress and strain‐dependent difference in response. Br. J. Pharmacol. 178, 827–844 (2021). · DOI
  34. Pflieger, F. J. et al. The role of neutrophil granulocytes in immune-to-brain communication. Temperature 5, 296–307 (2018). · DOI
  35. Vichaya, E. G. et al. Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats. J. Neuroinflammation 17, 1–14 (2020). · DOI
  36. Bosch, A. J. et al. CSF1R inhibition with PLX5622 affects multiple immune cell compartments and induces tissue-specific metabolic effects in lean mice. Diabetologia 66, 2292–2306 (2023). · DOI
  37. Green, K. N. & Hume, D. A. On the utility of CSF1R inhibitors. Proc. Natl Acad. Sci. USA 118, e2019695118 (2021). · DOI
  38. Tang, J., Yu, W., Chen, S., Gao, Z. & Xiao, B. Microglia polarization and endoplasmic reticulum stress in chronic social defeat stress induced depression mouse. Neurochem. Res. 43, 985–994 (2018). · DOI
  39. Bond, S., Lopez-Lloreda, C., Gannon, P. J., Akay-Espinoza, C. & Jordan-Sciutto, K. L. The integrated stress response and phosphorylated eukaryotic initiation factor 2α in neurodegeneration. J. Neuropathol. Exp. Neurol. 79, 123–143 (2020). · DOI
  40. Song, X. et al. Fcγ receptor I-and III-mediated macrophage inflammatory protein 1α induction in primary human and murine microglia. Infect. Immun. 70, 5177–5184 (2002). · DOI
  41. Cao, S., Standaert, D. G. & Harms, A. S. The gamma chain subunit of Fc receptors is required for alpha-synuclein-induced pro-inflammatory signaling in microglia. J. Neuroinflammation 9, 1–11 (2012). · DOI
  42. Milior, G. et al. Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress. Brain Behav. Immun. 55, 114–125 (2016). · DOI
  43. Bollinger, J. L. et al. Microglial P2Y12 mediates chronic stress-induced synapse loss in the prefrontal cortex and associated behavioral consequences. Neuropsychopharmacology 48, 1347–1357 (2023). · DOI
  44. Liang, T. et al. Galectin-9 promotes neuronal restoration via binding TLR-4 in a rat intracerebral hemorrhage model. Neuromolecular Med. 23, 267–284 (2021). · DOI
  45. Liu, J., Huang, S. & Lu, F. Galectin-3 and Galectin-9 may differently regulate the expressions of microglial M1/M2 markers and T helper 1/Th2 cytokines in the brains of genetically susceptible C57BL/6 and resistant BALB/c mice following peroral infection with Toxoplasma gondii. Front. Immunol. 9, 1648 (2018). · DOI
  46. Xia, C., Braunstein, Z., Toomey, A. C., Zhong, J. & Rao, X. S100 proteins as an important regulator of macrophage inflammation. Front. Immunol. 8, 1908 (2018). · DOI
  47. Gong, H. et al. Hippocampal Mrp8/14 signaling plays a critical role in the manifestation of depressive-like behaviors in mice. J. Neuroinflammation 15, 1–13 (2018). · DOI
  48. Schramm, E. & Waisman, A. Microglia as central protagonists in the chronic stress response. Neurol. Neuroimmunol. Neuroinflamm. 9, e200023 (2022). · DOI
  49. van den Brink, S. C. et al. Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations. Nat. Methods 14, 935–936 (2017). · DOI · Paper page
  50. Wahis, J. et al. Astrocytes mediate the effect of oxytocin in the central amygdala on neuronal activity and affective states in rodents. Nat. Neurosci. 24, 529–541 (2021). · DOI
  51. Lin, Y.-T. & Hsu, K.-S. Oxytocin receptor signaling in the hippocampus: role in regulating neuronal excitability, network oscillatory activity, synaptic plasticity and social memory. Prog. Neurobiol. 171, 1–14 (2018). · DOI
  52. Jin, Y., Song, D., Yan, Y., Quan, Z. & Qing, H. The role of oxytocin in early-life-stress-related neuropsychiatric disorders. Int. J. Mol. Sci. 24, 10430 (2023). · DOI
  53. Matusova, Z., Hol, E. M., Pekny, M., Kubista, M. & Valihrach, L. Reactive astrogliosis in the era of single-cell transcriptomics. Front. Cell. Neurosci. 17, 1173200 (2023). · DOI
  54. Joëls, M. & Krugers, H. J. LTP after stress: up or down? Neural Plasticity 2007, 93202 (2007). · DOI
  55. Ainge, J. A., Tamosiunaite, M., Woergoetter, F. & Dudchenko, P. A. Hippocampal CA1 place cells encode intended destination on a maze with multiple choice points. J. Neurosci. 27, 9769–9779 (2007). · DOI
  56. Kallarackal, A. J. et al. Chronic stress induces a selective decrease in AMPA receptor-mediated synaptic excitation at hippocampal temporoammonic-CA1 synapses. J. Neurosci. 33, 15669–15674 (2013). · DOI · Paper page
  57. Yu, J.-Y. et al. Dorsal CA1 interneurons contribute to acute stress-induced spatial memory deficits. Neuropharmacology 135, 474–486 (2018). · DOI
  58. Yin, W. et al. Repeated social defeat in female mice induces anxiety-like behavior associated with enhanced myelopoiesis and increased monocyte accumulation in the brain. Brain Behav. Immun. 78, 131–142 (2019). · DOI
  59. Dion-Albert, L. et al. Vascular and blood-brain barrier-related changes underlie stress responses and resilience in female mice and depression in human tissue. Nat. Commun. 13, 164 (2022). · DOI
  60. Takahashi, A. et al. Establishment of a repeated social defeat stress model in female mice. Sci. Rep. 7, 12838 (2017). · DOI · Paper page
  61. Govek, K. W. et al. CAJAL enables analysis and integration of single-cell morphological data using metric geometry. Nat. Commun. 14, 3672 (2023). · DOI
  62. Butler, A., Hoffman, P., Smibert, P., Papalexi, E. & Satija, R. Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat. Biotechnol. 36, 411–420 (2018). · DOI · Paper page
  63. O’Neil, S. M., Witcher, K. G., McKim, D. B. & Godbout, J. P. Forced turnover of aged microglia induces an intermediate phenotype but does not rebalance CNS environmental cues driving priming to immune challenge. Acta Neuropathol. Commun. 6, 129 (2018). · DOI
  64. Hao, Y. et al. Integrated analysis of multimodal single-cell data. Cell 184, 3573–3587.e3529 (2021). · DOI · Paper page
  65. Kalinina, A. & Lagace, D. Single-cell and single-nucleus RNAseq analysis of adult neurogenesis. Cells 11, 1633 (2022). · DOI
  66. Finak, G. et al. MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data. Genome Biol. 16, 1–13 (2015). · DOI · Paper page
  67. Kramer, A., Green, J., Pollard, J. Jr. & Tugendreich, S. Causal analysis approaches in Ingenuity Pathway Analysis. Bioinformatics 30, 523–530 (2014). · DOI · Paper page
  68. Zhou, Y. et al. Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nat. Commun. 10, 1523 (2019). · DOI · Paper page

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Metadata

Authors
Goodman, E. J., DiSabato, D. J., Sheridan, J. F., & Godbout, J. P.
ORCID
Venue
Communications Biology
Publisher
Springer Science and Business Media LLC
Published
2024-09-28
Volume
7
Issue
1
ISSN
2399-3642
DOI
10.1038/s42003-024-06898-9
PMC
PMC11438916
Cited by
19
References
17
Language
en
Licence
Funders
U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (R01-MH-119670, R01-MH-116670)

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