The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Oxygen and mammalian cell culture: are we repeating the experiment of Dr. Ox?
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“In such extreme cases, variations in culture conditions may resemble levels consistent with hypercapnia and hypoxia rather than conditions typical of in vivo extracellular fluids, although in vivo environments vary considerably among selected tissues (Ast and Mootha, 2019).”
From Toward Best Practices for Controlling Mammalian Cell Culture Environments (2022) · cites this paper as Ast and Mootha, 2019
In the citing paper
“For instance, O2 levels vary across human tissues and range from 13% O2 in the lung-pulmonary vein to 1–3% O2 in the uterus (Ast and Mootha, 2019).”
From Toward Best Practices for Controlling Mammalian Cell Culture Environments (2022) · cites this paper as Ast and Mootha, 2019
In the citing paper
“By considering how niche in vivo environments affect experimental outcomes, researchers could further increase the robustness of their experiments and increase the likelihood that findings have relevance to focal in vivo compartments (Ast and Mootha, 2019).”
From Toward Best Practices for Controlling Mammalian Cell Culture Environments (2022) · cites this paper as Ast and Mootha, 2019
In the citing paper
“although reliable reports of environmental parameters within selected human tissues are presently limited (Al-Ani et al., 2018; Ast and Mootha, 2019)”
From Toward Best Practices for Controlling Mammalian Cell Culture Environments (2022) · cites this paper as Ast and Mootha, 2019
Citations
Cites
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Hypoxia as a therapy for mitochondrial disease
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Self-citationHistone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
Chakraborty, A. A., Laukka, T., Myllykoski, M., Ringel, A. E., Booker, M. A., Tolstorukov, M. Y., Meng, Y. J., Meier, S. R., Jennings, R. B., Creech, A. L., et al. (2019) · Science · doi:10.1126/science.aaw1026 · Cited by 432
Low oxygen concentration extends the lifespan of cultured human diploid cells
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Hypoxia induces rapid changes to histone methylation and reprograms chromatin
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Self-citationThompson, J. W., Salahudeen, A. A., Chollangi, S., Ruiz, J. C., Brautigam, C. A., Makris, T. M., Lipscomb, J. D., Tomchick, D. R., & Bruick, R. K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.308684 · Cited by 71
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Cited by
Sorted by citations
Cellular Adaptation to Hypoxia through Hypoxia Inducible Factors and beyond
Lee, P., Chandel, N. S., & Simon, M. C. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0227-y · Cited by 1,272
The metabolic roots of senescence: mechanisms and opportunities for intervention
Wiley, C. D., & Campisi, J. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00483-8 · Cited by 691
Genetic Screen for Cell Fitness in High or Low Oxygen Highlights Mitochondrial and Lipid Metabolism
Jain, I. H., Calvo, S. E., Markhard, A. L., Skinner, O. S., To, T.-L., Ast, T., & Mootha, V. K. (2020) · Cell · doi:10.1016/j.cell.2020.03.029 · Cited by 224
Self-citationMetabolic Reprogramming of Cancer Cells during Tumor Progression and Metastasis
Ohshima, K., & Morii, E. (2021) · Metabolites · doi:10.3390/metabo11010028 · Cited by 236
Fumarate is a terminal electron acceptor in the mammalian electron transport chain
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Metadata
- Authors
- Ast, T., & Mootha, V. K.
- Affiliations
- Broad Institute (US)
- Corresponding author
- Mootha, Vamsi K.
- Venue
- Nature Metabolism
- Published
- 2019-08-05
- Volume
- 1
- Issue
- 9
- Pages
- 858-860
- ISSN
- 2522-5812 (ISSN-L)
- OpenAlex
- W2966730488
- Cited by
- 125
- References
- 20
- Citations by year
- 2026: 7 · 2025: 20 · 2024: 23 · 2023: 13 · 2022: 27 · 2021: 20 · 2020: 13 · 2019: 1
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Health & Human Services | National Institutes of Health (R35GM122455)
- Howard Hughes Medical Institute
- Marriot Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Viral Infectious Diseases and Gene Expression in Insects
- Keywords
- oxygen, mammalian cell culture, reproducibility, hypoxia, experimental interpretation
- MeSH terms
- Animals, Culture Media, Mammals, Oxygen, Research
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