Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours
Open accessAbstract
Branched-chain amino acids (BCAAs) supply both carbon and nitrogen in pancreatic cancers, and increased levels of BCAAs have been associated with increased risk of pancreatic ductal adenocarcinomas (PDACs). It remains unclear, however, how stromal cells regulate BCAA metabolism in PDAC cells and how mutualistic determinants control BCAA metabolism in the tumour milieu. Here, we show distinct catabolic, oxidative and protein turnover fluxes between cancer-associated fibroblasts (CAFs) and cancer cells, and a marked reliance on branched-chain α-ketoacid (BCKA) in PDAC cells in stroma-rich tumours. We report that cancer-induced stromal reprogramming fuels this BCKA demand. The TGF-β-SMAD5 axis directly targets BCAT1 in CAFs and dictates internalization of the extracellular matrix from the tumour microenvironment to supply amino-acid precursors for BCKA secretion by CAFs. The in vitro results were corroborated with circulating tumour cells (CTCs) and PDAC tissue slices derived from people with PDAC. Our findings reveal therapeutically actionable targets in pancreatic stromal and cancer cells.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lysophosphatidylcholines are hydrolyzed by autotaxin released from cancer cells to provide lysophosphatidic acid, which promotes PDAC proliferation and migration.
“Among these lysophosphatidylcholines are hydrolyzed by autotaxin released from cancer cells to provide the potent signaling molecule lysophosphatidic acid, which promotes PDAC proliferation and migration254”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [254]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Tissue-based map of the human proteome
Uhlén, M., Fagerberg, L., Hallström, B. M., Lindskog, C., Oksvold, P., Mardinoglu, A., Sivertsson, Å., Kampf, C., Sjöstedt, E., Asplund, A., et al. (2015) · Science · doi:10.1126/science.1260419 · Cited by 15,286 · see citing works
Integrating single-cell transcriptomic data across different conditions, technologies, and species
Butler, A., Hoffman, P., Smibert, P., Papalexi, E., & Satija, R. (2018) · Nature Biotechnology · doi:10.1038/nbt.4096 · Cited by 13,174 · see citing works
Genomic analyses identify molecular subtypes of pancreatic cancer
Bailey, P., Chang, D. K., Nones, K., Johns, A. L., Patch, A.-M., Gingras, M.-C., Miller, D. K., Christ, A. N., Bruxner, T. J. C., Quinn, M. C., et al. (2016) · Nature · doi:10.1038/nature16965 · Cited by 3,621 · see citing works
Self-citationDistinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
Öhlund, D., Handly-Santana, A., Biffi, G., Elyada, E., Almeida, A. S., Ponz-Sarvise, M., Corbo, V., Oni, T. E., Hearn, S. A., Lee, E. J., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162024 · Cited by 2,590 · see citing works
Allard, W. J., Matera, J., Miller, M. C., Repollet, M., Connelly, M. C., Rao, C., Tibbe, A. G. J., Uhr, J. W., & Terstappen, L. W. M. M. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-0378 · Cited by 2,542 · see citing works
Elyada, E., Bolisetty, M., Laise, P., Flynn, W. F., Courtois, E. T., Burkhart, R. A., Teinor, J. A., Belleau, P., Biffi, G., Lucito, M. S., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0094 · Cited by 2,241 · see citing works
Organoid models of human and mouse ductal pancreatic cancer
Boj, S. F., Hwang, C.-I., Baker, L. A., Chio, I. I. C., Engle, D. D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M. S., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.021 · Cited by 2,150 · see citing works
SUnSET, a nonradioactive method to monitor protein synthesis
Schmidt, E. K., Clavarino, G., Ceppi, M., & Pierre, P. (2009) · Nature Methods · doi:10.1038/nmeth.1314 · Cited by 1,706 · see citing works
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Commisso, C., Davidson, S. M., Soydaner-Azeloglu, R. G., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C. B., et al. (2013) · Nature · doi:10.1038/nature12138 · Cited by 1,683 · see citing works
Biffi, G., Oni, T. E., Spielman, B., Hao, Y., Elyada, E., Park, Y., Preall, J., & Tuveson, D. A. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-0710 · Cited by 1,360 · see citing works
Peng, J., Sun, B.-F., Chen, C.-Y., Zhou, J.-Y., Chen, Y.-S., Chen, H., Liu, L., Huang, D., Jiang, J., Cui, G.-S., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0195-y · Cited by 1,321 · see citing works
Sherman, M. H., Yu, R. T., Engle, D. D., Ding, N., Atkins, A. R., Tiriac, H., Collisson, E. A., Connor, F., Van Dyke, T., Kozlov, S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.007 · Cited by 1,158 · see citing works
Self-citationPancreatic stellate cells support tumour metabolism through autophagic alanine secretion
Sousa, C. M., Biancur, D. E., Wang, X., Halbrook, C. J., Sherman, M. H., Zhang, L., Kremer, D., Hwang, R. F., Witkiewicz, A. K., Ying, H., et al. (2016) · Nature · doi:10.1038/nature19084 · Cited by 1,122 · see citing works
Self-citationTumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism
Zhao, H., Yang, L., Baddour, J., Achreja, A., Bernard, V., Moss, T., Marini, J. C., Tudawe, T., Seviour, E. G., San Lucas, F. A., et al. (2016) · eLife · doi:10.7554/elife.10250 · Cited by 927 · see citing works
Self-citationCarcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells
Mishra, P. J., Mishra, P. J., Humeniuk, R., Medina, D. J., Alexe, G., Mesirov, J. P., Ganesan, S., Glod, J. W., & Banerjee, D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0943 · Cited by 912 · see citing works
Kamphorst, J. J., Nofal, M., Commisso, C., Hackett, S. R., Lu, W., Grabocka, E., Vander Heiden, M. G., Miller, G., Drebin, J. A., Bar-Sagi, D., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2211 · Cited by 893 · see citing works
A case of cancer in which cells similar to those in the tumours were seen in the blood after death
Ashworth, T. G. (1869) · Medical Entomology and Zoology · Cited by 848 · see citing works
Stromal biology and therapy in pancreatic cancer
Neeße, A., Michl, P., Frese, K. K., Feig, C., Cook, N., Jacobetz, M. A., Lolkema, M. P., Buchholz, M., Olive, K. P., Gress, T. M., et al. (2010) · Gut · doi:10.1136/gut.2010.226092 · Cited by 758 · see citing works
Tissue of origin dictates branched-chain amino acid metabolism in mutant <i>Kras</i> -driven cancers
Mayers, J. R., Torrence, M. E., Danai, L. V., Papagiannakopoulos, T., Davidson, S. M., Bauer, M. R., Lau, A. N., Ji, B. W., Dixit, P. D., Hosios, A. M., et al. (2016) · Science · doi:10.1126/science.aaf5171 · Cited by 582 · see citing works
Stromal biology and therapy in pancreatic cancer: a changing paradigm
Neeße, A., Algül, H., Tuveson, D. A., & Gress, T. M. (2015) · Gut · doi:10.1136/gutjnl-2015-309304 · Cited by 562 · see citing works
Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids
Neinast, M. D., Jang, C., Hui, S. T., Murashige, D., Chu, Q., Morscher, R. J., Li, X., Zhan, L., White, E., Anthony, T. G., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.10.013 · Cited by 500 · see citing works
BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1
Tönjes, M., Barbus, S., Park, Y. J., Wang, W., Schlotter, M., Lindroth, A. M., Pleier, S. V., Bai, A. H. C., Karra, D., Piro, R. M., et al. (2013) · Nature Medicine · doi:10.1038/nm.3217 · Cited by 486 · see citing works
Kim, Y.-R., Lee, E.-J., Shin, K., Kim, M. H., Pewzner‐Jung, Y., Lee, Y.-M., Park, J., Futerman, A. H., & Park, W. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0340-1 · Cited by 477 · see citing works
Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis
Green, C. R., Wallace, M., Divakaruni, A. S., Phillips, S. A., Murphy, A. N., Ciaraldi, T. P., & Metallo, C. M. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.1961 · Cited by 471 · see citing works
Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer
Halbrook, C. J., Pontious, C., Kovalenko, I., Lapienyte, L., Dreyer, S., Lee, H.-J., Thurston, G., Zhang, Y., Lazarus, J., Sajjakulnukit, P., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.02.001 · Cited by 419 · see citing works
Self-citationOlivares, O., Mayers, J. R., Gouirand, V., Torrence, M. E., Gicquel, T., Borge, L., Lac, S., Roques, J., Lavaut, M.-N., Berthezène, P., et al. (2017) · Nature Communications · doi:10.1038/ncomms16031 · Cited by 413 · see citing works
Yeung, T.-L., Leung, C. S., Wong, K., Samimi, G., Thompson, M. S., Liu, J., Zaid, T. M., Ghosh, S., Birrer, M. J., & Mok, S. C. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0023 · Cited by 394 · see citing works
Bernard, V., Semaan, A., Huang, J. H., Lucas, F. A. S., Mulu, F. C., Stephens, B. M., Guerrero, P. A., Huang, Y., Zhao, J., Kamyabi, N., et al. (2018) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-1955 · Cited by 387 · see citing works
Self-citationBCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation
Raffel, S., Falcone, M., Kneisel, N., Hansson, J., Wang, W., Lutz, C., Bullinger, L., Poschet, G., Nonnenmacher, Y., Barnert, A., et al. (2017) · Nature · doi:10.1038/nature24294 · Cited by 354 · see citing works
A Stromal Lysolipid–Autotaxin Signaling Axis Promotes Pancreatic Tumor Progression
Auciello, F. R., Bulusu, V., Oon, C., Tait-Mulder, J., Berry, M., Bhattacharyya, S., Tumanov, S., Allen-Petersen, B. L., Link, J., Kendsersky, N. D., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1212 · Cited by 332 · see citing works
Self-citationGenomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
Dey, P., Baddour, J., Muller, F., Wu, C. C., Wang, H., Liao, W.-T., Lan, Z., Chen, A., Gutschner, T., Kang, Y., et al. (2017) · Nature · doi:10.1038/nature21052 · Cited by 264 · see citing works
Self-citationBCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma
Li, J., Yin, M., Wang, D., Wang, J., Lei, M., Zhang, Y., Liu, Y., Zhang, L., Zou, S., Hu, L.-P., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-019-0455-6 · Cited by 248 · see citing works
A Six-Gene Signature Predicts Survival of Patients with Localized Pancreatic Ductal Adenocarcinoma
Stratford, J. K., Bentrem, D. J., Anderson, J. M., Fan, C., Volmar, K. A., Marron, J. S., Routh, E. D., Caskey, L. S., Samuel, J. C., Der, C. J., et al. (2010) · PLoS Medicine · doi:10.1371/journal.pmed.1000307 · Cited by 243 · see citing works
Lu, G., Sun, H., She, P., Youn, J.-Y., Warburton, S., Ping, P., Vondriska, T. M., Cai, H. “., Lynch, C. J., & Wang, Y. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38151 · Cited by 226 · see citing works
Experimental microdissection enables functional harmonisation of pancreatic cancer subtypes
Maurer, C., Holmstrom, S. R., He, J., Laise, P., Su, T., Ahmed, A., Hibshoosh, H., Chabot, J. A., Oberstein, P. E., Sepulveda, A. R., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-317706 · Cited by 216 · see citing works
Pancreatic Cancer Metabolism: Breaking It Down to Build It Back Up
Perera, R. M., & Bardeesy, N. M. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0671 · Cited by 213 · see citing works
Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma
Janky, R., Binda, M. M., Allemeersch, J., den broeck, A. V., Govaere, O., Swinnen, J. V., Roskams, T., Aerts, S., & Topal, B. (2016) · BMC Cancer · doi:10.1186/s12885-016-2540-6 · Cited by 202 · see citing works
Bhagat, T. D., Ahrens, D. V., Dawlaty, M. M., Zou, Y., Baddour, J., Achreja, A., Zhao, H., Yang, L., Patel, B., Kwak, C., et al. (2019) · eLife · doi:10.7554/elife.50663 · Cited by 170 · see citing works
Self-citationDeoxycytidine release from pancreatic stellate cells promotes gemcitabine resistance
Dalin, S., Sullivan, M. R., Lau, A. N., Grauman-Boss, B., Mueller, H. S., Kreidl, E., Fenoglio, S., Luengo, A., Lees, J. A., Vander Heiden, M. G., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-0960 · Cited by 156 · see citing works
Stromal cues regulate the pancreatic cancer epigenome and metabolome
Sherman, M. H., Yu, R. T., Tseng, T. W., Sousa, C. M., Liu, S., Truitt, M. L., He, N., Ding, N., Liddle, C., Atkins, A. R., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620164114 · Cited by 147 · see citing works
Self-citationAltered exocrine function can drive adipose wasting in early pancreatic cancer
Danai, L. V., Babic, A., Rosenthal, M. H., Dennstedt, E. A., Muir, A., Lien, E. C., Mayers, J. R., Tai, K., Lau, A. N., Jones-Sali, P., et al. (2018) · Nature · doi:10.1038/s41586-018-0235-7 · Cited by 141 · see citing works
Cancer Metabolism Drives a Stromal Regenerative Response
Schwörer, S., Vardhana, S. A., & Thompson, C. B. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.015 · Cited by 121 · see citing works
Bilan, D. S., Matlashov, M. E., Gorokhovatsky, A. Y., Schultz, C., Enikolopov, G., & Belousov, V. V. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.11.018 · Cited by 121 · see citing works
High-Throughput Microfluidic Labyrinth for the Label-free Isolation of Circulating Tumor Cells
Lin, E., Rivera-Báez, L., Fouladdel, S., Yoon, H. J., Guthrie, S. M., Wieger, J., Deol, Y. S., Keller, E. T., Sahai, V., Simeone, D. M., et al. (2017) · Cell Systems · doi:10.1016/j.cels.2017.08.012 · Cited by 121 · see citing works
Self-citationThe Non-phagocytic Route of Collagen Uptake
Madsen, D. H., Ingvarsen, S. Z., Jürgensen, H. J., Melander, M. C., Kjøller, L., Moyer, A., Honoré, C., Madsen, C. A., Garred, P., Burgdorf, S., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.208033 · Cited by 113 · see citing works
Franco-Barraza, J., Francescone, R., Luong, T., Shah, N., Madhani, R., Cukierman, G., Dulaimi, E., Devarajan, K., Egleston, B. L., Nicolas, E., et al. (2017) · eLife · doi:10.7554/elife.20600 · Cited by 112 · see citing works
Self-citationBranched-chain amino acids sustain pancreatic cancer growth by regulating lipid metabolism
Lee, J. H., Cho, Y.-R., Kim, J. H., Kim, J.-W., Nam, H. Y., Kim, S. W., & Son, J. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0350-z · Cited by 111 · see citing works
Opportunities and Challenges for Pancreatic Circulating Tumor Cells
Nagrath, S., Jack, R. M., Sahai, V., & Simeone, D. M. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.05.052 · Cited by 73 · see citing works
Self-citationRoife, D., Dai, B., Kang, Y., Perez, M. V. R., Pratt, M. F., Li, X., & Fleming, J. B. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2936 · Cited by 68 · see citing works
ROBO2 is a stroma suppressor gene in the pancreas and acts via TGF-β signalling
Pinho, A. V., Bulck, M. V., Chantrill, L. A., Arshi, M., Sklyarova, T., Herrmann, D., Vennin, C., Gallego‐Ortega, D., Mawson, A., Giry-Laterrière, M., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07497-z · Cited by 64 · see citing works
Rivera-Báez, L., Lohse, I., Lin, E., Raghavan, S. A., Owen, S., Harouaka, R. A., Herman, K., Mehta, G., Lawrence, T. S., Morgan, M. A., et al. (2020) · Cancers · doi:10.3390/cancers12041011 · Cited by 51 · see citing works
Self-citationEpigenetic changes in fibroblasts drive cancer metabolism and differentiation
Mishra, R., Haldar, S., Suchanti, S., & Bhowmick, N. A. (2019) · Endocrine Related Cancer · doi:10.1530/erc-19-0347 · Cited by 46 · see citing works
A continuous 96-well plate spectrophotometric assay for branched-chain amino acid aminotransferases
Cooper, A. J. L., Conway, M. E., & Hutson, S. M. (2002) · Analytical Biochemistry · doi:10.1016/s0003-2697(02)00243-9 · Cited by 42 · see citing works
Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic CancerPreprint
Halbrook, C. J., Pontious, C., Lee, H., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/463125 · Cited by 41 · see citing works
Pon, A., Jewison, T., Su, Y., Liang, Y., Knox, C., Maciejewski, A., Wilson, M., & Wishart, D. S. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv399 · Cited by 33 · see citing works
Ex-vivo evaluation of gene therapy vectors in human pancreatic (cancer) tissue slices
van Geer, M. A., Kuhlmann, K. F. D., Bakker, C., ten Kate, F. J. W., Elferink, R. P. J. O., & Bosma, P. J. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.1359 · Cited by 30 · see citing works
Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins
Jürgensen, H. J., Nørregaard, K. S., Sibree, M., Santoni‐Rugiu, E., Madsen, D. H., Wassilew, K., Krustrup, D., Garred, P., Bugge, T. H., Engelholm, L. H., et al. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201802148 · Cited by 19 · see citing works
Grankvist, N., Lagerborg, K. A., Jain, M., & Nilsson, R. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b01031 · Cited by 18 · see citing works
Sprangers, S., Behrendt, N., Engelholm, L. H., Cao, Y., & Everts, V. E. (2016) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25821 · Cited by 17 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cancer metabolism: looking forward
Martínez‐Reyes, I., & Chandel, N. S. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00378-6 · Cited by 1,852 · see citing works
The hallmarks of cancer metabolism: still emerging
Pavlova, N. N., Zhu, J., & Thompson, C. B. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.01.007 · Cited by 1,418 · see citing works
Pancreatic cancer: Advances and challenges
Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321 · see citing works
Self-citationYuan, Z., Li, Y., Zhang, S., Wang, X., Dou, H., Yu, X., Zhang, Z., Yang, S., & Xiao, M. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01744-8 · Cited by 977 · see citing works
Amino acid metabolism in health and disease
Ling, Z., Jiang, Y.-F., Ru, J.-N., Lu, J.-H., Ding, B., & Wu, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01569-3 · Cited by 574 · see citing works
Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives
Fang, Z., Meng, Q., Xu, J., Wang, W., Zhang, B., Liu, J., Liang, C., Hua, J., Zhao, Y., Yu, X., et al. (2022) · 癌症:英文版 · doi:10.1002/cac2.12392 · Cited by 292 · see citing works
TGF-β signaling in the tumor metabolic microenvironment and targeted therapies
Shi, X., Yang, J., Deng, S., Xu, H., Wu, D., Zeng, Q., Wang, S., Hu, T., Wu, F., & Zhou, H. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01349-6 · Cited by 262 · see citing works
Multifaceted role of branched-chain amino acid metabolism in cancer
Peng, H., Wang, Y., & Luo, W. (2020) · Oncogene · doi:10.1038/s41388-020-01480-z · Cited by 244 · see citing works
Helms, E. J., Berry, M. W., Chaw, R. C., DuFort, C. C., Sun, D., Onate, M. K., Oon, C., Bhattacharyya, S., Sanford-Crane, H., Horton, W., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0601 · Cited by 238 · see citing works
Self-citationMetabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment
Kerk, S. A., Papagiannakopoulos, T. Y., Shah, Y. M., & Lyssiotis, C. A. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00375-9 · Cited by 238 · see citing works
Cancer-associated fibroblasts: The chief architect in the tumor microenvironment
Sarkar, M., Nguyen, T., Gundre, E., Ogunlusi, O., El-Sobky, M. H., Giri, B., & Sarkar, T. R. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1089068 · Cited by 135 · see citing works
Role of hypoxia in the tumor microenvironment and targeted therapy
Chen, G., Wu, K., Li, H., Xia, D., & He, T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.961637 · Cited by 141 · see citing works
LaRue, M. M., Parker, S. J., Puccini, J., Cammer, M., Kimmelman, A. C., & Bar‐Sagi, D. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2119168119 · Cited by 120 · see citing works
Luo, L., Sun, W., Zhu, W., Li, S., Zhang, W., Xu, X., Fang, D., Grahn, T. H. M., Jiang, L., & Zheng, Y. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03456-7 · Cited by 101 · see citing works
Yao, C.-C., Sun, R.-M., Yang, Y., Zhou, H., Meng, Z., Chi, R., Xia, L., Ji, P., Chen, Y., Zhang, G., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112186 · Cited by 97 · see citing works
Yuan, M., Tu, B., Li, H., Pang, H., Zhang, N., Fan, M., Bai, J., Wang, W., Shu, Z., DuFort, C. C., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00426-6 · Cited by 96 · see citing works
Hyaluronic acid fuels pancreatic cancer cell growth
Kim, P. K., Halbrook, C. J., Kerk, S. A., Radyk, M., Wisner, S., Kremer, D. M., Sajjakulnukit, P., Andren, A., Hou, S. W., Trivedi, A., et al. (2021) · eLife · doi:10.7554/elife.62645 · Cited by 92 · see citing works
Amino acid metabolism, redox balance and epigenetic regulation in cancer
Li, X., & Zhang, H. (2024) · The FEBS Journal · doi:10.1111/febs.16803 · Cited by 90 · see citing works
Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression
Lin, Q., Li, N., Lu, X., Xu, M., Liu, Y., Li, K., Zhang, Y., Hu, K., Qi, Y.-T., Yao, J., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00818-7 · Cited by 89 · see citing works
Circulating tumor cells in precision medicine: challenges and opportunities
Rupp, B., Ball, H. G., Wuchu, F., Nagrath, D., & Nagrath, S. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2022.02.005 · Cited by 86 · see citing works
Self-citationFibroblast pyruvate carboxylase is required for collagen production in the tumour microenvironment
Schwörer, S., Pavlova, N. N., Cimino, F. V., King, B., Cai, X., Sizemore, G. M., & Thompson, C. B. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00480-x · Cited by 85 · see citing works
Peng, Z., Tong, Z., Ren, Z., Ye, M.-P., & Hu, K.-W. (2023) · Molecular Medicine · doi:10.1186/s10020-023-00665-y · Cited by 74 · see citing works
Tumor microenvironmental nutrients, cellular responses, and cancer
Lobel, G. P., Jiang, Y., & Simon, M. C. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.08.011 · Cited by 74 · see citing works
Carvalho, T. M. A., Molfetta, D. D., Greco, M. R., Koltai, T., Alfarouk, K. O., Reshkin, S. J., & Cardone, R. A. (2021) · Cancers · doi:10.3390/cancers13236135 · Cited by 69 · see citing works
Targeting PIKfyve-driven lipid metabolism in pancreatic cancer
Cheng, C., Hu, J., Mannan, R., He, T., Bhattacharyya, R., Magnuson, B., Wisniewski, J. P., Peters, S., Karim, S., MacLean, D. J., et al. (2025) · Nature · doi:10.1038/s41586-025-08917-z · Cited by 61 · see citing works
Self-citationRadiotherapy-induced metabolic hallmarks in the tumor microenvironment
Mittal, A., Nenwani, M., Sarangi, I., Achreja, A., Lawrence, T. S., & Nagrath, D. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.05.005 · Cited by 69 · see citing works
Self-citationInterplays of glucose metabolism and KRAS mutation in pancreatic ductal adenocarcinoma
Liu, Y.-H., Hu, C., Hsu, Y.-S., & Lee, W. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05259-w · Cited by 66 · see citing works
KRAS mutation: The booster of pancreatic ductal adenocarcinoma transformation and progression
Zhang, Z., Zhang, H., Liao, X., & Tsai, H. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1147676 · Cited by 62 · see citing works
Bo, T., & Fujii, J. (2024) · Molecules · doi:10.3390/molecules30010056 · Cited by 65 · see citing works
Li, J., Li, K.-Y., Su, Y., Shen, Y., Lei, M., Zhang, F., Yin, M., Chen, Z., Wen, W., Hu, W., et al. (2021) · National Science Review · doi:10.1093/nsr/nwab212 · Cited by 59 · see citing works
The tumor microenvironment is an ecosystem sustained by metabolic interactions
Kay, E. J., & Zanivan, S. R. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115432 · Cited by 60 · see citing works
Targeting BCAT1 Combined with α-Ketoglutarate Triggers Metabolic Synthetic Lethality in Glioblastoma
Zhang, B., Peng, H., Zhou, M., Bao, L., Wang, C., Cai, F., Zhang, H., Wang, J. E., Niu, Y.-L., Chen, Y., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-3868 · Cited by 59 · see citing works
The extracellular matrix in cancer: from understanding to targeting
Chitty, J. L., & Cox, T. R. (2025) · Trends in cancer · doi:10.1016/j.trecan.2025.05.003 · Cited by 56 · see citing works
Exploring the Clinical Utility of Pancreatic Cancer Circulating Tumor Cells
Yeo, D., Bastian, A., Strauss, H., Saxena, P., Grimison, P., & Rasko, J. E. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031671 · Cited by 55 · see citing works
Nong, X.-Z., Zhang, C., Wang, J., Ding, P., Ji, G., & Wu, T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.988290 · Cited by 55 · see citing works
Zhang, F., Hu, G., Chen, X., Zhang, L., Guo, L., Li, C., Zhao, H., Cui, Z., Guo, X., Sun, F., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00971-7 · Cited by 54 · see citing works
Rewiring of cortical glucose metabolism fuels human brain cancer growth
Scott, A. J., Mittal, A., Meghdadi, B., O’Brien, A. M., Bailleul, J., Palavalasa, S., Achreja, A., Zhou, W., Xu, J., Lin, A., et al. (2025) · Nature · doi:10.1038/s41586-025-09460-7 · Cited by 55 · see citing works
Self-citationTransporters at the Interface between Cytosolic and Mitochondrial Amino Acid Metabolism
Hewton, K. G., Johal, A. S., & Parker, S. J. (2021) · Metabolites · doi:10.3390/metabo11020112 · Cited by 49 · see citing works
The role of branched chain amino acids metabolic disorders in tumorigenesis and progression
Wang, J., Wang, W., Zhu, F., & Duan, Q. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113390 · Cited by 47 · see citing works
Immunometabolism – The Role of Branched-Chain Amino Acids
Yahsi, B., & Günaydın, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.886822 · Cited by 46 · see citing works
Han, K., Xie, F., Animasahun, O. H., Nenwani, M., Kitamoto, S., Kim, Y., Phoo, M. T., Xu, J., Wuchu, F., Omoloja, K., et al. (2024) · Nature Materials · doi:10.1038/s41563-024-01909-w · Cited by 48 · see citing works
Self-citationEmerging role for branched-chain amino acids metabolism in fibrosis
Wu, T., Wang, M., Ning, F., Zhou, S., Hu, X., Xin, H., Reilly, S. N., & Zhang, X. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106604 · Cited by 44 · see citing works
Metabolic adaptations of cancer in extreme tumor microenvironments
Nakahara, R., Maeda, K., Aki, S., & Osawa, T. (2023) · Cancer Science · doi:10.1111/cas.15722 · Cited by 44 · see citing works
Metabolic Pathways, Enzymes, and Metabolites: Opportunities in Cancer Therapy
Kumar, R., Mishra, A., Gautam, P., Feroz, Z., Vijayaraghavalu, S., Likos, E., Shukla, G. C., & Kumar, M. (2022) · Cancers · doi:10.3390/cancers14215268 · Cited by 48 · see citing works
Zhan, P., Shu, X., Chen, M., Sun, L., Yu, L., Liu, J., Sun, L., Yang, Z., & Ran, Y. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119405 · Cited by 41 · see citing works
RetractedBiswas, D., Slade, L., Duffley, L., Mueller, N., Dao, K. T., Mercer, A., Pakkiriswami, S., Hiani, Y. E., Kienesberger, P. C., & Pulinilkunnil, T. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00602-0 · Cited by 41 · see citing works
Raghavan, K. S., Francescone, R., Franco-Barraza, J., Gardiner, J. C., Vendramini-Costa, D. B., Luong, T., Pourmandi, N., Andren, A., Kurimchak, A., Ogier, C., et al. (2022) · Cancer Research Communications · doi:10.1158/2767-9764.crc-21-0147 · Cited by 40 · see citing works
Self-citationShafer, M., Low, V., Li, Z., & Blenis, J. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2025.01.005 · Cited by 40 · see citing works
Mechanisms Governing Metabolic Heterogeneity in Breast Cancer and Other Tumors
Patra, S., Elahi, N., Armorer, A., Arunachalam, S., Omala, J., Hamid, I., Ashton, A. W., Joyce, D. A., Jiao, X., & Pestell, R. G. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.700629 · Cited by 41 · see citing works
Whole-body metabolic fate of branched-chain amino acids
Blair, M. C., Neinast, M. D., & Arany, Z. P. (2021) · Biochemical Journal · doi:10.1042/bcj20200686 · Cited by 38 · see citing works
Metabolic profile of the Warburg effect as a tool for molecular prognosis and diagnosis of cancer
Nava, G. M., & Pérez, L. A. M. (2022) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2022.2065196 · Cited by 39 · see citing works
Amino acid metabolism in tumor: New shine in the fog?
Qiu, H., Shao, N., Liu, J., Zhao, J.-J., Chen, C., Li, Q., He, Z., Zhao, X., & Xu, L. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.06.011 · Cited by 38 · see citing works
Molecular and Metabolic Subtypes Correspondence for Pancreatic Ductal Adenocarcinoma Classification
Espiau-Romera, P., Courtois, S., Parejo-Alonso, B., & Sancho, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9124128 · Cited by 38 · see citing works
Murphy, K. J., Chambers, C. R., Herrmann, D., Timpson, P., & Pereira, B. (2021) · Cancers · doi:10.3390/cancers13143481 · Cited by 38 · see citing works
Cancer metabolism and dietary interventions
Qian, L., Zhang, F., Yin, M., & Lei, Q. (2021) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2021.0461 · Cited by 43 · see citing works
Pancreatic cancer: branched-chain amino acids as putative key metabolic regulators?
Rossmeislová, L., Gojda, J., & Smolková, K. (2021) · Cancer and Metastasis Reviews · doi:10.1007/s10555-021-10016-0 · Cited by 38 · see citing works
Cancer-Associated Fibroblast Diversity Shapes Tumor Metabolism in Pancreatic Cancer
Peiffer, R., Boumahd, Y., Gullo, C., Crake, R., Letellier, E., Bellahcène, A., & Peulen, O. (2022) · Cancers · doi:10.3390/cancers15010061 · Cited by 37 · see citing works
Achreja, A., Yu, T., Mittal, A., Choppara, S., Animasahun, O. H., Nenwani, M., Wuchu, F., Meurs, N., Mohan, A., Jeon, J. H., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00636-3 · Cited by 36 · see citing works
Self-citationProgress in research on the role of amino acid metabolic reprogramming in tumour therapy: A review
Wang, D., & Wan, X. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113923 · Cited by 34 · see citing works
Chen, A., Sun, X. Y., Xiao, S., Guo, L., Shang, M., Shi, D., Meng, D., Zhao, Y., Wang, X., & Li, J. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01979-z · Cited by 34 · see citing works
Chowdhury, T., Cressiot, B., Parisi, C., Smolyakov, G., Thiébot, B., Trichet, L., Fernandes, F. M., Pelta, J., & Manivet, P. (2023) · ACS Sensors · doi:10.1021/acssensors.2c02308 · Cited by 33 · see citing works
Li, X., Zhou, J., Wang, X., Li, C., Ma, Z., Wan, Q., & Fu, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1152312 · Cited by 33 · see citing works
Chisari, A. N., Golán, I., Campisano, S., Gélabert, C., Moustakas, A., Sancho, P., & Caja, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.723798 · Cited by 32 · see citing works
Do, L. K., Lee, H. M., Ha, Y., Lee, C., & Kim, J. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115529 · Cited by 35 · see citing works
Cancer metabolism within tumor microenvironments
Aki, S., Nakahara, R., Maeda, K., & Osawa, T. (2023) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2023.130330 · Cited by 31 · see citing works
Cai, Z., Li, W., Brenner, M., Bahiraii, S., Heiß, E. H., & Weckwerth, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.966158 · Cited by 30 · see citing works
Isotope tracing in health and disease
Dong, W., Rawat, E. S., Stephanopoulos, G. N., & Abu-Remaileh, M. (2022) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2022.102739 · Cited by 26 · see citing works
The Role of the Transforming Growth Factor-β Signaling Pathway in Gastrointestinal Cancers
Matsuoka, T., & Yashiro, M. (2023) · Biomolecules · doi:10.3390/biom13101551 · Cited by 31 · see citing works
BCAT1 redox function maintains mitotic fidelity
Francois, L., Boskovic, P., Knerr, J., He, W., Sigismondo, G., Schwan, C., More, T. H., Schlotter, M., Conway, M. E., Krijgsveld, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111524 · Cited by 27 · see citing works
Gotvaldová, K., Špačková, J., Novotný, J., Baslarová, K., Ježek, P., Rossmeislová, L., Gojda, J., & Smolková, K. (2024) · Cancer & Metabolism · doi:10.1186/s40170-024-00335-5 · Cited by 27 · see citing works
Ren, J., Ren, B., Liu, X., Cui, M., Fang, Y., Wang, X., Zhou, F., Gu, M., Xiao, R., Bai, J., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216649 · Cited by 27 · see citing works
Xu, H., Wang, X., Xu, X., Liu, L., Zhang, Y., Yan, X., Zhang, Y., Dang, K., & Li, Y. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.10.019 · Cited by 26 · see citing works
Metabolic and immune crosstalk between cancer-associated fibroblasts and pancreatic cancer cells
Zhang, Q., Cao, Z., Yan, S., Chen, B., Wu, H., Cao, H., Chen, L., & Liu, Z. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-07164-0 · Cited by 27 · see citing works
Branched-chain amino acid and cancer: metabolism, immune microenvironment and therapeutic targets
Xiong, H., Liu, R., Xu, K., Chen, X., Huang, L., Shou, Y., Huang, Y., Sheng, H., Lu, Y., & Zhang, H. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06664-3 · Cited by 25 · see citing works
Ding, Y., Wang, X., Lu, S., Lai, A., Xie, B., He, X., & Liu, Q. (2022) · Journal of Molecular Histology · doi:10.1007/s10735-022-10108-3 · Cited by 25 · see citing works
Ibrahim, S. L., Abed, M. N., Mohamed, G. G., Price, J. C., Abdullah, M. I., & Richardson, A. (2022) · British Journal of Cancer · doi:10.1038/s41416-022-02095-9 · Cited by 25 · see citing works
Hu, G., Cui, Z., Chen, X., Sun, F., Li, T., Li, C., Zhang, L., Guo, X., Zhao, H., Xia, Y., et al. (2023) · Advanced Science · doi:10.1002/advs.202206439 · Cited by 24 · see citing works
Dietary Manipulation of Amino Acids for Cancer Therapy
Jiménez‐Alonso, J. J., & López‐Lázaro, M. (2023) · Nutrients · doi:10.3390/nu15132879 · Cited by 24 · see citing works
Li, M., Freeman, S. R., Franco‐Barraza, J., Cai, K. Q., Kim, A., Jin, S., Cukierman, E., & Ye, K. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122631 · Cited by 22 · see citing works
Self-citationPancreatic stellate cells regulate branched-chain amino acid metabolism in pancreatic cancer
Jiang, W., Qiao, L., Han, Y., Zhang, A., An, H., Xiao, J., & Ren, L. (2021) · Annals of Translational Medicine · doi:10.21037/atm-21-761 · Cited by 21 · see citing works
Oyón, D., López-Pascual, A., Castelló-Uribe, B., Uriarte, I., Orsi, G., Llorente, S., Elurbide, J., Adán-Villaescusa, E., Valbuena-Goiricelaya, E., Irigaray-Miramon, A., et al. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-024-03268-5 · Cited by 21 · see citing works
Jonker, P. B., & Muir, A. (2024) · Disease Models & Mechanisms · doi:10.1242/dmm.050814 · Cited by 20 · see citing works
Wang, W., Li, Y., Tang, L., Shi, Y., Li, W., Zou, L., Zhang, L., Cheng, Y., Zheng, Y., Zhu, F., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216849 · Cited by 18 · see citing works
Ma, Q., Li, H., Song, Z., Deng, Z., Huang, W., & Liu, Q. (2024) · Metabolism · doi:10.1016/j.metabol.2024.156016 · Cited by 18 · see citing works
Mei, W., Wei, M., Tang, C., Li, W., Ye, B., Xin, S., Ma, W., & Ye, L. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07559-3 · Cited by 20 · see citing works
Ahmed, D. W., Tan, M. L., Liu, Y., Gabbard, J., Gao, E., Roy, A., Hu, M. M., Midekssa, F. S., Stevens, M., Wuchu, F., et al. (2025) · Nature Materials · doi:10.1038/s41563-025-02329-0 · Cited by 18 · see citing works
Self-citationThe Role of Stroma in Cancer MetabolismPreprint
Kimmelman, A. C., & Sherman, M. H. (2023) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a041540 · Cited by 18 · see citing works
Self-citationBoskovic, P., Wilke, N., Man, K.-H., Lichter, P., Francois, L., & Radlwimmer, B. (2023) · Neuro-Oncology · doi:10.1093/neuonc/noad190 · Cited by 18 · see citing works
What’s on the menu?: metabolic constraints in the pancreatic tumor microenvironment
Sheehan, C. S., & Muir, A. (2025) · Journal of Clinical Investigation · doi:10.1172/jci191940 · Cited by 18 · see citing works
Protein lipoylation in cancer: metabolic reprogramming and therapeutic potential
Li, S., Liu, Y., Hu, W., Deng, A., Ren, X., Chen, L., Lu, Y., Wu, Y., Huang, H., Cao, J., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02718-z · Cited by 17 · see citing works
The role of amino acid metabolism alterations in pancreatic cancer: From mechanism to application
Fu, S., Xu, S., & Zhang, S. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188893 · Cited by 17 · see citing works
Xue, M., Xiao, J., Jiang, W., Wang, Y., Zuo, D., An, H., & Ren, L. (2023) · Translational Oncology · doi:10.1016/j.tranon.2023.101696 · Cited by 17 · see citing works
Monteiro, M. V., Henriques‐Pereira, M., Neves, B. M., Duarte, I. D., Gaspar, V. M., & Mano, J. F. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202305473 · Cited by 17 · see citing works
Lyu, P., Gu, X., Wang, F., Sun, H., Zhou, Q., Yang, S., & Yuan, W. (2024) · Biomarker Research · doi:10.1186/s40364-024-00622-9 · Cited by 17 · see citing works
Epigenetic Mechanisms beyond Tumour–Stroma Crosstalk
Gagliano, T., & Brancolini, C. (2021) · Cancers · doi:10.3390/cancers13040914 · Cited by 17 · see citing works
Cancer knocks you out by fasting: Cachexia as a consequence of metabolic alterations in cancer
Cortellino, S., D’Angelo, M., Quintiliani, M., & Giordano, A. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31417 · Cited by 17 · see citing works
Research progress on the multi-omics and survival status of circulating tumor cells
Xie, Q., Liu, S., Zhang, S., Liao, L., Xiao, Z., Wang, S., & Zhang, P. (2024) · Clinical and Experimental Medicine · doi:10.1007/s10238-024-01309-z · Cited by 15 · see citing works
Metabolic pathways fuelling protumourigenic cancer-associated fibroblast functions
Kay, E. J., & Zanivan, S. R. (2021) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2021.100377 · Cited by 15 · see citing works
Graham, S., Dmitrieva, M., Costa, D. B. V., Francescone, R., Trujillo, M. A. M., Cukierman, E., & Wood, L. D. (2024) · Carcinogenesis · doi:10.1093/carcin/bgae064 · Cited by 15 · see citing works
Self-citationRegulation of metabolism in pancreatic ductal adenocarcinoma via nanotechnology-enabled strategies
Wang, Z., Wu, B., Nie, G., Wei, J., & Li, Y. (2023) · Cancer Letters · doi:10.1016/j.canlet.2023.216138 · Cited by 14 · see citing works
- Authors
- Zhu, Z., Achreja, A., Meurs, N., Animasahun, O., Owen, S., Mittal, A., Parikh, P., Lo, T.-W., Franco-Barraza, J., Shi, J., Gunchick, V., Sherman, M. H., Cukierman, E., Pickering, A. M., Maitra, A., Sahai, V., Morgan, M. A., Nagrath, S., Lawrence, T. S., & Nagrath, D.
- Affiliations
- University of Michigan (US)
- Oregon Health & Science University (US)
- Fox Chase Cancer Center (US)
- The University of Texas at San Antonio Health Science Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Nagrath, Deepak
- ORCID
- Venue
- Nature Metabolism
- Published
- 2020-07-06
- Volume
- 2
- Issue
- 8
- Pages
- 775-792
- ISSN
- 2522-5812 (ISSN-L)
- PMC
- PMC7438275
- OpenAlex
- W3040562565
- Cited by
- 204
- References
- 59
- Citations by year
- 2026: 31 · 2025: 36 · 2024: 37 · 2023: 34 · 2022: 33 · 2021: 27 · 2020: 6
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- Locations
- Nature Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Health & Human Services | NIH | National Cancer Institute (K08 CA234222, R01CA208335, R01CA227622, R01CA222251, R01CA204969)
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- pancreatic ductal adenocarcinoma, branched-chain amino acids, branched-chain keto acids, BCAT1, cancer-associated fibroblasts, tumor stroma, TGF-beta, Smad5, extracellular matrix degradation, tumor microenvironment, cancer metabolism, circulating tumor cells
- MeSH terms
- Cancer-Associated Fibroblasts, Amino Acids, Branched-Chain, Transaminases, Energy Metabolism, Humans, Keto Acids, Oxidation-Reduction, Pancreatic Neoplasms, Tumor Stem Cell Assay, Gene Expression Regulation, Neoplastic, Transforming Growth Factor beta, Stromal Cells, Computational Biology, Carcinoma, Pancreatic Ductal, Smad5 Protein, Gene Knockdown Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review