Cited by 602Gut microbiota and healthAdipokines, Inflammation, and Metabolic DiseasesAnimal Nutrition and Physiology

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Microbial regulation of organismal energy homeostasis

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Cani, Patrice D., Van Hul, Matthias, Lefort, Charlotte, Depommier, Clara, Rastelli, Marialetizia, Everard, Amandine·2019·Nature Metabolism

DOI 10.1038/s42255-018-0017-4

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Abstract

The gut microbiome has emerged as a key regulator of host metabolism. Here we review the various mechanisms through which the gut microbiome influences the energy metabolism of its host, highlighting the complex interactions between gut microbes, their metabolites and host cells. Among the most important bacterial metabolites are short-chain fatty acids, which serve as a direct energy source for host cells, stimulate the production of gut hormones and act in the brain to regulate food intake. Other microbial metabolites affect systemic energy expenditure by influencing thermogenesis and adipose tissue browning. Both direct and indirect mechanisms of action are known for specific metabolites, such as bile acids, branched chain amino acids, indole propionic acid and endocannabinoids. We also discuss the roles of specific bacteria in the production of specific metabolites and explore how external factors, such as antibiotics and exercise, affect the microbiome and thereby energy homeostasis. Collectively, we present a large body of evidence supporting the concept that gut microbiota-based therapies can be used to modulate host metabolism, and we expect to see such approaches moving from bench to bedside in the near future.

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Additional file 1 of The gut microbiome modifies the associations of short- and long-term physical activity with body weight changes
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Additional file 4 of Microbial composition differs between production systems and is associated with growth performance and carcass quality in pigs
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Additional file 2 of Obese-associated gut microbes and derived phenolic metabolite as mediators of excessive motivation for food reward
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Additional file 7 of Obese-associated gut microbes and derived phenolic metabolite as mediators of excessive motivation for food reward
d’Oplinter, A. D. W., Verce, M., Huwart, S. J. P., Lessard‐Lord, J., Depommier, C., Hul, M. V., Desjardins, Y., Cani, P. D., & Everard, A. (2024) · Figshare · doi:10.6084/m9.figshare.26585550
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Additional file 12 of Circadian dynamics of the teleost skin immune-microbiome interface
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Additional file 3 of Obese-associated gut microbes and derived phenolic metabolite as mediators of excessive motivation for food reward
d’Oplinter, A. D. W., Verce, M., Huwart, S. J. P., Lessard‐Lord, J., Depommier, C., Hul, M. V., Desjardins, Y., Cani, P. D., & Everard, A. (2024) · Figshare · doi:10.6084/m9.figshare.26585538
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Additional file 15 of Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
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Additional file 5 of Obese-associated gut microbes and derived phenolic metabolite as mediators of excessive motivation for food reward
d’Oplinter, A. D. W., Verce, M., Huwart, S. J. P., Lessard‐Lord, J., Depommier, C., Hul, M. V., Desjardins, Y., Cani, P. D., & Everard, A. (2024) · Figshare · doi:10.6084/m9.figshare.26585544
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Additional file 2 of Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
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Additional file 8 of Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
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Additional file 3 of Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
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Additional file 6 of Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
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Additional file 11 of Circadian dynamics of the teleost skin immune-microbiome interface
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Additional file 3 of Circadian dynamics of the teleost skin immune-microbiome interface
Ellison, A. R., Wilcockson, D. C., & Cable, J. (2021) · Figshare · doi:10.6084/m9.figshare.17020833
Additional file 12 of Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
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Additional file 10 of Circadian dynamics of the teleost skin immune-microbiome interface
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Additional file 4 of Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
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Additional file 13 of Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
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Additional file 1 of Obese-associated gut microbes and derived phenolic metabolite as mediators of excessive motivation for food reward
d’Oplinter, A. D. W., Verce, M., Huwart, S. J. P., Lessard‐Lord, J., Depommier, C., Hul, M. V., Desjardins, Y., Cani, P. D., & Everard, A. (2024) · Figshare · doi:10.6084/m9.figshare.26585532
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Additional file 1 of Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
Qiu, H., Kan, C., Han, F., Luo, Y., Qu, N., Zhang, K., Ma, Y., Hou, N., Wu, D., Sun, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26143644
Additional file 5 of Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
Qiu, H., Kan, C., Han, F., Luo, Y., Qu, N., Zhang, K., Ma, Y., Hou, N., Wu, D., Sun, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26741207
Additional file 14 of Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
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Additional file 4 of Obese-associated gut microbes and derived phenolic metabolite as mediators of excessive motivation for food reward
d’Oplinter, A. D. W., Verce, M., Huwart, S. J. P., Lessard‐Lord, J., Depommier, C., Hul, M. V., Desjardins, Y., Cani, P. D., & Everard, A. (2024) · Figshare · doi:10.6084/m9.figshare.26585541
Self-citation
Additional file 2 of Novel insights into the genetically obese (ob/ob) and diabetic (db/db) mice: two sides of the same coin
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Self-citation
Additional file 6 of Obese-associated gut microbes and derived phenolic metabolite as mediators of excessive motivation for food reward
d’Oplinter, A. D. W., Verce, M., Huwart, S. J. P., Lessard‐Lord, J., Depommier, C., Hul, M. V., Desjardins, Y., Cani, P. D., & Everard, A. (2024) · Figshare · doi:10.6084/m9.figshare.26585547
Self-citation
Additional file 2 of Microbial composition differs between production systems and is associated with growth performance and carcass quality in pigs
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Additional file 1 of Microbial composition differs between production systems and is associated with growth performance and carcass quality in pigs
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Additional file 10 of Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
Qiu, H., Kan, C., Han, F., Luo, Y., Qu, N., Zhang, K., Ma, Y., Hou, N., Wu, D., Sun, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26741222
Additional file 7 of Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
Qiu, H., Kan, C., Han, F., Luo, Y., Qu, N., Zhang, K., Ma, Y., Hou, N., Wu, D., Sun, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26741213
Additional file 11 of Metagenomic and metabolomic analysis showing the adverse risk–benefit trade-off of the ketogenic diet
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Authors: Cani, P. D., Van Hul, M., Lefort, C., Depommier, C., Rastelli, M., & Everard, A.
Affiliations: Walloon Excellence in Lifesciences and Biotechnology (BE)
Corresponding author: Cani, Patrice D.
ORCID: Cani, Patrice D.
Lefort, Charlotte
Depommier, Clara
Rastelli, Marialetizia
Everard, Amandine
Venue: Nature Metabolism
Publisher: Springer Science and Business Media LLC
Published: 2019-01-07
Volume: 1
Issue: 1
Pages: 34-46
ISSN: 2522-5812 (ISSN-L)
DOI: 10.1038/s42255-018-0017-4
OpenAlex: W2907048060
Cited by: 569
References: 210
Citations by year: 2026: 55 · 2025: 68 · 2024: 88 · 2023: 79 · 2022: 100 · 2021: 94 · 2020: 54 · 2019: 31
FWCI: 4.39
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature Metabolism (publishedVersion)
PubMed (publishedVersion)
Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords: gut microbiota, energy homeostasis, host metabolism, short-chain fatty acids, gastrointestinal hormones, food intake regulation, thermogenesis, brown adipose tissue, bile acids, branched-chain amino acids, endocannabinoids, antibiotics, physical activity, microbiota-based therapy, metabolic disorders
MeSH terms: Gastrointestinal Microbiome, Animals, Energy Metabolism, Fatty Acids, Volatile, Homeostasis, Humans, Organ Specificity, Biomarkers, Biodiversity, Host-Pathogen Interactions, Microbiota

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