Multifunctional oncolytic nanoparticles deliver self-replicating IL-12 RNA to eliminate established tumors and prime systemic immunity

Cluster analysis and display of genome-wide expression patterns

Eisen, M. B., Spellman, P. T., Brown, P. O., & Botstein, D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.25.14863 · Cited by 16,184

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

Wolchok, J. D., Chiarion-Sileni, V., Gonzalez, R., Rutkowski, P., Grob, J.-J., Cowey, C. L., Lao, C. D., Wagstaff, J., Schadendorf, D., Ferrucci, P. F., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1709684 · Cited by 5,357

Elements of cancer immunity and the cancer–immune set point

Chen, D. S., & Mellman, I. (2017) · Nature · doi:10.1038/nature21349 · Cited by 5,352

The future of immune checkpoint therapy

Sharma, P., & Allison, J. P. (2015) · Science · doi:10.1126/science.aaa8172 · Cited by 4,878

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221

Calreticulin exposure dictates the immunogenicity of cancer cell death

Obeid, M., Tesniere, A., Ghiringhelli, F., Fimia, G. M., Apetoh, L., Perfettini, J.-L., Castedo, M., Mignot, G., Panaretakis, T., Casares, N., et al. (2007) · Nature Medicine · doi:10.1038/nm1523 · Cited by 3,216

Immunogenic cell death in cancer and infectious disease

Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., et al. (2007) · Nature Medicine · doi:10.1038/nm1622 · Cited by 3,056

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

Andtbacka, R. H. I., Kaufman, H. L., Collichio, F. A., AMATRUDA, T. T., Senzer, N. N., Chesney, J. A., Delman, K. A., S̄pitler, L. E., Puzanov, I. J., Agarwala, S. S., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.58.3377 · Cited by 2,728

PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

Zou, W., Wolchok, J. D., & Chen, L. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad7118 · Cited by 2,400

Toward precision immunotherapy: In vivo gene editing of T, NK, and myeloid cells

Nguyen, K. H., Das, S., & Matosevic, S. (2026) · Med · doi:10.1016/j.medj.2025.100992 · Cited by 1

2-arm-PEG-Oligocations Transiently Shield the Liver Sinusoids to Mitigate Off-Target Hepatic Expression of mRNA Lipid Nanoparticles

Dirisala, A., Chatterjee, B., Nguyen, L. B. T., Toh, K., Matsui-Masai, M., Abbasi, S., Liu, X., Tockary, T. A., Qiao, N., Ishikawa, J., et al. (2026) · ACS Nano · doi:10.1021/acsnano.6c08403 · Cited by 1

mRNA Lipid Nanoparticles for Cell Engineering in Vivo and in Vitro: Current Applications and Future Directions

Li, L., Wang, M., Ye, X., Liu, Z., Duan, Y., Chen, X., Ouyang, Y., Wu, Q., Sun, M., & Xie, T. (2026) · MedComm · doi:10.1002/mco2.70700 · Cited by 1

Engineering a Synthetic RNA Segregation System

Hürtgen, D., Mascarenhas, J., Vibhute, M. A., Weise, L. I., Mayr, V., Sourjik, V., & Mutschler, H. (2023) · ChemSystemsChem · doi:10.1002/syst.202200028 · Cited by 1

pIL-12 delivered by polymer based nanovector for anti-tumor genetherapy

Wen, L., Zan, X., Pang, Q., Hu, Y., Zheng, S., Ran, M., Gao, X., Wang, X., & Wang, B. (2023) · Chinese Chemical Letters · doi:10.1016/j.cclet.2023.108224 · Cited by 1

Targeted delivery of interleukin‐12 plasmid into HepG2 cells through folic acid conjugated graphene oxide nanocarrier

Safari, F., Bardania, H., Dehshahri, A., Hallaj‐Nezhadi, S., Asfaram, A., Mohammadi, V., Baneshi, M., Bahramianpour, S., Akrami, N., Khalvati, B., et al. (2024) · Biotechnology Progress · doi:10.1002/btpr.3473 · Cited by 1

Molecular and Macroscopic Therapeutic Systems for Cytokine‐Based Cancer Immunotherapy

Jin, S. M., Lee, S. N., Yoo, Y. J., & Lim, Y. T. (2021) · Advanced Therapeutics · doi:10.1002/adtp.202100026 · Cited by 1

Engineering the Immune Adaptor Protein STING as a BiologicPreprint

Sun, X., Ni, Y., He, Y., Yang, M., Tani, T., Kitajima, S., Barbie, D. A., & Li, J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.02.18.431824 · Cited by 1

Cap-independent co-expression of dsRNA-sensing and NF-κB pathway inhibitors enables tunable self-amplifying RNA expression with reduced immunotoxicityPreprint

Lim, T. K. Y., Ritoux, A., Paine, L. W., Ferguson, L., Abdul, T., Grundy, L. J., & Smith, E. S. J. (2025) · eLife · doi:10.7554/elife.105978.2 · Cited by 1

Engineering tumor-homing bacteria as membrane-anchored immune checkpoint-blockade interfacesPreprint

Wang, Z., Fang, C., Zhou, X., Yang, S., Shah, Y. M., Romee, R., Moon, J. J., & Li, J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.10.731477 · Cited by 1

Engineered devices for tumor microenvironment immune modulation

Cryer, A. M., & Artzi, N. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-90949-5.00005-x

Vacinas baseadas em RNA mensageiro formuladas em nanopartículas lipídicas para tratamento de tumores induzidos pelo HPV-16.

da Silva, J. R. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2021.tde-17032022-102622

Nanoparticles as Gene Vectors in Tumor Therapy

Triantafyllopoulou, E., Kontogiannis, O., Lаgopati, N., Pippa, Ν., & Gazouli, M. (2023) · Wiley eBooks · doi:10.1002/9781394175635.ch9

Evaluation of Modified Vaccinia virus Ankara based locoregional immunotherapy in peritoneal carcinomatosis models

Bella, Á. (2024) · Deposito Adademico Digital Universidad De Navarra (University of Navarra) · doi:10.15581/10171/69184

Combined vaccination of personalized neoantigens and shared MICB α3 antigen enhances the antitumor response by eliciting ILC1s-mediated tumor pyroptosisPreprint

Liu, X., Cai, Z., Ye, H., Chen, G., Dong, X., Li, Z., Lin, F., Huang, T., Qiu, L., Lin, G., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-5451996/v1

Self-replicating nanomaterials as a new generation of smart nanostructures

Hasanzadeh, A., Saeedi, S., Dastanpour, L., Biabanaki, Z. S., Asadi, L., Noori, H., Hamblin, M. R., Liu, Y., & Karimi, M. (2025) · Biotechnology Advances · doi:10.1016/j.biotechadv.2025.108565

Broad-spectrum immune suppression encoded in self-amplifying RNA enables non-cytotoxic, non-immunostimulatory, externally controllable transgene expressionPreprint

Lim, T. K. Y., Ritoux, A., Paine, L. W., Ferguson, L., Abdul, T., & Smith, E. S. J. (2025) · eLife · doi:10.7554/elife.105978.1

Down-regulation of colon mucin production induced by Eimeria pragensis infection in mice

Setia, Y. D., Tanaka, M., Tanaka, R., Yoshida, A., Nagayasu, E., AHMADI, P., Yoshida, A., & Maruyama, H. (2025) · Frontiers in Parasitology · doi:10.3389/fpara.2025.1621486

Alphavirus replicon particle expressing IL-12 reprograms tumor-associated macrophages and neutrophils and induces anti-tumor immunityPreprint

Ishikawa, M., Nambiar, D. K., Sastri, J., Bowling, F., Ishimoto, K., Tao, F., Takahashi, K., Stephanek, I., Cao, H., Leitner, D., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.07.666585

Biomimetic universal CAR-mesenchymal stem cell nanohybrids for anti-tumor therapy

Yang, L.-Y., Huang, M., Zheng, X., Liu, M., Wu, Q., & Fan, X. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.11.004

Shooting two hawks with one arrow: manganese-doped mesoporous carriers coordinate STING activation and enhanced mRNA translation for in situ cytokine delivery

Yan, Y., Chen, L., Wu, Y., Qu, X., Ma, X., Sun, X., Xiang, G., & Lu, Y. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102802

Targeting IL-12 for pancreatic cancer immunotherapy: advances in delivery strategies and clinical translation

Schlatter, J. N., Wei, W., Chen, Y., Melse, A., Wang, Y., Guerra, S., & Oberholzer, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1755796

Neoantigens and shared MICB α3 antigen dual-targeted vaccine generates potent antitumor immunity

Tang, R., Ye, H., Chen, G., Dong, X., Li, Z., Lin, F., Huang, T., Qiu, L., Lin, G., Wu, M., et al. (2026) · EMBO Molecular Medicine · doi:10.1038/s44321-026-00424-6

mRNA-LNP vaccine providing antigen and co-stimulation in the tumor microenvironment enhances CAR T cell function (CART-Vac)

Nakashima, I., Saito, S., Zhao, J., Tanaka, M., Akahoshi, E., Hasegawa, A., Ishihara‐Sugano, M., Yagyu, S., & NAKAZAWA, Y. (2026) · Molecular Therapy Oncology · doi:10.1016/j.omton.2026.201234

Advances in RNA-Based Therapeutics in Oncology

Lopes-Cardoso, H., Panão-Costa, J., Amaral, A. T., Soares-Gonçalves, J., Neves, B. F., Voronovska, A., Batista, A., Biscaia-Caleiras, M., Fonseca, N. A., Simões, S., et al. (2026) · Springer handbooks · doi:10.1007/978-3-032-01636-2_19

GSH-Responsive PBAE Polymers for IL-12 mRNA Delivery in Melanoma Immunotherapy

Bao, X., Xu, Z., Wang, X., Zhang, T., Ye, H., & Yang, H. (2026) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.67.5.57

The self-replicating RNA platform expands to cancer immunotherapy with next-generation Eastern equine encephalitis virus vectors

Lundstrom, K. H. (2026) · Molecular Therapy · doi:10.1016/j.ymthe.2026.06.005

Polymeric Nanomedicines for Comprehensive Regulation of Tumor Microenvironment

Li, H., Wu, R.-Y., Mao, X.-T., Zhou, X.-R., Hao, K., & Tian, H.-Y. (2026) · Chinese Journal of Polymer Science · doi:10.1007/s10118-026-3678-6

T cell exhaustion: a two-sided blade in systemic lupus erythematosus, from molecular mechanisms to clinical translation

Bi, Y., Wu, F., Mao, J., Azad, T., Liu, P., Zhou, X. Y., Xie, H., Hong, K., Qiu, X., Li, B., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1871551

Nanotechnology-based self-amplifying RNA

Deng, Q., Zhou, H., Zhao, S., Zhu, J., Xie, Z., Li, L., Xu, Y., Huang, Y., Dong, P., Cao, T., et al. (2026) · iPharma · doi:10.1016/j.iphar.2026.100006

Emerging mRNA-based nanomedicines for cancer immunotherapy

Yu, C., Wu, X., Luo, S., Wang, H., Huang, C., Zhang, L., & Zhu, D. (2026) · Chinese Chemical Letters · doi:10.1016/j.cclet.2026.113288

mRNA Delivery with Lipopolymers to Rejuvenate TRAIL Therapy for Lung Cancer Treatment

Remant, K. C., Nasrullah, M., Sundaram, D. N. M., Patel, D., Sandhu, G., Kucharski, C., & Uludağ, H. (2026) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6c00483

Cytokine-based cancer therapy: Materials, strategies, and prospects

Zhou, R., Wang, Z., Li, Z.-H., An, Y., Shan, B., Gong, Q., & Wu, F. (2026) · Nano Today · doi:10.1016/j.nantod.2026.103205

Intravenous administration of IL-12 encoding self-replicating RNA-lipid nanoparticle complex leads to safe and effective antitumor responses

Wang, Z., Chen, Y., Wu, H., Wang, M., Mao, L., Guo, X., Zhu, J., Ye, Z., Luo, X., Yang, X., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-57997-w · Cited by 28

Source Data of Fig. 5h

Li, Y., Irvine, D. J., & Weiss, R. (2020) · Figshare · doi:10.6084/m9.figshare.12502124

Source Data of Fig. 3g

Li, Y., Irvine, D. J., & Weiss, R. (2020) · Figshare · doi:10.6084/m9.figshare.12502007

Morphology of DOTAP and TT3 lipid nanoparticles with or without self-replicating RNA

Li, Y., Irvine, D. J., & Weiss, R. (2020) · Figshare · doi:10.6084/m9.figshare.12498047

Pseudovirus for immunotherapy

Kepp, O., & Kroemer, G. (2020) · Nature Cancer · doi:10.1038/s43018-020-00107-2 · Cited by 4