The DOI matches its Crossref record; 210 of the 210 references it cites were found in a registry or an index.
Microbial regulation of organismal energy homeostasis
Open accessAbstract
The gut microbiome has emerged as a key regulator of host metabolism. Here we review the various mechanisms through which the gut microbiome influences the energy metabolism of its host, highlighting the complex interactions between gut microbes, their metabolites and host cells. Among the most important bacterial metabolites are short-chain fatty acids, which serve as a direct energy source for host cells, stimulate the production of gut hormones and act in the brain to regulate food intake. Other microbial metabolites affect systemic energy expenditure by influencing thermogenesis and adipose tissue browning. Both direct and indirect mechanisms of action are known for specific metabolites, such as bile acids, branched chain amino acids, indole propionic acid and endocannabinoids. We also discuss the roles of specific bacteria in the production of specific metabolites and explore how external factors, such as antibiotics and exercise, affect the microbiome and thereby energy homeostasis. Collectively, we present a large body of evidence supporting the concept that gut microbiota-based therapies can be used to modulate host metabolism, and we expect to see such approaches moving from bench to bedside in the near future.
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“Furthermore, gut microbiota has been described in the past two decades as a very important player in the regulation of whole‐body energy homeostasis, in response to diverse stimuli such as cold 165, 166, nutrition 167, 168, or fasting/feeding cycles 168, 169, 170, through the production of mediators such as short chain fatty acids (SCFAs) and secondary BAs 167, 169.”
From Inter‐organ communication: a gatekeeper for metabolic health (2019) · cites this paper as [169]
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Items 201–210 of 210
Fecal microbiota transplant in patients with Clostridium difficile infection
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CHANGES IN INTESTINAL BACTERIAL FLORA AND ROLE OF INFECTION IN KWASHIORKOR
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Severe obesity and gut microbiota: does bariatric surgery really reset the system?
Cani, P. D. (2018) · Gut · doi:10.1136/gutjnl-2018-316815 · Cited by 46
Self-citationGlucagon-like peptide-1 relaxes gastric antrum through nitric oxide in mice
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Phages of life – the path to pharma
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Bile Acids, the Microbiome, Immunity, and Liver Tumors
Schramm, C. (2018) · New England Journal of Medicine · doi:10.1056/nejmcibr1807106 · Cited by 41
Xenobiotics and the Human Gut Microbiome: Metatranscriptomics Reveal the Active Players
Ursell, L. K., & Knight, R. D. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.013 · Cited by 37
Nutritional Modulation of Innate Immunity: The Fat–Bile–Gut Connection
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Sorted by citations
Depommier, C., Everard, A., Druart, C., Plovier, H., Van Hul, M., Vieira-Silva, S., Falony, G., Raes, J., Maiter, D., Delzenne, N. M., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0495-2 · Cited by 2,357
Self-citationThe gut microbiome as a modulator of healthy ageing
Ghosh, T. S., Shanahan, F., & O’Toole, P. W. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00605-x · Cited by 817
Short chain fatty acids: Microbial metabolites for gut-brain axis signalling
O’Riordan, K. J., Collins, M., Moloney, G. M., Knox, E. G., Aburto, M. R., Fülling, C., Morley, S. J., Clarke, G. A., Schellekens, H., & Cryan, J. F. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111572 · Cited by 788
Liu, B., Liu, X., Liang, Z., & Wang, J. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i25.3837 · Cited by 662
Gut-Microbiota-Derived Metabolites Maintain Gut and Systemic Immune Homeostasis
Wang, J., Zhu, N., Su, L., Gao, Y., & Yang, R. (2023) · Cells · doi:10.3390/cells12050793 · Cited by 649
Metadata
- Authors
- Cani, P. D., Van Hul, M., Lefort, C., Depommier, C., Rastelli, M., & Everard, A.
- Affiliations
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- Corresponding author
- Cani, Patrice D.
- Venue
- Nature Metabolism
- Published
- 2019-01-07
- Volume
- 1
- Issue
- 1
- Pages
- 34-46
- ISSN
- 2522-5812 (ISSN-L)
- OpenAlex
- W2907048060
- Cited by
- 569
- References
- 210
- Citations by year
- 2026: 55 · 2025: 68 · 2024: 88 · 2023: 79 · 2022: 100 · 2021: 94 · 2020: 54 · 2019: 31
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Nature Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- gut microbiota, energy homeostasis, host metabolism, short-chain fatty acids, gastrointestinal hormones, food intake regulation, thermogenesis, brown adipose tissue, bile acids, branched-chain amino acids, endocannabinoids, antibiotics, physical activity, microbiota-based therapy, metabolic disorders
- MeSH terms
- Gastrointestinal Microbiome, Animals, Energy Metabolism, Fatty Acids, Volatile, Homeostasis, Humans, Organ Specificity, Biomarkers, Biodiversity, Host-Pathogen Interactions, Microbiota
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