Defining Physiological Normoxia for Improved Translation of Cell Physiology to Animal Models and Humans

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works

Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging

Fox, M. D., & Raichle, M. E. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2201 · Cited by 6,700 · see citing works

Global quantification of mammalian gene expression control

Schwanhäusser, B., Busse, D., Li, N., Dittmar, G., Schuchhardt, J., Wolf, J., Chen, W., & Selbach, M. (2011) · Nature · doi:10.1038/nature10098 · Cited by 6,566 · see citing works

Brain magnetic resonance imaging with contrast dependent on blood oxygenation.

Ogawa, S., Lee, T. M., Kay, A. R., & Tank, D. W. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9868 · Cited by 6,483 · see citing works

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212 · see citing works

GLUTATHIONE

Meister, A., & Anderson, M. E. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.003431 · Cited by 5,694 · see citing works

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

Zorov, D. B., Juhaszova, M., & Sollott, S. J. (2014) · Physiological Reviews · doi:10.1152/physrev.00026.2013 · Cited by 5,383 · see citing works

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617 · see citing works

AMPK: a nutrient and energy sensor that maintains energy homeostasis

Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602 · see citing works

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981 · see citing works

Hemodynamic shear stress and its role in atherosclerosis

Malek, A. M. (1999) · JAMA · doi:10.1001/jama.282.21.2035 · Cited by 3,650 · see citing works

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333 · see citing works

Hemoglobin and myoglobin in their reactions with ligands

Antonini, E., & Brunori, M. (1971) · Medical Entomology and Zoology · Cited by 2,681 · see citing works

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1

Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C. (2004) · Nature Medicine · doi:10.1038/nm1075 · Cited by 2,600 · see citing works

Regulation of angiogenesis by hypoxia: role of the HIF system

Pugh, C. W., & Ratcliffe, P. J. (2003) · Nature Medicine · doi:10.1038/nm0603-677 · Cited by 2,520 · see citing works

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

Maines, M. D. (1997) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.37.1.517 · Cited by 2,489 · see citing works

Cellular defenses against damage from reactive oxygen species

Yu, B. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.1.139 · Cited by 2,378 · see citing works

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

Chiu, J.-J., & Chien, S. (2011) · Physiological Reviews · doi:10.1152/physrev.00047.2009 · Cited by 2,280 · see citing works

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

Papandreou, I., Cairns, R. A., Fontana, L., Lim, A. L., & Denko, N. C. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.012 · Cited by 2,267 · see citing works

Identification of splenic reservoir monocytes and their deployment to inflammatory sites

Swirski, F. K., Nahrendorf, M., Etzrodt, M., Wildgruber, M., Cortez-Retamozo, V., Panizzi, P., Figueiredo, J.-L., Kohler, R. H., Chudnovskiy, A., Waterman, P., et al. (2009) · Science · doi:10.1126/science.1175202 · Cited by 2,221 · see citing works

Oxygen sensing by HIF hydroxylases

Schofield, C. J., & Ratcliffe, P. J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1366 · Cited by 2,068 · see citing works

Mitochondrial reactive oxygen species trigger hypoxia-induced transcription

Chandel, N. S., Maltepe, E., Goldwasser, E., Mathieu, C. E., Simon, M. C., & Schumacker, P. T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11715 · Cited by 1,926 · see citing works

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Weinberg, F., Hamanaka, R., Wheaton, W. W., Weinberg, S., Joseph, J., Lopez, M., Kalyanaraman, B., Mutlu, G. M., Budinger, G. R. S., & Chandel, N. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003428107 · Cited by 1,742 · see citing works

Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function

Kelly, C. J., Zheng, L., Campbell, E. L., Saeedi, B., Scholz, C. C., Bayless, A. J., Wilson, K. E., Glover, L. E., Kominsky, D. J., Magnuson, A., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.03.005 · Cited by 1,716 · see citing works

AMPK in Health and Disease

Steinberg, G. R., & Kemp, B. E. (2009) · Physiological Reviews · doi:10.1152/physrev.00011.2008 · Cited by 1,633 · see citing works

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J., & Whitelaw, M. L. (2002) · Science · doi:10.1126/science.1068592 · Cited by 1,558 · see citing works

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (2002) · Genes & Development · doi:10.1101/gad.991402 · Cited by 1,550 · see citing works

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing

Guzy, R. D., Hoyos, B., Robin, E., Chen, H., Liu, L., Mansfield, K. D., Simon, M. C., Hammerling, U., & Schumacker, P. T. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.05.001 · Cited by 1,545 · see citing works

Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

Mohyeldin, A., Garzón-Muvdi, T., & Quiñones‐Hinojosa, A. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.07.007 · Cited by 1,536 · see citing works

Bioreactor scale-up and oxygen transfer rate in microbial processes: An overview

García‐Ochoa, F., & Gómez, E. (2008) · Biotechnology Advances · doi:10.1016/j.biotechadv.2008.10.006 · Cited by 1,516 · see citing works

Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages

Ishii, T., Itoh, K., Takahashi, S., Sato, H., Yanagawa, T., Katoh, Y., Bannai, S., & Yamamoto, M. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.16023 · Cited by 1,460 · see citing works

The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue

Krogh, A. (1919) · The Journal of Physiology · doi:10.1113/jphysiol.1919.sp001839 · Cited by 1,433 · see citing works

Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

Hu, C.-J., Wang, L.-Y., Chodosh, L. A., Keith, B., & Simon, M. C. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9361-9374.2003 · Cited by 1,386 · see citing works

HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

Berra, E., Benizri, E., Ginouvès, A., Volmat, V., Roux, D., & Pouysségur, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg392 · Cited by 1,348 · see citing works

Arteriolar niches maintain haematopoietic stem cell quiescence

Kunisaki, Y., Bruns, I., Scheiermann, C., Ahmed, J. U., Pinho, S., Zhang, D., Mizoguchi, T., Wei, Q., Lucas, D., Ito, K., et al. (2013) · Nature · doi:10.1038/nature12612 · Cited by 1,236 · see citing works

Oxygen sensing and molecular adaptation to hypoxia

Bunn, H. F., & Poyton, R. Ο. (1996) · Physiological Reviews · doi:10.1152/physrev.1996.76.3.839 · Cited by 1,185 · see citing works

Direct measurement of local oxygen concentration in the bone marrow of live animals

Spencer, J. A., Ferraro, F., Roussakis, E., Klein, A., Wu, J., Runnels, J. M., Zaher, W., Mortensen, L. J., Alt, C., Turcotte, R., et al. (2014) · Nature · doi:10.1038/nature13034 · Cited by 1,167 · see citing works

Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology

Semenza, G. L. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104720 · Cited by 1,159 · see citing works

Transcriptional regulation of vascular endothelial cell responses to hypoxia by HIF-1

Manalo, D. J., Rowan, A., Lavoie, T., Natarajan, L., Kelly, B. D., Ye, S. Q., Garcia, J. G. N., & Semenza, G. L. (2005) · Blood · doi:10.1182/blood-2004-07-2958 · Cited by 1,154 · see citing works

Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field

Thulborn, K. R., Waterton, J. C., Matthews, P. M., & Radda, G. K. (1982) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(82)90333-6 · Cited by 1,134 · see citing works

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

Parrinello, S., Samper, E., Krtolica, A., Goldstein, J., Melov, S., & Campisi, J. (2003) · Nature Cell Biology · doi:10.1038/ncb1024 · Cited by 1,116 · see citing works

Ganong's Review of Medical Physiology

Barrett, K. E. (2009) · Repository of the University of Ljubljana (University of Ljubljana) · Cited by 1,100 · see citing works

Onset of Maternal Arterial Blood Flow and Placental Oxidative Stress

Jauniaux, E., Watson, A. L., Hempstock, J., Bao, Y.-P., Skepper, J. N., & Burton, G. J. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64849-3 · Cited by 1,057 · see citing works

Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells

Liu, Y., Cox, S. R., Morita, T., & Kourembanas, S. (1995) · Circulation Research · doi:10.1161/01.res.77.3.638 · Cited by 1,044 · see citing works

The role of oxygen availability in embryonic development and stem cell function

Simon, M. C., & Keith, B. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2354 · Cited by 966 · see citing works

V. On liquid diffusion

Fick, A. (1855) · The London Edinburgh and Dublin Philosophical Magazine and Journal of Science · doi:10.1080/14786445508641925 · Cited by 963 · see citing works

Neurogenesis in the striatum of the adult human brain

Ernst, A., Alkass, K., Bernard, S., Salehpour, M., Perl, S., Tisdale, J., Possnert, G., Druid, H., & Frisén, J. (2014) · Cell · doi:10.1016/j.cell.2014.01.044 · Cited by 937 · see citing works

Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients

Worlitzsch, D., Tarran, R., Ulrich, M., Schwab, U., Cekici, A., Meyer, K. C., Birrer, P., Bellon, G., Berger, J., Weiss, T., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0213870 · Cited by 932 · see citing works

The Oxygen-Rich Postnatal Environment Induces Cardiomyocyte Cell-Cycle Arrest through DNA Damage Response

Puente, B. N., Kimura, W., Muralidhar, S. A., Moon, J., Amatruda, J. F., Phelps, K. L., Grinsfelder, D. B., Rothermel, B. A., Chen, R., Garcia, J. A., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.032 · Cited by 905 · see citing works

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

Faubert, B., Boily, G., Izreig, S., Griss, T., Samborska, B., Dong, Z., Dupuy, F., Chambers, C., Fuerth, B. J., Viollet, B., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.001 · Cited by 901 · see citing works

Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity

Walmsley, S. R., Print, C., Farahi, N., Peyssonnaux, C., Johnson, R. S., Cramer, T., Sobolewski, A., Condliffe, A. M., Cowburn, A. S., Johnson, N., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20040624 · Cited by 891 · see citing works

Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota

Albenberg, L., Esipova, T. V., Judge, C. P., Bittinger, K., Chen, J., Laughlin, A., Grunberg, S., Baldassano, R. N., Lewis, J. D., Li, H., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.020 · Cited by 886 · see citing works

Continuous Recording of Blood Oxygen Tensions by Polarography

Clark, L. C., Wolf, R., Granger, D., & Taylor, Z. (1953) · Journal of Applied Physiology · doi:10.1152/jappl.1953.6.3.189 · Cited by 885 · see citing works

Hypoxia and Adipose Tissue Function and Dysfunction in Obesity

Trayhurn, P. (2013) · Physiological Reviews · doi:10.1152/physrev.00017.2012 · Cited by 884 · see citing works

Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia

Guzy, R. D., & Schumacker, P. T. (2006) · Experimental Physiology · doi:10.1113/expphysiol.2006.033506 · Cited by 881 · see citing works

Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of <i>ob</i> / <i>ob</i> and dietary obese mice

Ye, J., Gao, Z., Yin, J., & He, Q. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00435.2007 · Cited by 840 · see citing works

Untitled work

(2002) · PubMed · Cited by 840 · see citing works

Fibroblast biology in three-dimensional collagen matrices

Grinnell, F. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00057-6 · Cited by 819 · see citing works

AMP-Activated Protein Kinase – Development of the Energy Sensor Concept

Hardie, D. G., Hawley, S. A., & Scott, J. W. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.108944 · Cited by 813 · see citing works

Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survivalPreprint

Schipani, E., Ryan, H. E., Didrickson, S., Kobayashi, T., Knight, M. C., & Johnson, R. S. (2001) · Genes & Development · doi:10.1101/gad.934301 · Cited by 812 · see citing works

Low O 2 tensions and the prevention of differentiation of hES cells

Ezashi, T., Das, P., & Roberts, R. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501283102 · Cited by 804 · see citing works

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

Hirsilä, M., Koivunen, P., Günzler, V., Kivirikko, K. I., & Myllyharju, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304982200 · Cited by 794 · see citing works

Reduced Adipose Tissue Oxygenation in Human Obesity

Pasarica, M., Sereda, O. R., Redman, L. M., Albarado, D. C., Hymel, D. T., Roan, L. E., Rood, J. C., Burk, D. H., & Smith, S. R. (2009) · Diabetes · doi:10.2337/db08-1098 · Cited by 786 · see citing works

Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits

Fischer, B. M., & Bavister, B. D. (1993) · Reproduction · doi:10.1530/jrf.0.0990673 · Cited by 775 · see citing works

Ischemic acute renal failure: An inflammatory disease?

Bonventre, J. V., & Zuk, A. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.761_2.x · Cited by 768 · see citing works

The biological lifetime of nitric oxide: Implications for the perivascular dynamics of NO and O ₂

Thomas, D. D., Liu, X., Kantrow, S. P., & Lancaster, J. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.355 · Cited by 760 · see citing works

Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells

Yoshida, Y., Takahashi, K., Okita, K., Ichisaka, T., & Yamanaka, S. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.08.001 · Cited by 757 · see citing works

Oxygen measurements in endometrial and trophoblastic tissues during early pregnancy.

Rodesch, F., Simon, P., Donner, C., & Jauniaux, E. R. M. (1992) · PubMed · Cited by 753 · see citing works

Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma: HIF-2α promotes an aggressive phenotype

Holmquist-Mengelbier, L., Fredlund, E., Löfstedt, T., Noguera, R., Navarro, S., Nilsson, H., Pietras, A., Vallon-Christersson, J., Borg, Å., Gradin, K., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2006.08.026 · Cited by 735 · see citing works

Regulation of hypoxia-inducible factor-1α by NF-κB

van Uden, P., Kenneth, N. S., & Rocha, S. (2008) · Biochemical Journal · doi:10.1042/bj20080476 · Cited by 729 · see citing works

Hypoxic Pulmonary Vasoconstriction

Sylvester, J. T., Shimoda, L. A., Aaronson, P. I., & Ward, J. P. T. (2012) · Physiological Reviews · doi:10.1152/physrev.00041.2010 · Cited by 727 · see citing works

High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq

Schödel, J., Oikonomopoulos, S., Ragoussis, J., Pugh, C. W., Ratcliffe, P. J., & Mole, D. R. (2011) · Blood · doi:10.1182/blood-2010-10-314427 · Cited by 724 · see citing works

Reactive oxygen species released from mitochondria during brief hypoxia induce preconditioning in cardiomyocytes

Vanden Hoek, T. L., Becker, L. B., Shao, Z., Li, C., & Schumacker, P. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18092 · Cited by 721 · see citing works

Oxidative DNA damage and senescence of human diploid fibroblast cells.

Chen, Q., Fischer, A., Reagan, J. D., Yan, L. J., & Ames, B. N. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4337 · Cited by 720 · see citing works

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

Hewitson, K. S., McNeill, L. A., Riordan, M. V., Tian, Y.-M., Bullock, A. N., Welford, R. W., Elkins, J. M., Oldham, N. J., Bhattacharya, S., Gleadle, J. M., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200273200 · Cited by 719 · see citing works

Enhanced Proliferation, Survival, and Dopaminergic Differentiation of CNS Precursors in Lowered Oxygen

Studer, L., CSETE, M. E., Lee, S., Kabbani, N., Walikonis, J., Wold, B. J., & McKay, R. D. G. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07377.2000 · Cited by 709 · see citing works

Redistribution of Intracellular Oxygen in Hypoxia by Nitric Oxide: Effect on HIF1α

Hagen, T., Taylor, C. T., Lam, F., & Moncada, S. (2003) · Science · doi:10.1126/science.1088805 · Cited by 704 · see citing works

Ecto-5′-Nucleotidase (CD73) Regulation by Hypoxia-Inducible Factor-1 Mediates Permeability Changes in Intestinal Epithelia

Synnestvedt, K., Furuta, G. T., Comerford, K. M., Louis, N., Karhausen, J., Eltzschig, H. K., Hansen, K. R., Thompson, L. F., & Colgan, S. P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215337 · Cited by 660 · see citing works

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis

Karhausen, J., Furuta, G. T., Tomaszewski, J. E., Johnson, R. S., Colgan, S. P., & Haase, V. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421086 · Cited by 655 · see citing works

Reactive Oxygen Species Activate the HIF-1α Promoter Via a Functional NFκB Site

Bonello, S., Zähringer, C., BelAiba, R. S., Djordjevic, T., Hess, J., Michiels, C., Kietzmann, T., & Görlach, A. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000258979.92828.bc · Cited by 628 · see citing works

Glutathione: interorgan translocation, turnover, and metabolism.

Griffith, O. W., & Meister, A. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.11.5606 · Cited by 603 · see citing works

Independent regulation of collagen types by chondrocytes during the loss of differentiated function in culture

Benya, P. D., Padilla, S. R., & Nimni, M. E. (1978) · Cell · doi:10.1016/0092-8674(78)90056-9 · Cited by 602 · see citing works

An optical method for measurement of dioxygen concentration based upon quenching of phosphorescence.

Vanderkooi, J. M., Maniara, G., Green, T. J., & Wilson, D. F. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45596-2 · Cited by 592 · see citing works

Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration

Rausch, M. E., Weisberg, S., Vardhana, P., & Tortoriello, D. V. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803744 · Cited by 585 · see citing works

Myoglobin-facilitated oxygen diffusion: role of myoglobin in oxygen entry into muscle.

Wittenberg, J. B. (1970) · Physiological Reviews · doi:10.1152/physrev.1970.50.4.559 · Cited by 573 · see citing works

Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences

Ebert, B. L., Firth, J. D., & Ratcliffe, P. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29083 · Cited by 569 · see citing works

Expression of Hypoxia-Inducible Factor-1α and -2α in Hypoxic and Ischemic Rat Kidneys

Rosenberger, C., Mandriota, S. J., Jürgensen, J. S., Wiesener, M. S., Hörstrup, J. H., Frei, U. A., Ratcliffe, P. J., Maxwell, P. H., Bachmann, S., & Eckardt, K. (2002) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000017223.49823.2a · Cited by 566 · see citing works

The Energy-linked Reaction of Calcium with Mitochondria

Chance, B. (1965) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)97387-4 · Cited by 558 · see citing works

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

Nombela‐Arrieta, C., Pivarnik, G., Winkel, B., Canty, K. J., Harley, B. A. C., Mahoney, J. E., Park, S., Lu, J., Protopopov, A. I., & Silberstein, L. E. (2013) · Nature Cell Biology · doi:10.1038/ncb2730 · Cited by 543 · see citing works

Imaging of Phosphorescence: A Novel Method for Measuring Oxygen Distribution in Perfused Tissue

Rumsey, W. L., Vanderkooi, J. M., & Wilson, D. F. (1988) · Science · doi:10.1126/science.3420417 · Cited by 537 · see citing works

Oxidative stress in cell culture: an under‐appreciated problem?

Halliwell, B. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00235-7 · Cited by 534 · see citing works

Association of intraluminal thrombus in abdominal aortic aneurysm with local hypoxia and wall weakening

Vorp, D. A., Lee, P. C., Wang, D. H. J., Makaroun, M. S., Nemoto, E. M., Ogawa, S., & Webster, M. W. (2001) · Journal of Vascular Surgery · doi:10.1067/mva.2001.114813 · Cited by 507 · see citing works

HIF-2α, but not HIF-1α, promotes iron absorption in mice

Mastrogiannaki, M., Matak, P., Keith, B., Simon, M. C., Vaulont, S., & Peyssonnaux, C. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38499 · Cited by 502 · see citing works

Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan

Fehrer, C., Brunauer, R., Laschober, G. T., Unterluggauer, H., Reitinger, S., Kloss, F. R., Gülly, C., Gassner, R. J., & Lepperdinger, G. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00336.x · Cited by 498 · see citing works

Physiologic hypoxia and oxygen homeostasis in the healthy intestine. A Review in the Theme: Cellular Responses to Hypoxia

Zheng, L., Kelly, C. J., & Colgan, S. P. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00191.2015 · Cited by 488 · see citing works

Transmigrating Neutrophils Shape the Mucosal Microenvironment through Localized Oxygen Depletion to Influence Resolution of Inflammation

Campbell, E. L., Bruyninckx, W. J., Kelly, C. J., Glover, L. E., McNamee, E. N., Bowers, B., Bayless, A. J., Scully, M. M., Saeedi, B. J., Golden‐Mason, L., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.020 · Cited by 472 · see citing works

Longitudinal Gradients in Periarteriolar Oxygen Tension

Duling, B. R., & Berne, R. M. (1970) · Circulation Research · doi:10.1161/01.res.27.5.669 · Cited by 468 · see citing works

The mechanism of acute hypoxic pulmonary vasoconstriction: the tale of two channels

Weir, E. K., & Archer, S. L. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.2.7781921 · Cited by 466 · see citing works

Hypoxia: an alarm signal during intestinal inflammation

Colgan, S. P., & Taylor, C. T. (2010) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2010.39 · Cited by 461 · see citing works

Hemoxygenase-2 Is an Oxygen Sensor for a Calcium-Sensitive Potassium Channel

Williams, S. E. J., Wootton, P., Mason, H. S., Bould, J., Iles, D., Riccardi, D., Peers, C., & Kemp, P. J. (2004) · Science · doi:10.1126/science.1105010 · Cited by 458 · see citing works

Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue

Sakadžić, S., Roussakis, E., Yaseen, M. A., Mandeville, E. T., Srinivasan, V. J., Arai, K., Ruvinskaya, S., Devor, A., Lo, E. H., Vinogradov, S. A., et al. (2010) · Nature Methods · doi:10.1038/nmeth.1490 · Cited by 454 · see citing works

Oxygen Gradients in the Microcirculation

Tsai, A. G., Johnson, P. C., & Intaglietta, M. (2003) · Physiological Reviews · doi:10.1152/physrev.00034.2002 · Cited by 450 · see citing works

Hypoxia-Inducible Factor 1–Dependent Induction of Intestinal Trefoil Factor Protects Barrier Function during Hypoxia

Furuta, G. T., Turner, J. R., Taylor, C. T., Hershberg, R. M., Comerford, K., Narravula, S., Podolsky, D. K., & Colgan, S. P. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.9.1027 · Cited by 449 · see citing works

III. Experiments on the quantity of gases absorbed by water, at different temperatures, and under different pressures

Henry, W. (1803) · Philosophical Transactions of the Royal Society of London · doi:10.1098/rstl.1803.0004 · Cited by 446 · see citing works

Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications

Lei, X. G., Zhu, J., Cheng, W.-H., Bao, Y., Ho, Y.-S., Reddi, A. R., Holmgren, A., & Arnér, E. S. J. (2015) · Physiological Reviews · doi:10.1152/physrev.00010.2014 · Cited by 437 · see citing works

Limitations of Oxygen Delivery to Cells in Culture: An Underappreciated Problem in Basic and Translational Research

Place, T. L., Domann, F. E., & Case, A. J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.10.003 · Cited by 434 · see citing works

Prolonged Hypoxia Differentially Regulates Hypoxia-inducible Factor (HIF)-1α and HIF-2α Expression in Lung Epithelial Cells

Uchida, T., Rossignol, F., Matthay, M. A., Mounier, R., Couette, S., Clottes, E., & Clérici, C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400461200 · Cited by 429 · see citing works

Cultivation of rat marrow‐derived mesenchymal stem cells in reduced oxygen tension: Effects on in vitro and in vivo osteochondrogenesis

Lennon, D. P., Edmison, J. M., & Caplan, A. I. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.1081 · Cited by 425 · see citing works

Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein

Wong, A. P., Bear, C. E., Chin, S., Pasceri, P., Thompson, T., Huan, L., Ratjen, F. A., Ellis, J., & Rossant, J. (2012) · Nature Biotechnology · doi:10.1038/nbt.2328 · Cited by 425 · see citing works

Differential Effects of Physiologically Relevant Hypoxic Conditions on T Lymphocyte Development and Effector Functions

Caldwell, C. C., Kojima, H., Lukashev, D., Armstrong, J., Farber, M., Apasov, S. G., & Sitkovsky, M. V. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6140 · Cited by 420 · see citing works

Über die Konstitution der Salzlösungen auf Grund ihres Verhaltens zu Kohlensäure

Setschenow, J. (1889) · Zeitschrift für Physikalische Chemie · doi:10.1515/zpch-1889-0409 · Cited by 420 · see citing works

Markedly Decreased Oxygen Tension in Transplanted Rat Pancreatic Islets Irrespective of the Implantation Site

Carlsson, P., Palm, F., Andersson, A., & Liss, P. (2001) · Diabetes · doi:10.2337/diabetes.50.3.489 · Cited by 416 · see citing works

Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia

Rosenberger, P., Schwab, J. M., Mirakaj, V., Masekowsky, E., Mager, A., Morote–Garcia, J. C., Unertl, K. E., & Eltzschig, H. K. (2009) · Nature Immunology · doi:10.1038/ni.1683 · Cited by 406 · see citing works

Culture in Reduced Levels of Oxygen Promotes Clonogenic Sympathoadrenal Differentiation by Isolated Neural Crest Stem Cells

Morrison, S. J., CSETE, M. E., Groves, A. K., Melega, W. P., Wold, B. J., & Anderson, D. J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07370.2000 · Cited by 403 · see citing works

Derivation of Pre-X Inactivation Human Embryonic Stem Cells under Physiological Oxygen Concentrations

Lengner, C. J., Gimelbrant, A. A., Erwin, J. A., Cheng, A. W., Guenther, M. G., Welstead, G. G., Alagappan, R. K., Frampton, G. M., Xu, P. A., Muffat, J., et al. (2010) · Cell · doi:10.1016/j.cell.2010.04.010 · Cited by 398 · see citing works

Differentiating the functional role of hypoxia‐inducible factor (HIF)‐1α and HIF‐2α (EPAS‐1) by the use of RNA interference: erythropoietin is a HIF‐2α target gene in Hep3B and Kelly cells

Warnecke, C., Zaborowska, Z., Kurreck, J., Erdmann, V. A., Frei, U. A., Wiesener, M. S., & Eckardt, K. (2004) · The FASEB Journal · doi:10.1096/fj.04-1640fje · Cited by 395 · see citing works

The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia

Pezzulo, A. A., Starner, T. D., Scheetz, T. E., Traver, G. L., Tilley, A. E., Harvey, B., Crystal, R. G., McCray, P. B., & Zabner, J. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00256.2010 · Cited by 390 · see citing works

Low oxygen tension inhibits osteogenic differentiation and enhances stemness of human MIAMI cells

D’Ippolito, G., Diabira, S., Howard, G. A., Roos, B. A., & Schiller, P. C. (2006) · Bone · doi:10.1016/j.bone.2006.02.061 · Cited by 389 · see citing works

Culture of Calu-3 Cells at the Air Interface Provides a Representative Model of the Airway Epithelial Barrier

Grainger, C. I., Greenwell, L. L., Lockley, D. J., Martin, G. P., & Forbes, B. (2006) · Pharmaceutical Research · doi:10.1007/s11095-006-0255-0 · Cited by 388 · see citing works

Noninvasive measurement of anatomic structure and intraluminal oxygenation in the gastrointestinal tract of living mice with spatial and spectral EPR imaging

He, G., Shankar, R. A., Chzhan, M., Samouilov, A., Kuppusamy, P., & Zweier, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4586 · Cited by 383 · see citing works

Oxygen and Placental Development During the First Trimester: Implications for the Pathophysiology of Pre-eclampsia

Caniggia, I., Winter, J., Lye, S. J., & Post, M. (2000) · Placenta · doi:10.1053/plac.1999.0522 · Cited by 377 · see citing works

Obesity Decreases Perioperative Tissue Oxygenation

Kabon, B., Nagele, A., Reddy, D., Eagon, C., Fleshman, J. W., Sessler, D. I., & Kurz, A. (2004) · Anesthesiology · doi:10.1097/00000542-200402000-00015 · Cited by 376 · see citing works

Predominant role of hypoxia-inducible transcription factor (Hif)-1alpha versus Hif-2alpha in regulation of the transcriptional response to hypoxia.

Sowter, H., Raval, R. R., Moore, J. W., Ratcliffe, P. J., & Harris, A. L. (2003) · PubMed · Cited by 374 · see citing works

Model for Hypoxic Pulmonary Vasoconstriction Involving Mitochondrial Oxygen Sensing

Waypa, G. B., Chandel, N. S., & Schumacker, P. T. (2001) · Circulation Research · doi:10.1161/hh1201.091960 · Cited by 367 · see citing works

The oxygen dependence of cellular energy metabolism

Wilson, D. F., Erecińska, M., Drown, C., & Silver, I. A. (1979) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(79)90375-8 · Cited by 366 · see citing works

Signalling hypoxia by HIF hydroxylases

Schofield, C. J., & Ratcliffe, P. J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.111 · Cited by 343 · see citing works

Nature of Species Differences in the Medial Distribution of Aortic Vasa Vasorum in Mammals

Wolinsky, H., & Glagov, S. (1967) · Circulation Research · doi:10.1161/01.res.20.4.409 · Cited by 337 · see citing works

Oxygen tension in synovial fluids

Lund‐Olesen, K. (1970) · Arthritis & Rheumatism · doi:10.1002/art.1780130606 · Cited by 336 · see citing works

Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio

Emerling, B. M., Weinberg, F., Snyder, C., Burgess, Z., Mutlu, G. M., Viollet, B., Budinger, G. R. S., & Chandel, N. S. (2009) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.02.019 · Cited by 330 · see citing works

Hypoxia-inducible factors in the kidney

Haase, V. H. (2006) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00071.2006 · Cited by 329 · see citing works

Oxygen saturation in the bone marrow of healthy volunteers

Harrison, J. S., Rameshwar, P., Chang, V. T.-S., & Bandari, P. S. (2002) · Blood · doi:10.1182/blood.v99.1.394 · Cited by 328 · see citing works

Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors

Yamakawa, M., Liu, L. X., Date, T., Belanger, A. J., Vincent, K. A., Akita, G. Y., Kuriyama, T., Cheng, S. H., Gregory, R. J., & Jiang, C. (2003) · Circulation Research · doi:10.1161/01.res.0000093984.48643.d7 · Cited by 327 · see citing works

Increased Adipose Tissue Oxygen Tension in Obese Compared With Lean Men Is Accompanied by Insulin Resistance, Impaired Adipose Tissue Capillarization, and Inflammation

Goossens, G. H., Bizzarri, A., Venteclef, N., Essers, Y., Cleutjens, J. P., Konings, E., Jocken, J. W. E., Čajlaković, M., Ribitsch, V., Clément, K., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.027813 · Cited by 324 · see citing works

Clinical Experience with 118 Brain Tissue Oxygen Partial Pressure Catheter Probes

Dings, J. T. A., Meixensberger, J., Jäger, A., & Roosen, K. (1998) · Neurosurgery · doi:10.1097/00006123-199811000-00045 · Cited by 323 · see citing works

Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue.

Yin, J., Gao, Z., He, Q., Zhou, D., Guo, Z., & Ye, J. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90760.2008 · Cited by 319 · see citing works

Mitochondrial Oxygen Affinity, Respiratory Flux Control And Excess Capacity Of Cytochrome c Oxidase

Gnaiger, E., Lassnig, B., Kuznetsov, A. V., Rieger, G. E., & Margreiter, R. (1998) · Journal of Experimental Biology · doi:10.1242/jeb.201.8.1129 · Cited by 318 · see citing works

Evaluation of respiratory gases and acid-base gradients in human fetal fluids and uteroplacental tissue between 7 and 16 weeks’ gestation

Jauniaux, E. R. M., Watson, A. L., & Burton, G. J. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.111935 · Cited by 316 · see citing works

Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells

Holzwarth, C., Vaegler, M., Gieseke, F., Pfister, S. M., Handgretinger, R., Kerst, G., & Müller, I. (2010) · BMC Cell Biology · doi:10.1186/1471-2121-11-11 · Cited by 314 · see citing works

Diversity in Mitochondrial Function Explains Differences in Vascular Oxygen Sensing

Michelakis, E. D., Hampl, V., Nsair, A., Wu, X., Harry, G., Haromy, A., Gurtu, R., & Archer, S. L. (2002) · Circulation Research · doi:10.1161/01.res.0000024689.07590.c2 · Cited by 309 · see citing works

Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases

Treuhaft, P. S., & McCarty, D. J. (1971) · Arthritis & Rheumatism · doi:10.1002/art.1780140407 · Cited by 307 · see citing works

Comparisons among Pimonidazole Binding, Oxygen Electrode Measurements, and Radiation Response in C3H Mouse Tumors

Raleigh, J. A., Chou, S.-C., Arteel, G. E., & Horsman, M. R. (1999) · Radiation Research · doi:10.2307/3580034 · Cited by 304 · see citing works

The suffocating kidney: tubulointerstitial hypoxia in end-stage renal disease

Mimura, I., & Nangaku, M. (2010) · Nature Reviews Nephrology · doi:10.1038/nrneph.2010.124 · Cited by 300 · see citing works

Hypoxia inhibits the growth, differentiation and bone-forming capacity of rat osteoblasts

Utting, J. C., Robins, S. P., Brandao‐Burch, A., Orriss, I. R., Behar, J. M., & Arnett, T. R. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.02.007 · Cited by 296 · see citing works

On the mechanism by which vascular endothelial cells regulate their oxygen consumption

Clementi, E., Brown, G. C., Foxwell, N., & Moncada, S. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1559 · Cited by 296 · see citing works

Oxygen sensing and hypoxia signalling pathways in animals: The implications of physiology for cancer

Ratcliffe, P. J. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.251470 · Cited by 294 · see citing works

An Evaluation of Tumor Oxygenation and Gene Expression in Patients with Early Stage Non–Small Cell Lung Cancers

Le, Q., Chen, E. Y., Salim, A., Cao, H., Kong, C. S., Whyte, R. I., Donington, J. S., Cannon, W., Wakelee, H. A., Tibshirani, R. J., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2049 · Cited by 293 · see citing works

Cell turnover of capillaries.

Engerman, R. L., Pfaffenbach, D. D., & Davis (1967) · PubMed · Cited by 290 · see citing works

Evidence of Hypoxic Areas Within the Arterial Wall In Vivo

Björnheden, T., Levin, M., Evaldsson, M., & Wiklund, O. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.4.870 · Cited by 287 · see citing works

Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents

Braun, R. D., Lanzen, J. L., Snyder, S. A., & Dewhirst, M. W. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.6.h2533 · Cited by 285 · see citing works

Expression and Characterization of Hypoxia-Inducible Factor (HIF)-3α in Human Kidney: Suppression of HIF-Mediated Gene Expression by HIF-3α

Hara, S., Hamada, J., Kobayashi, C., Kondo, Y., & Imura, N. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5659 · Cited by 283 · see citing works

Microvascular and tissue oxygen distribution

Intaglietta, M., Johnson, P. C., & Winslow, R. M. (1996) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00110-1 · Cited by 282 · see citing works

Role of nitric oxide in renal medullary oxygenation. Studies in isolated and intact rat kidneys.

Brezis, M., Heyman, S. N., Dinour, D., Epstein, F. H., & Rosen, S. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115316 · Cited by 281 · see citing works

Oxygen: the Molecule that made the World

Carter, R. (2003) · Journal of the Royal Society of Medicine · doi:10.1258/jrsm.96.1.46 · Cited by 280 · see citing works

Heme oxygenase–carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide?

Siow, R. C. M. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00278-8 · Cited by 274 · see citing works

Effect of Gestational Age on Fetal and Intervillous Blood Gas and Acid-Base Values in Human Pregnancy

SOOTHILL, P. W., Nicolaides, K. H., Rodeck, C. H., & Campbell, S. C. (1986) · Fetal Diagnosis and Therapy · doi:10.1159/000262264 · Cited by 265 · see citing works

A theoretical analysis of the effect of the particulate nature of blood on oxygen release in capillaries

Federspiel, W. J., & Popel, A. S. (1986) · Microvascular Research · doi:10.1016/0026-2862(86)90052-x · Cited by 263 · see citing works

O 2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase

Archer, S. L., Reeve, H. L., Michelakis, E. D., Puttagunta, L., Waite, R. E., Nelson, D. P., Dinauer, M. C., & Weir, Ε. K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.14.7944 · Cited by 263 · see citing works

Relative mitochondrial membrane potential and [Ca2+]i in type I cells isolated from the rabbit carotid body.

Duchen, M. R., & Biscoe, T. J. (1992) · The Journal of Physiology · doi:10.1113/jphysiol.1992.sp019115 · Cited by 263 · see citing works

Simultaneous two-photon imaging of oxygen and blood flow in deep cerebral vessels

Lecoq, J. A., Parpaleix, A., Roussakis, E., Ducros, M. G., Houssen, Y. G., Vinogradov, S. A., & Charpak, S. (2011) · Nature Medicine · doi:10.1038/nm.2394 · Cited by 261 · see citing works

Arterial Chemoreceptors.

(1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-69-2-414_1 · Cited by 261 · see citing works

The concentration and isotopic fractionation of gases dissolved in freshwater in equilibrium with the atmosphere. 1. Oxygen

Benson, B. B., & Krause, D. F. (1980) · Limnology and Oceanography · doi:10.4319/lo.1980.25.4.0662 · Cited by 260 · see citing works

Redifferentiation of dedifferentiated bovine articular chondrocytes in alginate culture under low oxygen tension

Domm, C., Schünke, M., Christesen, K., & Kurz, B. (2002) · Osteoarthritis and Cartilage · doi:10.1053/joca.2001.0477 · Cited by 259 · see citing works

A biphasic chamber system for maintaining polarity of differentiation of culture respiratory tract epithelial cells

WHITCUTT, M. J., Adler, K. B., & Wu, R. (1988) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02628493 · Cited by 258 · see citing works

Regulation of Tissue Oxygenation

Pittman, R. N. (2011) · Colloquium Series on Integrated Systems Physiology From Molecule to Function · doi:10.4199/c00029ed1v01y201103isp017 · Cited by 258 · see citing works

Pulmonary Artery NADPH-Oxidase is Activated in Hypoxic Pulmonary Vasoconstriction

Marshall, C., Mamary, A. J., Verhoeven, A. J., & Marshall, B. E. (1996) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.15.5.8918370 · Cited by 257 · see citing works

PHDs overactivation during chronic hypoxia “desensitizes” HIFα and protects cells from necrosis

Ginouvès, A., Ilc, K., Cámara, N. M., Pouysségur, J., & Berra, E. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705680105 · Cited by 256 · see citing works

Modes of regulation of ubiquitin-mediated protein degradation

Kornitzer, D., & Ciechanover, A. J. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200001)182:1 · Cited by 256 · see citing works

Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock

VanderMeer, T. J., Wang, H., & Fink, M. P. (1995) · Critical Care Medicine · doi:10.1097/00003246-199507000-00011 · Cited by 255 · see citing works

Fibre-optic oxygen sensor with the fluorescence decay time as the information carrier

Lippitsch, M. E., Pusterhofer, J., Leiner, M., & Wolfbeis, O. S. (1988) · Analytica Chimica Acta · doi:10.1016/s0003-2670(00)82310-7 · Cited by 255 · see citing works

Negative regulation of Hif1a expression and TH17 differentiation by the hypoxia-regulated microRNA miR-210

Wang, H., Flach, H., Onizawa, M., Wei, L., McManus, M. T., & Weiss, A. (2014) · Nature Immunology · doi:10.1038/ni.2846 · Cited by 251 · see citing works

Two New “Protected” Oxyphors for Biological Oximetry: Properties and Application in Tumor Imaging

Esipova, T. V., Karagodov, A. I., Miller, J. M., Wilson, D. F., Busch, T. M., & Vinogradov, S. A. (2011) · Analytical Chemistry · doi:10.1021/ac2022234 · Cited by 248 · see citing works

Endothelial cell responses to hypoxia: initiation of a cascade of cellular interactions

Michiels, C., Arnould, T., & Remacle, J. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(00)00041-0 · Cited by 247 · see citing works

Cu–ATSM: A radiopharmaceutical for the PET imaging of hypoxia

Vāvere, A. L., & Lewis, J. S. (2007) · Dalton Transactions · doi:10.1039/b705989b · Cited by 245 · see citing works

Oxygen Tension in Zones of the Epiphyseal Plate, the Metaphysis and Diaphysis

Brighton, C. T., & Heppenstall, R. B. (1971) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197153040-00011 · Cited by 242 · see citing works

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

Yu, J.-X., Kodibagkar, V. D., Cui, W., & Mason, R. P. (2005) · Current Medicinal Chemistry · doi:10.2174/0929867053507342 · Cited by 239 · see citing works

Mechanical Strain Increases Smooth Muscle and Decreases Nonmuscle Myosin Expression in Rat Vascular Smooth Muscle Cells

Reusch, H. P., Wagdy, H. M., Reusch, R., Wilson, E., & Ives, H. E. (1996) · Circulation Research · doi:10.1161/01.res.79.5.1046 · Cited by 234 · see citing works

Optical probes and techniques for O2 measurement in live cells and tissue

Dmitriev, R. I., & Papkovsky, D. B. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0914-0 · Cited by 231 · see citing works

The Human First Trimester Gestational Sac Limits Rather than Facilitates Oxygen Transfer to the Foetus—A Review

Jauniaux, E. R. M., Gulbis, B., & Burton, G. J. (2003) · Placenta · doi:10.1053/plac.2002.0932 · Cited by 231 · see citing works

Hypoxic induction of an HIF-1α–dependent bFGF autocrine loop drives angiogenesis in human endothelial cells

Calvani, M., Rapisarda, A., Uranchimeg, B., Shoemaker, R. H., & Melillo, G. (2005) · Blood · doi:10.1182/blood-2005-09-3541 · Cited by 231 · see citing works

HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity

Saeedi, B. J., Kao, D. J., Kitzenberg, D., Dobrinskikh, E., Schwisow, K. D., Masterson, J. C., Kendrick, A. A., Kelly, C. J., Bayless, A. J., Kominsky, D. J., et al. (2015) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-07-1194 · Cited by 231 · see citing works

Microvascular and tissue oxygen gradients in the rat mesentery

Tsai, A. G., Friesenecker, B. E., Mazzoni, M. C., Kerger, H., Buerk, D. G., Johnson, P. C., & Intaglietta, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6590 · Cited by 230 · see citing works

Effect of Gestational Age on Fetal and Intervillous Blood Gas and Acid-Base Values in Human Pregnancy

SOOTHILL, P. W., Nicolaides, K. H., Rodeck, C. H., & Campbell, S. C. (1988) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198843010-00005 · Cited by 227 · see citing works

Wild-derived inbred mouse strains have short telomeres

Hemann, M. T. (2000) · Nucleic Acids Research · doi:10.1093/nar/28.22.4474 · Cited by 227 · see citing works

Respiratory gases of synovial fluids

Falchuk, K. H., Goetzl, E. J., & Kulka, J. (1970) · The American Journal of Medicine · doi:10.1016/s0002-9343(70)80078-x · Cited by 225 · see citing works

Enhanced Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells in Low Oxygen Environment Micropellet Cultures

Markway, B. D., Tan, G., Brooke, G. P., Hudson, J. E., Cooper-White, J. J., & Doran, M. R. (2010) · Cell Transplantation · doi:10.3727/096368909x478560 · Cited by 224 · see citing works

Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts.

Lord, E. M., Harwell, L. W., & Koch, C. J. (1993) · PubMed · Cited by 223 · see citing works

Bovine articular chondrocyte function depends upon oxygen tension

Grimshaw, M. J., & Mason, R. M. (2000) · Osteoarthritis and Cartilage · doi:10.1053/joca.1999.0314 · Cited by 223 · see citing works

Asparaginyl Hydroxylation of the Notch Ankyrin Repeat Domain by Factor Inhibiting Hypoxia-inducible Factor

Coleman, M. L., McDonough, M. A., Hewitson, K. S., Coles, C., Mecinovicí, J., Edelmann, M., Cook, K. M., Cockman, M. E., Lancaster, D. E., Kessler, B. M., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704102200 · Cited by 222 · see citing works

Oxygen Sensing and Homeostasis

Prabhakar, N. R., & Semenza, G. L. (2015) · Physiology · doi:10.1152/physiol.00022.2015 · Cited by 222 · see citing works

Oxygen sensors in context

Ward, J. P. T. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.10.010 · Cited by 221 · see citing works

OXYGEN TENSION WITHIN THE RABBIT FALLOPIAN TUBE

Mastroianni, L., & Jones, R. (1965) · Reproduction · doi:10.1530/jrf.0.0090099 · Cited by 221 · see citing works

In vivo Hypoxia and a Fungal Alcohol Dehydrogenase Influence the Pathogenesis of Invasive Pulmonary Aspergillosis

Grahl, N., Puttikamonkul, S., Macdonald, J. M., Gamcsik, M. P., Ngo, L. Y., Hohl, T. M., & Cramer, R. A. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002145 · Cited by 217 · see citing works

Fibre optic oxygen sensor based on fluorescence quenching of evanescent-wave excited ruthenium complexes in sol–gel derived porous coatings

MacCraith, B. D., McDonagh, C. M., O'Keeffe, G., Keyes, E. T., Vos, J. G., O’Kelly, B. C., & McGilp, J. F. (1993) · The Analyst · doi:10.1039/an9931800385 · Cited by 215 · see citing works

Nephron pO2 and renal oxygen usage in the hypertensive rat kidney

Welch, W. J., Baumgärtl, H., Lübbers, D. W., & Wilcox, C. S. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.00483.x · Cited by 213 · see citing works

Distribution of oxygen tension on the surface of arterioles, capillaries and venules of brain cortex and in tissue in normoxia: an experimental study on rats

Vovenko, E. P. (1999) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050825 · Cited by 207 · see citing works

Noninvasive in vivo fluorescence measurement of airway-surface liquid depth, salt concentration, and pH

Jayaraman, S., Song, Y., Vetrivel, L., Shankar, L., & Verkman, A. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11154 · Cited by 206 · see citing works

Tissue oxygen tension as a predictor of colonic anastomotic healing

Sheridan, W. G., Lowndes, R. H., & Young, H. L. (1987) · Diseases of the Colon & Rectum · doi:10.1007/bf02555426 · Cited by 205 · see citing works

The von Hippel Lindau/Hypoxia-inducible Factor (HIF) Pathway Regulates the Transcription of the HIF-Proline Hydroxylase Genes in Response to Low Oxygen

del Peso, L., Castellanos, M. C., Temes, E., Martı́n-Puig, S., Cuevas, Y., Olmos, G., & Landázuri, M. O. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308862200 · Cited by 205 · see citing works

Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

Sies, H., Belousov, V. V., Chandel, N. S., Davies, M. J., Jones, D. P., Mann, G. E., Murphy, M. P., Yamamoto, M., & Winterbourn, C. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00456-z · Cited by 1,735 · see citing works

Faecalibacterium : a bacterial genus with promising human health applications

Martín, R., Ríos-Covián, D., Huillet, E., Auger, S., Khazaal, S., Bermúdez‐Humarán, L. G., Sokol, H., Chatel, J., & Langella, P. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad039 · Cited by 583 · see citing works

Pathophysiological implications of hypoxia in human diseases

Chen, P.-S., Chiu, W.-T., Hsu, P.-L., Lin, S.-C., Peng, I.-C., Wang, C.-Y., & Tsai, S.-J. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-00658-7 · Cited by 318 · see citing works

Mechanisms of hypoxia signalling: new implications for nephrology

Schödel, J., & Ratcliffe, P. J. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0182-z · Cited by 309 · see citing works

Short-chain fatty acids as modulators of redox signaling in health and disease

González‐Bosch, C., Boorman, E., Zunszain, P. A., & Mann, G. E. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102165 · Cited by 285 · see citing works

Partial pressure of oxygen in the human body: a general review.

Ortiz‐Prado, E., Dunn, J. F., Vásconez-González, J., Castillo, D., & Viscor, G. (2019) · Europe PMC (PubMed Central) · Cited by 263 · see citing works

Relevance of Oxygen Concentration in Stem Cell Culture for Regenerative Medicine

Mas‐Bargues, C., Sanz‐Ros, J., Román-Domínguez, A., Inglés, M., Gimeno-Mallench, L., Alami, M. E., Viña‐Almunia, J., Gambini, J., Viña, J., & Borrás, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051195 · Cited by 219 · see citing works

Regulation of the Hypoxia-Inducible Factor (HIF) by Pro-Inflammatory Cytokines

Malkov, M. I., Lee, C. T., & Taylor, C. T. (2021) · Cells · doi:10.3390/cells10092340 · Cited by 185 · see citing works

Metabolic Heterogeneity of Cancer Cells: An Interplay between HIF-1, GLUTs, and AMPK

Moldogazieva, N. T., Mokhosoev, I. M., & Terentiev, A. A. (2020) · Cancers · doi:10.3390/cancers12040862 · Cited by 176 · see citing works

Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression

van Vliet, T., Varela-Eirin, M., Wang, B., Borghesan, M., Brandenburg, S. M., Franzin, R., Evangelou, K., Seelen, M., Gorgoulis, V., & Demaria, M. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.03.018 · Cited by 172 · see citing works

Oxygen toxicity: cellular mechanisms in normobaric hyperoxia

Alva, R., Mirza, M., Baiton, A., Lazuran, L., Samokysh, L., Bobinski, A. R., Cowan, C., Jaimon, A., Obioru, D., Makhoul, T. A., et al. (2022) · Cell Biology and Toxicology · doi:10.1007/s10565-022-09773-7 · Cited by 128 · see citing works

Oxygen and Mammalian Cell Culture: Are We Repeating the experiment of Dr. Ox?

Ast, T., & Mootha, V. K. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0105-0 · Cited by 125 · see citing works

Energy metabolism in mammalian sperm motility

Amaral, A. (2022) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1569 · Cited by 123 · see citing works

Preferential Targeting Cerebral Ischemic Lesions with Cancer Cell-Inspired Nanovehicle for Ischemic Stroke Treatment

He, W., Mei, Q., Li, J., Zhai, Y., Chen, Y., Wang, R., Lu, E., Zhang, X., Zhang, Z., & Sha, X. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c00231 · Cited by 106 · see citing works

Guidance document on Good cell and tissue culture practice 2.0 (GCCP 2.0)

Pamies, D. (2021) · ALTEX · doi:10.14573/altex.2111011 · Cited by 100 · see citing works

Revitalizing Ancient Mitochondria with Nano‐Strategies: Mitochondria‐Remedying Nanodrugs Concentrate on Disease Control

Long, X., Liu, M., Nan, Y., Chen, Q., Xiao, Z., Xiang, Y., Ying, X., Sun, J., Huang, Q., & Ai, K. (2024) · Advanced Materials · doi:10.1002/adma.202308239 · Cited by 96 · see citing works

Personalized redox medicine in inflammatory bowel diseases: an emerging role for HIF-1α and NRF2 as therapeutic targets

Bourgonje, A. R., Klóska, D., Grochot‐Przeczek, A., Feelisch, M., Cuadrado, A., & van Goor, H. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102603 · Cited by 95 · see citing works

Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin

Henry, E. R., Metaferia, B. B., Li, Q., Delenko, J., Best, R. B., Glass, K. E., Cellmer, T., Dunkelberger, E. B., Conrey, A. K., Thein, S. L., et al. (2021) · Blood · doi:10.1182/blood.2021012070 · Cited by 91 · see citing works

Peroxynitrite: a multifaceted oxidizing and nitrating metabolite

Prolo, C., Piacenza, L., & Radí, R. (2024) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2024.102459 · Cited by 95 · see citing works

Redox signaling in the pancreas in health and disease

Sastre, J., Pérez, S., Sabater-Orti, L., & Rius‐Pérez, S. (2024) · Physiological Reviews · doi:10.1152/physrev.00044.2023 · Cited by 92 · see citing works

Nrf2-regulated redox signaling in brain endothelial cells adapted to physiological oxygen levels: Consequences for sulforaphane mediated protection against hypoxia-reoxygenation

Warpsinski, G., Smith, M. J., Srivastava, S., Keeley, T. P., Siow, R. C. M., Fraser, P. A., & Mann, G. E. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101708 · Cited by 79 · see citing works

Renal Normothermic Machine Perfusion: The Road Toward Clinical Implementation of a Promising Pretransplant Organ Assessment Tool

Hamelink, T. L., Ogurlu, B., Beule, J. D., Lantinga, V. A., Pool, M. B. F., Venema, L. H., Leuvenink, H. G. D., Jochmans, I., & Moers, C. (2021) · Transplantation · doi:10.1097/tp.0000000000003817 · Cited by 77 · see citing works

Hypoxia-inducible factor in breast cancer: role and target for breast cancer treatment

Zhi, S., Chen, C., Huang, H., Zhang, Z., Zeng, F., & Zhang, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1370800 · Cited by 84 · see citing works

Establishment of physiologically relevant oxygen gradients in microfluidic organ chips

Grant, J. L., Lee, E., Almeida, M., Kim, S., LoGrande, N., Goyal, G., Sesay, A. M., Breault, D. T., Prantil‐Baun, R., & Ingber, D. E. (2022) · Lab on a Chip · doi:10.1039/d2lc00069e · Cited by 74 · see citing works

Reactive oxygen species or reactive sulfur species: why we should consider the latter

Olson, K. R. (2020) · Journal of Experimental Biology · doi:10.1242/jeb.196352 · Cited by 69 · see citing works

Allosteric control of hemoglobin S fiber formation by oxygen and its relation to the pathophysiology of sickle cell disease

Henry, E. R., Cellmer, T., Dunkelberger, E. B., Metaferia, B., Hofrichter, J., Li, Q., Ostrowski, D., Ghirlando, R., Louis, J. M., Moutereau, S., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922004117 · Cited by 65 · see citing works

Oxygenation Status of Malignant Tumors vs. Normal Tissues: Critical Evaluation and Updated Data Source Based on Direct Measurements with pO2 Microsensors

Vaupel, P. W., Flood, A. B., & Swartz, H. M. (2021) · Applied Magnetic Resonance · doi:10.1007/s00723-021-01383-6 · Cited by 68 · see citing works

How oxygenation shapes immune responses: emerging roles for physioxia and pathological hypoxia

Mirchandani, A. S., Sánchez-García, M. A., & Walmsley, S. R. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01087-5 · Cited by 70 · see citing works

Responses of Clostridia to oxygen: from detoxification to adaptive strategies

Morvan, C., Folgosa, F., Kint, N., Teixeira, M. S., & Martin‐Verstraete, I. (2021) · Environmental Microbiology · doi:10.1111/1462-2920.15665 · Cited by 64 · see citing works

Nitric Oxide and Hydrogen Sulfide Regulation of Ischemic Vascular Growth and Remodeling

Rajendran, S., Shen, X., Glawe, J. D., Kolluru, G. K., & Kevil, C. G. (2019) · Comprehensive physiology · doi:10.1002/cphy.c180026 · Cited by 68 · see citing works

The contribution of an imbalanced redox signalling to neurological and neurodegenerative conditions

Steinert, J. R., & Amal, H. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.11.035 · Cited by 62 · see citing works

How best to interpret measures of levels of oxygen in tissues to make them effective clinical tools for care of patients with cancer and other oxygen‐dependent pathologies

Swartz, H. M., Flood, A. B., Schaner, P. E., Halpern, H. J., Williams, B. B., Pogue, B. W., Gallez, B., & Vaupel, P. W. (2020) · Physiological Reports · doi:10.14814/phy2.14541 · Cited by 60 · see citing works

Limited oxygen in standard cell culture alters metabolism and function of differentiated cells

Tan, J., Virtue, S., Norris, D. M., Conway, O. J., Yang, M. H., Bidault, G., Gribben, C., Lugtu, F., Kamzolas, I., Krycer, J. R., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00084-7 · Cited by 61 · see citing works

In Vitro Oxygen Glucose Deprivation Model of Ischemic Stroke: A Proteomics-Driven Systems Biological Perspective

Babu, M., Singh, N., & Datta, A. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02745-2 · Cited by 61 · see citing works

Hypoxia in Human Obesity: New Insights from Inflammation towards Insulin Resistance—A Narrative Review

Mirabelli, M., Misiti, R., Sicilia, L., Brunetti, F. S., CHIEFARI, E. D., Brunetti, A., & FOTI, D. P. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25189802 · Cited by 65 · see citing works

Fisetin protects against cardiac cell death through reduction of ROS production and caspases activity

Rodius, S., de Klein, N., Jeanty, C., Sánchez-Iranzo, H., Crespo, I., Ibberson, M. R., Xénarios, I., Dittmar, G. A. G., Mercader, N., Niclou, S. P., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-59894-4 · Cited by 59 · see citing works

Supraphysiological Oxygen Levels in Mammalian Cell Culture: Current State and Future Perspectives

Alva, R., Gardner, G. L., Liang, P., & Stuart, J. A. (2022) · Cells · doi:10.3390/cells11193123 · Cited by 55 · see citing works

Interplay of carbon dioxide and peroxide metabolism in mammalian cells

Radí, R. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102358 · Cited by 52 · see citing works

Cell Culture Process Scale-Up Challenges for Commercial-Scale Manufacturing of Allogeneic Pluripotent Stem Cell Products

Lee, B., Jung, S., Hashimura, Y., Lee, M., Borys, B. S., Dang, T., Kallos, M. S., Rodrigues, C. A. V., Silva, T. P., & Cabral, J. M. S. (2022) · Bioengineering · doi:10.3390/bioengineering9030092 · Cited by 49 · see citing works

Dynamic regulation of epigenetic demethylation by oxygen availability and cellular redox

Lamadema, N., Burr, S., & Brewer, A. C. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.12.009 · Cited by 48 · see citing works

Are Reactive Sulfur Species the New Reactive Oxygen Species?

Olson, K. R. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8132 · Cited by 49 · see citing works

Coenzyme Q redox signalling and longevity

Scialò, F., & Sanz, A. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.01.018 · Cited by 46 · see citing works

Photosynthetic Microorganisms for the Oxygenation of Advanced 3D Bioprinted Tissues

Ortega, J. S., Corrales-Orovio, R., Ralph, P., Egaña, J. T., & Gentile, C. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2022.05.009 · Cited by 47 · see citing works

High glutathionylation of placental endothelial nitric oxide synthase in preeclampsia

Guerby, P., Swiader, A., Augè, N., Parant, O., Vayssière, C., Uchida, K., Salvayre, R., & Nègre‐Salvayre, A. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101126 · Cited by 46 · see citing works

Pathophysiology and clinical consequences of arterial blood gases and pH after cardiac arrest

Robba, C., Siwicka-Gieroba, D., Sikter, A., Battaglini, D., Dąbrowski, W., Schultz, M. J., de Jonge, E., Grim, C. C. A., Rocco, P. R. M., & Pelosi, P. P. (2020) · Intensive Care Medicine Experimental · doi:10.1186/s40635-020-00307-1 · Cited by 45 · see citing works

Mechanisms underlying Nrf2 nuclear translocation by non-lethal levels of hydrogen peroxide: p38 MAPK-dependent neutral sphingomyelinase2 membrane trafficking and ceramide/PKCζ/CK2 signaling

Ishii, T., Warabi, E., & Mann, G. E. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.08.036 · Cited by 45 · see citing works

Single cell-based fluorescence lifetime imaging of intracellular oxygenation and metabolism

Penjweini, R., Roarke, B., Alspaugh, G., Gevorgyan, A., Andreoni, A., Pasut, A., Sackett, D. L., & Knutson, J. R. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101549 · Cited by 45 · see citing works

Hypoxia Inducible Factors as Central Players in the Pathogenesis and Pathophysiology of Cardiovascular Diseases

Garcia-Rojas, E. Y. L., Villanueva, C., & Bond, R. A. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.709509 · Cited by 46 · see citing works

Long‐Term Oxygen Storage Nanosystem for Near‐Infrared Light‐Triggered Oxygen Supplies to Antagonize Hypoxia‐Induced Therapeutic Resistance in Nasopharyngeal Carcinoma

You, Y., Zhao, Z., He, L., Sun, Z., Zhang, D., Shi, C., Cheng, Q., Liu, Y., Luo, L., & Chen, T. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202002369 · Cited by 45 · see citing works

Redox control of antioxidants, metabolism, immunity, and development at the core of stress adaptation of the oyster Crassostrea gigas to the dynamic intertidal environment

Trevisan, R., & Mello, D. F. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.11.003 · Cited by 43 · see citing works

Oxygen-releasing biomaterials for regenerative medicine.

Wang, Z., Chen, T., Li, X., Guo, B., Liu, P., Zhu, Z., & Xu, R. X. (2023) · Journal of materials chemistry. B · doi:10.1039/d3tb00670k · Cited by 28 · see citing works

Hypoxia influences polysome distribution of human ribosomal protein S12 and alternative splicing of ribosomal protein mRNAs

Brumwell, A., Fell, L., Obress, L., & Uniacke, J. (2020) · RNA · doi:10.1261/rna.070318.119 · Cited by 42 · see citing works

Bioengineering the Oxygen-Deprived Tumor Microenvironment Within a Three-Dimensional Platform for Studying Tumor-Immune Interactions

Bhattacharya, S., Calar, K., Evans, C. M., Petrasko, M., & de la Puente, P. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.01040 · Cited by 39 · see citing works

Severe hypoxia is a typical characteristic of human hepatocellular carcinoma: Scientific fact or fallacy?

Cramer, T., & Vaupel, P. W. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2021.12.028 · Cited by 41 · see citing works

Consolidating and re‐evaluating the human disc nutrient microenvironment

McDonnell, E. E., & Buckley, C. T. (2022) · JOR Spine · doi:10.1002/jsp2.1192 · Cited by 40 · see citing works

Hypoxia Drives Dihydropyrimidine Dehydrogenase Expression in Macrophages and Confers Chemoresistance in Colorectal Cancer

Malier, M., Court, M., Gharzeddine, K., Laverierre, M.-H., Marsili, S., Thomas, F., Decaens, T., Roth, G. S., & Millet, A. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-1572 · Cited by 37 · see citing works

Strategies to improve regenerative potential of mesenchymal stem cells

Choudhery, M. S. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i12.1845 · Cited by 40 · see citing works

Hypoxia and renal fibrosis

Naas, S., Schiffer, M., & Schödel, J. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00201.2023 · Cited by 40 · see citing works

Considerations for the Bioengineering of Advanced Cardiac In Vitro Models of Myocardial Infarction

Sharma, P., Wang, X., Ming, C. L. C., Vettori, L., Figtree, G. A., Boyle, A., & Gentile, C. (2021) · Small · doi:10.1002/smll.202003765 · Cited by 37 · see citing works

Hypoxia-Induced Reactivity of Tumor-Associated Astrocytes Affects Glioma Cell Properties

Pantazopoulou, V., Jeannot, P., Rosberg, R., Berg, T. J., & Pietras, A. (2021) · Cells · doi:10.3390/cells10030613 · Cited by 35 · see citing works

O2 affects mitochondrial functionality ex vivo

Nanadikar, M. S., Leon, A. M. V., Borowik, S., Hillemann, A., Zieseniß, A., Belousov, V. V., Bogeski, I., Rehling, P., Dudek, J., & Katschinski, D. M. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101152 · Cited by 33 · see citing works

Recent advances in the biology of tumour hypoxia with relevance to diagnostic practice and tissue‐based research

Macklin, P. S., Yamamoto, A., Browning, L., Hofer, M., Adam, J., & Pugh, C. W. (2020) · The Journal of Pathology · doi:10.1002/path.5402 · Cited by 33 · see citing works

Down syndrome is an oxidative phosphorylation disorder

Bayona‐Bafaluy, M. P., Garrido-Pérez, N., Meade, P., Iglesias, E., Jiménez-Salvador, I., Montoya, J., Martínez‐Cué, C., & Ruiz‐Pesini, E. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101871 · Cited by 33 · see citing works

Physiological hypoxia improves growth and functional differentiation of human intestinal epithelial organoids

Walaas, G. A., Gopalakrishnan, S., Bakke, I., Skovdahl, H. K., Flatberg, A., Østvik, A. E., Sandvik, A. K., & Bruland, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1095812 · Cited by 33 · see citing works

Vertebrate cell culture as an experimental approach – limitations and solutions

Abbas, M., Moradi, F., Hu, W., Regudo, K. L., Osborne, M., Pettipas, J., Atallah, D. S., Hachem, R., Ott-Peron, N., & Stuart, J. A. (2021) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2021.110570 · Cited by 32 · see citing works

Succinate metabolism in the retinal pigment epithelium uncouples respiration from ATP synthesis

Hass, D. T., Bisbach, C. M., Robbings, B. M., Sadı́lek, M., Sweet, I. R., & Hurley, J. B. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110917 · Cited by 33 · see citing works

How the Disruption of Mitochondrial Redox Signalling Contributes to Ageing

Castejón‐Vega, B., Cordero, M. D., & Sanz, A. (2023) · Antioxidants · doi:10.3390/antiox12040831 · Cited by 30 · see citing works

Immune consequences of exercise in hypoxia: A narrative review

Burtscher, J., Pasha, Q., Chanana, N., Millet, G. P., Burtscher, M., & Strasser, B. (2023) · Journal of sport and health science/Journal of Sport and Health Science · doi:10.1016/j.jshs.2023.09.007 · Cited by 34 · see citing works

Interactions between zinc and NRF2 in vascular redox signalling

Yang, F., Smith, M. J., Siow, R. C. M., Aarsland, D., Maret, W., & Mann, G. E. (2024) · Biochemical Society Transactions · doi:10.1042/bst20230490 · Cited by 32 · see citing works

Systemic silencing of Phd2 causes reversible immune regulatory dysfunction

Yamamoto, A., Hester, J., Macklin, P. S., Kawai, K., Uchiyama, M., Biggs, D., Bishop, T., Bull, K. R., Cheng, X., Cawthorne, E., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124099 · Cited by 31 · see citing works

Circumventing the Crabtree effect in cell culture: A systematic review

de Kok, M. J. C., Schaapherder, A. F., Wüst, R. C. I., Zuiderwijk, M. C., Bakker, J. A., Lindeman, J. H. N., & Dévédec, S. E. L. (2021) · Mitochondrion · doi:10.1016/j.mito.2021.03.014 · Cited by 32 · see citing works

The Effect of Oxygen and Micronutrient Composition of Cell Growth Media on Cancer Cell Bioenergetics and Mitochondrial Networks

Moradi, F., Moffatt, C., & Stuart, J. A. (2021) · Biomolecules · doi:10.3390/biom11081177 · Cited by 30 · see citing works

Mitochondrial reactive oxygen species modify extracellular vesicles secretion rate

Nørgård, M. Ø., Lund, P. M., Kalisi, N., Andresen, T. L., Larsen, J. B., Vogel, S., & Svenningsen, P. (2023) · FASEB BioAdvances · doi:10.1096/fba.2023-00053 · Cited by 29 · see citing works

Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling

de Souza, D. C., Hebert, N., Esrick, E. B., Ciuculescu, M. F., Archer, N. M., Armant, M. A., Audureau, É., Brendel, C., Caprio, G. D., Galactéros, F., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40923-5 · Cited by 30 · see citing works

Crosstalk between hypoxia-inducible factor-1α and short-chain fatty acids in inflammatory bowel disease: key clues toward unraveling the mystery

Xiao, J., Guo, X., & Wang, Z. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1385907 · Cited by 29 · see citing works

Detrimental effects of hypoxia on glomerular podocytes

Singh, A., Kolligundla, L. P., Francis, J., & Pasupulati, A. K. (2021) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-021-00788-y · Cited by 29 · see citing works

Hypoxia inducible factors as mediators of reactive oxygen/nitrogen species homeostasis in physiological normoxia

Stuart, J. A., Aibueku, O., Bagshaw, O. R. M., & Moradi, F. (2019) · Medical Hypotheses · doi:10.1016/j.mehy.2019.109249 · Cited by 29 · see citing works

Hypoxia as a medicine

Rogers, R. S., & Mootha, V. K. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adr4049 · Cited by 28 · see citing works

Rhodoquinone carries electrons in the mammalian electron transport chain

Valeros, J., Jerome, M., Tseyang, T., Vo, P., Do, T., Palomino, D. F., Grotehans, N., Kunala, M., Jerrett, A. E., Hathiramani, N. R., et al. (2025) · Cell · doi:10.1016/j.cell.2024.12.007 · Cited by 28 · see citing works

Role of oxygen in fetoplacental endothelial responses: hypoxia, physiological normoxia, or hyperoxia?

Zhou, C., Zou, Q., Jiang, Y.-Z., & Zheng, J. J. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00528.2019 · Cited by 27 · see citing works

How the Anaerobic Enteropathogen Clostridioides difficile Tolerates Low O 2 Tensions

Kint, N., Feliciano, C. A., Martins, M. C., Morvan, C., Fernandes, S. F., Folgosa, F., Dupuy, B., Texeira, M., & Martin‐Verstraete, I. (2020) · mBio · doi:10.1128/mbio.01559-20 · Cited by 28 · see citing works

Conditioned medium produced by fibroblasts cultured in low oxygen pressure allows the formation of highly structured capillary-like networks in fibrin gels

Caneparo, C., Baratange, C., Chabaud, S., & Bolduc, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-66145-z · Cited by 27 · see citing works

The human periconceptional maternal-embryonic space in health and disease

Moreno, I., Capalbo, A., Mas, A., Garrido‐Gómez, T., Rosón, B., Poli, M., Dimitriadis, E., Santamaría, X., Vilella, F., & Simón, C. (2023) · Physiological Reviews · doi:10.1152/physrev.00050.2021 · Cited by 27 · see citing works

Circadian Clock and Hypoxia.

Sartor, F., Ferrero-Bordera, B., Haspel, J., Sperandio, M., Holloway, P. M., & Merrow, M. (2024) · Circulation Research · doi:10.1161/circresaha.124.323518 · Cited by 16 · see citing works

Mechanisms underlying unidirectional laminar shear stress-mediated Nrf2 activation in endothelial cells: Amplification of low shear stress signaling by primary cilia

Ishii, T., Warabi, E., & Mann, G. E. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102103 · Cited by 26 · see citing works

Control of Redox Homeostasis by Short-Chain Fatty Acids: Implications for the Prevention and Treatment of Breast Cancer

González‐Bosch, C., Zunszain, P. A., & Mann, G. E. (2023) · Pathogens · doi:10.3390/pathogens12030486 · Cited by 27 · see citing works

Monitoring mitochondrial PO2: the next step

Mik, E. G., Balestra, G. M., & Harms, F. A. (2020) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000719 · Cited by 25 · see citing works

Physioxic human cell culture improves viability, metabolism, and mitochondrial morphology while reducing DNA damage

Timpano, S., Guild, B. D., Specker, E. J., Melanson, G., Medeiros, P. J., Sproul, S. L. J., & Uniacke, J. (2019) · The FASEB Journal · doi:10.1096/fj.201802279r · Cited by 25 · see citing works

Clostridioides difficile strain-dependent and strain-independent adaptations to a microaerobic environment

Weiss, A., Lopez, C. A., Beavers, W. N., Rodriguez, J., & Skaar, E. P. (2021) · Microbial Genomics · doi:10.1099/mgen.0.000738 · Cited by 23 · see citing works

Toward Best Practices for Controlling Mammalian Cell Culture Environments

Klein, S. G., Steckbauer, A., Alsolami, S. M., Arossa, S., Parry, A. J., Li, M., & Duarte, C. M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.788808 · Cited by 23 · see citing works

Redox and metal profiles in human coronary endothelial and smooth muscle cells under hyperoxia, physiological normoxia and hypoxia: Effects of NRF2 signaling on intracellular zinc

Smith, M. J., Yang, F., Griffiths, A., Morrell, A. P., Chapple, S. J., Siow, R. C. M., Stewart, T. J., Maret, W., & Mann, G. E. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102712 · Cited by 23 · see citing works

Revisiting reactive oxygen species production in hypoxia

Alva, R., Wiebe, J. E., & Stuart, J. A. (2024) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-024-02986-1 · Cited by 25 · see citing works

Environmental and behavioral regulation of HIF-mitochondria crosstalk

Burtscher, J., Hohenauer, E., Burtscher, M., Millet, G. P., & Egg, M. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.06.015 · Cited by 23 · see citing works

RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis

Pode‐Shakked, N., Slack, M., Sundaram, N., Schreiber, R., McCracken, K. W., Dekel, B., Helmrath, M. A., & Kopan, R. (2023) · Nature Communications · doi:10.1038/s41467-023-43795-x · Cited by 22 · see citing works

An Experimentally Defined Hypoxia Gene Signature in Glioblastoma and Its Modulation by Metformin

Tardón, M. C., Marinari, E., Migliorini, D., Bes, V., Tankov, S., Charrier, E., McKee, T., Dutoit, V., Dietrich, P., Cosset, E. C., et al. (2020) · Biology · doi:10.3390/biology9090264 · Cited by 20 · see citing works

Pros and cons of NRF2 activation as adjunctive therapy in rheumatoid arthritis

Manda, G., Milanesi, E., Genç, Ş., Niculite, C. M., Neagoe, I. V., Tastan, B., Dragnea, E. M., & Cuadrado, A. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.08.012 · Cited by 22 · see citing works

Culture of Cancer Cells at Physiological Oxygen Levels Affects Gene Expression in a Cell-Type Specific Manner

Alva, R., Moradi, F., Liang, P., & Stuart, J. A. (2022) · Biomolecules · doi:10.3390/biom12111684 · Cited by 21 · see citing works

Stress Activated MAP Kinases and Cyclin-Dependent Kinase 5 Mediate Nuclear Translocation of Nrf2 via Hsp90α-Pin1-Dynein Motor Transport Machinery

Ishii, T., Warabi, E., & Mann, G. E. (2023) · Antioxidants · doi:10.3390/antiox12020274 · Cited by 21 · see citing works

Metal profiling in coronary ischemia-reperfusion injury: Implications for KEAP1/NRF2 regulated redox signaling

Yang, F., & Smith, M. J. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.11.013 · Cited by 21 · see citing works

Primary culture of mouse adipose and fibrous synovial fibroblasts under normoxic and hypoxic conditions

Sugimoto, H., Murahashi, Y., Chijimatsu, R., Miwa, S., Yano, F., Tanaka, S., & Saito, T. (2020) · Biomedical Research · doi:10.2220/biomedres.41.43 · Cited by 20 · see citing works

Redox regulation under physiological oxygen levels

Keeley, T. P., Chapple, S. J., Siow, R. C. M., Jacob, R., & Mann, G. E. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.04.042

Defining a Model of Physiological Normoxia in Vitro: Key Factors and Considerations When Performing Research Under Low O2

Keeley, T. P., Chapple, S. J., Jacob, R., & Mann, G. E. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.10.255

Technical Feasibility and Physiological Relevance of Hypoxic Cell Culture Models

Pavlacký, J., & Polak, J. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00057 · Cited by 93 · see citing works

Supraphysiological Oxygen Levels in Mammalian Cell Culture: Current State and Future Perspectives

Alva, R., Gardner, G. L., Liang, P., & Stuart, J. A. (2022) · Cells · doi:10.3390/cells11193123 · Cited by 55 · see citing works

AN INVESTIGATION OF THE MOLECULAR AND CELLULAR BIOLOGY OF HUMAN PHYSIOXIC CELL CULTURE

Timpano, S. (2018) · The Atrium (University of Guelph)