The DOI matches its Crossref record; 210 of the 210 references it cites were found in a registry or an index.
Microbial regulation of organismal energy homeostasis
Open accessAbstract
The gut microbiome has emerged as a key regulator of host metabolism. Here we review the various mechanisms through which the gut microbiome influences the energy metabolism of its host, highlighting the complex interactions between gut microbes, their metabolites and host cells. Among the most important bacterial metabolites are short-chain fatty acids, which serve as a direct energy source for host cells, stimulate the production of gut hormones and act in the brain to regulate food intake. Other microbial metabolites affect systemic energy expenditure by influencing thermogenesis and adipose tissue browning. Both direct and indirect mechanisms of action are known for specific metabolites, such as bile acids, branched chain amino acids, indole propionic acid and endocannabinoids. We also discuss the roles of specific bacteria in the production of specific metabolites and explore how external factors, such as antibiotics and exercise, affect the microbiome and thereby energy homeostasis. Collectively, we present a large body of evidence supporting the concept that gut microbiota-based therapies can be used to modulate host metabolism, and we expect to see such approaches moving from bench to bedside in the near future.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Furthermore, gut microbiota has been described in the past two decades as a very important player in the regulation of whole‐body energy homeostasis, in response to diverse stimuli such as cold 165, 166, nutrition 167, 168, or fasting/feeding cycles 168, 169, 170, through the production of mediators such as short chain fatty acids (SCFAs) and secondary BAs 167, 169.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [169]
Citations
Cites
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444
A human gut microbial gene catalogue established by metagenomic sequencing
MetaHIT Consortium, Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K. S., Manichanh, C., Nielsen, T., Pons, N., Levenez, F., et al. (2010) · Nature · doi:10.1038/nature08821 · Cited by 11,624
A core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597
De Filippo, C., Cavalieri, D., Di Paola, M., Ramazzotti, M., Poullet, J. B., Massart, S., Collini, S., Pieraccini, G., & Lionetti, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005963107 · Cited by 5,579
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819
Self-citationRichness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity
Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511
Self-citation
Cited by
Sorted by citations
Depommier, C., Everard, A., Druart, C., Plovier, H., Van Hul, M., Vieira-Silva, S., Falony, G., Raes, J., Maiter, D., Delzenne, N. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0495-2 · Cited by 2,357
Self-citationThe gut microbiome as a modulator of healthy ageing
Ghosh, T. S., Shanahan, F., & O’Toole, P. W. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00605-x · Cited by 817
Short chain fatty acids: Microbial metabolites for gut-brain axis signalling
O’Riordan, K. J., Collins, M., Moloney, G. M., Knox, E. G., Aburto, M. R., Fülling, C., Morley, S. J., Clarke, G. A., Schellekens, H., & Cryan, J. F. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111572 · Cited by 788
Liu, B., Liu, X., Liang, Z., & Wang, J. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i25.3837 · Cited by 662
Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune Homeostasis
Wang, J., Zhu, N., Su, L., Gao, Y., & Yang, R. (2023) · Cells · doi:10.3390/cells12050793 · Cited by 649
Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells
Ang, Q. Y., Alexander, M., Newman, J. C., Tian, Y., Cai, J., Upadhyay, V., Turnbaugh, J. A., Verdin, E. M., Hall, K. D., Leibel, R. L., et al. (2020) · Cell · doi:10.1016/j.cell.2020.04.027 · Cited by 589
How Probiotics Affect the Microbiota
Wieërs, G., Belkhir, L., Enaud, R., Leclercq, S., de Foy, J.-M. P., Dequenne, I., de Timary, P., & Cani, P. D. (2020) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00454 · Cited by 557
Self-citationFunctions of Gut Microbiota Metabolites, Current Status and Future Perspectives
Liu, J., Tan, Y., Cheng, H., Zhang, D., Feng, W., & Peng, C. (2022) · Aging and disease · doi:10.14336/ad.2022.0104 · Cited by 529
What defines a healthy gut microbiome?
Hul, M. V., Cani, P. D., Petitfils, C., de Vos, W. M., Tilg, H., & El-Omar, E. M. (2024) · Gut · doi:10.1136/gutjnl-2024-333378 · Cited by 448
Self-citationGut microbiome-related effects of berberine and probiotics on type 2 diabetes (the PREMOTE study)
Zhang, Y., Gu, Y., Ren, H., Wang, S., Zhong, H., Zhao, X., Ma, J., Gu, X., Xue, Y., Huang, S., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18414-8 · Cited by 380
Corrêa, T. A. F., Rogero, M. M., Hassimotto, N. M. A., & Lajolo, F. M. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00188 · Cited by 327
Gut microbiota-derived succinate: Friend or foe in human metabolic diseases?
Fernández‐Veledo, S., & Vendrell, J. J. (2019) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-019-09513-z · Cited by 323
Tavella, T., Rampelli, S., Guidarelli, G., Bazzocchi, A., Gasperini, C., Pujos‐Guillot, E., Comte, B., Barone, M., Biagi, E., Candela, M., et al. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1880221 · Cited by 310
Suriano, F., Vieira‐Silva, S., Falony, G., Roumain, M., Paquot, A., Pelicaen, R., Régnier, M., Delzenne, N. M., Raes, J., Muccioli, G. G., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01097-8 · Cited by 293
Self-citationDepommier, C., Hul, M. V., Everard, A., Delzenne, N. M., de Vos, W. M., & Cani, P. D. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1737307 · Cited by 278
Self-citationRole of the gut-brain axis in energy and glucose metabolism
Wachsmuth, H. R., Weninger, S. N., & Duca, F. A. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00677-w · Cited by 269
Excess body weight: Novel insights into its roles in obesity comorbidities
Zhang, X., Ha, S., Lau, H. C.-H., & Yu, J. Q. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.03.008 · Cited by 255
Hosseinkhani, F., Heinken, A., Thiele, I., Lindenburg, P. W., Harms, A. C., & Hankemeier, T. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1882927 · Cited by 249
Pascale, A., Marchesi, N., Govoni, S. M., Coppola, A., & Gazzaruso, C. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.03.011 · Cited by 243
Blanco‐Pérez, F., Steigerwald, H., Schülke, S., Vieths, S., Toda, M., & Scheurer, S. (2021) · Current Allergy and Asthma Reports · doi:10.1007/s11882-021-01020-z · Cited by 241
From correlation to causality: the case of Subdoligranulum
Hul, M. V., Roy, T. L., Prifti, E., Dao, M. C., Paquot, A., Zucker, J., Delzenne, N. M., Muccioli, G. G., Clément, K., & Cani, P. D. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1849998 · Cited by 230
Self-citationRoy, T. L., de Hase, E. M., Hul, M. V., Paquot, A., Pelicaen, R., Régnier, M., Depommier, C., Druart, C., Everard, A., Maiter, D. M., et al. (2021) · Gut · doi:10.1136/gutjnl-2020-323778 · Cited by 228
Self-citationBioaccessibility and Bioavailability of Diet Polyphenols and Their Modulation of Gut Microbiota
Lippolis, T., Cofano, M., Caponio, G. R., Nunzio, V. D., & Notarnicola, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043813 · Cited by 220
Gut microbiota in overweight and obesity: crosstalk with adipose tissue
Cani, P. D., & Hul, M. V. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00867-z · Cited by 230
Self-citationCaloric restriction disrupts the microbiota and colonization resistance
von Schwartzenberg, R. J., Bisanz, J. E., Lyalina, S., Spanogiannopoulos, P., Ang, Q. Y., Cai, J., Dickmann, S., Friedrich, M., Liu, S.-Y., Collins, S. L., et al. (2021) · Nature · doi:10.1038/s41586-021-03663-4 · Cited by 216
Kim, H. S., Whon, T. W., Sung, H., Jeong, Y., Jung, E. S., Shin, N., Hyun, D., Kim, P. S., Lee, J., Lee, C. H., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20389-5 · Cited by 210
Mas‐Capdevila, A., Teichenne-Jané, J., Domenech-Coca, C., Caimari, A., Bas-Prior, J. M. D., Escoté, X., & Crescenti, A. (2020) · Nutrients · doi:10.3390/nu12051488 · Cited by 205
The gut microbiota and its interactions with cardiovascular disease
Xu, H., Wang, X., Feng, W., Liu, Q., Zhou, S., Liu, Q., & Cai, L. (2020) · Microbial Biotechnology · doi:10.1111/1751-7915.13524 · Cited by 196
Bariatric Surgery in Obesity: Effects on Gut Microbiota and Micronutrient Status
Ciobârcă, D., Cătoi, A. F., Copăescu, C., Miere, D., & Crișan, G. (2020) · Nutrients · doi:10.3390/nu12010235 · Cited by 194
El‐Saadony, M. T., Yang, T., Saad, A. M., Alkafaas, S. S., Elkafas, S. S., Eldeeb, G. S. S., Mohammed, D. M., Salem, H. M., Korma, S. A., Loutfy, S. A., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134223 · Cited by 193
Dietary short-chain fatty acid intake improves the hepatic metabolic condition via FFAR3
Shimizu, H., Masujima, Y., Ushiroda, C., Mizushima, R., Taira, S., Ohue‐Kitano, R., & Kimura, I. (2019) · Scientific Reports · doi:10.1038/s41598-019-53242-x · Cited by 192
Genetic manipulation of gut microbes enables single-gene interrogation in a complex microbiome
Jin, W., Li, T., Huo, D., Qu, S., Li, X. V., Arifuzzaman, M., Lima, S. F., Shi, H., Wang, A., Putzel, G., et al. (2022) · Cell · doi:10.1016/j.cell.2021.12.035 · Cited by 183
Breton, J., Galmiche, M. C., & Déchelotte, P. (2022) · Microorganisms · doi:10.3390/microorganisms10020452 · Cited by 184
Inter‐organ communication: a gatekeeper for metabolic health
Castillo‐Armengol, J., Fajas, L., & Lopez‐Mejia, I. C. (2019) · The EMBO Reports · doi:10.15252/embr.201947903 · Cited by 178
Prebiotics and the Human Gut Microbiota: From Breakdown Mechanisms to the Impact on Metabolic Health
Bedu-Ferrari, C., Biscarrat, P., Langella, P., & Cherbuy, C. (2022) · Nutrients · doi:10.3390/nu14102096 · Cited by 168
The clinical evidence for postbiotics as microbial therapeutics
Mosca, A., y Abreu, A. T. A., Gwee, K., Ianiro, G., Tack, J. F., Nguyễn, T. V. H., & Hill, C. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2117508 · Cited by 156
Sun, Y., Zhang, H., Zhang, X., Wang, W., Chen, Y., Cai, Z., Wang, Q., Wang, J., & Shi, Y. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102690 · Cited by 151
Gao, H., Jiang, Q., Ji, H., Ning, J., Li, C., & Zheng, H. X. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165541 · Cited by 141
Antioxidants and Sports Performance
Clemente‐Suárez, V. J., Bustamante-Sánchez, Á., Mielgo‐Ayuso, J., Martínez‐Guardado, I., Martín-Rodríguez, A., & Tornero-Aguilera, J. F. (2023) · Nutrients · doi:10.3390/nu15102371 · Cited by 138
The biological underpinnings of therapeutic resistance in pancreatic cancerPreprint
Beatty, G. L., Werba, G., Lyssiotis, C. A., & Simeone, D. M. (2021) · Genes & Development · doi:10.1101/gad.348523.121 · Cited by 139
Schellekens, H., Torres‐Fuentes, C., van de Wouw, M., Long-Smith, C. M., Mitchell, A., Strain, C., Berding, K., Bastiaanssen, T. F. S., Rea, K., Golubeva, A. V., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.103176 · Cited by 134
Sohail, M. U., Yassine, H. M., Sohail, A., & Thani, A. A. A. (2019) · Review of Diabetic Studies · doi:10.1900/rds.2019.15.35 · Cited by 128
Ribeiro, C. F. A., Silveira, G. G. D. O. S., Cândido, E. D. S., Cardoso, M. H. E. S., Carvalho, C. M. E., & Franco, O. L. (2020) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.0c00036 · Cited by 126
Qi, Q., Zhang, H., Jin, Z., Wang, C., Xia, M., Chen, B., Lv, B., Diaz, L. P., Li, X., Feng, R., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01068-x · Cited by 129
Liebisch, G., Ecker, J., Roth, S., Schweizer, S., Öttl, V., Schött, H.-F., Yoon, H., Haller, D., Holler, E., Burkhardt, R., et al. (2019) · Biomolecules · doi:10.3390/biom9040121 · Cited by 124
Paone, P., Suriano, F., Jian, C., Korpela, K., Delzenne, N. M., Hul, M. V., Salonen, A., & Cani, P. D. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2152307 · Cited by 124
Self-citationGut Microbiota-Derived Metabolites in Colorectal Cancer: The Bad and the Challenges
Zhang, W., An, Y., Qin, X., Wu, X., Wang, X., Hou, H., Song, X., Liu, T., Wang, B., Huang, X., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.739648 · Cited by 122
Swine gut microbiota and its interaction with host nutrient metabolism
Wang, H., Xu, R., Zhang, H., Su, Y., & Zhu, W. (2020) · Animal nutrition · doi:10.1016/j.aninu.2020.10.002 · Cited by 117
Gut Microbiota and Host Metabolism: From Proof of Concept to Therapeutic Intervention
Cani, P. D., de Hase, E. M., & Hul, M. V. (2021) · Microorganisms · doi:10.3390/microorganisms9061302 · Cited by 116
Self-citationObesity phenotypes and cardiovascular risk: From pathophysiology to clinical management
Preda, A., Carbone, F., Tirandi, A., Montecucco, F., & Liberale, L. (2023) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09813-5 · Cited by 114
Resident Innate Immune Cells in the Cornea
Liu, J., & Li, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.620284 · Cited by 114
Gao, G., Ma, T., Zhang, T., Jin, H., Li, Y., Kwok, L.-Y., Zhang, H., & Sun, Z. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.772532 · Cited by 111
Jian, C., Carpén, N., Helve, O., de Vos, W. M., Korpela, K., & Salonen, A. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103475 · Cited by 111
Roles of the gut microbiome in weight management
Carmody, R. N., & Bisanz, J. E. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00888-0 · Cited by 113
The hypothalamus for whole-body physiology: from metabolism to aging
Liu, T., Xu, Y., Yi, C., Tong, Q., & Cai, D. (2021) · Protein & Cell · doi:10.1007/s13238-021-00834-x · Cited by 109
Nutrition Concepts for the Treatment of Obesity in Adults
Wiechert, M., & Holzapfel, C. (2021) · Nutrients · doi:10.3390/nu14010169 · Cited by 107
Tokuhara, D. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.700058 · Cited by 106
Jang, H. R., Park, H., Kang, D., Chung, H., Nam, M. H., Lee, Y., Park, J., & Lee, H. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0293-4 · Cited by 105
Och, A., Och, M., Nowak, R., Podgórska, D., & Podgórski, R. (2022) · Molecules · doi:10.3390/molecules27041351 · Cited by 104
Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations
Lamichhane, S., Sen, P., Alves, M. A., Ribeiro, H. C., Raunioniemi, P., Hyötyläinen, T., & Orešič, M. (2021) · Metabolites · doi:10.3390/metabo11010055 · Cited by 101
Moutsoglou, D., Tatah, J., Prisco, S. Z., Prins, K. W., Staley, C. M., Lopez, S., Blake, M., Teigen, L. M., Kazmirczak, F., Weir, Ε. K., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202203-0490oc · Cited by 100
Probiotics in microbiome ecological balance providing a therapeutic window against cancer
Sehrawat, N., Yadav, M. K., Singh, M. P., Kumar, V., Sharma, V., & Sharma, A. K. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.06.009 · Cited by 99
Probiotics and Psychobiotics: the Role of Microbial Neurochemicals
Oleskin, A. V., & Ba, S. (2019) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-019-09583-0 · Cited by 94
Kefir and Intestinal Microbiota Modulation: Implications in Human Health
Peluzio, M. D. C. G., Dias, M. D. M. E., Martinez, J. A., & Milagro, F. I. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.638740 · Cited by 92
Zhong, W., Wang, H., Yang, Y., Zhang, Y., Lai, H., Cheng, Y., Yu, H., Feng, N., Huang, R., Liu, S., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00687-6 · Cited by 90
Mucins, gut microbiota, and postbiotics role in colorectal cancer
Pothuraju, R., Chaudhary, S., Rachagani, S., Kaur, S., Roy, H. K., Bouvet, M., & Batra, S. K. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1974795 · Cited by 89
Gut Microbiota and Host Thermoregulation in Response to Ambient Temperature Fluctuations
Khakisahneh, S., Zhang, X., Nouri, Z., & Wang, D. (2020) · mSystems · doi:10.1128/msystems.00514-20 · Cited by 91
Gut Microbiota Characteristics of People with Obesity by Meta-Analysis of Existing Datasets
Gong, J., Shen, Y., Zhang, H., Cao, M., Guo, M., He, J., Zhang, B., & Xiao, C. (2022) · Nutrients · doi:10.3390/nu14142993 · Cited by 84
Shin, J. H., Bozadjieva-Kramer, N., Shao, Y., Lyons‐Abbott, S., Rupp, A. C., Sandoval, D. A., & Seeley, R. J. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.024 · Cited by 80
Jing, W., Dong, S., Xu, Y., Liu, J., Ren, J., Liu, X., Zhu, M., Zhang, M., Shi, H., Li, N., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.11.009 · Cited by 80
The Role of Gut Microbiome in Sleep Quality and Health: Dietary Strategies for Microbiota Support
Sejbuk, M., Siebieszuk, A., & Witkowska, A. M. (2024) · Nutrients · doi:10.3390/nu16142259 · Cited by 83
Mastrocola, R., Collotta, D., Gaudioso, G., Berre, M. L., Cento, A. S., Alves, G. F., Chiazza, F., Verta, R., Bertocchi, I., Manig, F., et al. (2020) · Nutrients · doi:10.3390/nu12092497 · Cited by 76
Bakkar, N. Z., Dwaib, H. S., Fares, S. A., Eid, A. H., Al-Dhaheri, Y., & EL‐Yazbi, A. F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239005 · Cited by 75
Déchelotte, P., Breton, J., Trotin-Picolo, C., Grube, B., Erlenbeck, C., Bothe, G., Fetissov, S. O., & Lambert, G. (2021) · Nutrients · doi:10.3390/nu13061902 · Cited by 75
Local and systemic effects of microbiome‐derived metabolites
Spivak, I., Fluhr, L., & Elinav, E. (2022) · EMBO Reports · doi:10.15252/embr.202255664 · Cited by 75
Chen, Y.-K., Liu, T.-T., Teia, F. K. F., & Xie, M.-Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1218880 · Cited by 74
Arnoriaga‐Rodríguez, M., Mayneris‐Perxachs, J., Burokas, A., Pérez‐Brocal, V., Moyá, A., Portero‐Otín, M., Ricart, W., Maldonado, R. J., & Fernández‐Real, J. M. (2020) · Microbiome · doi:10.1186/s40168-020-00837-6 · Cited by 74
Wu, G., Shi, Y., Han, L., Feng, C., Ge, Y., Yu, Y., Xue Ming, T. A. N. G., Cheng, X., Sun, J., & Le, G. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c02965 · Cited by 74
From taxonomy to metabolic output: what factors define gut microbiome health?
Wilmanski, T., Rappaport, N., Diener, C., Gibbons, S. M., & Price, N. D. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1907270 · Cited by 73
Luna, E., Parkar, S. G., Kirmiz, N., Hartel, S., Hearn, E., Hossine, M., Kurdian, A., Mendoza, C., Orr, K., Padilla, L., et al. (2022) · Applied and Environmental Microbiology · doi:10.1128/aem.01487-21 · Cited by 73
Liu, K., Yang, J., & Yuan, H. (2021) · Journal of Evolutionary Biology · doi:10.1111/jeb.13924 · Cited by 73
Digesting the complex metabolic effects of diet on the host and microbiome
Carmody, R. N., Varady, K. A., & Turnbaugh, P. J. (2024) · Cell · doi:10.1016/j.cell.2024.06.032 · Cited by 76
Regulatory T cells as metabolic sensors
de Candia, P., Procaccini, C., Russo, C., Lepore, M. T., & Matarese, G. (2022) · Immunity · doi:10.1016/j.immuni.2022.10.006 · Cited by 71
Chen, H., Nie, Q., Hu, J., Huang, X., Yin, J., & Nie, S. (2021) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c07871 · Cited by 69
Cao, L., Wu, Y., Liu, K., Qi, N.-X., Zhang, J., Tie, S., Li, X., Tian, P., & Gu, S. (2024) · Food & medicine homology. · doi:10.26599/fmh.2024.9420002 · Cited by 69
Zikou, E., Koliaki, C. C., & Makrilakis, K. (2024) · Biomedicines · doi:10.3390/biomedicines12081871 · Cited by 68
Liu, X., Wang, L., Jing, N., Jiang, G., & Liu, Z. (2020) · Microorganisms · doi:10.3390/microorganisms8020175 · Cited by 68
Targeting the Microbiota in Pharmacology of Psychiatric Disorders
Pascale, A., Marchesi, N., Govoni, S., & Barbieri, A. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104856 · Cited by 67
Polyphenols and their anti-obesity role mediated by the gut microbiota: a comprehensive review
Duarte-Silva, L., Gasaly, N., Poblete-Aro, C., Uribe, D., Echeverría, F., Gotteland, M., & García‐Díaz, D. F. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-020-09622-0 · Cited by 67
Zhang, X., Sun, J., Han, Z., Chen, F., Lv, A., Hu, X., Sun, X., Qi, H., & Guo, Y. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737061 · Cited by 67
Wu, Z., He, J., Zhang, Z., Li, J., Zou, H., Tan, X., Wang, Y., Yao, Y., & Xiong, W. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c00278 · Cited by 67
Niu, B., Pan, T., Xiao, Y., Wang, H., Zhu, J., Tian, F., Lu, W., & Chen, W. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2299744 · Cited by 66
Oba, S., Sunagawa, T., Tanihiro, R., Awashima, K., Sugiyama, H., Odani, T., Nakamura, Y., Kondo, A., Sasaki, D., & Sasaki, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-74379-0 · Cited by 66
A guide to germ‐free and gnotobiotic mouse technology to study health and disease
Jans, M., & Vereecke, L. (2024) · FEBS Journal · doi:10.1111/febs.17124 · Cited by 67
Jiang, H., Fang, S., Yang, H., & Chen, C. (2021) · Journal of Animal Science · doi:10.1093/jas/skab045 · Cited by 63
Zhou, C., Wang, Y., Li, C., Xie, Z., & Dai, L. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.03330-22 · Cited by 65
Recent insights of obesity-induced gut and adipose tissue dysbiosis in type 2 diabetes
Patra, D., Banerjee, D., Ramprasad, P., Roy, S., Pal, D., & Dasgupta, S. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1224982 · Cited by 63
Immunometabolism and metainflammation in obesity
Romantsova, T. I., & Sych, Y. P. (2019) · Obesity and metabolism · doi:10.14341/omet12218 · Cited by 63
Microbial Metabolite Dysbiosis and Colorectal Cancer
Niekamp, P., & Kim, C. H. (2023) · Gut and Liver · doi:10.5009/gnl220260 · Cited by 60
Martemucci, G., Khalil, M., Luca, A. D., Abdallah, H., & D‘Alessandro, A. G. (2024) · Metabolites · doi:10.3390/metabo14060327 · Cited by 60
Metadata
- Authors
- Cani, P. D., Van Hul, M., Lefort, C., Depommier, C., Rastelli, M., & Everard, A.
- Affiliations
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- Corresponding author
- Cani, Patrice D.
- Venue
- Nature Metabolism
- Published
- 2019-01-07
- Volume
- 1
- Issue
- 1
- Pages
- 34-46
- ISSN
- 2522-5812 (ISSN-L)
- OpenAlex
- W2907048060
- Cited by
- 569
- References
- 210
- Citations by year
- 2026: 55 · 2025: 68 · 2024: 88 · 2023: 79 · 2022: 100 · 2021: 94 · 2020: 54 · 2019: 31
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Nature Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- gut microbiota, energy homeostasis, host metabolism, short-chain fatty acids, gastrointestinal hormones, food intake regulation, thermogenesis, brown adipose tissue, bile acids, branched-chain amino acids, endocannabinoids, antibiotics, physical activity, microbiota-based therapy, metabolic disorders
- MeSH terms
- Gastrointestinal Microbiome, Animals, Energy Metabolism, Fatty Acids, Volatile, Homeostasis, Humans, Organ Specificity, Biomarkers, Biodiversity, Host-Pathogen Interactions, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
